Amino acid dipepetide frequency for Corynebacterium stationis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.347AlaAla: 14.347 ± 0.217	0.78AlaCys: 0.78 ± 0.037	6.668AlaAsp: 6.668 ± 0.11	8.041AlaGlu: 8.041 ± 0.126	3.615AlaPhe: 3.615 ± 0.071	9.676AlaGly: 9.676 ± 0.122	2.352AlaHis: 2.352 ± 0.054	6.124AlaIle: 6.124 ± 0.104	4.2AlaLys: 4.2 ± 0.089	11.421AlaLeu: 11.421 ± 0.146	2.811AlaMet: 2.811 ± 0.066	3.143AlaAsn: 3.143 ± 0.06	4.625AlaPro: 4.625 ± 0.089	4.673AlaGln: 4.673 ± 0.088	6.182AlaArg: 6.182 ± 0.111	6.236AlaSer: 6.236 ± 0.097	6.333AlaThr: 6.333 ± 0.087	8.75AlaVal: 8.75 ± 0.113	1.501AlaTrp: 1.501 ± 0.044	2.234AlaTyr: 2.234 ± 0.061	0.001AlaXaa: 0.001 ± 0.001
Cys	0.729CysAla: 0.729 ± 0.029	0.055CysCys: 0.055 ± 0.009	0.397CysAsp: 0.397 ± 0.024	0.389CysGlu: 0.389 ± 0.022	0.203CysPhe: 0.203 ± 0.016	0.676CysGly: 0.676 ± 0.034	0.143CysHis: 0.143 ± 0.013	0.362CysIle: 0.362 ± 0.023	0.16CysLys: 0.16 ± 0.014	0.477CysLeu: 0.477 ± 0.027	0.128CysMet: 0.128 ± 0.011	0.184CysAsn: 0.184 ± 0.014	0.372CysPro: 0.372 ± 0.023	0.212CysGln: 0.212 ± 0.018	0.285CysArg: 0.285 ± 0.021	0.454CysSer: 0.454 ± 0.025	0.365CysThr: 0.365 ± 0.022	0.471CysVal: 0.471 ± 0.025	0.081CysTrp: 0.081 ± 0.009	0.14CysTyr: 0.14 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.941AspAla: 6.941 ± 0.104	0.349AspCys: 0.349 ± 0.02	3.814AspAsp: 3.814 ± 0.084	4.622AspGlu: 4.622 ± 0.09	2.286AspPhe: 2.286 ± 0.059	4.927AspGly: 4.927 ± 0.087	1.176AspHis: 1.176 ± 0.041	3.594AspIle: 3.594 ± 0.06	2.291AspLys: 2.291 ± 0.057	5.372AspLeu: 5.372 ± 0.08	1.268AspMet: 1.268 ± 0.042	2.037AspAsn: 2.037 ± 0.058	3.306AspPro: 3.306 ± 0.069	1.617AspGln: 1.617 ± 0.043	3.085AspArg: 3.085 ± 0.066	3.597AspSer: 3.597 ± 0.079	3.251AspThr: 3.251 ± 0.067	4.769AspVal: 4.769 ± 0.08	0.77AspTrp: 0.77 ± 0.036	1.593AspTyr: 1.593 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.079GluAla: 7.079 ± 0.099	0.326GluCys: 0.326 ± 0.023	4.003GluAsp: 4.003 ± 0.073	5.152GluGlu: 5.152 ± 0.083	2.376GluPhe: 2.376 ± 0.052	4.545GluGly: 4.545 ± 0.09	1.613GluHis: 1.613 ± 0.05	3.909GluIle: 3.909 ± 0.078	2.794GluLys: 2.794 ± 0.059	7.079GluLeu: 7.079 ± 0.104	1.378GluMet: 1.378 ± 0.042	2.174GluAsn: 2.174 ± 0.048	2.869GluPro: 2.869 ± 0.081	2.779GluGln: 2.779 ± 0.074	3.819GluArg: 3.819 ± 0.077	3.718GluSer: 3.718 ± 0.079	3.412GluThr: 3.412 ± 0.062	5.177GluVal: 5.177 ± 0.089	0.809GluTrp: 0.809 ± 0.035	1.545GluTyr: 1.545 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.979PheAla: 3.979 ± 0.076	0.244PheCys: 0.244 ± 0.016	2.602PheAsp: 2.602 ± 0.061	2.016PheGlu: 2.016 ± 0.052	1.332PhePhe: 1.332 ± 0.05	3.573PheGly: 3.573 ± 0.073	0.722PheHis: 0.722 ± 0.031	2.122PheIle: 2.122 ± 0.055	1.0PheLys: 1.0 ± 0.035	2.983PheLeu: 2.983 ± 0.066	0.767PheMet: 0.767 ± 0.034	1.263PheAsn: 1.263 ± 0.038	1.474PhePro: 1.474 ± 0.048	0.942PheGln: 0.942 ± 0.038	1.653PheArg: 1.653 ± 0.048	2.213PheSer: 2.213 ± 0.056	2.115PheThr: 2.115 ± 0.051	2.613PheVal: 2.613 ± 0.06	0.505PheTrp: 0.505 ± 0.026	0.87PheTyr: 0.87 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.52GlyAla: 8.52 ± 0.123	0.583GlyCys: 0.583 ± 0.028	4.35GlyAsp: 4.35 ± 0.075	5.104GlyGlu: 5.104 ± 0.082	3.355GlyPhe: 3.355 ± 0.063	6.6GlyGly: 6.6 ± 0.124	1.797GlyHis: 1.797 ± 0.046	5.177GlyIle: 5.177 ± 0.092	3.311GlyLys: 3.311 ± 0.077	7.953GlyLeu: 7.953 ± 0.105	2.192GlyMet: 2.192 ± 0.057	2.584GlyAsn: 2.584 ± 0.063	3.101GlyPro: 3.101 ± 0.066	2.779GlyGln: 2.779 ± 0.065	4.33GlyArg: 4.33 ± 0.085	4.824GlySer: 4.824 ± 0.085	5.003GlyThr: 5.003 ± 0.082	6.691GlyVal: 6.691 ± 0.093	1.31GlyTrp: 1.31 ± 0.039	2.213GlyTyr: 2.213 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.153HisAla: 2.153 ± 0.057	0.16HisCys: 0.16 ± 0.014	1.282HisAsp: 1.282 ± 0.043	1.277HisGlu: 1.277 ± 0.039	0.679HisPhe: 0.679 ± 0.027	1.818HisGly: 1.818 ± 0.045	0.605HisHis: 0.605 ± 0.032	1.138HisIle: 1.138 ± 0.037	0.627HisLys: 0.627 ± 0.029	1.956HisLeu: 1.956 ± 0.05	0.453HisMet: 0.453 ± 0.025	0.72HisAsn: 0.72 ± 0.035	1.331HisPro: 1.331 ± 0.045	0.679HisGln: 0.679 ± 0.026	1.275HisArg: 1.275 ± 0.04	1.189HisSer: 1.189 ± 0.042	1.242HisThr: 1.242 ± 0.043	1.603HisVal: 1.603 ± 0.047	0.293HisTrp: 0.293 ± 0.022	0.516HisTyr: 0.516 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.389IleAla: 7.389 ± 0.112	0.394IleCys: 0.394 ± 0.023	3.996IleAsp: 3.996 ± 0.078	3.553IleGlu: 3.553 ± 0.077	1.917IlePhe: 1.917 ± 0.057	4.868IleGly: 4.868 ± 0.075	1.012IleHis: 1.012 ± 0.033	3.287IleIle: 3.287 ± 0.083	1.726IleLys: 1.726 ± 0.051	4.473IleLeu: 4.473 ± 0.084	1.128IleMet: 1.128 ± 0.038	1.848IleAsn: 1.848 ± 0.053	2.884IlePro: 2.884 ± 0.06	1.359IleGln: 1.359 ± 0.041	2.662IleArg: 2.662 ± 0.052	3.59IleSer: 3.59 ± 0.069	3.478IleThr: 3.478 ± 0.066	4.566IleVal: 4.566 ± 0.087	0.587IleTrp: 0.587 ± 0.027	1.187IleTyr: 1.187 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.747LysAla: 3.747 ± 0.075	0.145LysCys: 0.145 ± 0.015	2.088LysAsp: 2.088 ± 0.06	2.292LysGlu: 2.292 ± 0.054	1.096LysPhe: 1.096 ± 0.038	2.178LysGly: 2.178 ± 0.059	0.835LysHis: 0.835 ± 0.033	1.858LysIle: 1.858 ± 0.045	1.957LysLys: 1.957 ± 0.064	3.454LysLeu: 3.454 ± 0.079	0.849LysMet: 0.849 ± 0.032	1.262LysAsn: 1.262 ± 0.046	1.851LysPro: 1.851 ± 0.063	1.409LysGln: 1.409 ± 0.044	2.215LysArg: 2.215 ± 0.053	2.068LysSer: 2.068 ± 0.051	2.076LysThr: 2.076 ± 0.056	2.764LysVal: 2.764 ± 0.059	0.45LysTrp: 0.45 ± 0.024	0.873LysTyr: 0.873 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.383LeuAla: 11.383 ± 0.159	0.633LeuCys: 0.633 ± 0.031	5.893LeuAsp: 5.893 ± 0.085	5.704LeuGlu: 5.704 ± 0.097	3.084LeuPhe: 3.084 ± 0.069	8.308LeuGly: 8.308 ± 0.12	1.876LeuHis: 1.876 ± 0.058	5.295LeuIle: 5.295 ± 0.1	2.942LeuLys: 2.942 ± 0.063	8.665LeuLeu: 8.665 ± 0.153	2.061LeuMet: 2.061 ± 0.055	2.923LeuAsn: 2.923 ± 0.067	4.753LeuPro: 4.753 ± 0.088	2.727LeuGln: 2.727 ± 0.061	5.684LeuArg: 5.684 ± 0.088	6.214LeuSer: 6.214 ± 0.097	5.558LeuThr: 5.558 ± 0.081	7.573LeuVal: 7.573 ± 0.112	1.145LeuTrp: 1.145 ± 0.046	1.851LeuTyr: 1.851 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.807MetAla: 2.807 ± 0.06	0.146MetCys: 0.146 ± 0.013	1.227MetAsp: 1.227 ± 0.044	1.225MetGlu: 1.225 ± 0.041	0.756MetPhe: 0.756 ± 0.03	1.797MetGly: 1.797 ± 0.047	0.438MetHis: 0.438 ± 0.023	1.126MetIle: 1.126 ± 0.034	0.824MetLys: 0.824 ± 0.037	2.234MetLeu: 2.234 ± 0.059	0.557MetMet: 0.557 ± 0.029	0.764MetAsn: 0.764 ± 0.029	1.244MetPro: 1.244 ± 0.038	0.719MetGln: 0.719 ± 0.028	1.328MetArg: 1.328 ± 0.042	1.847MetSer: 1.847 ± 0.05	1.725MetThr: 1.725 ± 0.045	1.861MetVal: 1.861 ± 0.054	0.311MetTrp: 0.311 ± 0.022	0.414MetTyr: 0.414 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.333AsnAla: 3.333 ± 0.072	0.175AsnCys: 0.175 ± 0.014	1.712AsnAsp: 1.712 ± 0.055	1.792AsnGlu: 1.792 ± 0.055	1.156AsnPhe: 1.156 ± 0.043	2.433AsnGly: 2.433 ± 0.068	0.668AsnHis: 0.668 ± 0.027	1.723AsnIle: 1.723 ± 0.051	1.145AsnLys: 1.145 ± 0.04	2.919AsnLeu: 2.919 ± 0.065	0.741AsnMet: 0.741 ± 0.032	1.182AsnAsn: 1.182 ± 0.04	2.307AsnPro: 2.307 ± 0.048	1.137AsnGln: 1.137 ± 0.043	1.749AsnArg: 1.749 ± 0.051	2.076AsnSer: 2.076 ± 0.06	1.802AsnThr: 1.802 ± 0.049	2.295AsnVal: 2.295 ± 0.053	0.469AsnTrp: 0.469 ± 0.027	0.856AsnTyr: 0.856 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.396ProAla: 5.396 ± 0.1	0.216ProCys: 0.216 ± 0.017	3.034ProAsp: 3.034 ± 0.063	4.268ProGlu: 4.268 ± 0.076	1.66ProPhe: 1.66 ± 0.044	4.041ProGly: 4.041 ± 0.075	1.073ProHis: 1.073 ± 0.032	2.198ProIle: 2.198 ± 0.053	1.658ProLys: 1.658 ± 0.048	4.089ProLeu: 4.089 ± 0.078	1.0ProMet: 1.0 ± 0.041	1.48ProAsn: 1.48 ± 0.048	1.572ProPro: 1.572 ± 0.048	2.084ProGln: 2.084 ± 0.06	2.547ProArg: 2.547 ± 0.058	2.845ProSer: 2.845 ± 0.071	2.988ProThr: 2.988 ± 0.07	4.117ProVal: 4.117 ± 0.07	0.689ProTrp: 0.689 ± 0.03	1.053ProTyr: 1.053 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.243GlnAla: 4.243 ± 0.074	0.161GlnCys: 0.161 ± 0.013	1.799GlnAsp: 1.799 ± 0.044	2.312GlnGlu: 2.312 ± 0.06	1.031GlnPhe: 1.031 ± 0.035	2.434GlnGly: 2.434 ± 0.057	0.757GlnHis: 0.757 ± 0.03	1.729GlnIle: 1.729 ± 0.05	1.107GlnLys: 1.107 ± 0.038	3.817GlnLeu: 3.817 ± 0.08	0.822GlnMet: 0.822 ± 0.032	0.883GlnAsn: 0.883 ± 0.034	1.791GlnPro: 1.791 ± 0.061	1.605GlnGln: 1.605 ± 0.062	2.567GlnArg: 2.567 ± 0.066	1.837GlnSer: 1.837 ± 0.059	1.658GlnThr: 1.658 ± 0.045	2.768GlnVal: 2.768 ± 0.061	0.592GlnTrp: 0.592 ± 0.027	0.714GlnTyr: 0.714 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.679ArgAla: 5.679 ± 0.097	0.321ArgCys: 0.321 ± 0.02	3.316ArgAsp: 3.316 ± 0.076	4.022ArgGlu: 4.022 ± 0.069	1.938ArgPhe: 1.938 ± 0.052	4.219ArgGly: 4.219 ± 0.085	1.175ArgHis: 1.175 ± 0.036	3.164ArgIle: 3.164 ± 0.066	2.222ArgLys: 2.222 ± 0.059	5.117ArgLeu: 5.117 ± 0.091	1.521ArgMet: 1.521 ± 0.048	1.849ArgAsn: 1.849 ± 0.053	2.519ArgPro: 2.519 ± 0.052	2.018ArgGln: 2.018 ± 0.047	3.973ArgArg: 3.973 ± 0.087	3.095ArgSer: 3.095 ± 0.068	3.425ArgThr: 3.425 ± 0.067	4.1ArgVal: 4.1 ± 0.075	0.828ArgTrp: 0.828 ± 0.031	1.438ArgTyr: 1.438 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.653SerAla: 6.653 ± 0.105	0.37SerCys: 0.37 ± 0.023	3.391SerAsp: 3.391 ± 0.065	3.692SerGlu: 3.692 ± 0.074	2.203SerPhe: 2.203 ± 0.052	5.364SerGly: 5.364 ± 0.08	1.27SerHis: 1.27 ± 0.039	3.147SerIle: 3.147 ± 0.06	2.13SerLys: 2.13 ± 0.059	5.529SerLeu: 5.529 ± 0.091	1.663SerMet: 1.663 ± 0.043	1.971SerAsn: 1.971 ± 0.054	3.077SerPro: 3.077 ± 0.062	2.329SerGln: 2.329 ± 0.064	3.332SerArg: 3.332 ± 0.065	4.182SerSer: 4.182 ± 0.086	4.05SerThr: 4.05 ± 0.078	4.441SerVal: 4.441 ± 0.074	0.854SerTrp: 0.854 ± 0.031	1.428SerTyr: 1.428 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.508ThrAla: 6.508 ± 0.092	0.372ThrCys: 0.372 ± 0.023	3.424ThrAsp: 3.424 ± 0.075	3.465ThrGlu: 3.465 ± 0.078	1.965ThrPhe: 1.965 ± 0.05	5.173ThrGly: 5.173 ± 0.087	1.171ThrHis: 1.171 ± 0.032	3.227ThrIle: 3.227 ± 0.074	1.928ThrLys: 1.928 ± 0.05	5.396ThrLeu: 5.396 ± 0.101	1.346ThrMet: 1.346 ± 0.041	1.79ThrAsn: 1.79 ± 0.042	3.431ThrPro: 3.431 ± 0.067	1.975ThrGln: 1.975 ± 0.051	2.912ThrArg: 2.912 ± 0.065	3.902ThrSer: 3.902 ± 0.075	3.747ThrThr: 3.747 ± 0.07	5.177ThrVal: 5.177 ± 0.077	0.876ThrTrp: 0.876 ± 0.031	1.319ThrTyr: 1.319 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	9.106ValAla: 9.106 ± 0.114	0.577ValCys: 0.577 ± 0.028	5.434ValAsp: 5.434 ± 0.085	5.481ValGlu: 5.481 ± 0.094	2.734ValPhe: 2.734 ± 0.062	6.222ValGly: 6.222 ± 0.092	1.587ValHis: 1.587 ± 0.045	4.9ValIle: 4.9 ± 0.076	2.364ValLys: 2.364 ± 0.061	7.584ValLeu: 7.584 ± 0.114	1.78ValMet: 1.78 ± 0.047	2.435ValAsn: 2.435 ± 0.058	3.666ValPro: 3.666 ± 0.068	2.184ValGln: 2.184 ± 0.044	4.134ValArg: 4.134 ± 0.079	4.868ValSer: 4.868 ± 0.075	4.849ValThr: 4.849 ± 0.083	6.956ValVal: 6.956 ± 0.111	0.942ValTrp: 0.942 ± 0.034	1.551ValTyr: 1.551 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.39TrpAla: 1.39 ± 0.051	0.118TrpCys: 0.118 ± 0.014	0.764TrpAsp: 0.764 ± 0.032	0.741TrpGlu: 0.741 ± 0.029	0.568TrpPhe: 0.568 ± 0.028	0.94TrpGly: 0.94 ± 0.036	0.298TrpHis: 0.298 ± 0.02	0.8TrpIle: 0.8 ± 0.034	0.474TrpLys: 0.474 ± 0.028	1.478TrpLeu: 1.478 ± 0.05	0.435TrpMet: 0.435 ± 0.025	0.471TrpAsn: 0.471 ± 0.024	0.691TrpPro: 0.691 ± 0.031	0.549TrpGln: 0.549 ± 0.024	0.798TrpArg: 0.798 ± 0.036	0.786TrpSer: 0.786 ± 0.034	0.751TrpThr: 0.751 ± 0.027	1.01TrpVal: 1.01 ± 0.037	0.307TrpTrp: 0.307 ± 0.02	0.26TrpTyr: 0.26 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.059	0.159TyrCys: 0.159 ± 0.016	1.473TyrAsp: 1.473 ± 0.042	1.407TyrGlu: 1.407 ± 0.044	1.035TyrPhe: 1.035 ± 0.04	1.986TyrGly: 1.986 ± 0.048	0.426TyrHis: 0.426 ± 0.022	1.027TyrIle: 1.027 ± 0.038	0.605TyrLys: 0.605 ± 0.029	2.276TyrLeu: 2.276 ± 0.063	0.45TyrMet: 0.45 ± 0.024	0.708TyrAsn: 0.708 ± 0.035	1.144TyrPro: 1.144 ± 0.036	0.851TyrGln: 0.851 ± 0.033	1.407TyrArg: 1.407 ± 0.048	1.536TyrSer: 1.536 ± 0.043	1.274TyrThr: 1.274 ± 0.042	1.655TyrVal: 1.655 ± 0.043	0.308TyrTrp: 0.308 ± 0.02	0.562TyrTyr: 0.562 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2428 proteins (788366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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