Amino acid dipepetide frequency for Ochrobactrum phage vB_OspM_OC

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.539AlaAla: 3.539 ± 0.284
0.51AlaCys: 0.51 ± 0.085
3.666AlaAsp: 3.666 ± 0.254
3.468AlaGlu: 3.468 ± 0.245
2.491AlaPhe: 2.491 ± 0.152
3.85AlaGly: 3.85 ± 0.257
1.047AlaHis: 1.047 ± 0.145
4.699AlaIle: 4.699 ± 0.24
4.954AlaLys: 4.954 ± 0.307
4.827AlaLeu: 4.827 ± 0.3
1.968AlaMet: 1.968 ± 0.146
3.751AlaAsn: 3.751 ± 0.253
1.26AlaPro: 1.26 ± 0.161
1.67AlaGln: 1.67 ± 0.158
2.435AlaArg: 2.435 ± 0.183
3.595AlaSer: 3.595 ± 0.233
3.779AlaThr: 3.779 ± 0.28
3.468AlaVal: 3.468 ± 0.272
0.764AlaTrp: 0.764 ± 0.105
2.604AlaTyr: 2.604 ± 0.211
0.0AlaXaa: 0.0 ± 0.0
Cys
0.467CysAla: 0.467 ± 0.093
0.156CysCys: 0.156 ± 0.049
0.637CysAsp: 0.637 ± 0.091
0.821CysGlu: 0.821 ± 0.131
0.453CysPhe: 0.453 ± 0.074
0.665CysGly: 0.665 ± 0.098
0.354CysHis: 0.354 ± 0.075
0.764CysIle: 0.764 ± 0.133
0.651CysLys: 0.651 ± 0.097
0.821CysLeu: 0.821 ± 0.109
0.184CysMet: 0.184 ± 0.054
0.75CysAsn: 0.75 ± 0.093
0.495CysPro: 0.495 ± 0.1
0.311CysGln: 0.311 ± 0.062
0.58CysArg: 0.58 ± 0.087
0.623CysSer: 0.623 ± 0.106
0.354CysThr: 0.354 ± 0.071
0.708CysVal: 0.708 ± 0.105
0.17CysTrp: 0.17 ± 0.047
0.439CysTyr: 0.439 ± 0.084
0.0CysXaa: 0.0 ± 0.0
Asp
4.077AspAla: 4.077 ± 0.248
0.609AspCys: 0.609 ± 0.105
4.77AspAsp: 4.77 ± 0.374
4.714AspGlu: 4.714 ± 0.357
3.114AspPhe: 3.114 ± 0.191
5.223AspGly: 5.223 ± 0.321
1.43AspHis: 1.43 ± 0.153
6.044AspIle: 6.044 ± 0.265
4.119AspLys: 4.119 ± 0.217
5.237AspLeu: 5.237 ± 0.245
1.784AspMet: 1.784 ± 0.159
3.794AspAsn: 3.794 ± 0.271
2.052AspPro: 2.052 ± 0.154
1.529AspGln: 1.529 ± 0.126
2.789AspArg: 2.789 ± 0.185
3.723AspSer: 3.723 ± 0.251
3.312AspThr: 3.312 ± 0.223
4.119AspVal: 4.119 ± 0.23
1.033AspTrp: 1.033 ± 0.123
3.496AspTyr: 3.496 ± 0.206
0.0AspXaa: 0.0 ± 0.0
Glu
3.921GluAla: 3.921 ± 0.342
0.793GluCys: 0.793 ± 0.114
4.261GluAsp: 4.261 ± 0.303
4.742GluGlu: 4.742 ± 0.344
3.709GluPhe: 3.709 ± 0.221
3.043GluGly: 3.043 ± 0.207
1.331GluHis: 1.331 ± 0.127
5.393GluIle: 5.393 ± 0.312
5.152GluLys: 5.152 ± 0.305
5.45GluLeu: 5.45 ± 0.283
2.038GluMet: 2.038 ± 0.194
3.963GluAsn: 3.963 ± 0.212
1.6GluPro: 1.6 ± 0.177
1.953GluGln: 1.953 ± 0.168
3.482GluArg: 3.482 ± 0.247
3.454GluSer: 3.454 ± 0.228
4.473GluThr: 4.473 ± 0.34
3.581GluVal: 3.581 ± 0.279
1.033GluTrp: 1.033 ± 0.127
3.341GluTyr: 3.341 ± 0.198
0.0GluXaa: 0.0 ± 0.0
Phe
2.562PheAla: 2.562 ± 0.204
0.595PheCys: 0.595 ± 0.099
4.204PheAsp: 4.204 ± 0.248
3.341PheGlu: 3.341 ± 0.221
2.293PhePhe: 2.293 ± 0.216
3.128PheGly: 3.128 ± 0.23
1.231PheHis: 1.231 ± 0.143
3.737PheIle: 3.737 ± 0.217
3.765PheLys: 3.765 ± 0.227
3.496PheLeu: 3.496 ± 0.229
1.316PheMet: 1.316 ± 0.144
3.142PheAsn: 3.142 ± 0.198
1.203PhePro: 1.203 ± 0.14
1.43PheGln: 1.43 ± 0.137
2.052PheArg: 2.052 ± 0.171
3.595PheSer: 3.595 ± 0.224
2.647PheThr: 2.647 ± 0.196
3.652PheVal: 3.652 ± 0.244
0.481PheTrp: 0.481 ± 0.091
2.052PheTyr: 2.052 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
3.553GlyAla: 3.553 ± 0.281
0.623GlyCys: 0.623 ± 0.099
4.133GlyAsp: 4.133 ± 0.304
3.992GlyGlu: 3.992 ± 0.269
3.397GlyPhe: 3.397 ± 0.232
5.237GlyGly: 5.237 ± 0.835
1.175GlyHis: 1.175 ± 0.153
4.94GlyIle: 4.94 ± 0.33
4.473GlyLys: 4.473 ± 0.284
3.878GlyLeu: 3.878 ± 0.237
1.784GlyMet: 1.784 ± 0.16
4.912GlyAsn: 4.912 ± 0.729
0.92GlyPro: 0.92 ± 0.116
1.897GlyGln: 1.897 ± 0.166
2.59GlyArg: 2.59 ± 0.248
4.19GlySer: 4.19 ± 0.332
4.246GlyThr: 4.246 ± 0.356
3.893GlyVal: 3.893 ± 0.267
0.878GlyTrp: 0.878 ± 0.112
3.086GlyTyr: 3.086 ± 0.177
0.0GlyXaa: 0.0 ± 0.0
His
1.161HisAla: 1.161 ± 0.135
0.425HisCys: 0.425 ± 0.082
1.359HisAsp: 1.359 ± 0.128
1.132HisGlu: 1.132 ± 0.131
1.231HisPhe: 1.231 ± 0.135
1.076HisGly: 1.076 ± 0.117
0.524HisHis: 0.524 ± 0.077
1.614HisIle: 1.614 ± 0.157
1.515HisLys: 1.515 ± 0.159
1.43HisLeu: 1.43 ± 0.142
0.623HisMet: 0.623 ± 0.102
1.033HisAsn: 1.033 ± 0.129
0.892HisPro: 0.892 ± 0.103
0.524HisGln: 0.524 ± 0.093
0.892HisArg: 0.892 ± 0.103
1.274HisSer: 1.274 ± 0.144
0.863HisThr: 0.863 ± 0.12
1.274HisVal: 1.274 ± 0.143
0.269HisTrp: 0.269 ± 0.071
1.345HisTyr: 1.345 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
4.671IleAla: 4.671 ± 0.247
0.878IleCys: 0.878 ± 0.125
6.115IleAsp: 6.115 ± 0.272
5.846IleGlu: 5.846 ± 0.269
3.355IlePhe: 3.355 ± 0.228
4.261IleGly: 4.261 ± 0.32
1.585IleHis: 1.585 ± 0.156
5.209IleIle: 5.209 ± 0.297
5.86IleLys: 5.86 ± 0.305
5.591IleLeu: 5.591 ± 0.269
2.109IleMet: 2.109 ± 0.172
4.501IleAsn: 4.501 ± 0.249
2.817IlePro: 2.817 ± 0.192
2.208IleGln: 2.208 ± 0.195
2.944IleArg: 2.944 ± 0.195
5.577IleSer: 5.577 ± 0.272
4.43IleThr: 4.43 ± 0.227
5.181IleVal: 5.181 ± 0.319
0.722IleTrp: 0.722 ± 0.103
2.548IleTyr: 2.548 ± 0.193
0.0IleXaa: 0.0 ± 0.0
Lys
4.756LysAla: 4.756 ± 0.271
0.566LysCys: 0.566 ± 0.084
4.855LysAsp: 4.855 ± 0.263
5.591LysGlu: 5.591 ± 0.323
3.51LysPhe: 3.51 ± 0.199
3.808LysGly: 3.808 ± 0.271
1.515LysHis: 1.515 ± 0.148
5.619LysIle: 5.619 ± 0.275
5.832LysLys: 5.832 ± 0.323
6.044LysLeu: 6.044 ± 0.312
2.109LysMet: 2.109 ± 0.164
4.544LysAsn: 4.544 ± 0.25
2.534LysPro: 2.534 ± 0.198
1.968LysGln: 1.968 ± 0.196
3.581LysArg: 3.581 ± 0.226
3.85LysSer: 3.85 ± 0.287
4.232LysThr: 4.232 ± 0.23
4.756LysVal: 4.756 ± 0.271
0.963LysTrp: 0.963 ± 0.116
3.199LysTyr: 3.199 ± 0.196
0.0LysXaa: 0.0 ± 0.0
Leu
4.756LeuAla: 4.756 ± 0.275
0.835LeuCys: 0.835 ± 0.115
4.926LeuAsp: 4.926 ± 0.27
5.662LeuGlu: 5.662 ± 0.29
3.68LeuPhe: 3.68 ± 0.224
4.374LeuGly: 4.374 ± 0.254
1.359LeuHis: 1.359 ± 0.142
5.237LeuIle: 5.237 ± 0.274
5.959LeuLys: 5.959 ± 0.338
5.28LeuLeu: 5.28 ± 0.304
2.194LeuMet: 2.194 ± 0.197
4.416LeuAsn: 4.416 ± 0.246
2.944LeuPro: 2.944 ± 0.186
2.18LeuGln: 2.18 ± 0.175
2.732LeuArg: 2.732 ± 0.186
5.492LeuSer: 5.492 ± 0.302
4.742LeuThr: 4.742 ± 0.3
4.799LeuVal: 4.799 ± 0.266
0.58LeuTrp: 0.58 ± 0.093
3.326LeuTyr: 3.326 ± 0.22
0.0LeuXaa: 0.0 ± 0.0
Met
1.996MetAla: 1.996 ± 0.169
0.255MetCys: 0.255 ± 0.054
1.387MetAsp: 1.387 ± 0.146
1.939MetGlu: 1.939 ± 0.165
1.331MetPhe: 1.331 ± 0.151
1.515MetGly: 1.515 ± 0.147
0.382MetHis: 0.382 ± 0.079
1.897MetIle: 1.897 ± 0.181
2.378MetLys: 2.378 ± 0.214
2.067MetLeu: 2.067 ± 0.181
0.637MetMet: 0.637 ± 0.095
1.571MetAsn: 1.571 ± 0.166
0.821MetPro: 0.821 ± 0.125
0.736MetGln: 0.736 ± 0.095
1.359MetArg: 1.359 ± 0.128
1.911MetSer: 1.911 ± 0.147
1.826MetThr: 1.826 ± 0.149
1.472MetVal: 1.472 ± 0.153
0.255MetTrp: 0.255 ± 0.059
0.906MetTyr: 0.906 ± 0.109
0.0MetXaa: 0.0 ± 0.0
Asn
3.609AsnAla: 3.609 ± 0.203
0.58AsnCys: 0.58 ± 0.103
3.935AsnAsp: 3.935 ± 0.227
3.836AsnGlu: 3.836 ± 0.256
2.817AsnPhe: 2.817 ± 0.192
5.407AsnGly: 5.407 ± 0.619
1.529AsnHis: 1.529 ± 0.136
4.699AsnIle: 4.699 ± 0.31
3.921AsnLys: 3.921 ± 0.286
4.926AsnLeu: 4.926 ± 0.281
1.415AsnMet: 1.415 ± 0.131
3.765AsnAsn: 3.765 ± 0.296
2.534AsnPro: 2.534 ± 0.189
1.911AsnGln: 1.911 ± 0.168
2.109AsnArg: 2.109 ± 0.163
3.765AsnSer: 3.765 ± 0.236
4.19AsnThr: 4.19 ± 0.413
4.147AsnVal: 4.147 ± 0.32
0.835AsnTrp: 0.835 ± 0.116
2.435AsnTyr: 2.435 ± 0.181
0.0AsnXaa: 0.0 ± 0.0
Pro
1.656ProAla: 1.656 ± 0.152
0.241ProCys: 0.241 ± 0.056
2.477ProAsp: 2.477 ± 0.165
2.279ProGlu: 2.279 ± 0.187
1.784ProPhe: 1.784 ± 0.153
0.977ProGly: 0.977 ± 0.118
0.779ProHis: 0.779 ± 0.112
2.208ProIle: 2.208 ± 0.168
2.435ProLys: 2.435 ± 0.182
1.953ProLeu: 1.953 ± 0.144
0.651ProMet: 0.651 ± 0.105
2.307ProAsn: 2.307 ± 0.169
0.849ProPro: 0.849 ± 0.121
0.736ProGln: 0.736 ± 0.133
1.231ProArg: 1.231 ± 0.142
2.123ProSer: 2.123 ± 0.189
2.378ProThr: 2.378 ± 0.184
2.392ProVal: 2.392 ± 0.241
0.382ProTrp: 0.382 ± 0.07
1.911ProTyr: 1.911 ± 0.174
0.0ProXaa: 0.0 ± 0.0
Gln
1.642GlnAla: 1.642 ± 0.14
0.226GlnCys: 0.226 ± 0.054
1.543GlnAsp: 1.543 ± 0.145
1.826GlnGlu: 1.826 ± 0.176
1.571GlnPhe: 1.571 ± 0.156
1.217GlnGly: 1.217 ± 0.119
0.595GlnHis: 0.595 ± 0.101
2.633GlnIle: 2.633 ± 0.215
2.18GlnLys: 2.18 ± 0.171
2.208GlnLeu: 2.208 ± 0.199
0.75GlnMet: 0.75 ± 0.108
1.84GlnAsn: 1.84 ± 0.205
1.062GlnPro: 1.062 ± 0.131
0.863GlnGln: 0.863 ± 0.11
1.543GlnArg: 1.543 ± 0.139
1.812GlnSer: 1.812 ± 0.199
1.713GlnThr: 1.713 ± 0.169
1.529GlnVal: 1.529 ± 0.159
0.439GlnTrp: 0.439 ± 0.077
1.628GlnTyr: 1.628 ± 0.143
0.0GlnXaa: 0.0 ± 0.0
Arg
2.038ArgAla: 2.038 ± 0.166
0.524ArgCys: 0.524 ± 0.087
2.491ArgAsp: 2.491 ± 0.191
2.76ArgGlu: 2.76 ± 0.206
2.619ArgPhe: 2.619 ± 0.187
2.675ArgGly: 2.675 ± 0.208
1.076ArgHis: 1.076 ± 0.136
3.624ArgIle: 3.624 ± 0.236
3.454ArgLys: 3.454 ± 0.239
3.525ArgLeu: 3.525 ± 0.229
1.033ArgMet: 1.033 ± 0.122
2.152ArgAsn: 2.152 ± 0.195
1.161ArgPro: 1.161 ± 0.13
1.515ArgGln: 1.515 ± 0.158
1.6ArgArg: 1.6 ± 0.16
2.279ArgSer: 2.279 ± 0.187
2.038ArgThr: 2.038 ± 0.151
2.463ArgVal: 2.463 ± 0.206
0.651ArgTrp: 0.651 ± 0.116
2.378ArgTyr: 2.378 ± 0.192
0.0ArgXaa: 0.0 ± 0.0
Ser
3.298SerAla: 3.298 ± 0.227
0.708SerCys: 0.708 ± 0.098
4.19SerAsp: 4.19 ± 0.254
3.723SerGlu: 3.723 ± 0.219
3.27SerPhe: 3.27 ± 0.173
4.968SerGly: 4.968 ± 0.401
1.062SerHis: 1.062 ± 0.131
4.756SerIle: 4.756 ± 0.262
4.048SerLys: 4.048 ± 0.238
4.997SerLeu: 4.997 ± 0.275
1.515SerMet: 1.515 ± 0.13
3.737SerAsn: 3.737 ± 0.317
1.769SerPro: 1.769 ± 0.142
1.798SerGln: 1.798 ± 0.162
2.732SerArg: 2.732 ± 0.23
3.652SerSer: 3.652 ± 0.293
4.289SerThr: 4.289 ± 0.341
4.246SerVal: 4.246 ± 0.281
0.963SerTrp: 0.963 ± 0.122
3.114SerTyr: 3.114 ± 0.189
0.0SerXaa: 0.0 ± 0.0
Thr
3.737ThrAla: 3.737 ± 0.355
0.467ThrCys: 0.467 ± 0.082
3.609ThrAsp: 3.609 ± 0.208
3.326ThrGlu: 3.326 ± 0.275
3.157ThrPhe: 3.157 ± 0.225
5.011ThrGly: 5.011 ± 0.53
0.977ThrHis: 0.977 ± 0.114
4.728ThrIle: 4.728 ± 0.281
4.02ThrLys: 4.02 ± 0.213
4.728ThrLeu: 4.728 ± 0.307
1.288ThrMet: 1.288 ± 0.14
4.218ThrAsn: 4.218 ± 0.336
2.222ThrPro: 2.222 ± 0.209
1.84ThrGln: 1.84 ± 0.155
1.868ThrArg: 1.868 ± 0.161
3.864ThrSer: 3.864 ± 0.367
4.162ThrThr: 4.162 ± 0.396
4.034ThrVal: 4.034 ± 0.27
0.623ThrTrp: 0.623 ± 0.1
2.619ThrTyr: 2.619 ± 0.21
0.0ThrXaa: 0.0 ± 0.0
Val
3.822ValAla: 3.822 ± 0.241
0.708ValCys: 0.708 ± 0.103
4.289ValAsp: 4.289 ± 0.237
4.133ValGlu: 4.133 ± 0.282
3.227ValPhe: 3.227 ± 0.231
3.609ValGly: 3.609 ± 0.26
1.09ValHis: 1.09 ± 0.117
4.402ValIle: 4.402 ± 0.275
4.827ValLys: 4.827 ± 0.273
4.473ValLeu: 4.473 ± 0.299
1.713ValMet: 1.713 ± 0.143
3.992ValAsn: 3.992 ± 0.279
2.52ValPro: 2.52 ± 0.194
1.331ValGln: 1.331 ± 0.126
2.944ValArg: 2.944 ± 0.207
4.586ValSer: 4.586 ± 0.302
4.062ValThr: 4.062 ± 0.318
4.558ValVal: 4.558 ± 0.354
0.878ValTrp: 0.878 ± 0.12
2.987ValTyr: 2.987 ± 0.208
0.0ValXaa: 0.0 ± 0.0
Trp
0.623TrpAla: 0.623 ± 0.112
0.099TrpCys: 0.099 ± 0.037
0.694TrpAsp: 0.694 ± 0.094
0.623TrpGlu: 0.623 ± 0.087
0.793TrpPhe: 0.793 ± 0.134
0.764TrpGly: 0.764 ± 0.104
0.34TrpHis: 0.34 ± 0.066
0.977TrpIle: 0.977 ± 0.121
1.118TrpLys: 1.118 ± 0.121
1.076TrpLeu: 1.076 ± 0.116
0.396TrpMet: 0.396 ± 0.065
0.934TrpAsn: 0.934 ± 0.117
0.368TrpPro: 0.368 ± 0.065
0.495TrpGln: 0.495 ± 0.082
0.538TrpArg: 0.538 ± 0.096
0.552TrpSer: 0.552 ± 0.085
0.75TrpThr: 0.75 ± 0.086
0.736TrpVal: 0.736 ± 0.113
0.184TrpTrp: 0.184 ± 0.05
0.595TrpTyr: 0.595 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.463TyrAla: 2.463 ± 0.197
0.609TyrCys: 0.609 ± 0.091
3.425TyrAsp: 3.425 ± 0.19
2.958TyrGlu: 2.958 ± 0.23
2.123TyrPhe: 2.123 ± 0.193
2.987TyrGly: 2.987 ± 0.23
1.076TyrHis: 1.076 ± 0.116
3.227TyrIle: 3.227 ± 0.18
3.171TyrLys: 3.171 ± 0.213
3.468TyrLeu: 3.468 ± 0.186
1.118TyrMet: 1.118 ± 0.118
3.043TyrAsn: 3.043 ± 0.214
1.727TyrPro: 1.727 ± 0.166
1.925TyrGln: 1.925 ± 0.161
2.067TyrArg: 2.067 ± 0.187
2.916TyrSer: 2.916 ± 0.208
2.01TyrThr: 2.01 ± 0.183
3.142TyrVal: 3.142 ± 0.167
0.552TyrTrp: 0.552 ± 0.083
1.911TyrTyr: 1.911 ± 0.194
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 390 proteins (70648 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski