Amino acid dipepetide frequency for Dehalogenimonas alkenigignens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.149AlaAla: 14.149 ± 0.29	1.312AlaCys: 1.312 ± 0.05	5.367AlaAsp: 5.367 ± 0.094	7.296AlaGlu: 7.296 ± 0.158	3.573AlaPhe: 3.573 ± 0.086	9.127AlaGly: 9.127 ± 0.157	1.464AlaHis: 1.464 ± 0.058	5.703AlaIle: 5.703 ± 0.114	3.988AlaLys: 3.988 ± 0.094	10.01AlaLeu: 10.01 ± 0.174	2.555AlaMet: 2.555 ± 0.061	2.557AlaAsn: 2.557 ± 0.09	3.803AlaPro: 3.803 ± 0.102	2.858AlaGln: 2.858 ± 0.075	6.187AlaArg: 6.187 ± 0.135	5.583AlaSer: 5.583 ± 0.099	4.587AlaThr: 4.587 ± 0.126	8.675AlaVal: 8.675 ± 0.156	1.147AlaTrp: 1.147 ± 0.049	2.408AlaTyr: 2.408 ± 0.078	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.05	0.203CysCys: 0.203 ± 0.02	0.593CysAsp: 0.593 ± 0.036	0.481CysGlu: 0.481 ± 0.028	0.425CysPhe: 0.425 ± 0.029	1.453CysGly: 1.453 ± 0.056	0.388CysHis: 0.388 ± 0.03	0.515CysIle: 0.515 ± 0.033	0.396CysLys: 0.396 ± 0.028	1.063CysLeu: 1.063 ± 0.047	0.203CysMet: 0.203 ± 0.021	0.368CysAsn: 0.368 ± 0.028	1.0CysPro: 1.0 ± 0.048	0.468CysGln: 0.468 ± 0.03	0.982CysArg: 0.982 ± 0.047	0.61CysSer: 0.61 ± 0.037	0.499CysThr: 0.499 ± 0.025	0.702CysVal: 0.702 ± 0.042	0.123CysTrp: 0.123 ± 0.015	0.35CysTyr: 0.35 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.661AspAla: 4.661 ± 0.099	0.597AspCys: 0.597 ± 0.039	2.41AspAsp: 2.41 ± 0.076	3.484AspGlu: 3.484 ± 0.097	2.393AspPhe: 2.393 ± 0.064	3.767AspGly: 3.767 ± 0.095	0.826AspHis: 0.826 ± 0.035	3.854AspIle: 3.854 ± 0.094	2.377AspLys: 2.377 ± 0.065	5.427AspLeu: 5.427 ± 0.101	1.187AspMet: 1.187 ± 0.046	1.638AspAsn: 1.638 ± 0.055	2.453AspPro: 2.453 ± 0.068	1.401AspGln: 1.401 ± 0.053	3.242AspArg: 3.242 ± 0.092	2.78AspSer: 2.78 ± 0.069	2.58AspThr: 2.58 ± 0.075	3.339AspVal: 3.339 ± 0.082	0.719AspTrp: 0.719 ± 0.037	1.755AspTyr: 1.755 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	6.534GluAla: 6.534 ± 0.135	0.615GluCys: 0.615 ± 0.038	2.602GluAsp: 2.602 ± 0.073	3.861GluGlu: 3.861 ± 0.103	2.337GluPhe: 2.337 ± 0.07	3.879GluGly: 3.879 ± 0.092	1.236GluHis: 1.236 ± 0.058	4.373GluIle: 4.373 ± 0.092	3.848GluLys: 3.848 ± 0.1	6.697GluLeu: 6.697 ± 0.142	1.822GluMet: 1.822 ± 0.061	2.174GluAsn: 2.174 ± 0.07	2.587GluPro: 2.587 ± 0.076	2.019GluGln: 2.019 ± 0.058	3.887GluArg: 3.887 ± 0.11	3.406GluSer: 3.406 ± 0.081	3.611GluThr: 3.611 ± 0.082	4.442GluVal: 4.442 ± 0.096	0.651GluTrp: 0.651 ± 0.037	1.858GluTyr: 1.858 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.337PheAla: 3.337 ± 0.08	0.548PheCys: 0.548 ± 0.035	2.397PheAsp: 2.397 ± 0.066	2.228PheGlu: 2.228 ± 0.067	1.686PhePhe: 1.686 ± 0.061	3.513PheGly: 3.513 ± 0.102	0.789PheHis: 0.789 ± 0.043	2.889PheIle: 2.889 ± 0.086	1.938PheLys: 1.938 ± 0.057	3.487PheLeu: 3.487 ± 0.09	0.951PheMet: 0.951 ± 0.043	1.6PheAsn: 1.6 ± 0.054	1.718PhePro: 1.718 ± 0.055	1.145PheGln: 1.145 ± 0.049	2.154PheArg: 2.154 ± 0.056	2.665PheSer: 2.665 ± 0.071	2.332PheThr: 2.332 ± 0.072	2.322PheVal: 2.322 ± 0.066	0.533PheTrp: 0.533 ± 0.036	1.129PheTyr: 1.129 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	7.515GlyAla: 7.515 ± 0.148	1.17GlyCys: 1.17 ± 0.057	3.707GlyAsp: 3.707 ± 0.083	4.77GlyGlu: 4.77 ± 0.097	3.669GlyPhe: 3.669 ± 0.095	6.851GlyGly: 6.851 ± 0.145	1.68GlyHis: 1.68 ± 0.06	5.877GlyIle: 5.877 ± 0.123	4.391GlyLys: 4.391 ± 0.104	8.488GlyLeu: 8.488 ± 0.154	2.208GlyMet: 2.208 ± 0.058	2.357GlyAsn: 2.357 ± 0.079	2.433GlyPro: 2.433 ± 0.064	2.513GlyGln: 2.513 ± 0.071	5.06GlyArg: 5.06 ± 0.107	4.478GlySer: 4.478 ± 0.115	4.21GlyThr: 4.21 ± 0.102	6.095GlyVal: 6.095 ± 0.111	1.103GlyTrp: 1.103 ± 0.05	2.74GlyTyr: 2.74 ± 0.083	0.0GlyXaa: 0.0 ± 0.0
His	1.404HisAla: 1.404 ± 0.057	0.267HisCys: 0.267 ± 0.026	0.963HisAsp: 0.963 ± 0.044	0.987HisGlu: 0.987 ± 0.044	0.835HisPhe: 0.835 ± 0.043	1.477HisGly: 1.477 ± 0.056	0.543HisHis: 0.543 ± 0.039	1.152HisIle: 1.152 ± 0.041	0.708HisLys: 0.708 ± 0.033	2.17HisLeu: 2.17 ± 0.066	0.323HisMet: 0.323 ± 0.024	0.664HisAsn: 0.664 ± 0.041	1.272HisPro: 1.272 ± 0.053	0.737HisGln: 0.737 ± 0.035	1.303HisArg: 1.303 ± 0.053	1.076HisSer: 1.076 ± 0.043	0.842HisThr: 0.842 ± 0.039	1.061HisVal: 1.061 ± 0.043	0.249HisTrp: 0.249 ± 0.023	0.611HisTyr: 0.611 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.703IleAla: 6.703 ± 0.132	0.708IleCys: 0.708 ± 0.034	4.003IleAsp: 4.003 ± 0.086	4.456IleGlu: 4.456 ± 0.099	2.159IlePhe: 2.159 ± 0.064	5.447IleGly: 5.447 ± 0.114	1.145IleHis: 1.145 ± 0.047	4.603IleIle: 4.603 ± 0.108	3.092IleLys: 3.092 ± 0.08	5.637IleLeu: 5.637 ± 0.135	1.383IleMet: 1.383 ± 0.052	2.146IleAsn: 2.146 ± 0.062	3.007IlePro: 3.007 ± 0.071	1.644IleGln: 1.644 ± 0.052	3.574IleArg: 3.574 ± 0.083	4.073IleSer: 4.073 ± 0.086	3.712IleThr: 3.712 ± 0.109	4.487IleVal: 4.487 ± 0.097	0.642IleTrp: 0.642 ± 0.033	1.551IleTyr: 1.551 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.799LysAla: 4.799 ± 0.117	0.582LysCys: 0.582 ± 0.04	2.361LysAsp: 2.361 ± 0.07	3.159LysGlu: 3.159 ± 0.082	1.482LysPhe: 1.482 ± 0.054	3.222LysGly: 3.222 ± 0.079	0.895LysHis: 0.895 ± 0.047	2.95LysIle: 2.95 ± 0.073	2.74LysLys: 2.74 ± 0.078	4.821LysLeu: 4.821 ± 0.113	1.279LysMet: 1.279 ± 0.053	1.649LysAsn: 1.649 ± 0.055	2.482LysPro: 2.482 ± 0.085	1.441LysGln: 1.441 ± 0.051	2.89LysArg: 2.89 ± 0.067	2.72LysSer: 2.72 ± 0.075	3.09LysThr: 3.09 ± 0.079	3.435LysVal: 3.435 ± 0.082	0.523LysTrp: 0.523 ± 0.033	1.39LysTyr: 1.39 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	11.03LeuAla: 11.03 ± 0.178	0.983LeuCys: 0.983 ± 0.043	5.463LeuAsp: 5.463 ± 0.103	6.211LeuGlu: 6.211 ± 0.129	3.854LeuPhe: 3.854 ± 0.12	8.29LeuGly: 8.29 ± 0.136	1.629LeuHis: 1.629 ± 0.052	6.002LeuIle: 6.002 ± 0.123	5.764LeuLys: 5.764 ± 0.116	9.531LeuLeu: 9.531 ± 0.188	2.01LeuMet: 2.01 ± 0.067	3.31LeuAsn: 3.31 ± 0.082	5.536LeuPro: 5.536 ± 0.1	2.344LeuGln: 2.344 ± 0.066	5.719LeuArg: 5.719 ± 0.122	7.113LeuSer: 7.113 ± 0.137	5.501LeuThr: 5.501 ± 0.094	6.964LeuVal: 6.964 ± 0.122	1.014LeuTrp: 1.014 ± 0.046	2.203LeuTyr: 2.203 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.787MetAla: 2.787 ± 0.077	0.161MetCys: 0.161 ± 0.016	1.103MetAsp: 1.103 ± 0.048	1.334MetGlu: 1.334 ± 0.051	0.742MetPhe: 0.742 ± 0.041	1.755MetGly: 1.755 ± 0.059	0.316MetHis: 0.316 ± 0.026	1.243MetIle: 1.243 ± 0.047	1.491MetLys: 1.491 ± 0.048	2.368MetLeu: 2.368 ± 0.068	0.704MetMet: 0.704 ± 0.041	0.9MetAsn: 0.9 ± 0.042	1.562MetPro: 1.562 ± 0.046	0.559MetGln: 0.559 ± 0.03	1.265MetArg: 1.265 ± 0.045	1.49MetSer: 1.49 ± 0.06	1.613MetThr: 1.613 ± 0.055	2.0MetVal: 2.0 ± 0.071	0.207MetTrp: 0.207 ± 0.022	0.486MetTyr: 0.486 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.655AsnAla: 2.655 ± 0.081	0.417AsnCys: 0.417 ± 0.029	1.315AsnAsp: 1.315 ± 0.056	1.687AsnGlu: 1.687 ± 0.056	1.257AsnPhe: 1.257 ± 0.051	2.395AsnGly: 2.395 ± 0.088	0.606AsnHis: 0.606 ± 0.036	2.295AsnIle: 2.295 ± 0.073	1.354AsnLys: 1.354 ± 0.053	3.556AsnLeu: 3.556 ± 0.075	0.782AsnMet: 0.782 ± 0.039	1.169AsnAsn: 1.169 ± 0.06	2.205AsnPro: 2.205 ± 0.068	1.052AsnGln: 1.052 ± 0.047	2.045AsnArg: 2.045 ± 0.055	1.747AsnSer: 1.747 ± 0.064	1.782AsnThr: 1.782 ± 0.058	2.085AsnVal: 2.085 ± 0.067	0.434AsnTrp: 0.434 ± 0.027	1.025AsnTyr: 1.025 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.022ProAla: 5.022 ± 0.091	0.432ProCys: 0.432 ± 0.03	2.99ProAsp: 2.99 ± 0.064	3.941ProGlu: 3.941 ± 0.085	1.958ProPhe: 1.958 ± 0.061	4.487ProGly: 4.487 ± 0.101	0.798ProHis: 0.798 ± 0.041	2.324ProIle: 2.324 ± 0.067	1.905ProLys: 1.905 ± 0.069	4.168ProLeu: 4.168 ± 0.083	1.063ProMet: 1.063 ± 0.048	1.504ProAsn: 1.504 ± 0.06	2.616ProPro: 2.616 ± 0.094	1.564ProGln: 1.564 ± 0.054	2.324ProArg: 2.324 ± 0.065	2.849ProSer: 2.849 ± 0.087	2.435ProThr: 2.435 ± 0.064	4.171ProVal: 4.171 ± 0.092	0.575ProTrp: 0.575 ± 0.031	1.256ProTyr: 1.256 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.622GlnAla: 3.622 ± 0.085	0.265GlnCys: 0.265 ± 0.023	1.277GlnAsp: 1.277 ± 0.054	1.637GlnGlu: 1.637 ± 0.051	1.034GlnPhe: 1.034 ± 0.048	2.014GlnGly: 2.014 ± 0.058	0.586GlnHis: 0.586 ± 0.036	1.9GlnIle: 1.9 ± 0.061	1.502GlnLys: 1.502 ± 0.047	2.841GlnLeu: 2.841 ± 0.077	0.86GlnMet: 0.86 ± 0.045	1.085GlnAsn: 1.085 ± 0.042	1.58GlnPro: 1.58 ± 0.055	1.109GlnGln: 1.109 ± 0.051	1.894GlnArg: 1.894 ± 0.068	1.789GlnSer: 1.789 ± 0.062	1.733GlnThr: 1.733 ± 0.055	2.399GlnVal: 2.399 ± 0.065	0.325GlnTrp: 0.325 ± 0.024	0.764GlnTyr: 0.764 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.055ArgAla: 5.055 ± 0.119	0.851ArgCys: 0.851 ± 0.039	3.012ArgAsp: 3.012 ± 0.075	3.785ArgGlu: 3.785 ± 0.09	2.43ArgPhe: 2.43 ± 0.076	4.157ArgGly: 4.157 ± 0.093	1.424ArgHis: 1.424 ± 0.047	3.858ArgIle: 3.858 ± 0.091	2.918ArgLys: 2.918 ± 0.082	7.405ArgLeu: 7.405 ± 0.137	1.488ArgMet: 1.488 ± 0.055	1.782ArgAsn: 1.782 ± 0.058	2.555ArgPro: 2.555 ± 0.07	2.54ArgGln: 2.54 ± 0.072	4.77ArgArg: 4.77 ± 0.118	3.215ArgSer: 3.215 ± 0.084	2.76ArgThr: 2.76 ± 0.069	4.298ArgVal: 4.298 ± 0.094	0.742ArgTrp: 0.742 ± 0.04	1.981ArgTyr: 1.981 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	5.676SerAla: 5.676 ± 0.115	0.758SerCys: 0.758 ± 0.038	2.725SerAsp: 2.725 ± 0.075	3.172SerGlu: 3.172 ± 0.081	2.439SerPhe: 2.439 ± 0.076	6.071SerGly: 6.071 ± 0.12	1.196SerHis: 1.196 ± 0.044	3.643SerIle: 3.643 ± 0.097	2.315SerLys: 2.315 ± 0.068	6.24SerLeu: 6.24 ± 0.117	1.453SerMet: 1.453 ± 0.051	1.687SerAsn: 1.687 ± 0.066	3.081SerPro: 3.081 ± 0.083	1.952SerGln: 1.952 ± 0.057	4.057SerArg: 4.057 ± 0.083	3.562SerSer: 3.562 ± 0.088	2.885SerThr: 2.885 ± 0.079	4.228SerVal: 4.228 ± 0.102	0.624SerTrp: 0.624 ± 0.035	1.484SerTyr: 1.484 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.817ThrAla: 5.817 ± 0.142	0.575ThrCys: 0.575 ± 0.032	2.867ThrAsp: 2.867 ± 0.087	3.197ThrGlu: 3.197 ± 0.089	2.107ThrPhe: 2.107 ± 0.08	5.378ThrGly: 5.378 ± 0.114	0.976ThrHis: 0.976 ± 0.036	3.239ThrIle: 3.239 ± 0.084	1.892ThrLys: 1.892 ± 0.072	5.126ThrLeu: 5.126 ± 0.09	1.109ThrMet: 1.109 ± 0.046	1.497ThrAsn: 1.497 ± 0.058	3.126ThrPro: 3.126 ± 0.074	1.424ThrGln: 1.424 ± 0.054	2.93ThrArg: 2.93 ± 0.07	3.09ThrSer: 3.09 ± 0.092	3.059ThrThr: 3.059 ± 0.107	4.38ThrVal: 4.38 ± 0.129	0.577ThrTrp: 0.577 ± 0.038	1.384ThrTyr: 1.384 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	7.358ValAla: 7.358 ± 0.143	0.9ValCys: 0.9 ± 0.041	3.598ValAsp: 3.598 ± 0.08	4.632ValGlu: 4.632 ± 0.105	3.259ValPhe: 3.259 ± 0.086	4.901ValGly: 4.901 ± 0.107	1.219ValHis: 1.219 ± 0.05	5.578ValIle: 5.578 ± 0.091	3.874ValLys: 3.874 ± 0.094	6.891ValLeu: 6.891 ± 0.128	1.891ValMet: 1.891 ± 0.056	2.428ValAsn: 2.428 ± 0.076	3.391ValPro: 3.391 ± 0.076	1.76ValGln: 1.76 ± 0.057	3.865ValArg: 3.865 ± 0.088	4.703ValSer: 4.703 ± 0.099	4.64ValThr: 4.64 ± 0.137	5.461ValVal: 5.461 ± 0.105	0.751ValTrp: 0.751 ± 0.038	1.876ValTyr: 1.876 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.86TrpAla: 0.86 ± 0.039	0.116TrpCys: 0.116 ± 0.014	0.646TrpAsp: 0.646 ± 0.034	0.646TrpGlu: 0.646 ± 0.034	0.45TrpPhe: 0.45 ± 0.036	0.851TrpGly: 0.851 ± 0.036	0.308TrpHis: 0.308 ± 0.023	0.65TrpIle: 0.65 ± 0.038	0.443TrpLys: 0.443 ± 0.029	1.452TrpLeu: 1.452 ± 0.063	0.279TrpMet: 0.279 ± 0.022	0.47TrpAsn: 0.47 ± 0.028	0.533TrpPro: 0.533 ± 0.031	0.602TrpGln: 0.602 ± 0.035	0.778TrpArg: 0.778 ± 0.042	0.595TrpSer: 0.595 ± 0.035	0.526TrpThr: 0.526 ± 0.038	0.797TrpVal: 0.797 ± 0.034	0.276TrpTrp: 0.276 ± 0.029	0.303TrpTyr: 0.303 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.062	0.417TyrCys: 0.417 ± 0.029	1.488TyrAsp: 1.488 ± 0.054	1.475TyrGlu: 1.475 ± 0.059	1.274TyrPhe: 1.274 ± 0.048	2.281TyrGly: 2.281 ± 0.083	0.619TyrHis: 0.619 ± 0.029	1.526TyrIle: 1.526 ± 0.068	0.974TyrLys: 0.974 ± 0.046	3.094TyrLeu: 3.094 ± 0.076	0.533TyrMet: 0.533 ± 0.033	0.878TyrAsn: 0.878 ± 0.045	1.442TyrPro: 1.442 ± 0.059	1.083TyrGln: 1.083 ± 0.041	2.099TyrArg: 2.099 ± 0.062	1.706TyrSer: 1.706 ± 0.059	1.355TyrThr: 1.355 ± 0.057	1.635TyrVal: 1.635 ± 0.051	0.367TyrTrp: 0.367 ± 0.025	0.884TyrTyr: 0.884 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1927 proteins (551133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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