Amino acid dipepetide frequency for Rhodobaca barguzinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.012AlaAla: 16.012 ± 0.173
1.191AlaCys: 1.191 ± 0.038
6.644AlaAsp: 6.644 ± 0.085
7.97AlaGlu: 7.97 ± 0.088
4.357AlaPhe: 4.357 ± 0.07
10.262AlaGly: 10.262 ± 0.103
2.618AlaHis: 2.618 ± 0.054
5.967AlaIle: 5.967 ± 0.084
3.324AlaLys: 3.324 ± 0.069
15.394AlaLeu: 15.394 ± 0.156
3.808AlaMet: 3.808 ± 0.059
2.687AlaAsn: 2.687 ± 0.053
5.948AlaPro: 5.948 ± 0.085
5.82AlaGln: 5.82 ± 0.086
10.001AlaArg: 10.001 ± 0.118
5.77AlaSer: 5.77 ± 0.071
5.96AlaThr: 5.96 ± 0.074
7.997AlaVal: 7.997 ± 0.101
1.421AlaTrp: 1.421 ± 0.037
2.374AlaTyr: 2.374 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.247CysAla: 1.247 ± 0.036
0.119CysCys: 0.119 ± 0.01
0.678CysAsp: 0.678 ± 0.026
0.425CysGlu: 0.425 ± 0.019
0.355CysPhe: 0.355 ± 0.019
0.925CysGly: 0.925 ± 0.031
0.253CysHis: 0.253 ± 0.016
0.462CysIle: 0.462 ± 0.022
0.206CysLys: 0.206 ± 0.015
0.913CysLeu: 0.913 ± 0.033
0.191CysMet: 0.191 ± 0.013
0.239CysAsn: 0.239 ± 0.015
0.561CysPro: 0.561 ± 0.025
0.242CysGln: 0.242 ± 0.015
0.558CysArg: 0.558 ± 0.025
0.43CysSer: 0.43 ± 0.02
0.456CysThr: 0.456 ± 0.023
0.6CysVal: 0.6 ± 0.022
0.122CysTrp: 0.122 ± 0.009
0.193CysTyr: 0.193 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.305AspAla: 7.305 ± 0.093
0.545AspCys: 0.545 ± 0.02
3.207AspAsp: 3.207 ± 0.074
3.12AspGlu: 3.12 ± 0.063
2.18AspPhe: 2.18 ± 0.043
5.137AspGly: 5.137 ± 0.101
1.312AspHis: 1.312 ± 0.037
3.13AspIle: 3.13 ± 0.052
1.527AspLys: 1.527 ± 0.04
6.478AspLeu: 6.478 ± 0.087
1.877AspMet: 1.877 ± 0.038
1.21AspAsn: 1.21 ± 0.032
3.568AspPro: 3.568 ± 0.061
2.023AspGln: 2.023 ± 0.047
3.914AspArg: 3.914 ± 0.068
2.421AspSer: 2.421 ± 0.054
2.881AspThr: 2.881 ± 0.059
3.855AspVal: 3.855 ± 0.062
1.242AspTrp: 1.242 ± 0.039
1.362AspTyr: 1.362 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.566GluAla: 7.566 ± 0.108
0.382GluCys: 0.382 ± 0.019
3.125GluAsp: 3.125 ± 0.063
3.126GluGlu: 3.126 ± 0.07
2.038GluPhe: 2.038 ± 0.053
4.795GluGly: 4.795 ± 0.077
1.14GluHis: 1.14 ± 0.026
3.641GluIle: 3.641 ± 0.065
1.824GluLys: 1.824 ± 0.048
5.287GluLeu: 5.287 ± 0.077
1.863GluMet: 1.863 ± 0.046
1.722GluAsn: 1.722 ± 0.041
2.308GluPro: 2.308 ± 0.048
2.118GluGln: 2.118 ± 0.045
4.332GluArg: 4.332 ± 0.066
2.258GluSer: 2.258 ± 0.044
3.353GluThr: 3.353 ± 0.063
4.026GluVal: 4.026 ± 0.057
0.731GluTrp: 0.731 ± 0.023
1.056GluTyr: 1.056 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.581PheAla: 4.581 ± 0.056
0.421PheCys: 0.421 ± 0.018
2.747PheAsp: 2.747 ± 0.049
2.108PheGlu: 2.108 ± 0.05
1.414PhePhe: 1.414 ± 0.04
3.68PheGly: 3.68 ± 0.066
0.767PheHis: 0.767 ± 0.027
1.848PheIle: 1.848 ± 0.044
0.776PheLys: 0.776 ± 0.026
3.65PheLeu: 3.65 ± 0.074
0.909PheMet: 0.909 ± 0.03
1.051PheAsn: 1.051 ± 0.035
1.594PhePro: 1.594 ± 0.036
1.055PheGln: 1.055 ± 0.036
2.247PheArg: 2.247 ± 0.045
2.214PheSer: 2.214 ± 0.052
2.046PheThr: 2.046 ± 0.052
2.645PheVal: 2.645 ± 0.054
0.603PheTrp: 0.603 ± 0.026
0.862PheTyr: 0.862 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.251GlyAla: 10.251 ± 0.103
0.877GlyCys: 0.877 ± 0.03
4.123GlyAsp: 4.123 ± 0.073
4.236GlyGlu: 4.236 ± 0.057
3.717GlyPhe: 3.717 ± 0.065
6.879GlyGly: 6.879 ± 0.104
1.968GlyHis: 1.968 ± 0.05
4.246GlyIle: 4.246 ± 0.068
2.745GlyLys: 2.745 ± 0.047
9.591GlyLeu: 9.591 ± 0.111
2.691GlyMet: 2.691 ± 0.049
2.106GlyAsn: 2.106 ± 0.06
3.555GlyPro: 3.555 ± 0.054
3.498GlyGln: 3.498 ± 0.058
5.881GlyArg: 5.881 ± 0.088
3.988GlySer: 3.988 ± 0.095
4.418GlyThr: 4.418 ± 0.083
6.365GlyVal: 6.365 ± 0.082
1.458GlyTrp: 1.458 ± 0.037
2.148GlyTyr: 2.148 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.543HisAla: 2.543 ± 0.051
0.248HisCys: 0.248 ± 0.015
1.434HisAsp: 1.434 ± 0.042
1.088HisGlu: 1.088 ± 0.031
0.851HisPhe: 0.851 ± 0.025
1.857HisGly: 1.857 ± 0.045
0.585HisHis: 0.585 ± 0.026
1.066HisIle: 1.066 ± 0.032
0.533HisLys: 0.533 ± 0.023
2.342HisLeu: 2.342 ± 0.053
0.595HisMet: 0.595 ± 0.022
0.47HisAsn: 0.47 ± 0.022
1.388HisPro: 1.388 ± 0.042
0.682HisGln: 0.682 ± 0.024
1.36HisArg: 1.36 ± 0.036
1.046HisSer: 1.046 ± 0.031
0.816HisThr: 0.816 ± 0.027
1.573HisVal: 1.573 ± 0.04
0.363HisTrp: 0.363 ± 0.019
0.483HisTyr: 0.483 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.263IleAla: 7.263 ± 0.087
0.669IleCys: 0.669 ± 0.03
3.32IleAsp: 3.32 ± 0.053
3.434IleGlu: 3.434 ± 0.057
1.762IlePhe: 1.762 ± 0.048
4.829IleGly: 4.829 ± 0.071
0.922IleHis: 0.922 ± 0.031
2.563IleIle: 2.563 ± 0.056
1.263IleLys: 1.263 ± 0.032
4.86IleLeu: 4.86 ± 0.081
1.21IleMet: 1.21 ± 0.033
1.392IleAsn: 1.392 ± 0.036
2.339IlePro: 2.339 ± 0.045
1.218IleGln: 1.218 ± 0.03
3.397IleArg: 3.397 ± 0.059
3.313IleSer: 3.313 ± 0.055
2.997IleThr: 2.997 ± 0.051
3.763IleVal: 3.763 ± 0.079
0.832IleTrp: 0.832 ± 0.028
1.094IleTyr: 1.094 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.402LysAla: 3.402 ± 0.066
0.178LysCys: 0.178 ± 0.012
1.428LysAsp: 1.428 ± 0.034
1.167LysGlu: 1.167 ± 0.038
0.809LysPhe: 0.809 ± 0.025
2.277LysGly: 2.277 ± 0.046
0.574LysHis: 0.574 ± 0.024
1.436LysIle: 1.436 ± 0.038
0.938LysLys: 0.938 ± 0.036
3.031LysLeu: 3.031 ± 0.056
0.743LysMet: 0.743 ± 0.025
0.624LysAsn: 0.624 ± 0.023
1.724LysPro: 1.724 ± 0.04
0.814LysGln: 0.814 ± 0.027
2.13LysArg: 2.13 ± 0.048
1.611LysSer: 1.611 ± 0.043
1.668LysThr: 1.668 ± 0.042
1.861LysVal: 1.861 ± 0.04
0.321LysTrp: 0.321 ± 0.016
0.542LysTyr: 0.542 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.72LeuAla: 13.72 ± 0.153
0.983LeuCys: 0.983 ± 0.031
6.234LeuAsp: 6.234 ± 0.077
5.689LeuGlu: 5.689 ± 0.074
3.576LeuPhe: 3.576 ± 0.062
8.989LeuGly: 8.989 ± 0.095
2.206LeuHis: 2.206 ± 0.052
5.412LeuIle: 5.412 ± 0.083
2.774LeuLys: 2.774 ± 0.051
9.42LeuLeu: 9.42 ± 0.134
2.875LeuMet: 2.875 ± 0.056
2.78LeuAsn: 2.78 ± 0.05
5.829LeuPro: 5.829 ± 0.073
3.305LeuGln: 3.305 ± 0.061
8.233LeuArg: 8.233 ± 0.096
6.871LeuSer: 6.871 ± 0.08
5.715LeuThr: 5.715 ± 0.084
7.369LeuVal: 7.369 ± 0.101
1.472LeuTrp: 1.472 ± 0.047
1.905LeuTyr: 1.905 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.433MetAla: 3.433 ± 0.059
0.191MetCys: 0.191 ± 0.012
1.404MetAsp: 1.404 ± 0.037
1.328MetGlu: 1.328 ± 0.033
0.868MetPhe: 0.868 ± 0.028
2.353MetGly: 2.353 ± 0.055
0.561MetHis: 0.561 ± 0.022
1.636MetIle: 1.636 ± 0.038
0.897MetLys: 0.897 ± 0.027
2.933MetLeu: 2.933 ± 0.055
0.834MetMet: 0.834 ± 0.032
0.835MetAsn: 0.835 ± 0.029
1.608MetPro: 1.608 ± 0.041
1.129MetGln: 1.129 ± 0.036
2.242MetArg: 2.242 ± 0.048
1.805MetSer: 1.805 ± 0.041
2.075MetThr: 2.075 ± 0.039
1.972MetVal: 1.972 ± 0.044
0.229MetTrp: 0.229 ± 0.014
0.357MetTyr: 0.357 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.205AsnAla: 3.205 ± 0.051
0.253AsnCys: 0.253 ± 0.015
1.343AsnAsp: 1.343 ± 0.046
1.151AsnGlu: 1.151 ± 0.031
0.995AsnPhe: 0.995 ± 0.035
2.138AsnGly: 2.138 ± 0.063
0.503AsnHis: 0.503 ± 0.021
1.353AsnIle: 1.353 ± 0.04
0.59AsnLys: 0.59 ± 0.024
2.648AsnLeu: 2.648 ± 0.049
0.716AsnMet: 0.716 ± 0.028
0.631AsnAsn: 0.631 ± 0.026
1.861AsnPro: 1.861 ± 0.038
0.728AsnGln: 0.728 ± 0.03
1.757AsnArg: 1.757 ± 0.044
1.281AsnSer: 1.281 ± 0.035
1.392AsnThr: 1.392 ± 0.041
1.781AsnVal: 1.781 ± 0.04
0.444AsnTrp: 0.444 ± 0.022
0.652AsnTyr: 0.652 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.915ProAla: 5.915 ± 0.074
0.43ProCys: 0.43 ± 0.02
4.162ProAsp: 4.162 ± 0.078
4.267ProGlu: 4.267 ± 0.075
1.931ProPhe: 1.931 ± 0.042
4.03ProGly: 4.03 ± 0.067
1.129ProHis: 1.129 ± 0.034
2.232ProIle: 2.232 ± 0.046
1.512ProLys: 1.512 ± 0.038
4.84ProLeu: 4.84 ± 0.073
1.355ProMet: 1.355 ± 0.032
1.284ProAsn: 1.284 ± 0.036
2.382ProPro: 2.382 ± 0.057
1.843ProGln: 1.843 ± 0.04
3.043ProArg: 3.043 ± 0.059
2.589ProSer: 2.589 ± 0.045
2.298ProThr: 2.298 ± 0.049
4.214ProVal: 4.214 ± 0.066
0.646ProTrp: 0.646 ± 0.022
1.094ProTyr: 1.094 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.871GlnAla: 4.871 ± 0.066
0.243GlnCys: 0.243 ± 0.014
1.945GlnAsp: 1.945 ± 0.047
1.715GlnGlu: 1.715 ± 0.042
1.188GlnPhe: 1.188 ± 0.032
3.001GlnGly: 3.001 ± 0.056
0.689GlnHis: 0.689 ± 0.026
2.365GlnIle: 2.365 ± 0.052
0.941GlnLys: 0.941 ± 0.031
3.057GlnLeu: 3.057 ± 0.058
1.217GlnMet: 1.217 ± 0.031
0.967GlnAsn: 0.967 ± 0.029
1.872GlnPro: 1.872 ± 0.046
1.251GlnGln: 1.251 ± 0.039
2.592GlnArg: 2.592 ± 0.054
1.929GlnSer: 1.929 ± 0.04
2.058GlnThr: 2.058 ± 0.041
2.508GlnVal: 2.508 ± 0.045
0.439GlnTrp: 0.439 ± 0.02
0.578GlnTyr: 0.578 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.459ArgAla: 9.459 ± 0.113
0.479ArgCys: 0.479 ± 0.024
4.5ArgAsp: 4.5 ± 0.069
4.102ArgGlu: 4.102 ± 0.064
2.879ArgPhe: 2.879 ± 0.056
4.846ArgGly: 4.846 ± 0.07
1.662ArgHis: 1.662 ± 0.039
4.097ArgIle: 4.097 ± 0.058
2.248ArgLys: 2.248 ± 0.049
7.794ArgLeu: 7.794 ± 0.096
2.13ArgMet: 2.13 ± 0.043
2.07ArgAsn: 2.07 ± 0.05
3.398ArgPro: 3.398 ± 0.056
2.443ArgGln: 2.443 ± 0.057
5.101ArgArg: 5.101 ± 0.08
3.332ArgSer: 3.332 ± 0.065
2.922ArgThr: 2.922 ± 0.045
4.842ArgVal: 4.842 ± 0.07
0.977ArgTrp: 0.977 ± 0.033
1.574ArgTyr: 1.574 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.203SerAla: 6.203 ± 0.088
0.462SerCys: 0.462 ± 0.02
3.34SerAsp: 3.34 ± 0.057
3.011SerGlu: 3.011 ± 0.058
2.249SerPhe: 2.249 ± 0.05
5.358SerGly: 5.358 ± 0.065
1.105SerHis: 1.105 ± 0.033
2.478SerIle: 2.478 ± 0.047
1.295SerLys: 1.295 ± 0.038
5.145SerLeu: 5.145 ± 0.08
1.383SerMet: 1.383 ± 0.037
1.337SerAsn: 1.337 ± 0.035
2.652SerPro: 2.652 ± 0.049
1.688SerGln: 1.688 ± 0.037
3.35SerArg: 3.35 ± 0.048
2.499SerSer: 2.499 ± 0.054
2.472SerThr: 2.472 ± 0.048
3.977SerVal: 3.977 ± 0.065
0.674SerTrp: 0.674 ± 0.025
1.25SerTyr: 1.25 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.827ThrAla: 5.827 ± 0.072
0.496ThrCys: 0.496 ± 0.023
2.945ThrAsp: 2.945 ± 0.067
2.894ThrGlu: 2.894 ± 0.047
1.701ThrPhe: 1.701 ± 0.044
5.284ThrGly: 5.284 ± 0.07
1.161ThrHis: 1.161 ± 0.033
2.536ThrIle: 2.536 ± 0.051
1.225ThrLys: 1.225 ± 0.034
6.094ThrLeu: 6.094 ± 0.073
1.22ThrMet: 1.22 ± 0.032
1.207ThrAsn: 1.207 ± 0.031
3.413ThrPro: 3.413 ± 0.056
1.833ThrGln: 1.833 ± 0.047
3.924ThrArg: 3.924 ± 0.065
2.605ThrSer: 2.605 ± 0.05
2.654ThrThr: 2.654 ± 0.058
3.888ThrVal: 3.888 ± 0.071
0.654ThrTrp: 0.654 ± 0.027
1.09ThrTyr: 1.09 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
8.786ValAla: 8.786 ± 0.103
0.621ValCys: 0.621 ± 0.023
3.606ValAsp: 3.606 ± 0.064
4.157ValGlu: 4.157 ± 0.07
2.943ValPhe: 2.943 ± 0.058
5.139ValGly: 5.139 ± 0.071
1.34ValHis: 1.34 ± 0.038
4.402ValIle: 4.402 ± 0.07
1.745ValLys: 1.745 ± 0.043
7.917ValLeu: 7.917 ± 0.104
2.186ValMet: 2.186 ± 0.047
1.861ValAsn: 1.861 ± 0.047
3.449ValPro: 3.449 ± 0.058
2.326ValGln: 2.326 ± 0.043
4.049ValArg: 4.049 ± 0.067
4.081ValSer: 4.081 ± 0.064
4.665ValThr: 4.665 ± 0.073
5.323ValVal: 5.323 ± 0.081
1.02ValTrp: 1.02 ± 0.03
1.314ValTyr: 1.314 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.491TrpAla: 1.491 ± 0.039
0.145TrpCys: 0.145 ± 0.012
0.749TrpAsp: 0.749 ± 0.032
0.603TrpGlu: 0.603 ± 0.023
0.576TrpPhe: 0.576 ± 0.022
1.041TrpGly: 1.041 ± 0.035
0.337TrpHis: 0.337 ± 0.014
0.647TrpIle: 0.647 ± 0.025
0.402TrpLys: 0.402 ± 0.021
1.747TrpLeu: 1.747 ± 0.042
0.408TrpMet: 0.408 ± 0.019
0.418TrpAsn: 0.418 ± 0.019
0.721TrpPro: 0.721 ± 0.027
0.742TrpGln: 0.742 ± 0.026
1.208TrpArg: 1.208 ± 0.037
0.764TrpSer: 0.764 ± 0.026
0.705TrpThr: 0.705 ± 0.025
1.014TrpVal: 1.014 ± 0.032
0.22TrpTrp: 0.22 ± 0.013
0.259TrpTyr: 0.259 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.445TyrAla: 2.445 ± 0.044
0.242TyrCys: 0.242 ± 0.016
1.36TyrAsp: 1.36 ± 0.037
1.099TyrGlu: 1.099 ± 0.034
0.832TyrPhe: 0.832 ± 0.025
1.92TyrGly: 1.92 ± 0.046
0.49TyrHis: 0.49 ± 0.021
0.92TyrIle: 0.92 ± 0.029
0.513TyrLys: 0.513 ± 0.021
2.215TyrLeu: 2.215 ± 0.046
0.479TyrMet: 0.479 ± 0.023
0.531TyrAsn: 0.531 ± 0.021
1.026TyrPro: 1.026 ± 0.03
0.67TyrGln: 0.67 ± 0.024
1.534TyrArg: 1.534 ± 0.035
1.122TyrSer: 1.122 ± 0.032
1.098TyrThr: 1.098 ± 0.038
1.361TyrVal: 1.361 ± 0.032
0.33TyrTrp: 0.33 ± 0.018
0.475TyrTyr: 0.475 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3617 proteins (1148357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski