Amino acid dipepetide frequency for Lake Sarah-associated circular virus-14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.013AlaAla: 7.013 ± 1.932
1.403AlaCys: 1.403 ± 0.809
0.0AlaAsp: 0.0 ± 0.0
2.805AlaGlu: 2.805 ± 0.374
0.0AlaPhe: 0.0 ± 0.0
9.818AlaGly: 9.818 ± 1.678
0.0AlaHis: 0.0 ± 0.0
4.208AlaIle: 4.208 ± 1.557
2.805AlaLys: 2.805 ± 2.366
2.805AlaLeu: 2.805 ± 0.374
1.403AlaMet: 1.403 ± 1.183
5.61AlaAsn: 5.61 ± 3.235
5.61AlaPro: 5.61 ± 0.749
2.805AlaGln: 2.805 ± 1.618
0.0AlaArg: 0.0 ± 0.0
4.208AlaSer: 4.208 ± 2.426
7.013AlaThr: 7.013 ± 2.052
5.61AlaVal: 5.61 ± 3.235
0.0AlaTrp: 0.0 ± 0.0
9.818AlaTyr: 9.818 ± 0.314
0.0AlaXaa: 0.0 ± 0.0
Cys
1.403CysAla: 1.403 ± 1.183
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
2.805CysGlu: 2.805 ± 0.374
2.805CysPhe: 2.805 ± 1.618
1.403CysGly: 1.403 ± 1.183
1.403CysHis: 1.403 ± 1.183
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.403CysLeu: 1.403 ± 0.809
1.403CysMet: 1.403 ± 0.809
2.805CysAsn: 2.805 ± 0.374
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.403CysArg: 1.403 ± 1.183
4.208CysSer: 4.208 ± 3.549
2.805CysThr: 2.805 ± 0.374
0.0CysVal: 0.0 ± 0.0
1.403CysTrp: 1.403 ± 0.809
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.013AspAla: 7.013 ± 2.052
0.0AspCys: 0.0 ± 0.0
4.208AspAsp: 4.208 ± 3.549
4.208AspGlu: 4.208 ± 1.557
4.208AspPhe: 4.208 ± 1.557
4.208AspGly: 4.208 ± 1.557
0.0AspHis: 0.0 ± 0.0
1.403AspIle: 1.403 ± 1.183
1.403AspLys: 1.403 ± 0.809
4.208AspLeu: 4.208 ± 1.557
1.403AspMet: 1.403 ± 0.809
1.403AspAsn: 1.403 ± 0.809
4.208AspPro: 4.208 ± 1.557
1.403AspGln: 1.403 ± 0.809
2.805AspArg: 2.805 ± 0.374
1.403AspSer: 1.403 ± 1.183
4.208AspThr: 4.208 ± 2.426
2.805AspVal: 2.805 ± 0.374
0.0AspTrp: 0.0 ± 0.0
1.403AspTyr: 1.403 ± 1.183
0.0AspXaa: 0.0 ± 0.0
Glu
1.403GluAla: 1.403 ± 0.809
1.403GluCys: 1.403 ± 0.809
4.208GluAsp: 4.208 ± 3.549
0.0GluGlu: 0.0 ± 0.0
2.805GluPhe: 2.805 ± 0.374
0.0GluGly: 0.0 ± 0.0
1.403GluHis: 1.403 ± 1.183
4.208GluIle: 4.208 ± 0.434
1.403GluLys: 1.403 ± 1.183
2.805GluLeu: 2.805 ± 2.366
1.403GluMet: 1.403 ± 0.809
2.805GluAsn: 2.805 ± 2.366
0.0GluPro: 0.0 ± 0.0
1.403GluGln: 1.403 ± 0.809
1.403GluArg: 1.403 ± 0.809
7.013GluSer: 7.013 ± 0.06
1.403GluThr: 1.403 ± 0.809
2.805GluVal: 2.805 ± 0.374
2.805GluTrp: 2.805 ± 0.374
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.403PheAla: 1.403 ± 1.183
4.208PheCys: 4.208 ± 1.557
2.805PheAsp: 2.805 ± 2.366
1.403PheGlu: 1.403 ± 0.809
0.0PhePhe: 0.0 ± 0.0
4.208PheGly: 4.208 ± 1.557
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
2.805PheLys: 2.805 ± 2.366
2.805PheLeu: 2.805 ± 2.366
0.0PheMet: 0.0 ± 0.0
1.403PheAsn: 1.403 ± 0.809
1.403PhePro: 1.403 ± 0.809
0.0PheGln: 0.0 ± 0.0
0.0PheArg: 0.0 ± 0.0
1.403PheSer: 1.403 ± 0.809
2.805PheThr: 2.805 ± 0.374
2.805PheVal: 2.805 ± 1.618
0.0PheTrp: 0.0 ± 0.0
1.403PheTyr: 1.403 ± 1.183
0.0PheXaa: 0.0 ± 0.0
Gly
4.208GlyAla: 4.208 ± 0.434
0.0GlyCys: 0.0 ± 0.0
4.208GlyAsp: 4.208 ± 0.434
4.208GlyGlu: 4.208 ± 1.557
5.61GlyPhe: 5.61 ± 0.749
8.415GlyGly: 8.415 ± 1.123
1.403GlyHis: 1.403 ± 1.183
5.61GlyIle: 5.61 ± 3.235
7.013GlyLys: 7.013 ± 1.932
0.0GlyLeu: 0.0 ± 0.0
1.403GlyMet: 1.403 ± 0.66
8.415GlyAsn: 8.415 ± 2.861
2.805GlyPro: 2.805 ± 0.374
4.208GlyGln: 4.208 ± 2.426
0.0GlyArg: 0.0 ± 0.0
5.61GlySer: 5.61 ± 1.243
11.22GlyThr: 11.22 ± 0.494
4.208GlyVal: 4.208 ± 0.434
2.805GlyTrp: 2.805 ± 0.374
8.415GlyTyr: 8.415 ± 1.123
0.0GlyXaa: 0.0 ± 0.0
His
2.805HisAla: 2.805 ± 2.366
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
2.805HisPhe: 2.805 ± 2.366
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.403HisIle: 1.403 ± 0.809
1.403HisLys: 1.403 ± 1.183
1.403HisLeu: 1.403 ± 1.183
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
2.805HisGln: 2.805 ± 0.374
2.805HisArg: 2.805 ± 0.374
0.0HisSer: 0.0 ± 0.0
1.403HisThr: 1.403 ± 0.809
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.208IleAla: 4.208 ± 0.434
1.403IleCys: 1.403 ± 1.183
4.208IleAsp: 4.208 ± 1.557
4.208IleGlu: 4.208 ± 2.426
1.403IlePhe: 1.403 ± 0.809
4.208IleGly: 4.208 ± 2.426
0.0IleHis: 0.0 ± 0.0
7.013IleIle: 7.013 ± 5.916
4.208IleLys: 4.208 ± 0.434
2.805IleLeu: 2.805 ± 2.366
4.208IleMet: 4.208 ± 2.426
2.805IleAsn: 2.805 ± 0.374
1.403IlePro: 1.403 ± 0.809
0.0IleGln: 0.0 ± 0.0
1.403IleArg: 1.403 ± 0.809
8.415IleSer: 8.415 ± 0.869
2.805IleThr: 2.805 ± 0.374
1.403IleVal: 1.403 ± 0.809
1.403IleTrp: 1.403 ± 0.809
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.403LysAla: 1.403 ± 0.809
0.0LysCys: 0.0 ± 0.0
4.208LysAsp: 4.208 ± 0.434
4.208LysGlu: 4.208 ± 1.557
2.805LysPhe: 2.805 ± 2.366
4.208LysGly: 4.208 ± 1.557
1.403LysHis: 1.403 ± 0.809
5.61LysIle: 5.61 ± 2.741
7.013LysLys: 7.013 ± 4.044
2.805LysLeu: 2.805 ± 0.374
1.403LysMet: 1.403 ± 0.809
2.805LysAsn: 2.805 ± 0.374
2.805LysPro: 2.805 ± 0.374
1.403LysGln: 1.403 ± 0.809
4.208LysArg: 4.208 ± 1.557
8.415LysSer: 8.415 ± 2.861
9.818LysThr: 9.818 ± 2.306
1.403LysVal: 1.403 ± 1.183
1.403LysTrp: 1.403 ± 1.183
7.013LysTyr: 7.013 ± 2.052
0.0LysXaa: 0.0 ± 0.0
Leu
5.61LeuAla: 5.61 ± 1.243
0.0LeuCys: 0.0 ± 0.0
1.403LeuAsp: 1.403 ± 1.183
1.403LeuGlu: 1.403 ± 0.809
1.403LeuPhe: 1.403 ± 1.183
4.208LeuGly: 4.208 ± 0.434
4.208LeuHis: 4.208 ± 1.557
0.0LeuIle: 0.0 ± 0.0
7.013LeuLys: 7.013 ± 1.932
2.805LeuLeu: 2.805 ± 0.374
2.805LeuMet: 2.805 ± 1.618
5.61LeuAsn: 5.61 ± 0.749
1.403LeuPro: 1.403 ± 1.183
1.403LeuGln: 1.403 ± 1.183
1.403LeuArg: 1.403 ± 1.183
1.403LeuSer: 1.403 ± 0.809
5.61LeuThr: 5.61 ± 0.749
4.208LeuVal: 4.208 ± 3.549
0.0LeuTrp: 0.0 ± 0.0
2.805LeuTyr: 2.805 ± 0.374
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
2.805MetCys: 2.805 ± 0.374
0.0MetAsp: 0.0 ± 0.0
2.805MetGlu: 2.805 ± 2.366
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
2.805MetIle: 2.805 ± 1.618
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.403MetAsn: 1.403 ± 0.809
4.208MetPro: 4.208 ± 0.434
0.0MetGln: 0.0 ± 0.0
1.403MetArg: 1.403 ± 0.809
1.403MetSer: 1.403 ± 0.809
5.61MetThr: 5.61 ± 3.235
1.403MetVal: 1.403 ± 0.809
0.0MetTrp: 0.0 ± 0.0
1.403MetTyr: 1.403 ± 0.809
0.0MetXaa: 0.0 ± 0.0
Asn
5.61AsnAla: 5.61 ± 3.235
4.208AsnCys: 4.208 ± 0.434
1.403AsnAsp: 1.403 ± 0.809
2.805AsnGlu: 2.805 ± 2.366
1.403AsnPhe: 1.403 ± 1.183
11.22AsnGly: 11.22 ± 4.478
0.0AsnHis: 0.0 ± 0.0
5.61AsnIle: 5.61 ± 1.243
2.805AsnLys: 2.805 ± 1.618
1.403AsnLeu: 1.403 ± 0.809
0.0AsnMet: 0.0 ± 0.0
5.61AsnAsn: 5.61 ± 0.749
7.013AsnPro: 7.013 ± 0.06
1.403AsnGln: 1.403 ± 0.809
1.403AsnArg: 1.403 ± 0.809
1.403AsnSer: 1.403 ± 0.809
0.0AsnThr: 0.0 ± 0.0
0.0AsnVal: 0.0 ± 0.0
1.403AsnTrp: 1.403 ± 0.809
4.208AsnTyr: 4.208 ± 3.549
0.0AsnXaa: 0.0 ± 0.0
Pro
5.61ProAla: 5.61 ± 1.243
1.403ProCys: 1.403 ± 0.809
1.403ProAsp: 1.403 ± 0.809
0.0ProGlu: 0.0 ± 0.0
0.0ProPhe: 0.0 ± 0.0
4.208ProGly: 4.208 ± 1.557
1.403ProHis: 1.403 ± 1.183
4.208ProIle: 4.208 ± 0.434
2.805ProLys: 2.805 ± 2.366
0.0ProLeu: 0.0 ± 0.0
1.403ProMet: 1.403 ± 0.809
1.403ProAsn: 1.403 ± 0.809
1.403ProPro: 1.403 ± 1.183
1.403ProGln: 1.403 ± 0.809
4.208ProArg: 4.208 ± 1.557
7.013ProSer: 7.013 ± 0.06
2.805ProThr: 2.805 ± 0.374
1.403ProVal: 1.403 ± 0.809
1.403ProTrp: 1.403 ± 1.183
7.013ProTyr: 7.013 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
2.805GlnAla: 2.805 ± 1.618
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
0.0GlnGlu: 0.0 ± 0.0
0.0GlnPhe: 0.0 ± 0.0
2.805GlnGly: 2.805 ± 2.366
0.0GlnHis: 0.0 ± 0.0
2.805GlnIle: 2.805 ± 1.618
2.805GlnLys: 2.805 ± 1.618
1.403GlnLeu: 1.403 ± 0.809
1.403GlnMet: 1.403 ± 0.809
2.805GlnAsn: 2.805 ± 1.618
1.403GlnPro: 1.403 ± 0.809
0.0GlnGln: 0.0 ± 0.0
1.403GlnArg: 1.403 ± 0.809
0.0GlnSer: 0.0 ± 0.0
1.403GlnThr: 1.403 ± 0.809
4.208GlnVal: 4.208 ± 0.434
0.0GlnTrp: 0.0 ± 0.0
1.403GlnTyr: 1.403 ± 0.809
0.0GlnXaa: 0.0 ± 0.0
Arg
1.403ArgAla: 1.403 ± 1.183
4.208ArgCys: 4.208 ± 1.557
2.805ArgAsp: 2.805 ± 0.374
0.0ArgGlu: 0.0 ± 0.0
1.403ArgPhe: 1.403 ± 0.809
2.805ArgGly: 2.805 ± 2.366
1.403ArgHis: 1.403 ± 0.809
2.805ArgIle: 2.805 ± 1.618
4.208ArgLys: 4.208 ± 2.426
0.0ArgLeu: 0.0 ± 0.0
2.805ArgMet: 2.805 ± 1.618
0.0ArgAsn: 0.0 ± 0.0
1.403ArgPro: 1.403 ± 0.809
0.0ArgGln: 0.0 ± 0.0
4.208ArgArg: 4.208 ± 1.557
1.403ArgSer: 1.403 ± 1.183
2.805ArgThr: 2.805 ± 1.618
5.61ArgVal: 5.61 ± 2.741
0.0ArgTrp: 0.0 ± 0.0
4.208ArgTyr: 4.208 ± 3.549
0.0ArgXaa: 0.0 ± 0.0
Ser
7.013SerAla: 7.013 ± 4.044
0.0SerCys: 0.0 ± 0.0
7.013SerAsp: 7.013 ± 1.932
0.0SerGlu: 0.0 ± 0.0
0.0SerPhe: 0.0 ± 0.0
7.013SerGly: 7.013 ± 2.052
1.403SerHis: 1.403 ± 0.809
4.208SerIle: 4.208 ± 0.434
7.013SerLys: 7.013 ± 1.932
9.818SerLeu: 9.818 ± 3.669
1.403SerMet: 1.403 ± 1.183
5.61SerAsn: 5.61 ± 0.749
1.403SerPro: 1.403 ± 1.183
4.208SerGln: 4.208 ± 0.434
2.805SerArg: 2.805 ± 1.618
5.61SerSer: 5.61 ± 1.243
2.805SerThr: 2.805 ± 1.618
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
5.61SerTyr: 5.61 ± 1.243
0.0SerXaa: 0.0 ± 0.0
Thr
4.208ThrAla: 4.208 ± 0.434
0.0ThrCys: 0.0 ± 0.0
7.013ThrAsp: 7.013 ± 4.044
0.0ThrGlu: 0.0 ± 0.0
0.0ThrPhe: 0.0 ± 0.0
9.818ThrGly: 9.818 ± 1.678
1.403ThrHis: 1.403 ± 1.183
2.805ThrIle: 2.805 ± 1.618
7.013ThrLys: 7.013 ± 0.06
7.013ThrLeu: 7.013 ± 1.932
1.403ThrMet: 1.403 ± 1.183
4.208ThrAsn: 4.208 ± 0.434
8.415ThrPro: 8.415 ± 2.861
0.0ThrGln: 0.0 ± 0.0
1.403ThrArg: 1.403 ± 1.183
7.013ThrSer: 7.013 ± 0.06
8.415ThrThr: 8.415 ± 2.861
4.208ThrVal: 4.208 ± 2.426
1.403ThrTrp: 1.403 ± 0.809
4.208ThrTyr: 4.208 ± 2.426
0.0ThrXaa: 0.0 ± 0.0
Val
5.61ValAla: 5.61 ± 0.749
1.403ValCys: 1.403 ± 1.183
1.403ValAsp: 1.403 ± 0.809
1.403ValGlu: 1.403 ± 0.809
2.805ValPhe: 2.805 ± 2.366
1.403ValGly: 1.403 ± 0.809
0.0ValHis: 0.0 ± 0.0
2.805ValIle: 2.805 ± 0.374
8.415ValLys: 8.415 ± 2.861
2.805ValLeu: 2.805 ± 2.366
0.0ValMet: 0.0 ± 0.0
1.403ValAsn: 1.403 ± 0.809
2.805ValPro: 2.805 ± 0.374
1.403ValGln: 1.403 ± 0.809
1.403ValArg: 1.403 ± 1.183
7.013ValSer: 7.013 ± 4.044
0.0ValThr: 0.0 ± 0.0
2.805ValVal: 2.805 ± 2.366
1.403ValTrp: 1.403 ± 0.809
1.403ValTyr: 1.403 ± 1.183
0.0ValXaa: 0.0 ± 0.0
Trp
1.403TrpAla: 1.403 ± 0.809
0.0TrpCys: 0.0 ± 0.0
1.403TrpAsp: 1.403 ± 1.183
4.208TrpGlu: 4.208 ± 0.434
1.403TrpPhe: 1.403 ± 0.809
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.403TrpLeu: 1.403 ± 1.183
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.403TrpGln: 1.403 ± 0.809
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
2.805TrpThr: 2.805 ± 1.618
0.0TrpVal: 0.0 ± 0.0
1.403TrpTrp: 1.403 ± 1.183
1.403TrpTyr: 1.403 ± 1.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.805TyrAla: 2.805 ± 2.366
2.805TyrCys: 2.805 ± 2.366
4.208TyrAsp: 4.208 ± 0.434
4.208TyrGlu: 4.208 ± 1.557
0.0TyrPhe: 0.0 ± 0.0
9.818TyrGly: 9.818 ± 3.669
1.403TyrHis: 1.403 ± 1.183
0.0TyrIle: 0.0 ± 0.0
4.208TyrLys: 4.208 ± 1.557
7.013TyrLeu: 7.013 ± 0.06
0.0TyrMet: 0.0 ± 0.789
2.805TyrAsn: 2.805 ± 1.618
2.805TyrPro: 2.805 ± 2.366
1.403TyrGln: 1.403 ± 0.809
9.818TyrArg: 9.818 ± 0.314
0.0TyrSer: 0.0 ± 0.0
4.208TyrThr: 4.208 ± 0.434
2.805TyrVal: 2.805 ± 0.374
0.0TyrTrp: 0.0 ± 0.0
2.805TyrTyr: 2.805 ± 1.618
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski