Amino acid dipepetide frequency for Bacillariodnavirus LDMD-2013

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.361AlaAla: 3.361 ± 2.029
0.84AlaCys: 0.84 ± 0.589
0.84AlaAsp: 0.84 ± 0.782
7.563AlaGlu: 7.563 ± 2.483
3.361AlaPhe: 3.361 ± 1.282
5.042AlaGly: 5.042 ± 1.793
2.521AlaHis: 2.521 ± 0.892
1.681AlaIle: 1.681 ± 1.058
2.521AlaLys: 2.521 ± 1.55
2.521AlaLeu: 2.521 ± 1.563
0.84AlaMet: 0.84 ± 0.672
5.042AlaAsn: 5.042 ± 1.18
1.681AlaPro: 1.681 ± 1.058
3.361AlaGln: 3.361 ± 1.686
2.521AlaArg: 2.521 ± 1.053
5.042AlaSer: 5.042 ± 1.18
3.361AlaThr: 3.361 ± 0.569
8.403AlaVal: 8.403 ± 2.188
0.0AlaTrp: 0.0 ± 0.0
1.681AlaTyr: 1.681 ± 0.526
0.0AlaXaa: 0.0 ± 0.0
Cys
0.84CysAla: 0.84 ± 0.589
0.0CysCys: 0.0 ± 0.0
1.681CysAsp: 1.681 ± 1.059
0.84CysGlu: 0.84 ± 0.988
0.0CysPhe: 0.0 ± 0.0
2.521CysGly: 2.521 ± 0.892
1.681CysHis: 1.681 ± 1.059
1.681CysIle: 1.681 ± 0.526
0.0CysLys: 0.0 ± 0.0
0.84CysLeu: 0.84 ± 0.589
0.0CysMet: 0.0 ± 0.0
1.681CysAsn: 1.681 ± 1.059
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.84CysArg: 0.84 ± 0.988
0.84CysSer: 0.84 ± 0.589
0.84CysThr: 0.84 ± 0.988
0.84CysVal: 0.84 ± 0.988
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.521AspAla: 2.521 ± 1.55
0.0AspCys: 0.0 ± 0.0
3.361AspAsp: 3.361 ± 1.869
2.521AspGlu: 2.521 ± 1.053
2.521AspPhe: 2.521 ± 0.861
5.042AspGly: 5.042 ± 1.402
1.681AspHis: 1.681 ± 1.059
5.042AspIle: 5.042 ± 1.777
1.681AspLys: 1.681 ± 0.817
3.361AspLeu: 3.361 ± 2.117
1.681AspMet: 1.681 ± 0.902
2.521AspAsn: 2.521 ± 0.861
0.84AspPro: 0.84 ± 0.589
5.882AspGln: 5.882 ± 1.461
1.681AspArg: 1.681 ± 1.059
3.361AspSer: 3.361 ± 1.418
1.681AspThr: 1.681 ± 0.817
3.361AspVal: 3.361 ± 1.418
2.521AspTrp: 2.521 ± 0.861
2.521AspTyr: 2.521 ± 0.996
0.0AspXaa: 0.0 ± 0.0
Glu
5.042GluAla: 5.042 ± 2.82
0.84GluCys: 0.84 ± 0.988
4.202GluAsp: 4.202 ± 2.392
5.042GluGlu: 5.042 ± 2.476
3.361GluPhe: 3.361 ± 0.759
5.882GluGly: 5.882 ± 1.216
1.681GluHis: 1.681 ± 1.344
3.361GluIle: 3.361 ± 0.569
3.361GluLys: 3.361 ± 1.692
6.723GluLeu: 6.723 ± 2.211
0.84GluMet: 0.84 ± 0.988
2.521GluAsn: 2.521 ± 1.053
3.361GluPro: 3.361 ± 0.569
3.361GluGln: 3.361 ± 2.232
5.042GluArg: 5.042 ± 2.728
5.042GluSer: 5.042 ± 0.32
1.681GluThr: 1.681 ± 1.179
2.521GluVal: 2.521 ± 0.975
0.84GluTrp: 0.84 ± 0.988
0.84GluTyr: 0.84 ± 0.589
0.0GluXaa: 0.0 ± 0.0
Phe
3.361PheAla: 3.361 ± 2.029
0.84PheCys: 0.84 ± 0.589
5.042PheAsp: 5.042 ± 2.105
4.202PheGlu: 4.202 ± 1.063
3.361PhePhe: 3.361 ± 1.869
1.681PheGly: 1.681 ± 1.058
1.681PheHis: 1.681 ± 0.526
1.681PheIle: 1.681 ± 1.564
1.681PheLys: 1.681 ± 0.526
3.361PheLeu: 3.361 ± 2.095
0.0PheMet: 0.0 ± 0.0
2.521PheAsn: 2.521 ± 1.768
2.521PhePro: 2.521 ± 0.892
2.521PheGln: 2.521 ± 0.892
0.84PheArg: 0.84 ± 0.988
2.521PheSer: 2.521 ± 1.053
1.681PheThr: 1.681 ± 1.179
0.0PheVal: 0.0 ± 0.0
2.521PheTrp: 2.521 ± 1.4
0.84PheTyr: 0.84 ± 0.589
0.0PheXaa: 0.0 ± 0.0
Gly
5.042GlyAla: 5.042 ± 1.265
0.84GlyCys: 0.84 ± 0.672
4.202GlyAsp: 4.202 ± 1.407
3.361GlyGlu: 3.361 ± 1.282
2.521GlyPhe: 2.521 ± 1.386
8.403GlyGly: 8.403 ± 1.903
0.84GlyHis: 0.84 ± 0.589
4.202GlyIle: 4.202 ± 2.615
6.723GlyLys: 6.723 ± 2.277
0.84GlyLeu: 0.84 ± 0.988
0.84GlyMet: 0.84 ± 0.672
3.361GlyAsn: 3.361 ± 1.445
1.681GlyPro: 1.681 ± 0.526
5.042GlyGln: 5.042 ± 1.019
4.202GlyArg: 4.202 ± 2.341
6.723GlySer: 6.723 ± 0.88
5.042GlyThr: 5.042 ± 1.245
5.042GlyVal: 5.042 ± 2.82
0.84GlyTrp: 0.84 ± 0.672
1.681GlyTyr: 1.681 ± 1.048
0.0GlyXaa: 0.0 ± 0.0
His
3.361HisAla: 3.361 ± 1.869
0.84HisCys: 0.84 ± 0.589
3.361HisAsp: 3.361 ± 1.778
2.521HisGlu: 2.521 ± 0.892
0.84HisPhe: 0.84 ± 0.988
1.681HisGly: 1.681 ± 1.344
1.681HisHis: 1.681 ± 0.526
2.521HisIle: 2.521 ± 0.892
1.681HisLys: 1.681 ± 0.817
0.84HisLeu: 0.84 ± 0.589
0.84HisMet: 0.84 ± 0.988
0.84HisAsn: 0.84 ± 0.672
4.202HisPro: 4.202 ± 1.656
0.0HisGln: 0.0 ± 0.0
2.521HisArg: 2.521 ± 1.768
1.681HisSer: 1.681 ± 0.526
2.521HisThr: 2.521 ± 0.861
2.521HisVal: 2.521 ± 1.053
0.84HisTrp: 0.84 ± 0.589
0.84HisTyr: 0.84 ± 0.672
0.0HisXaa: 0.0 ± 0.0
Ile
5.042IleAla: 5.042 ± 1.034
2.521IleCys: 2.521 ± 1.961
2.521IleAsp: 2.521 ± 1.386
1.681IleGlu: 1.681 ± 1.179
0.0IlePhe: 0.0 ± 0.0
5.882IleGly: 5.882 ± 1.444
4.202IleHis: 4.202 ± 1.838
1.681IleIle: 1.681 ± 1.179
1.681IleLys: 1.681 ± 0.526
4.202IleLeu: 4.202 ± 1.838
1.681IleMet: 1.681 ± 0.526
0.84IleAsn: 0.84 ± 0.988
3.361IlePro: 3.361 ± 1.125
1.681IleGln: 1.681 ± 1.048
2.521IleArg: 2.521 ± 0.59
0.84IleSer: 0.84 ± 0.589
3.361IleThr: 3.361 ± 0.759
5.042IleVal: 5.042 ± 0.32
2.521IleTrp: 2.521 ± 1.768
3.361IleTyr: 3.361 ± 1.445
0.0IleXaa: 0.0 ± 0.0
Lys
3.361LysAla: 3.361 ± 2.283
0.84LysCys: 0.84 ± 0.589
2.521LysAsp: 2.521 ± 1.487
4.202LysGlu: 4.202 ± 2.237
1.681LysPhe: 1.681 ± 1.059
3.361LysGly: 3.361 ± 1.635
0.84LysHis: 0.84 ± 0.589
2.521LysIle: 2.521 ± 0.861
12.605LysLys: 12.605 ± 5.319
1.681LysLeu: 1.681 ± 0.526
0.84LysMet: 0.84 ± 0.672
0.84LysAsn: 0.84 ± 0.672
4.202LysPro: 4.202 ± 2.237
5.882LysGln: 5.882 ± 2.294
9.244LysArg: 9.244 ± 6.706
1.681LysSer: 1.681 ± 0.817
8.403LysThr: 8.403 ± 1.995
2.521LysVal: 2.521 ± 1.55
0.0LysTrp: 0.0 ± 0.0
0.84LysTyr: 0.84 ± 0.589
0.0LysXaa: 0.0 ± 0.0
Leu
6.723LeuAla: 6.723 ± 2.67
3.361LeuCys: 3.361 ± 1.869
5.882LeuAsp: 5.882 ± 2.89
7.563LeuGlu: 7.563 ± 4.335
3.361LeuPhe: 3.361 ± 1.029
2.521LeuGly: 2.521 ± 0.59
4.202LeuHis: 4.202 ± 1.341
2.521LeuIle: 2.521 ± 0.861
2.521LeuLys: 2.521 ± 1.4
4.202LeuLeu: 4.202 ± 1.257
0.84LeuMet: 0.84 ± 0.822
5.042LeuAsn: 5.042 ± 2.105
1.681LeuPro: 1.681 ± 1.564
3.361LeuGln: 3.361 ± 2.283
4.202LeuArg: 4.202 ± 0.774
4.202LeuSer: 4.202 ± 1.98
1.681LeuThr: 1.681 ± 0.526
5.042LeuVal: 5.042 ± 2.944
1.681LeuTrp: 1.681 ± 1.059
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.84MetCys: 0.84 ± 0.988
1.681MetAsp: 1.681 ± 1.564
0.0MetGlu: 0.0 ± 0.0
1.681MetPhe: 1.681 ± 1.976
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.84MetIle: 0.84 ± 0.672
0.0MetLys: 0.0 ± 0.0
3.361MetLeu: 3.361 ± 2.029
0.84MetMet: 0.84 ± 0.633
0.84MetAsn: 0.84 ± 0.988
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.84MetSer: 0.84 ± 0.589
0.84MetThr: 0.84 ± 0.672
1.681MetVal: 1.681 ± 1.058
0.0MetTrp: 0.0 ± 0.0
1.681MetTyr: 1.681 ± 0.526
0.0MetXaa: 0.0 ± 0.0
Asn
1.681AsnAla: 1.681 ± 0.902
0.84AsnCys: 0.84 ± 0.672
0.84AsnAsp: 0.84 ± 0.672
3.361AsnGlu: 3.361 ± 1.445
1.681AsnPhe: 1.681 ± 0.902
2.521AsnGly: 2.521 ± 1.934
3.361AsnHis: 3.361 ± 1.869
4.202AsnIle: 4.202 ± 1.439
3.361AsnLys: 3.361 ± 0.759
3.361AsnLeu: 3.361 ± 1.686
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
5.042AsnPro: 5.042 ± 2.105
4.202AsnGln: 4.202 ± 1.03
2.521AsnArg: 2.521 ± 1.961
3.361AsnSer: 3.361 ± 1.686
1.681AsnThr: 1.681 ± 1.059
3.361AsnVal: 3.361 ± 1.282
0.84AsnTrp: 0.84 ± 0.589
1.681AsnTyr: 1.681 ± 0.817
0.0AsnXaa: 0.0 ± 0.0
Pro
1.681ProAla: 1.681 ± 0.526
0.0ProCys: 0.0 ± 0.0
3.361ProAsp: 3.361 ± 1.418
2.521ProGlu: 2.521 ± 0.975
4.202ProPhe: 4.202 ± 1.341
0.84ProGly: 0.84 ± 0.672
0.84ProHis: 0.84 ± 0.589
2.521ProIle: 2.521 ± 1.961
2.521ProLys: 2.521 ± 0.892
4.202ProLeu: 4.202 ± 1.063
0.84ProMet: 0.84 ± 0.672
2.521ProAsn: 2.521 ± 0.861
1.681ProPro: 1.681 ± 1.179
0.84ProGln: 0.84 ± 0.672
1.681ProArg: 1.681 ± 0.817
5.882ProSer: 5.882 ± 1.226
5.042ProThr: 5.042 ± 1.952
2.521ProVal: 2.521 ± 0.59
0.0ProTrp: 0.0 ± 0.0
0.84ProTyr: 0.84 ± 0.988
0.0ProXaa: 0.0 ± 0.0
Gln
0.84GlnAla: 0.84 ± 0.672
0.84GlnCys: 0.84 ± 0.988
0.84GlnAsp: 0.84 ± 0.589
2.521GlnGlu: 2.521 ± 0.892
2.521GlnPhe: 2.521 ± 1.768
4.202GlnGly: 4.202 ± 1.257
0.84GlnHis: 0.84 ± 0.672
3.361GlnIle: 3.361 ± 1.869
1.681GlnLys: 1.681 ± 1.048
8.403GlnLeu: 8.403 ± 1.995
0.84GlnMet: 0.84 ± 0.672
4.202GlnAsn: 4.202 ± 2.615
0.84GlnPro: 0.84 ± 0.672
2.521GlnGln: 2.521 ± 2.016
3.361GlnArg: 3.361 ± 1.692
3.361GlnSer: 3.361 ± 1.805
3.361GlnThr: 3.361 ± 1.051
1.681GlnVal: 1.681 ± 0.817
0.0GlnTrp: 0.0 ± 0.0
3.361GlnTyr: 3.361 ± 1.051
0.0GlnXaa: 0.0 ± 0.0
Arg
5.042ArgAla: 5.042 ± 2.241
0.84ArgCys: 0.84 ± 0.988
1.681ArgAsp: 1.681 ± 1.344
0.84ArgGlu: 0.84 ± 0.672
2.521ArgPhe: 2.521 ± 0.892
0.84ArgGly: 0.84 ± 0.782
0.84ArgHis: 0.84 ± 0.589
5.042ArgIle: 5.042 ± 0.32
8.403ArgLys: 8.403 ± 3.312
6.723ArgLeu: 6.723 ± 0.659
0.84ArgMet: 0.84 ± 0.988
2.521ArgAsn: 2.521 ± 0.975
3.361ArgPro: 3.361 ± 1.418
5.042ArgGln: 5.042 ± 1.265
5.882ArgArg: 5.882 ± 1.137
3.361ArgSer: 3.361 ± 1.445
1.681ArgThr: 1.681 ± 1.048
5.042ArgVal: 5.042 ± 1.075
1.681ArgTrp: 1.681 ± 1.179
0.84ArgTyr: 0.84 ± 0.589
0.0ArgXaa: 0.0 ± 0.0
Ser
4.202SerAla: 4.202 ± 0.774
0.0SerCys: 0.0 ± 0.0
3.361SerAsp: 3.361 ± 0.759
3.361SerGlu: 3.361 ± 0.759
3.361SerPhe: 3.361 ± 1.686
5.882SerGly: 5.882 ± 3.296
0.84SerHis: 0.84 ± 0.589
4.202SerIle: 4.202 ± 1.936
6.723SerLys: 6.723 ± 3.269
5.042SerLeu: 5.042 ± 2.105
0.84SerMet: 0.84 ± 0.745
5.042SerAsn: 5.042 ± 1.019
1.681SerPro: 1.681 ± 1.564
1.681SerGln: 1.681 ± 0.526
4.202SerArg: 4.202 ± 0.798
5.042SerSer: 5.042 ± 1.019
5.042SerThr: 5.042 ± 2.241
3.361SerVal: 3.361 ± 2.232
3.361SerTrp: 3.361 ± 2.357
0.84SerTyr: 0.84 ± 0.672
0.0SerXaa: 0.0 ± 0.0
Thr
4.202ThrAla: 4.202 ± 1.225
0.0ThrCys: 0.0 ± 0.0
1.681ThrAsp: 1.681 ± 0.526
7.563ThrGlu: 7.563 ± 0.897
0.84ThrPhe: 0.84 ± 0.589
4.202ThrGly: 4.202 ± 1.407
1.681ThrHis: 1.681 ± 0.526
0.84ThrIle: 0.84 ± 0.672
5.042ThrLys: 5.042 ± 1.793
3.361ThrLeu: 3.361 ± 1.869
1.681ThrMet: 1.681 ± 1.976
3.361ThrAsn: 3.361 ± 1.224
0.0ThrPro: 0.0 ± 0.0
2.521ThrGln: 2.521 ± 0.861
5.042ThrArg: 5.042 ± 3.003
5.882ThrSer: 5.882 ± 2.783
9.244ThrThr: 9.244 ± 4.468
3.361ThrVal: 3.361 ± 0.759
0.84ThrTrp: 0.84 ± 0.988
0.84ThrTyr: 0.84 ± 0.589
0.0ThrXaa: 0.0 ± 0.0
Val
4.202ValAla: 4.202 ± 0.774
0.0ValCys: 0.0 ± 0.0
3.361ValAsp: 3.361 ± 1.778
4.202ValGlu: 4.202 ± 1.809
1.681ValPhe: 1.681 ± 0.902
6.723ValGly: 6.723 ± 2.67
1.681ValHis: 1.681 ± 1.059
3.361ValIle: 3.361 ± 1.418
5.042ValLys: 5.042 ± 1.952
5.882ValLeu: 5.882 ± 1.61
0.0ValMet: 0.0 ± 0.0
2.521ValAsn: 2.521 ± 0.892
4.202ValPro: 4.202 ± 2.1
1.681ValGln: 1.681 ± 0.902
3.361ValArg: 3.361 ± 1.686
6.723ValSer: 6.723 ± 3.53
4.202ValThr: 4.202 ± 1.407
3.361ValVal: 3.361 ± 1.416
0.84ValTrp: 0.84 ± 0.589
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.84TrpCys: 0.84 ± 0.589
2.521TrpAsp: 2.521 ± 1.768
0.84TrpGlu: 0.84 ± 0.589
1.681TrpPhe: 1.681 ± 0.526
2.521TrpGly: 2.521 ± 0.892
0.84TrpHis: 0.84 ± 0.988
0.84TrpIle: 0.84 ± 0.988
0.0TrpLys: 0.0 ± 0.0
0.84TrpLeu: 0.84 ± 0.589
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
2.521TrpPro: 2.521 ± 1.4
0.0TrpGln: 0.0 ± 0.0
1.681TrpArg: 1.681 ± 0.526
1.681TrpSer: 1.681 ± 1.059
0.0TrpThr: 0.0 ± 0.0
2.521TrpVal: 2.521 ± 1.4
1.681TrpTrp: 1.681 ± 1.059
0.84TrpTyr: 0.84 ± 0.589
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.681TyrAla: 1.681 ± 0.902
0.0TyrCys: 0.0 ± 0.0
0.84TyrAsp: 0.84 ± 0.988
0.84TyrGlu: 0.84 ± 0.782
1.681TyrPhe: 1.681 ± 1.059
1.681TyrGly: 1.681 ± 1.059
4.202TyrHis: 4.202 ± 1.257
2.521TyrIle: 2.521 ± 1.053
0.84TyrLys: 0.84 ± 0.589
0.84TyrLeu: 0.84 ± 0.589
0.0TyrMet: 0.0 ± 0.0
1.681TyrAsn: 1.681 ± 1.058
1.681TyrPro: 1.681 ± 0.526
0.0TyrGln: 0.0 ± 0.0
1.681TyrArg: 1.681 ± 0.817
0.84TyrSer: 0.84 ± 0.589
0.84TyrThr: 0.84 ± 0.672
0.84TyrVal: 0.84 ± 0.589
0.84TyrTrp: 0.84 ± 0.672
0.84TyrTyr: 0.84 ± 0.589
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski