Amino acid dipepetide frequency for Streptomyces palmae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.869AlaAla: 22.869 ± 0.173
1.131AlaCys: 1.131 ± 0.029
8.498AlaAsp: 8.498 ± 0.075
9.984AlaGlu: 9.984 ± 0.114
3.484AlaPhe: 3.484 ± 0.045
13.7AlaGly: 13.7 ± 0.1
2.93AlaHis: 2.93 ± 0.041
3.617AlaIle: 3.617 ± 0.048
2.748AlaLys: 2.748 ± 0.053
14.822AlaLeu: 14.822 ± 0.115
2.536AlaMet: 2.536 ± 0.038
1.78AlaAsn: 1.78 ± 0.033
7.603AlaPro: 7.603 ± 0.077
3.982AlaGln: 3.982 ± 0.044
11.006AlaArg: 11.006 ± 0.095
5.484AlaSer: 5.484 ± 0.053
6.838AlaThr: 6.838 ± 0.063
12.191AlaVal: 12.191 ± 0.093
1.82AlaTrp: 1.82 ± 0.033
2.612AlaTyr: 2.612 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.183CysAla: 1.183 ± 0.025
0.107CysCys: 0.107 ± 0.008
0.476CysAsp: 0.476 ± 0.016
0.428CysGlu: 0.428 ± 0.016
0.222CysPhe: 0.222 ± 0.01
1.014CysGly: 1.014 ± 0.024
0.194CysHis: 0.194 ± 0.01
0.141CysIle: 0.141 ± 0.009
0.123CysLys: 0.123 ± 0.009
0.745CysLeu: 0.745 ± 0.019
0.127CysMet: 0.127 ± 0.009
0.113CysAsn: 0.113 ± 0.007
0.548CysPro: 0.548 ± 0.018
0.216CysGln: 0.216 ± 0.012
0.673CysArg: 0.673 ± 0.019
0.446CysSer: 0.446 ± 0.015
0.508CysThr: 0.508 ± 0.017
0.662CysVal: 0.662 ± 0.018
0.13CysTrp: 0.13 ± 0.009
0.156CysTyr: 0.156 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.47AspAla: 7.47 ± 0.075
0.427AspCys: 0.427 ± 0.015
3.014AspAsp: 3.014 ± 0.052
3.649AspGlu: 3.649 ± 0.042
1.57AspPhe: 1.57 ± 0.031
6.184AspGly: 6.184 ± 0.067
1.393AspHis: 1.393 ± 0.027
1.86AspIle: 1.86 ± 0.034
1.099AspLys: 1.099 ± 0.031
6.175AspLeu: 6.175 ± 0.063
0.791AspMet: 0.791 ± 0.019
0.844AspAsn: 0.844 ± 0.022
4.792AspPro: 4.792 ± 0.053
1.725AspGln: 1.725 ± 0.031
5.381AspArg: 5.381 ± 0.055
2.541AspSer: 2.541 ± 0.041
3.223AspThr: 3.223 ± 0.042
3.902AspVal: 3.902 ± 0.049
1.081AspTrp: 1.081 ± 0.029
1.122AspTyr: 1.122 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
7.998GluAla: 7.998 ± 0.105
0.426GluCys: 0.426 ± 0.015
3.022GluAsp: 3.022 ± 0.046
3.827GluGlu: 3.827 ± 0.055
1.452GluPhe: 1.452 ± 0.028
4.528GluGly: 4.528 ± 0.051
1.604GluHis: 1.604 ± 0.026
2.196GluIle: 2.196 ± 0.035
1.257GluLys: 1.257 ± 0.026
7.309GluLeu: 7.309 ± 0.07
0.862GluMet: 0.862 ± 0.02
0.892GluAsn: 0.892 ± 0.021
3.618GluPro: 3.618 ± 0.05
2.335GluGln: 2.335 ± 0.038
5.933GluArg: 5.933 ± 0.065
2.608GluSer: 2.608 ± 0.041
2.791GluThr: 2.791 ± 0.043
4.88GluVal: 4.88 ± 0.055
0.755GluTrp: 0.755 ± 0.019
1.084GluTyr: 1.084 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.579PheAla: 3.579 ± 0.042
0.251PheCys: 0.251 ± 0.01
1.914PheAsp: 1.914 ± 0.032
1.415PheGlu: 1.415 ± 0.025
0.82PhePhe: 0.82 ± 0.024
2.934PheGly: 2.934 ± 0.047
0.662PheHis: 0.662 ± 0.019
0.674PheIle: 0.674 ± 0.021
0.455PheLys: 0.455 ± 0.017
2.5PheLeu: 2.5 ± 0.041
0.368PheMet: 0.368 ± 0.014
0.497PheAsn: 0.497 ± 0.016
1.354PhePro: 1.354 ± 0.024
0.708PheGln: 0.708 ± 0.018
1.837PheArg: 1.837 ± 0.031
1.367PheSer: 1.367 ± 0.027
1.939PheThr: 1.939 ± 0.035
1.995PheVal: 1.995 ± 0.034
0.382PheTrp: 0.382 ± 0.014
0.518PheTyr: 0.518 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.644GlyAla: 11.644 ± 0.093
0.908GlyCys: 0.908 ± 0.024
4.945GlyAsp: 4.945 ± 0.058
5.415GlyGlu: 5.415 ± 0.058
2.794GlyPhe: 2.794 ± 0.041
9.346GlyGly: 9.346 ± 0.089
2.439GlyHis: 2.439 ± 0.038
3.334GlyIle: 3.334 ± 0.042
2.34GlyLys: 2.34 ± 0.045
9.422GlyLeu: 9.422 ± 0.092
2.086GlyMet: 2.086 ± 0.033
1.571GlyAsn: 1.571 ± 0.029
5.715GlyPro: 5.715 ± 0.074
2.792GlyGln: 2.792 ± 0.041
8.215GlyArg: 8.215 ± 0.072
5.388GlySer: 5.388 ± 0.058
6.532GlyThr: 6.532 ± 0.072
7.505GlyVal: 7.505 ± 0.074
1.708GlyTrp: 1.708 ± 0.033
2.333GlyTyr: 2.333 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.714HisAla: 2.714 ± 0.04
0.213HisCys: 0.213 ± 0.012
1.233HisAsp: 1.233 ± 0.023
1.144HisGlu: 1.144 ± 0.021
0.626HisPhe: 0.626 ± 0.023
2.527HisGly: 2.527 ± 0.039
0.732HisHis: 0.732 ± 0.02
0.697HisIle: 0.697 ± 0.017
0.341HisLys: 0.341 ± 0.014
2.49HisLeu: 2.49 ± 0.035
0.317HisMet: 0.317 ± 0.012
0.339HisAsn: 0.339 ± 0.013
2.112HisPro: 2.112 ± 0.035
0.816HisGln: 0.816 ± 0.023
2.31HisArg: 2.31 ± 0.037
1.077HisSer: 1.077 ± 0.021
1.423HisThr: 1.423 ± 0.029
1.51HisVal: 1.51 ± 0.03
0.373HisTrp: 0.373 ± 0.014
0.462HisTyr: 0.462 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.826IleAla: 4.826 ± 0.053
0.277IleCys: 0.277 ± 0.011
2.186IleAsp: 2.186 ± 0.034
2.065IleGlu: 2.065 ± 0.035
0.655IlePhe: 0.655 ± 0.018
3.495IleGly: 3.495 ± 0.047
0.62IleHis: 0.62 ± 0.017
0.792IleIle: 0.792 ± 0.022
0.706IleLys: 0.706 ± 0.021
2.208IleLeu: 2.208 ± 0.038
0.414IleMet: 0.414 ± 0.015
0.647IleAsn: 0.647 ± 0.019
1.788IlePro: 1.788 ± 0.029
0.691IleGln: 0.691 ± 0.02
2.334IleArg: 2.334 ± 0.032
1.662IleSer: 1.662 ± 0.03
2.263IleThr: 2.263 ± 0.041
2.458IleVal: 2.458 ± 0.041
0.369IleTrp: 0.369 ± 0.015
0.524IleTyr: 0.524 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
2.664LysAla: 2.664 ± 0.049
0.104LysCys: 0.104 ± 0.009
1.267LysAsp: 1.267 ± 0.032
1.146LysGlu: 1.146 ± 0.029
0.396LysPhe: 0.396 ± 0.015
1.705LysGly: 1.705 ± 0.037
0.404LysHis: 0.404 ± 0.014
0.773LysIle: 0.773 ± 0.021
0.776LysLys: 0.776 ± 0.031
1.837LysLeu: 1.837 ± 0.036
0.341LysMet: 0.341 ± 0.012
0.462LysAsn: 0.462 ± 0.017
1.284LysPro: 1.284 ± 0.032
0.631LysGln: 0.631 ± 0.019
1.424LysArg: 1.424 ± 0.031
1.016LysSer: 1.016 ± 0.027
1.17LysThr: 1.17 ± 0.029
1.704LysVal: 1.704 ± 0.032
0.21LysTrp: 0.21 ± 0.011
0.395LysTyr: 0.395 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.848LeuAla: 15.848 ± 0.132
0.872LeuCys: 0.872 ± 0.022
6.783LeuAsp: 6.783 ± 0.06
4.943LeuGlu: 4.943 ± 0.06
2.531LeuPhe: 2.531 ± 0.041
9.393LeuGly: 9.393 ± 0.077
2.422LeuHis: 2.422 ± 0.036
3.186LeuIle: 3.186 ± 0.049
1.763LeuLys: 1.763 ± 0.03
11.513LeuLeu: 11.513 ± 0.096
1.533LeuMet: 1.533 ± 0.031
1.538LeuAsn: 1.538 ± 0.033
6.728LeuPro: 6.728 ± 0.059
2.005LeuGln: 2.005 ± 0.034
9.325LeuArg: 9.325 ± 0.071
5.301LeuSer: 5.301 ± 0.051
6.756LeuThr: 6.756 ± 0.061
8.532LeuVal: 8.532 ± 0.073
1.292LeuTrp: 1.292 ± 0.024
1.764LeuTyr: 1.764 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
2.383MetAla: 2.383 ± 0.034
0.141MetCys: 0.141 ± 0.009
0.946MetAsp: 0.946 ± 0.021
0.774MetGlu: 0.774 ± 0.019
0.432MetPhe: 0.432 ± 0.015
1.332MetGly: 1.332 ± 0.027
0.324MetHis: 0.324 ± 0.013
0.576MetIle: 0.576 ± 0.015
0.344MetLys: 0.344 ± 0.014
1.655MetLeu: 1.655 ± 0.034
0.282MetMet: 0.282 ± 0.013
0.396MetAsn: 0.396 ± 0.013
1.089MetPro: 1.089 ± 0.026
0.387MetGln: 0.387 ± 0.013
1.438MetArg: 1.438 ± 0.028
1.232MetSer: 1.232 ± 0.023
1.406MetThr: 1.406 ± 0.027
1.322MetVal: 1.322 ± 0.029
0.193MetTrp: 0.193 ± 0.009
0.296MetTyr: 0.296 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.036AsnAla: 2.036 ± 0.029
0.151AsnCys: 0.151 ± 0.008
0.838AsnAsp: 0.838 ± 0.025
0.758AsnGlu: 0.758 ± 0.019
0.409AsnPhe: 0.409 ± 0.015
1.708AsnGly: 1.708 ± 0.033
0.388AsnHis: 0.388 ± 0.016
0.597AsnIle: 0.597 ± 0.017
0.368AsnLys: 0.368 ± 0.014
1.573AsnLeu: 1.573 ± 0.029
0.268AsnMet: 0.268 ± 0.012
0.354AsnAsn: 0.354 ± 0.015
1.275AsnPro: 1.275 ± 0.026
0.475AsnGln: 0.475 ± 0.015
1.215AsnArg: 1.215 ± 0.024
0.778AsnSer: 0.778 ± 0.019
1.0AsnThr: 1.0 ± 0.03
1.172AsnVal: 1.172 ± 0.028
0.266AsnTrp: 0.266 ± 0.011
0.36AsnTyr: 0.36 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.314ProAla: 9.314 ± 0.079
0.362ProCys: 0.362 ± 0.013
4.579ProAsp: 4.579 ± 0.058
4.817ProGlu: 4.817 ± 0.053
1.488ProPhe: 1.488 ± 0.025
7.259ProGly: 7.259 ± 0.096
1.454ProHis: 1.454 ± 0.025
1.422ProIle: 1.422 ± 0.026
1.135ProLys: 1.135 ± 0.028
5.553ProLeu: 5.553 ± 0.059
1.008ProMet: 1.008 ± 0.023
0.875ProAsn: 0.875 ± 0.023
3.739ProPro: 3.739 ± 0.062
1.893ProGln: 1.893 ± 0.034
4.466ProArg: 4.466 ± 0.049
3.131ProSer: 3.131 ± 0.042
3.203ProThr: 3.203 ± 0.042
5.451ProVal: 5.451 ± 0.049
0.945ProTrp: 0.945 ± 0.024
1.33ProTyr: 1.33 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.086GlnAla: 4.086 ± 0.052
0.165GlnCys: 0.165 ± 0.009
1.493GlnAsp: 1.493 ± 0.028
1.555GlnGlu: 1.555 ± 0.03
0.57GlnPhe: 0.57 ± 0.016
2.502GlnGly: 2.502 ± 0.037
0.688GlnHis: 0.688 ± 0.022
1.012GlnIle: 1.012 ± 0.022
0.522GlnLys: 0.522 ± 0.021
3.017GlnLeu: 3.017 ± 0.041
0.448GlnMet: 0.448 ± 0.017
0.439GlnAsn: 0.439 ± 0.014
1.871GlnPro: 1.871 ± 0.039
1.22GlnGln: 1.22 ± 0.031
2.664GlnArg: 2.664 ± 0.034
1.168GlnSer: 1.168 ± 0.024
1.315GlnThr: 1.315 ± 0.024
2.508GlnVal: 2.508 ± 0.036
0.474GlnTrp: 0.474 ± 0.016
0.502GlnTyr: 0.502 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
10.541ArgAla: 10.541 ± 0.099
0.687ArgCys: 0.687 ± 0.016
4.22ArgAsp: 4.22 ± 0.06
5.087ArgGlu: 5.087 ± 0.054
2.362ArgPhe: 2.362 ± 0.033
6.347ArgGly: 6.347 ± 0.056
2.309ArgHis: 2.309 ± 0.034
3.349ArgIle: 3.349 ± 0.042
1.616ArgLys: 1.616 ± 0.035
9.681ArgLeu: 9.681 ± 0.098
1.81ArgMet: 1.81 ± 0.031
1.349ArgAsn: 1.349 ± 0.027
5.515ArgPro: 5.515 ± 0.057
2.64ArgGln: 2.64 ± 0.038
8.223ArgArg: 8.223 ± 0.089
4.027ArgSer: 4.027 ± 0.052
5.557ArgThr: 5.557 ± 0.056
6.052ArgVal: 6.052 ± 0.057
1.423ArgTrp: 1.423 ± 0.028
1.89ArgTyr: 1.89 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.69SerAla: 6.69 ± 0.058
0.451SerCys: 0.451 ± 0.014
2.529SerAsp: 2.529 ± 0.043
2.379SerGlu: 2.379 ± 0.034
1.478SerPhe: 1.478 ± 0.03
5.987SerGly: 5.987 ± 0.054
1.022SerHis: 1.022 ± 0.025
1.365SerIle: 1.365 ± 0.028
0.905SerLys: 0.905 ± 0.025
4.675SerLeu: 4.675 ± 0.049
1.002SerMet: 1.002 ± 0.023
0.787SerAsn: 0.787 ± 0.021
3.118SerPro: 3.118 ± 0.042
1.238SerGln: 1.238 ± 0.025
3.612SerArg: 3.612 ± 0.047
2.651SerSer: 2.651 ± 0.045
2.859SerThr: 2.859 ± 0.041
3.926SerVal: 3.926 ± 0.048
0.869SerTrp: 0.869 ± 0.022
1.152SerTyr: 1.152 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
9.035ThrAla: 9.035 ± 0.075
0.403ThrCys: 0.403 ± 0.015
3.36ThrAsp: 3.36 ± 0.043
3.377ThrGlu: 3.377 ± 0.045
1.448ThrPhe: 1.448 ± 0.03
6.984ThrGly: 6.984 ± 0.067
1.163ThrHis: 1.163 ± 0.028
1.632ThrIle: 1.632 ± 0.032
1.001ThrLys: 1.001 ± 0.026
5.58ThrLeu: 5.58 ± 0.048
0.915ThrMet: 0.915 ± 0.022
0.88ThrAsn: 0.88 ± 0.022
4.06ThrPro: 4.06 ± 0.051
1.273ThrGln: 1.273 ± 0.03
3.965ThrArg: 3.965 ± 0.043
2.881ThrSer: 2.881 ± 0.038
3.58ThrThr: 3.58 ± 0.058
5.892ThrVal: 5.892 ± 0.054
0.804ThrTrp: 0.804 ± 0.021
1.186ThrTyr: 1.186 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
10.387ValAla: 10.387 ± 0.079
0.802ValCys: 0.802 ± 0.019
4.82ValAsp: 4.82 ± 0.057
4.696ValGlu: 4.696 ± 0.052
2.368ValPhe: 2.368 ± 0.04
6.222ValGly: 6.222 ± 0.07
1.935ValHis: 1.935 ± 0.033
2.784ValIle: 2.784 ± 0.043
1.557ValLys: 1.557 ± 0.031
9.439ValLeu: 9.439 ± 0.081
1.337ValMet: 1.337 ± 0.025
1.552ValAsn: 1.552 ± 0.031
5.297ValPro: 5.297 ± 0.062
1.909ValGln: 1.909 ± 0.032
7.365ValArg: 7.365 ± 0.063
4.163ValSer: 4.163 ± 0.047
4.931ValThr: 4.931 ± 0.052
7.439ValVal: 7.439 ± 0.076
1.072ValTrp: 1.072 ± 0.026
1.506ValTyr: 1.506 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.693TrpAla: 1.693 ± 0.033
0.159TrpCys: 0.159 ± 0.01
0.81TrpAsp: 0.81 ± 0.019
0.759TrpGlu: 0.759 ± 0.018
0.465TrpPhe: 0.465 ± 0.017
1.091TrpGly: 1.091 ± 0.024
0.375TrpHis: 0.375 ± 0.014
0.522TrpIle: 0.522 ± 0.017
0.318TrpLys: 0.318 ± 0.014
1.766TrpLeu: 1.766 ± 0.032
0.264TrpMet: 0.264 ± 0.012
0.323TrpAsn: 0.323 ± 0.014
0.787TrpPro: 0.787 ± 0.022
0.602TrpGln: 0.602 ± 0.018
1.389TrpArg: 1.389 ± 0.026
0.895TrpSer: 0.895 ± 0.024
0.946TrpThr: 0.946 ± 0.024
0.996TrpVal: 0.996 ± 0.022
0.326TrpTrp: 0.326 ± 0.014
0.348TrpTyr: 0.348 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.04
0.176TyrCys: 0.176 ± 0.008
1.312TyrAsp: 1.312 ± 0.031
1.159TyrGlu: 1.159 ± 0.027
0.599TyrPhe: 0.599 ± 0.017
2.178TyrGly: 2.178 ± 0.04
0.395TyrHis: 0.395 ± 0.013
0.449TyrIle: 0.449 ± 0.016
0.335TyrLys: 0.335 ± 0.013
2.069TyrLeu: 2.069 ± 0.038
0.242TyrMet: 0.242 ± 0.011
0.348TyrAsn: 0.348 ± 0.013
1.135TyrPro: 1.135 ± 0.024
0.68TyrGln: 0.68 ± 0.019
1.911TyrArg: 1.911 ± 0.031
0.878TyrSer: 0.878 ± 0.023
1.177TyrThr: 1.177 ± 0.027
1.485TyrVal: 1.485 ± 0.03
0.341TyrTrp: 0.341 ± 0.013
0.415TyrTyr: 0.415 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6120 proteins (2028746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski