Amino acid dipepetide frequency for Hubei tombus-like virus 22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.901AlaAla: 9.901 ± 2.503
1.65AlaCys: 1.65 ± 0.632
2.475AlaAsp: 2.475 ± 0.14
2.475AlaGlu: 2.475 ± 1.855
3.3AlaPhe: 3.3 ± 1.263
8.251AlaGly: 8.251 ± 2.681
1.65AlaHis: 1.65 ± 0.635
6.601AlaIle: 6.601 ± 0.735
6.601AlaLys: 6.601 ± 1.524
5.776AlaLeu: 5.776 ± 1.006
1.65AlaMet: 1.65 ± 0.574
2.475AlaAsn: 2.475 ± 0.14
4.95AlaPro: 4.95 ± 1.043
2.475AlaGln: 2.475 ± 2.253
6.601AlaArg: 6.601 ± 0.735
5.776AlaSer: 5.776 ± 3.195
4.95AlaThr: 4.95 ± 1.73
4.125AlaVal: 4.125 ± 1.844
1.65AlaTrp: 1.65 ± 1.236
2.475AlaTyr: 2.475 ± 0.14
0.0AlaXaa: 0.0 ± 0.0
Cys
0.825CysAla: 0.825 ± 0.618
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.65CysGlu: 1.65 ± 0.635
0.0CysPhe: 0.0 ± 0.0
0.825CysGly: 0.825 ± 0.628
0.825CysHis: 0.825 ± 0.618
0.825CysIle: 0.825 ± 0.751
0.825CysLys: 0.825 ± 0.618
1.65CysLeu: 1.65 ± 0.632
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.825CysPro: 0.825 ± 0.618
1.65CysGln: 1.65 ± 1.236
0.0CysArg: 0.0 ± 0.0
2.475CysSer: 2.475 ± 1.884
0.825CysThr: 0.825 ± 0.628
0.825CysVal: 0.825 ± 0.618
0.825CysTrp: 0.825 ± 0.751
0.825CysTyr: 0.825 ± 0.628
0.0CysXaa: 0.0 ± 0.0
Asp
4.125AspAla: 4.125 ± 1.271
0.825AspCys: 0.825 ± 0.751
4.125AspAsp: 4.125 ± 1.562
6.601AspGlu: 6.601 ± 0.735
0.0AspPhe: 0.0 ± 0.0
5.776AspGly: 5.776 ± 0.702
3.3AspHis: 3.3 ± 1.542
3.3AspIle: 3.3 ± 1.271
1.65AspLys: 1.65 ± 0.635
3.3AspLeu: 3.3 ± 2.473
0.0AspMet: 0.0 ± 0.0
0.0AspAsn: 0.0 ± 0.0
4.125AspPro: 4.125 ± 1.844
1.65AspGln: 1.65 ± 1.502
1.65AspArg: 1.65 ± 0.632
4.95AspSer: 4.95 ± 0.941
2.475AspThr: 2.475 ± 0.14
4.95AspVal: 4.95 ± 0.28
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
6.601GluAla: 6.601 ± 2.023
0.0GluCys: 0.0 ± 0.0
8.251GluAsp: 8.251 ± 2.924
14.026GluGlu: 14.026 ± 5.046
2.475GluPhe: 2.475 ± 0.14
7.426GluGly: 7.426 ± 1.435
2.475GluHis: 2.475 ± 1.855
4.125GluIle: 4.125 ± 1.627
1.65GluLys: 1.65 ± 0.632
4.95GluLeu: 4.95 ± 0.941
2.475GluMet: 2.475 ± 1.246
1.65GluAsn: 1.65 ± 0.635
4.125GluPro: 4.125 ± 0.878
0.825GluGln: 0.825 ± 0.751
3.3GluArg: 3.3 ± 1.271
3.3GluSer: 3.3 ± 1.957
1.65GluThr: 1.65 ± 0.747
5.776GluVal: 5.776 ± 0.702
0.825GluTrp: 0.825 ± 0.628
1.65GluTyr: 1.65 ± 1.236
0.0GluXaa: 0.0 ± 0.0
Phe
4.125PheAla: 4.125 ± 2.123
0.825PheCys: 0.825 ± 0.618
2.475PheAsp: 2.475 ± 1.855
0.825PheGlu: 0.825 ± 0.618
0.825PhePhe: 0.825 ± 0.628
0.825PheGly: 0.825 ± 0.628
0.825PheHis: 0.825 ± 0.618
1.65PheIle: 1.65 ± 0.632
3.3PheLys: 3.3 ± 1.706
1.65PheLeu: 1.65 ± 1.502
0.0PheMet: 0.0 ± 0.0
3.3PheAsn: 3.3 ± 1.673
1.65PhePro: 1.65 ± 0.747
0.0PheGln: 0.0 ± 0.0
1.65PheArg: 1.65 ± 0.635
4.125PheSer: 4.125 ± 1.112
0.825PheThr: 0.825 ± 0.618
2.475PheVal: 2.475 ± 1.157
0.0PheTrp: 0.0 ± 0.0
2.475PheTyr: 2.475 ± 1.081
0.0PheXaa: 0.0 ± 0.0
Gly
10.726GlyAla: 10.726 ± 1.931
3.3GlyCys: 3.3 ± 0.651
2.475GlyAsp: 2.475 ± 1.004
4.95GlyGlu: 4.95 ± 1.337
0.825GlyPhe: 0.825 ± 0.751
4.95GlyGly: 4.95 ± 2.719
1.65GlyHis: 1.65 ± 1.256
3.3GlyIle: 3.3 ± 1.263
1.65GlyLys: 1.65 ± 0.632
3.3GlyLeu: 3.3 ± 1.542
2.475GlyMet: 2.475 ± 1.097
2.475GlyAsn: 2.475 ± 1.081
1.65GlyPro: 1.65 ± 0.635
4.95GlyGln: 4.95 ± 2.377
8.251GlyArg: 8.251 ± 3.292
9.076GlySer: 9.076 ± 3.117
4.95GlyThr: 4.95 ± 2.89
4.125GlyVal: 4.125 ± 1.627
0.0GlyTrp: 0.0 ± 0.0
2.475GlyTyr: 2.475 ± 1.884
0.0GlyXaa: 0.0 ± 0.0
His
0.825HisAla: 0.825 ± 0.618
0.0HisCys: 0.0 ± 0.0
1.65HisAsp: 1.65 ± 0.635
1.65HisGlu: 1.65 ± 0.632
0.0HisPhe: 0.0 ± 0.0
1.65HisGly: 1.65 ± 1.236
0.825HisHis: 0.825 ± 0.628
0.0HisIle: 0.0 ± 0.0
1.65HisLys: 1.65 ± 1.236
4.125HisLeu: 4.125 ± 1.659
0.0HisMet: 0.0 ± 0.0
0.825HisAsn: 0.825 ± 0.618
2.475HisPro: 2.475 ± 1.246
1.65HisGln: 1.65 ± 0.635
0.825HisArg: 0.825 ± 0.618
1.65HisSer: 1.65 ± 0.635
1.65HisThr: 1.65 ± 1.502
4.95HisVal: 4.95 ± 1.73
0.0HisTrp: 0.0 ± 0.0
0.825HisTyr: 0.825 ± 0.628
0.0HisXaa: 0.0 ± 0.0
Ile
2.475IleAla: 2.475 ± 1.246
0.0IleCys: 0.0 ± 0.0
2.475IleAsp: 2.475 ± 1.081
3.3IleGlu: 3.3 ± 1.957
3.3IlePhe: 3.3 ± 1.673
3.3IleGly: 3.3 ± 1.643
0.0IleHis: 0.0 ± 0.0
0.825IleIle: 0.825 ± 0.628
1.65IleLys: 1.65 ± 0.632
1.65IleLeu: 1.65 ± 0.635
0.825IleMet: 0.825 ± 0.751
2.475IleAsn: 2.475 ± 1.004
4.125IlePro: 4.125 ± 0.673
2.475IleGln: 2.475 ± 1.097
4.125IleArg: 4.125 ± 0.878
2.475IleSer: 2.475 ± 1.004
1.65IleThr: 1.65 ± 1.256
1.65IleVal: 1.65 ± 0.747
1.65IleTrp: 1.65 ± 1.256
4.125IleTyr: 4.125 ± 1.112
0.0IleXaa: 0.0 ± 0.0
Lys
3.3LysAla: 3.3 ± 1.271
0.825LysCys: 0.825 ± 0.618
1.65LysAsp: 1.65 ± 1.256
3.3LysGlu: 3.3 ± 1.542
1.65LysPhe: 1.65 ± 0.632
2.475LysGly: 2.475 ± 1.004
0.825LysHis: 0.825 ± 0.618
1.65LysIle: 1.65 ± 0.632
1.65LysLys: 1.65 ± 0.632
7.426LysLeu: 7.426 ± 0.802
1.65LysMet: 1.65 ± 0.605
1.65LysAsn: 1.65 ± 0.635
4.125LysPro: 4.125 ± 0.673
0.825LysGln: 0.825 ± 0.751
1.65LysArg: 1.65 ± 0.635
3.3LysSer: 3.3 ± 1.673
2.475LysThr: 2.475 ± 1.884
2.475LysVal: 2.475 ± 1.097
1.65LysTrp: 1.65 ± 1.236
3.3LysTyr: 3.3 ± 1.542
0.0LysXaa: 0.0 ± 0.0
Leu
5.776LeuAla: 5.776 ± 1.006
0.825LeuCys: 0.825 ± 0.628
4.125LeuAsp: 4.125 ± 2.123
4.125LeuGlu: 4.125 ± 0.878
1.65LeuPhe: 1.65 ± 0.632
4.95LeuGly: 4.95 ± 2.314
1.65LeuHis: 1.65 ± 0.632
0.825LeuIle: 0.825 ± 0.618
4.125LeuLys: 4.125 ± 1.112
3.3LeuLeu: 3.3 ± 0.496
4.125LeuMet: 4.125 ± 1.659
2.475LeuAsn: 2.475 ± 1.097
4.125LeuPro: 4.125 ± 1.677
0.0LeuGln: 0.0 ± 0.0
9.076LeuArg: 9.076 ± 2.842
4.95LeuSer: 4.95 ± 2.839
4.125LeuThr: 4.125 ± 0.878
6.601LeuVal: 6.601 ± 0.735
0.825LeuTrp: 0.825 ± 0.618
0.825LeuTyr: 0.825 ± 0.628
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
1.65MetCys: 1.65 ± 0.632
0.0MetAsp: 0.0 ± 0.0
1.65MetGlu: 1.65 ± 0.747
0.825MetPhe: 0.825 ± 0.618
0.825MetGly: 0.825 ± 0.751
0.825MetHis: 0.825 ± 0.618
2.475MetIle: 2.475 ± 1.097
1.65MetLys: 1.65 ± 0.632
0.825MetLeu: 0.825 ± 0.751
2.475MetMet: 2.475 ± 1.855
0.0MetAsn: 0.0 ± 0.0
0.825MetPro: 0.825 ± 0.628
1.65MetGln: 1.65 ± 0.635
4.125MetArg: 4.125 ± 1.112
0.825MetSer: 0.825 ± 0.618
0.0MetThr: 0.0 ± 0.0
1.65MetVal: 1.65 ± 1.256
0.825MetTrp: 0.825 ± 0.618
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.125AsnAla: 4.125 ± 0.522
1.65AsnCys: 1.65 ± 1.236
0.0AsnAsp: 0.0 ± 0.0
1.65AsnGlu: 1.65 ± 0.632
1.65AsnPhe: 1.65 ± 0.635
3.3AsnGly: 3.3 ± 0.496
0.825AsnHis: 0.825 ± 0.618
0.0AsnIle: 0.0 ± 0.0
1.65AsnLys: 1.65 ± 1.236
2.475AsnLeu: 2.475 ± 0.14
0.825AsnMet: 0.825 ± 0.618
2.475AsnAsn: 2.475 ± 1.157
0.825AsnPro: 0.825 ± 0.618
0.0AsnGln: 0.0 ± 0.0
3.3AsnArg: 3.3 ± 0.496
2.475AsnSer: 2.475 ± 1.884
2.475AsnThr: 2.475 ± 1.157
1.65AsnVal: 1.65 ± 0.632
2.475AsnTrp: 2.475 ± 1.097
1.65AsnTyr: 1.65 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
4.125ProAla: 4.125 ± 2.061
0.0ProCys: 0.0 ± 0.0
2.475ProAsp: 2.475 ± 1.004
4.95ProGlu: 4.95 ± 1.25
1.65ProPhe: 1.65 ± 1.236
3.3ProGly: 3.3 ± 2.511
0.0ProHis: 0.0 ± 0.0
3.3ProIle: 3.3 ± 1.271
4.95ProLys: 4.95 ± 0.949
3.3ProLeu: 3.3 ± 1.263
0.825ProMet: 0.825 ± 0.628
0.825ProAsn: 0.825 ± 0.618
4.125ProPro: 4.125 ± 0.522
2.475ProGln: 2.475 ± 1.246
7.426ProArg: 7.426 ± 1.639
2.475ProSer: 2.475 ± 1.097
4.95ProThr: 4.95 ± 1.25
4.125ProVal: 4.125 ± 0.878
0.0ProTrp: 0.0 ± 0.0
1.65ProTyr: 1.65 ± 0.632
0.0ProXaa: 0.0 ± 0.0
Gln
9.901GlnAla: 9.901 ± 3.8
0.0GlnCys: 0.0 ± 0.0
1.65GlnAsp: 1.65 ± 0.632
4.95GlnGlu: 4.95 ± 2.493
0.0GlnPhe: 0.0 ± 0.0
3.3GlnGly: 3.3 ± 2.066
0.0GlnHis: 0.0 ± 0.0
0.825GlnIle: 0.825 ± 0.751
0.0GlnLys: 0.0 ± 0.0
0.825GlnLeu: 0.825 ± 0.618
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
2.475GlnPro: 2.475 ± 2.253
0.0GlnGln: 0.0 ± 0.0
1.65GlnArg: 1.65 ± 1.236
1.65GlnSer: 1.65 ± 0.635
0.825GlnThr: 0.825 ± 0.628
1.65GlnVal: 1.65 ± 1.236
0.825GlnTrp: 0.825 ± 0.628
0.825GlnTyr: 0.825 ± 0.628
0.0GlnXaa: 0.0 ± 0.0
Arg
6.601ArgAla: 6.601 ± 1.537
1.65ArgCys: 1.65 ± 0.635
4.95ArgAsp: 4.95 ± 1.337
3.3ArgGlu: 3.3 ± 1.957
6.601ArgPhe: 6.601 ± 2.023
6.601ArgGly: 6.601 ± 0.992
4.95ArgHis: 4.95 ± 2.008
2.475ArgIle: 2.475 ± 0.14
2.475ArgLys: 2.475 ± 2.253
7.426ArgLeu: 7.426 ± 1.607
0.825ArgMet: 0.825 ± 0.618
3.3ArgAsn: 3.3 ± 1.263
2.475ArgPro: 2.475 ± 1.081
4.125ArgGln: 4.125 ± 0.878
7.426ArgArg: 7.426 ± 1.949
7.426ArgSer: 7.426 ± 3.544
4.125ArgThr: 4.125 ± 3.139
4.125ArgVal: 4.125 ± 1.112
1.65ArgTrp: 1.65 ± 0.635
3.3ArgTyr: 3.3 ± 0.651
0.0ArgXaa: 0.0 ± 0.0
Ser
1.65SerAla: 1.65 ± 1.236
0.825SerCys: 0.825 ± 0.618
2.475SerAsp: 2.475 ± 1.36
3.3SerGlu: 3.3 ± 1.493
0.825SerPhe: 0.825 ± 0.628
10.726SerGly: 10.726 ± 3.379
1.65SerHis: 1.65 ± 0.635
4.125SerIle: 4.125 ± 1.271
4.95SerLys: 4.95 ± 0.28
4.95SerLeu: 4.95 ± 1.043
0.825SerMet: 0.825 ± 0.628
1.65SerAsn: 1.65 ± 0.632
4.95SerPro: 4.95 ± 0.941
1.65SerGln: 1.65 ± 1.236
5.776SerArg: 5.776 ± 1.454
11.551SerSer: 11.551 ± 5.617
3.3SerThr: 3.3 ± 1.263
4.95SerVal: 4.95 ± 0.28
2.475SerTrp: 2.475 ± 2.253
1.65SerTyr: 1.65 ± 1.256
0.0SerXaa: 0.0 ± 0.0
Thr
3.3ThrAla: 3.3 ± 1.263
0.0ThrCys: 0.0 ± 0.0
2.475ThrAsp: 2.475 ± 1.884
2.475ThrGlu: 2.475 ± 1.246
2.475ThrPhe: 2.475 ± 1.097
4.95ThrGly: 4.95 ± 1.25
0.825ThrHis: 0.825 ± 0.751
3.3ThrIle: 3.3 ± 0.496
0.825ThrLys: 0.825 ± 0.628
1.65ThrLeu: 1.65 ± 1.256
0.825ThrMet: 0.825 ± 0.628
4.125ThrAsn: 4.125 ± 1.271
1.65ThrPro: 1.65 ± 1.256
0.825ThrGln: 0.825 ± 0.628
8.251ThrArg: 8.251 ± 1.62
1.65ThrSer: 1.65 ± 1.256
1.65ThrThr: 1.65 ± 0.747
4.125ThrVal: 4.125 ± 0.522
0.0ThrTrp: 0.0 ± 0.0
0.825ThrTyr: 0.825 ± 0.628
0.0ThrXaa: 0.0 ± 0.0
Val
4.95ValAla: 4.95 ± 1.043
0.825ValCys: 0.825 ± 0.628
5.776ValAsp: 5.776 ± 0.702
8.251ValGlu: 8.251 ± 1.366
3.3ValPhe: 3.3 ± 1.271
1.65ValGly: 1.65 ± 0.747
2.475ValHis: 2.475 ± 1.246
1.65ValIle: 1.65 ± 0.632
3.3ValLys: 3.3 ± 1.643
6.601ValLeu: 6.601 ± 2.255
0.825ValMet: 0.825 ± 0.681
3.3ValAsn: 3.3 ± 1.493
5.776ValPro: 5.776 ± 1.624
3.3ValGln: 3.3 ± 0.877
3.3ValArg: 3.3 ± 1.957
3.3ValSer: 3.3 ± 1.263
1.65ValThr: 1.65 ± 0.632
3.3ValVal: 3.3 ± 1.643
0.825ValTrp: 0.825 ± 0.628
1.65ValTyr: 1.65 ± 0.635
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.628
0.0TrpCys: 0.0 ± 0.0
2.475TrpAsp: 2.475 ± 1.004
1.65TrpGlu: 1.65 ± 1.256
1.65TrpPhe: 1.65 ± 0.747
0.0TrpGly: 0.0 ± 0.0
0.825TrpHis: 0.825 ± 0.628
0.0TrpIle: 0.0 ± 0.0
1.65TrpLys: 1.65 ± 1.236
0.0TrpLeu: 0.0 ± 0.0
0.825TrpMet: 0.825 ± 0.618
1.65TrpAsn: 1.65 ± 1.236
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
4.95TrpArg: 4.95 ± 1.499
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.825TrpVal: 0.825 ± 0.751
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.65TyrAla: 1.65 ± 0.747
0.825TyrCys: 0.825 ± 0.628
0.825TyrAsp: 0.825 ± 0.751
2.475TyrGlu: 2.475 ± 0.14
0.825TyrPhe: 0.825 ± 0.618
2.475TyrGly: 2.475 ± 1.081
0.825TyrHis: 0.825 ± 0.628
3.3TyrIle: 3.3 ± 1.263
1.65TyrLys: 1.65 ± 0.747
3.3TyrLeu: 3.3 ± 1.263
0.825TyrMet: 0.825 ± 0.751
0.825TyrAsn: 0.825 ± 0.618
1.65TyrPro: 1.65 ± 0.632
0.825TyrGln: 0.825 ± 0.628
2.475TyrArg: 2.475 ± 1.081
0.825TyrSer: 0.825 ± 0.628
1.65TyrThr: 1.65 ± 0.632
2.475TyrVal: 2.475 ± 1.097
0.825TyrTrp: 0.825 ± 0.751
1.65TyrTyr: 1.65 ± 0.632
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski