Amino acid dipepetide frequency for Heliocybe sulcata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.749AlaAla: 8.749 ± 0.053	1.18AlaCys: 1.18 ± 0.018	4.286AlaAsp: 4.286 ± 0.031	5.031AlaGlu: 5.031 ± 0.04	3.198AlaPhe: 3.198 ± 0.033	5.845AlaGly: 5.845 ± 0.039	2.036AlaHis: 2.036 ± 0.023	4.015AlaIle: 4.015 ± 0.033	3.845AlaLys: 3.845 ± 0.035	8.428AlaLeu: 8.428 ± 0.048	2.064AlaMet: 2.064 ± 0.02	2.635AlaAsn: 2.635 ± 0.024	5.384AlaPro: 5.384 ± 0.042	3.339AlaGln: 3.339 ± 0.026	5.47AlaArg: 5.47 ± 0.036	8.016AlaSer: 8.016 ± 0.054	5.118AlaThr: 5.118 ± 0.036	5.819AlaVal: 5.819 ± 0.038	1.241AlaTrp: 1.241 ± 0.015	2.356AlaTyr: 2.356 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.016	0.286CysCys: 0.286 ± 0.008	0.652CysAsp: 0.652 ± 0.013	0.594CysGlu: 0.594 ± 0.012	0.535CysPhe: 0.535 ± 0.011	0.946CysGly: 0.946 ± 0.016	0.363CysHis: 0.363 ± 0.01	0.713CysIle: 0.713 ± 0.013	0.522CysLys: 0.522 ± 0.011	1.35CysLeu: 1.35 ± 0.019	0.314CysMet: 0.314 ± 0.008	0.408CysAsn: 0.408 ± 0.01	0.811CysPro: 0.811 ± 0.014	0.462CysGln: 0.462 ± 0.011	0.856CysArg: 0.856 ± 0.014	1.061CysSer: 1.061 ± 0.019	0.78CysThr: 0.78 ± 0.011	0.83CysVal: 0.83 ± 0.013	0.237CysTrp: 0.237 ± 0.006	0.388CysTyr: 0.388 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.028AspAla: 5.028 ± 0.034	0.625AspCys: 0.625 ± 0.011	3.88AspAsp: 3.88 ± 0.035	4.341AspGlu: 4.341 ± 0.039	1.984AspPhe: 1.984 ± 0.023	3.972AspGly: 3.972 ± 0.034	1.194AspHis: 1.194 ± 0.015	2.907AspIle: 2.907 ± 0.024	2.136AspLys: 2.136 ± 0.025	5.006AspLeu: 5.006 ± 0.035	1.301AspMet: 1.301 ± 0.015	1.575AspAsn: 1.575 ± 0.017	3.463AspPro: 3.463 ± 0.031	1.62AspGln: 1.62 ± 0.02	3.028AspArg: 3.028 ± 0.029	3.904AspSer: 3.904 ± 0.028	2.826AspThr: 2.826 ± 0.026	4.096AspVal: 4.096 ± 0.032	0.92AspTrp: 0.92 ± 0.016	1.559AspTyr: 1.559 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.163GluAla: 5.163 ± 0.04	0.66GluCys: 0.66 ± 0.012	4.305GluAsp: 4.305 ± 0.038	5.887GluGlu: 5.887 ± 0.067	1.745GluPhe: 1.745 ± 0.02	4.085GluGly: 4.085 ± 0.034	1.433GluHis: 1.433 ± 0.017	2.619GluIle: 2.619 ± 0.024	3.269GluLys: 3.269 ± 0.028	5.197GluLeu: 5.197 ± 0.04	1.392GluMet: 1.392 ± 0.015	1.785GluAsn: 1.785 ± 0.018	2.796GluPro: 2.796 ± 0.029	2.269GluGln: 2.269 ± 0.026	4.247GluArg: 4.247 ± 0.037	4.069GluSer: 4.069 ± 0.034	3.042GluThr: 3.042 ± 0.029	3.814GluVal: 3.814 ± 0.03	0.976GluTrp: 0.976 ± 0.016	1.672GluTyr: 1.672 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.045PheAla: 3.045 ± 0.026	0.543PheCys: 0.543 ± 0.01	2.11PheAsp: 2.11 ± 0.023	1.878PheGlu: 1.878 ± 0.017	1.436PhePhe: 1.436 ± 0.022	2.659PheGly: 2.659 ± 0.025	0.887PheHis: 0.887 ± 0.014	1.684PheIle: 1.684 ± 0.018	1.384PheLys: 1.384 ± 0.016	3.453PheLeu: 3.453 ± 0.028	0.773PheMet: 0.773 ± 0.012	1.191PheAsn: 1.191 ± 0.017	2.034PhePro: 2.034 ± 0.021	1.209PheGln: 1.209 ± 0.016	1.973PheArg: 1.973 ± 0.021	2.953PheSer: 2.953 ± 0.026	2.071PheThr: 2.071 ± 0.023	2.438PheVal: 2.438 ± 0.024	0.579PheTrp: 0.579 ± 0.011	1.01PheTyr: 1.01 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.358GlyAla: 5.358 ± 0.038	0.897GlyCys: 0.897 ± 0.014	3.503GlyAsp: 3.503 ± 0.025	3.713GlyGlu: 3.713 ± 0.031	2.493GlyPhe: 2.493 ± 0.025	5.447GlyGly: 5.447 ± 0.053	1.722GlyHis: 1.722 ± 0.021	3.241GlyIle: 3.241 ± 0.029	3.389GlyLys: 3.389 ± 0.031	5.871GlyLeu: 5.871 ± 0.039	1.611GlyMet: 1.611 ± 0.02	2.187GlyAsn: 2.187 ± 0.026	3.467GlyPro: 3.467 ± 0.026	2.435GlyGln: 2.435 ± 0.021	4.486GlyArg: 4.486 ± 0.032	5.828GlySer: 5.828 ± 0.04	4.045GlyThr: 4.045 ± 0.034	4.373GlyVal: 4.373 ± 0.032	1.178GlyTrp: 1.178 ± 0.019	2.027GlyTyr: 2.027 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.104HisAla: 2.104 ± 0.019	0.382HisCys: 0.382 ± 0.009	1.267HisAsp: 1.267 ± 0.015	1.281HisGlu: 1.281 ± 0.014	0.905HisPhe: 0.905 ± 0.012	1.687HisGly: 1.687 ± 0.018	0.825HisHis: 0.825 ± 0.015	1.272HisIle: 1.272 ± 0.02	0.872HisLys: 0.872 ± 0.014	2.499HisLeu: 2.499 ± 0.025	0.531HisMet: 0.531 ± 0.01	0.742HisAsn: 0.742 ± 0.012	1.905HisPro: 1.905 ± 0.018	0.859HisGln: 0.859 ± 0.012	1.64HisArg: 1.64 ± 0.02	2.02HisSer: 2.02 ± 0.022	1.36HisThr: 1.36 ± 0.017	1.642HisVal: 1.642 ± 0.021	0.367HisTrp: 0.367 ± 0.009	0.717HisTyr: 0.717 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.024IleAla: 4.024 ± 0.031	0.746IleCys: 0.746 ± 0.011	2.544IleAsp: 2.544 ± 0.022	2.489IleGlu: 2.489 ± 0.027	1.746IlePhe: 1.746 ± 0.022	2.887IleGly: 2.887 ± 0.028	1.173IleHis: 1.173 ± 0.017	2.252IleIle: 2.252 ± 0.025	1.877IleLys: 1.877 ± 0.02	4.438IleLeu: 4.438 ± 0.033	0.947IleMet: 0.947 ± 0.013	1.441IleAsn: 1.441 ± 0.017	3.121IlePro: 3.121 ± 0.026	1.701IleGln: 1.701 ± 0.017	2.843IleArg: 2.843 ± 0.024	3.704IleSer: 3.704 ± 0.029	2.595IleThr: 2.595 ± 0.028	3.182IleVal: 3.182 ± 0.025	0.748IleTrp: 0.748 ± 0.014	1.3IleTyr: 1.3 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.183LysAla: 4.183 ± 0.04	0.495LysCys: 0.495 ± 0.011	2.504LysAsp: 2.504 ± 0.024	3.251LysGlu: 3.251 ± 0.028	1.262LysPhe: 1.262 ± 0.018	2.918LysGly: 2.918 ± 0.026	1.057LysHis: 1.057 ± 0.016	1.87LysIle: 1.87 ± 0.02	2.861LysLys: 2.861 ± 0.041	3.734LysLeu: 3.734 ± 0.029	0.928LysMet: 0.928 ± 0.014	1.354LysAsn: 1.354 ± 0.018	2.467LysPro: 2.467 ± 0.024	1.607LysGln: 1.607 ± 0.019	3.382LysArg: 3.382 ± 0.032	3.195LysSer: 3.195 ± 0.032	2.488LysThr: 2.488 ± 0.025	2.728LysVal: 2.728 ± 0.025	0.653LysTrp: 0.653 ± 0.011	1.239LysTyr: 1.239 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.193LeuAla: 8.193 ± 0.047	1.353LeuCys: 1.353 ± 0.019	5.102LeuAsp: 5.102 ± 0.036	5.421LeuGlu: 5.421 ± 0.043	3.369LeuPhe: 3.369 ± 0.03	5.874LeuGly: 5.874 ± 0.038	2.473LeuHis: 2.473 ± 0.026	3.709LeuIle: 3.709 ± 0.029	3.891LeuLys: 3.891 ± 0.031	8.912LeuLeu: 8.912 ± 0.052	1.829LeuMet: 1.829 ± 0.019	2.896LeuAsn: 2.896 ± 0.023	6.279LeuPro: 6.279 ± 0.04	3.701LeuGln: 3.701 ± 0.027	6.267LeuArg: 6.267 ± 0.045	8.15LeuSer: 8.15 ± 0.04	5.125LeuThr: 5.125 ± 0.036	5.875LeuVal: 5.875 ± 0.038	1.294LeuTrp: 1.294 ± 0.016	2.487LeuTyr: 2.487 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.025MetAla: 2.025 ± 0.021	0.259MetCys: 0.259 ± 0.007	1.286MetAsp: 1.286 ± 0.015	1.292MetGlu: 1.292 ± 0.016	0.722MetPhe: 0.722 ± 0.013	1.366MetGly: 1.366 ± 0.018	0.582MetHis: 0.582 ± 0.011	0.909MetIle: 0.909 ± 0.015	1.002MetLys: 1.002 ± 0.013	1.92MetLeu: 1.92 ± 0.02	0.518MetMet: 0.518 ± 0.01	0.765MetAsn: 0.765 ± 0.013	1.446MetPro: 1.446 ± 0.018	0.899MetGln: 0.899 ± 0.014	1.354MetArg: 1.354 ± 0.015	2.083MetSer: 2.083 ± 0.021	1.292MetThr: 1.292 ± 0.016	1.27MetVal: 1.27 ± 0.016	0.281MetTrp: 0.281 ± 0.007	0.578MetTyr: 0.578 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.983AsnAla: 2.983 ± 0.027	0.391AsnCys: 0.391 ± 0.009	1.604AsnAsp: 1.604 ± 0.016	1.683AsnGlu: 1.683 ± 0.019	1.115AsnPhe: 1.115 ± 0.018	2.521AsnGly: 2.521 ± 0.028	0.735AsnHis: 0.735 ± 0.011	1.732AsnIle: 1.732 ± 0.019	1.25AsnLys: 1.25 ± 0.016	2.855AsnLeu: 2.855 ± 0.025	0.729AsnMet: 0.729 ± 0.012	1.089AsnAsn: 1.089 ± 0.015	2.192AsnPro: 2.192 ± 0.022	1.039AsnGln: 1.039 ± 0.018	1.704AsnArg: 1.704 ± 0.018	2.329AsnSer: 2.329 ± 0.024	1.856AsnThr: 1.856 ± 0.023	2.26AsnVal: 2.26 ± 0.022	0.484AsnTrp: 0.484 ± 0.01	0.893AsnTyr: 0.893 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.823ProAla: 5.823 ± 0.046	0.609ProCys: 0.609 ± 0.015	3.395ProAsp: 3.395 ± 0.027	3.915ProGlu: 3.915 ± 0.034	2.132ProPhe: 2.132 ± 0.02	4.113ProGly: 4.113 ± 0.034	1.495ProHis: 1.495 ± 0.019	2.487ProIle: 2.487 ± 0.021	2.441ProLys: 2.441 ± 0.024	5.344ProLeu: 5.344 ± 0.035	1.165ProMet: 1.165 ± 0.017	1.989ProAsn: 1.989 ± 0.023	6.189ProPro: 6.189 ± 0.08	2.284ProGln: 2.284 ± 0.029	3.791ProArg: 3.791 ± 0.036	7.349ProSer: 7.349 ± 0.067	4.178ProThr: 4.178 ± 0.035	4.065ProVal: 4.065 ± 0.033	0.764ProTrp: 0.764 ± 0.013	1.696ProTyr: 1.696 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.406GlnAla: 3.406 ± 0.032	0.463GlnCys: 0.463 ± 0.009	1.984GlnAsp: 1.984 ± 0.02	2.29GlnGlu: 2.29 ± 0.023	1.168GlnPhe: 1.168 ± 0.017	2.315GlnGly: 2.315 ± 0.024	0.974GlnHis: 0.974 ± 0.013	1.6GlnIle: 1.6 ± 0.019	1.574GlnLys: 1.574 ± 0.02	3.316GlnLeu: 3.316 ± 0.029	0.851GlnMet: 0.851 ± 0.013	1.215GlnAsn: 1.215 ± 0.015	2.316GlnPro: 2.316 ± 0.028	1.742GlnGln: 1.742 ± 0.03	2.457GlnArg: 2.457 ± 0.025	2.974GlnSer: 2.974 ± 0.029	2.15GlnThr: 2.15 ± 0.023	2.249GlnVal: 2.249 ± 0.022	0.547GlnTrp: 0.547 ± 0.01	1.136GlnTyr: 1.136 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.338ArgAla: 5.338 ± 0.032	0.888ArgCys: 0.888 ± 0.014	3.385ArgAsp: 3.385 ± 0.029	3.979ArgGlu: 3.979 ± 0.041	2.141ArgPhe: 2.141 ± 0.022	3.85ArgGly: 3.85 ± 0.032	1.653ArgHis: 1.653 ± 0.02	2.994ArgIle: 2.994 ± 0.025	3.413ArgLys: 3.413 ± 0.03	5.973ArgLeu: 5.973 ± 0.037	1.459ArgMet: 1.459 ± 0.017	2.015ArgAsn: 2.015 ± 0.021	3.905ArgPro: 3.905 ± 0.04	2.42ArgGln: 2.42 ± 0.024	5.699ArgArg: 5.699 ± 0.045	5.366ArgSer: 5.366 ± 0.043	3.736ArgThr: 3.736 ± 0.028	3.843ArgVal: 3.843 ± 0.032	1.033ArgTrp: 1.033 ± 0.013	1.748ArgTyr: 1.748 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.423SerAla: 7.423 ± 0.053	1.021SerCys: 1.021 ± 0.015	4.384SerAsp: 4.384 ± 0.035	4.205SerGlu: 4.205 ± 0.03	2.961SerPhe: 2.961 ± 0.026	5.913SerGly: 5.913 ± 0.042	2.105SerHis: 2.105 ± 0.021	3.792SerIle: 3.792 ± 0.026	3.384SerLys: 3.384 ± 0.03	7.943SerLeu: 7.943 ± 0.05	1.839SerMet: 1.839 ± 0.021	2.602SerAsn: 2.602 ± 0.021	6.414SerPro: 6.414 ± 0.058	3.143SerGln: 3.143 ± 0.031	5.547SerArg: 5.547 ± 0.049	10.017SerSer: 10.017 ± 0.079	5.743SerThr: 5.743 ± 0.038	5.213SerVal: 5.213 ± 0.032	1.152SerTrp: 1.152 ± 0.014	2.143SerTyr: 2.143 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.152ThrAla: 5.152 ± 0.031	0.782ThrCys: 0.782 ± 0.012	2.717ThrAsp: 2.717 ± 0.025	2.846ThrGlu: 2.846 ± 0.025	2.265ThrPhe: 2.265 ± 0.025	3.965ThrGly: 3.965 ± 0.031	1.365ThrHis: 1.365 ± 0.016	2.802ThrIle: 2.802 ± 0.028	2.254ThrLys: 2.254 ± 0.021	5.615ThrLeu: 5.615 ± 0.033	1.197ThrMet: 1.197 ± 0.016	1.759ThrAsn: 1.759 ± 0.019	4.448ThrPro: 4.448 ± 0.039	1.938ThrGln: 1.938 ± 0.02	3.388ThrArg: 3.388 ± 0.026	5.642ThrSer: 5.642 ± 0.042	3.839ThrThr: 3.839 ± 0.034	3.943ThrVal: 3.943 ± 0.031	0.86ThrTrp: 0.86 ± 0.014	1.631ThrTyr: 1.631 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.515ValAla: 5.515 ± 0.037	0.908ValCys: 0.908 ± 0.015	3.819ValAsp: 3.819 ± 0.03	3.904ValGlu: 3.904 ± 0.029	2.466ValPhe: 2.466 ± 0.023	4.018ValGly: 4.018 ± 0.033	1.655ValHis: 1.655 ± 0.017	3.04ValIle: 3.04 ± 0.029	2.984ValLys: 2.984 ± 0.029	6.339ValLeu: 6.339 ± 0.036	1.405ValMet: 1.405 ± 0.017	2.131ValAsn: 2.131 ± 0.023	4.262ValPro: 4.262 ± 0.034	2.504ValGln: 2.504 ± 0.022	3.936ValArg: 3.936 ± 0.029	5.039ValSer: 5.039 ± 0.042	3.564ValThr: 3.564 ± 0.027	4.717ValVal: 4.717 ± 0.037	0.992ValTrp: 0.992 ± 0.017	1.871ValTyr: 1.871 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.143TrpAla: 1.143 ± 0.015	0.232TrpCys: 0.232 ± 0.007	0.931TrpAsp: 0.931 ± 0.017	0.89TrpGlu: 0.89 ± 0.014	0.56TrpPhe: 0.56 ± 0.011	0.886TrpGly: 0.886 ± 0.014	0.41TrpHis: 0.41 ± 0.01	0.742TrpIle: 0.742 ± 0.013	0.778TrpLys: 0.778 ± 0.011	1.386TrpLeu: 1.386 ± 0.018	0.388TrpMet: 0.388 ± 0.009	0.613TrpAsn: 0.613 ± 0.013	0.671TrpPro: 0.671 ± 0.014	0.544TrpGln: 0.544 ± 0.012	1.102TrpArg: 1.102 ± 0.017	1.138TrpSer: 1.138 ± 0.015	0.954TrpThr: 0.954 ± 0.015	0.929TrpVal: 0.929 ± 0.013	0.312TrpTrp: 0.312 ± 0.01	0.458TrpTyr: 0.458 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.023	0.429TyrCys: 0.429 ± 0.009	1.71TyrAsp: 1.71 ± 0.019	1.535TyrGlu: 1.535 ± 0.018	1.108TyrPhe: 1.108 ± 0.016	2.005TyrGly: 2.005 ± 0.023	0.742TyrHis: 0.742 ± 0.012	1.375TyrIle: 1.375 ± 0.015	1.049TyrLys: 1.049 ± 0.015	2.619TyrLeu: 2.619 ± 0.026	0.608TyrMet: 0.608 ± 0.012	1.051TyrAsn: 1.051 ± 0.017	1.65TyrPro: 1.65 ± 0.022	1.012TyrGln: 1.012 ± 0.013	1.668TyrArg: 1.668 ± 0.021	2.108TyrSer: 2.108 ± 0.023	1.648TyrThr: 1.648 ± 0.019	1.782TyrVal: 1.782 ± 0.021	0.45TyrTrp: 0.45 ± 0.009	0.927TyrTyr: 0.927 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12554 proteins (5216656 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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