Amino acid dipepetide frequency for Candidatus Nitromaritima sp. SCGC AAA799-A02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.852AlaAla: 5.852 ± 0.143
0.967AlaCys: 0.967 ± 0.057
3.867AlaAsp: 3.867 ± 0.127
4.99AlaGlu: 4.99 ± 0.148
3.191AlaPhe: 3.191 ± 0.113
5.965AlaGly: 5.965 ± 0.166
1.396AlaHis: 1.396 ± 0.076
4.683AlaIle: 4.683 ± 0.147
3.851AlaLys: 3.851 ± 0.119
8.037AlaLeu: 8.037 ± 0.2
1.952AlaMet: 1.952 ± 0.083
2.599AlaAsn: 2.599 ± 0.114
2.688AlaPro: 2.688 ± 0.105
2.529AlaGln: 2.529 ± 0.091
4.453AlaArg: 4.453 ± 0.134
3.971AlaSer: 3.971 ± 0.109
3.013AlaThr: 3.013 ± 0.106
5.376AlaVal: 5.376 ± 0.117
0.875AlaTrp: 0.875 ± 0.052
2.136AlaTyr: 2.136 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.81CysAla: 0.81 ± 0.048
0.175CysCys: 0.175 ± 0.024
0.58CysAsp: 0.58 ± 0.042
0.598CysGlu: 0.598 ± 0.041
0.537CysPhe: 0.537 ± 0.041
0.918CysGly: 0.918 ± 0.058
0.405CysHis: 0.405 ± 0.068
0.608CysIle: 0.608 ± 0.039
0.605CysLys: 0.605 ± 0.043
1.157CysLeu: 1.157 ± 0.052
0.227CysMet: 0.227 ± 0.022
0.387CysAsn: 0.387 ± 0.032
0.608CysPro: 0.608 ± 0.042
0.344CysGln: 0.344 ± 0.032
0.684CysArg: 0.684 ± 0.049
0.749CysSer: 0.749 ± 0.053
0.393CysThr: 0.393 ± 0.035
0.647CysVal: 0.647 ± 0.046
0.163CysTrp: 0.163 ± 0.022
0.292CysTyr: 0.292 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.587AspAla: 3.587 ± 0.104
0.589AspCys: 0.589 ± 0.045
2.759AspAsp: 2.759 ± 0.118
3.998AspGlu: 3.998 ± 0.149
2.82AspPhe: 2.82 ± 0.102
3.56AspGly: 3.56 ± 0.11
1.203AspHis: 1.203 ± 0.06
3.584AspIle: 3.584 ± 0.105
3.072AspLys: 3.072 ± 0.098
6.015AspLeu: 6.015 ± 0.142
1.273AspMet: 1.273 ± 0.058
1.789AspAsn: 1.789 ± 0.077
2.955AspPro: 2.955 ± 0.1
1.814AspGln: 1.814 ± 0.081
3.348AspArg: 3.348 ± 0.108
3.099AspSer: 3.099 ± 0.106
2.415AspThr: 2.415 ± 0.103
3.127AspVal: 3.127 ± 0.107
0.73AspTrp: 0.73 ± 0.047
1.814AspTyr: 1.814 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.401GluAla: 5.401 ± 0.173
0.614GluCys: 0.614 ± 0.048
3.507GluAsp: 3.507 ± 0.123
5.763GluGlu: 5.763 ± 0.202
2.863GluPhe: 2.863 ± 0.085
4.585GluGly: 4.585 ± 0.122
1.243GluHis: 1.243 ± 0.064
5.358GluIle: 5.358 ± 0.137
5.76GluLys: 5.76 ± 0.187
5.8GluLeu: 5.8 ± 0.148
1.909GluMet: 1.909 ± 0.079
3.541GluAsn: 3.541 ± 0.103
2.412GluPro: 2.412 ± 0.101
2.096GluGln: 2.096 ± 0.088
3.609GluArg: 3.609 ± 0.126
4.219GluSer: 4.219 ± 0.121
3.928GluThr: 3.928 ± 0.113
4.385GluVal: 4.385 ± 0.119
0.871GluTrp: 0.871 ± 0.057
1.909GluTyr: 1.909 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.915PheAla: 2.915 ± 0.101
0.629PheCys: 0.629 ± 0.044
3.001PheAsp: 3.001 ± 0.093
2.805PheGlu: 2.805 ± 0.095
2.94PhePhe: 2.94 ± 0.13
3.314PheGly: 3.314 ± 0.1
1.132PheHis: 1.132 ± 0.061
3.148PheIle: 3.148 ± 0.103
2.842PheLys: 2.842 ± 0.1
5.751PheLeu: 5.751 ± 0.198
1.166PheMet: 1.166 ± 0.064
2.124PheAsn: 2.124 ± 0.098
2.237PhePro: 2.237 ± 0.082
1.709PheGln: 1.709 ± 0.072
2.32PheArg: 2.32 ± 0.082
3.692PheSer: 3.692 ± 0.119
2.455PheThr: 2.455 ± 0.084
2.75PheVal: 2.75 ± 0.083
0.635PheTrp: 0.635 ± 0.055
1.74PheTyr: 1.74 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
4.845GlyAla: 4.845 ± 0.145
0.899GlyCys: 0.899 ± 0.055
3.523GlyAsp: 3.523 ± 0.129
4.864GlyGlu: 4.864 ± 0.132
3.774GlyPhe: 3.774 ± 0.116
5.091GlyGly: 5.091 ± 0.167
1.301GlyHis: 1.301 ± 0.065
5.478GlyIle: 5.478 ± 0.131
5.22GlyLys: 5.22 ± 0.154
7.214GlyLeu: 7.214 ± 0.164
2.001GlyMet: 2.001 ± 0.085
2.98GlyAsn: 2.98 ± 0.108
2.271GlyPro: 2.271 ± 0.084
2.326GlyGln: 2.326 ± 0.078
3.661GlyArg: 3.661 ± 0.111
4.397GlySer: 4.397 ± 0.111
3.937GlyThr: 3.937 ± 0.124
4.649GlyVal: 4.649 ± 0.131
0.97GlyTrp: 0.97 ± 0.059
2.237GlyTyr: 2.237 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
1.372HisAla: 1.372 ± 0.063
0.267HisCys: 0.267 ± 0.03
0.967HisAsp: 0.967 ± 0.061
1.289HisGlu: 1.289 ± 0.054
1.089HisPhe: 1.089 ± 0.072
1.498HisGly: 1.498 ± 0.065
0.605HisHis: 0.605 ± 0.045
1.27HisIle: 1.27 ± 0.066
1.2HisLys: 1.2 ± 0.066
2.394HisLeu: 2.394 ± 0.093
0.427HisMet: 0.427 ± 0.034
0.783HisAsn: 0.783 ± 0.058
1.396HisPro: 1.396 ± 0.067
0.715HisGln: 0.715 ± 0.05
1.188HisArg: 1.188 ± 0.056
1.316HisSer: 1.316 ± 0.07
0.899HisThr: 0.899 ± 0.054
1.037HisVal: 1.037 ± 0.057
0.276HisTrp: 0.276 ± 0.029
0.804HisTyr: 0.804 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
4.904IleAla: 4.904 ± 0.134
0.694IleCys: 0.694 ± 0.049
4.044IleAsp: 4.044 ± 0.125
4.551IleGlu: 4.551 ± 0.114
3.262IlePhe: 3.262 ± 0.112
4.594IleGly: 4.594 ± 0.127
1.525IleHis: 1.525 ± 0.071
4.127IleIle: 4.127 ± 0.128
4.038IleLys: 4.038 ± 0.131
7.122IleLeu: 7.122 ± 0.163
1.415IleMet: 1.415 ± 0.083
2.796IleAsn: 2.796 ± 0.102
3.507IlePro: 3.507 ± 0.096
2.464IleGln: 2.464 ± 0.094
3.925IleArg: 3.925 ± 0.111
4.262IleSer: 4.262 ± 0.107
3.345IleThr: 3.345 ± 0.101
4.382IleVal: 4.382 ± 0.131
0.69IleTrp: 0.69 ± 0.05
2.044IleTyr: 2.044 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
4.376LysAla: 4.376 ± 0.132
0.534LysCys: 0.534 ± 0.041
3.422LysAsp: 3.422 ± 0.122
4.999LysGlu: 4.999 ± 0.127
2.661LysPhe: 2.661 ± 0.097
4.222LysGly: 4.222 ± 0.122
1.129LysHis: 1.129 ± 0.062
5.201LysIle: 5.201 ± 0.14
6.11LysLys: 6.11 ± 0.204
5.459LysLeu: 5.459 ± 0.168
1.654LysMet: 1.654 ± 0.068
3.621LysAsn: 3.621 ± 0.121
2.716LysPro: 2.716 ± 0.091
2.114LysGln: 2.114 ± 0.083
3.305LysArg: 3.305 ± 0.105
3.968LysSer: 3.968 ± 0.116
3.679LysThr: 3.679 ± 0.123
3.885LysVal: 3.885 ± 0.13
0.632LysTrp: 0.632 ± 0.048
1.835LysTyr: 1.835 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
8.273LeuAla: 8.273 ± 0.184
0.982LeuCys: 0.982 ± 0.057
5.379LeuAsp: 5.379 ± 0.124
6.926LeuGlu: 6.926 ± 0.181
5.146LeuPhe: 5.146 ± 0.17
7.245LeuGly: 7.245 ± 0.173
1.979LeuHis: 1.979 ± 0.075
6.558LeuIle: 6.558 ± 0.167
7.488LeuLys: 7.488 ± 0.18
9.55LeuLeu: 9.55 ± 0.242
2.458LeuMet: 2.458 ± 0.087
4.486LeuAsn: 4.486 ± 0.117
4.634LeuPro: 4.634 ± 0.118
3.053LeuGln: 3.053 ± 0.102
4.987LeuArg: 4.987 ± 0.136
7.03LeuSer: 7.03 ± 0.167
5.085LeuThr: 5.085 ± 0.135
6.521LeuVal: 6.521 ± 0.148
1.16LeuTrp: 1.16 ± 0.068
2.572LeuTyr: 2.572 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.09MetAla: 2.09 ± 0.083
0.175MetCys: 0.175 ± 0.023
1.415MetAsp: 1.415 ± 0.066
1.863MetGlu: 1.863 ± 0.075
0.991MetPhe: 0.991 ± 0.068
2.074MetGly: 2.074 ± 0.072
0.411MetHis: 0.411 ± 0.032
1.657MetIle: 1.657 ± 0.065
1.998MetLys: 1.998 ± 0.085
1.804MetLeu: 1.804 ± 0.077
0.614MetMet: 0.614 ± 0.045
1.114MetAsn: 1.114 ± 0.062
0.982MetPro: 0.982 ± 0.062
0.669MetGln: 0.669 ± 0.044
1.27MetArg: 1.27 ± 0.054
1.405MetSer: 1.405 ± 0.067
1.516MetThr: 1.516 ± 0.069
1.807MetVal: 1.807 ± 0.081
0.215MetTrp: 0.215 ± 0.026
0.482MetTyr: 0.482 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.593AsnAla: 2.593 ± 0.093
0.46AsnCys: 0.46 ± 0.036
1.804AsnAsp: 1.804 ± 0.091
2.311AsnGlu: 2.311 ± 0.088
2.016AsnPhe: 2.016 ± 0.096
2.854AsnGly: 2.854 ± 0.108
0.982AsnHis: 0.982 ± 0.056
2.967AsnIle: 2.967 ± 0.096
2.519AsnLys: 2.519 ± 0.097
4.815AsnLeu: 4.815 ± 0.144
1.053AsnMet: 1.053 ± 0.055
1.617AsnAsn: 1.617 ± 0.082
2.562AsnPro: 2.562 ± 0.093
1.639AsnGln: 1.639 ± 0.07
2.421AsnArg: 2.421 ± 0.092
2.415AsnSer: 2.415 ± 0.096
1.823AsnThr: 1.823 ± 0.073
2.225AsnVal: 2.225 ± 0.091
0.522AsnTrp: 0.522 ± 0.042
1.405AsnTyr: 1.405 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
3.342ProAla: 3.342 ± 0.109
0.476ProCys: 0.476 ± 0.034
3.01ProAsp: 3.01 ± 0.096
4.051ProGlu: 4.051 ± 0.125
2.274ProPhe: 2.274 ± 0.087
3.48ProGly: 3.48 ± 0.113
0.942ProHis: 0.942 ± 0.056
2.381ProIle: 2.381 ± 0.087
2.372ProLys: 2.372 ± 0.092
4.066ProLeu: 4.066 ± 0.122
0.982ProMet: 0.982 ± 0.052
1.568ProAsn: 1.568 ± 0.066
1.93ProPro: 1.93 ± 0.092
1.593ProGln: 1.593 ± 0.067
2.136ProArg: 2.136 ± 0.082
2.657ProSer: 2.657 ± 0.089
1.946ProThr: 1.946 ± 0.084
3.477ProVal: 3.477 ± 0.12
0.546ProTrp: 0.546 ± 0.042
1.231ProTyr: 1.231 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.691GlnAla: 2.691 ± 0.1
0.319GlnCys: 0.319 ± 0.035
1.694GlnAsp: 1.694 ± 0.067
2.397GlnGlu: 2.397 ± 0.087
1.476GlnPhe: 1.476 ± 0.068
2.222GlnGly: 2.222 ± 0.079
0.485GlnHis: 0.485 ± 0.041
2.231GlnIle: 2.231 ± 0.092
2.59GlnLys: 2.59 ± 0.088
2.958GlnLeu: 2.958 ± 0.107
0.841GlnMet: 0.841 ± 0.056
1.488GlnAsn: 1.488 ± 0.075
1.412GlnPro: 1.412 ± 0.064
1.056GlnGln: 1.056 ± 0.061
1.801GlnArg: 1.801 ± 0.077
2.231GlnSer: 2.231 ± 0.073
1.832GlnThr: 1.832 ± 0.084
2.464GlnVal: 2.464 ± 0.095
0.479GlnTrp: 0.479 ± 0.042
0.893GlnTyr: 0.893 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
3.468ArgAla: 3.468 ± 0.104
0.555ArgCys: 0.555 ± 0.047
2.854ArgAsp: 2.854 ± 0.082
4.523ArgGlu: 4.523 ± 0.133
2.857ArgPhe: 2.857 ± 0.103
3.348ArgGly: 3.348 ± 0.119
1.188ArgHis: 1.188 ± 0.064
3.848ArgIle: 3.848 ± 0.12
3.974ArgLys: 3.974 ± 0.118
5.619ArgLeu: 5.619 ± 0.148
1.504ArgMet: 1.504 ± 0.07
2.17ArgAsn: 2.17 ± 0.093
1.995ArgPro: 1.995 ± 0.078
2.019ArgGln: 2.019 ± 0.071
3.084ArgArg: 3.084 ± 0.104
3.099ArgSer: 3.099 ± 0.101
2.51ArgThr: 2.51 ± 0.088
3.621ArgVal: 3.621 ± 0.108
0.66ArgTrp: 0.66 ± 0.048
1.725ArgTyr: 1.725 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.64SerAla: 4.64 ± 0.124
0.663SerCys: 0.663 ± 0.042
3.237SerAsp: 3.237 ± 0.106
3.646SerGlu: 3.646 ± 0.112
3.287SerPhe: 3.287 ± 0.132
5.017SerGly: 5.017 ± 0.135
1.341SerHis: 1.341 ± 0.065
4.287SerIle: 4.287 ± 0.132
3.36SerLys: 3.36 ± 0.099
6.653SerLeu: 6.653 ± 0.153
1.565SerMet: 1.565 ± 0.063
2.179SerAsn: 2.179 ± 0.094
3.084SerPro: 3.084 ± 0.1
2.17SerGln: 2.17 ± 0.089
3.606SerArg: 3.606 ± 0.114
4.213SerSer: 4.213 ± 0.138
2.762SerThr: 2.762 ± 0.112
3.992SerVal: 3.992 ± 0.103
0.853SerTrp: 0.853 ± 0.05
1.725SerTyr: 1.725 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
3.946ThrAla: 3.946 ± 0.124
0.522ThrCys: 0.522 ± 0.039
2.587ThrAsp: 2.587 ± 0.089
2.866ThrGlu: 2.866 ± 0.107
2.286ThrPhe: 2.286 ± 0.088
4.339ThrGly: 4.339 ± 0.136
1.157ThrHis: 1.157 ± 0.051
3.201ThrIle: 3.201 ± 0.103
2.142ThrLys: 2.142 ± 0.078
5.901ThrLeu: 5.901 ± 0.123
0.988ThrMet: 0.988 ± 0.062
1.654ThrAsn: 1.654 ± 0.07
2.372ThrPro: 2.372 ± 0.095
1.682ThrGln: 1.682 ± 0.069
2.783ThrArg: 2.783 ± 0.103
2.799ThrSer: 2.799 ± 0.107
2.624ThrThr: 2.624 ± 0.095
3.633ThrVal: 3.633 ± 0.127
0.632ThrTrp: 0.632 ± 0.046
1.39ThrTyr: 1.39 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
4.594ValAla: 4.594 ± 0.147
0.838ValCys: 0.838 ± 0.05
3.489ValAsp: 3.489 ± 0.107
4.674ValGlu: 4.674 ± 0.122
3.363ValPhe: 3.363 ± 0.109
4.471ValGly: 4.471 ± 0.124
1.335ValHis: 1.335 ± 0.066
4.496ValIle: 4.496 ± 0.119
3.796ValLys: 3.796 ± 0.13
6.65ValLeu: 6.65 ± 0.159
1.534ValMet: 1.534 ± 0.071
2.464ValAsn: 2.464 ± 0.094
2.78ValPro: 2.78 ± 0.089
1.952ValGln: 1.952 ± 0.09
3.529ValArg: 3.529 ± 0.106
4.229ValSer: 4.229 ± 0.116
3.449ValThr: 3.449 ± 0.099
4.634ValVal: 4.634 ± 0.12
0.727ValTrp: 0.727 ± 0.048
1.942ValTyr: 1.942 ± 0.086
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.05
0.129TrpCys: 0.129 ± 0.018
0.632TrpAsp: 0.632 ± 0.046
0.881TrpGlu: 0.881 ± 0.061
0.666TrpPhe: 0.666 ± 0.046
0.838TrpGly: 0.838 ± 0.059
0.276TrpHis: 0.276 ± 0.033
0.878TrpIle: 0.878 ± 0.058
0.918TrpLys: 0.918 ± 0.064
1.145TrpLeu: 1.145 ± 0.061
0.341TrpMet: 0.341 ± 0.033
0.583TrpAsn: 0.583 ± 0.05
0.393TrpPro: 0.393 ± 0.037
0.396TrpGln: 0.396 ± 0.039
0.651TrpArg: 0.651 ± 0.042
0.647TrpSer: 0.647 ± 0.048
0.574TrpThr: 0.574 ± 0.043
0.89TrpVal: 0.89 ± 0.056
0.144TrpTrp: 0.144 ± 0.02
0.387TrpTyr: 0.387 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.85TyrAla: 1.85 ± 0.072
0.399TyrCys: 0.399 ± 0.035
1.78TyrAsp: 1.78 ± 0.08
1.78TyrGlu: 1.78 ± 0.086
1.804TyrPhe: 1.804 ± 0.092
2.004TyrGly: 2.004 ± 0.079
0.755TyrHis: 0.755 ± 0.052
1.731TyrIle: 1.731 ± 0.075
1.669TyrLys: 1.669 ± 0.08
3.403TyrLeu: 3.403 ± 0.114
0.647TyrMet: 0.647 ± 0.047
1.062TyrAsn: 1.062 ± 0.058
1.525TyrPro: 1.525 ± 0.081
1.221TyrGln: 1.221 ± 0.059
1.86TyrArg: 1.86 ± 0.078
1.878TyrSer: 1.878 ± 0.087
1.323TyrThr: 1.323 ± 0.057
1.442TyrVal: 1.442 ± 0.074
0.427TyrTrp: 0.427 ± 0.039
1.258TyrTyr: 1.258 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1139 proteins (325876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski