Amino acid dipepetide frequency for Gluconobacter morbifer G707

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.983AlaAla: 12.983 ± 0.183
1.379AlaCys: 1.379 ± 0.045
5.761AlaAsp: 5.761 ± 0.086
6.101AlaGlu: 6.101 ± 0.111
3.963AlaPhe: 3.963 ± 0.063
9.427AlaGly: 9.427 ± 0.129
2.462AlaHis: 2.462 ± 0.049
5.435AlaIle: 5.435 ± 0.094
2.975AlaLys: 2.975 ± 0.068
12.916AlaLeu: 12.916 ± 0.167
3.055AlaMet: 3.055 ± 0.065
2.54AlaAsn: 2.54 ± 0.057
5.651AlaPro: 5.651 ± 0.095
4.036AlaGln: 4.036 ± 0.076
8.097AlaArg: 8.097 ± 0.13
6.629AlaSer: 6.629 ± 0.087
5.705AlaThr: 5.705 ± 0.099
7.346AlaVal: 7.346 ± 0.113
1.385AlaTrp: 1.385 ± 0.039
2.261AlaTyr: 2.261 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
1.191CysAla: 1.191 ± 0.036
0.164CysCys: 0.164 ± 0.013
0.532CysAsp: 0.532 ± 0.026
0.464CysGlu: 0.464 ± 0.026
0.398CysPhe: 0.398 ± 0.025
1.102CysGly: 1.102 ± 0.041
0.324CysHis: 0.324 ± 0.023
0.511CysIle: 0.511 ± 0.026
0.173CysLys: 0.173 ± 0.014
1.117CysLeu: 1.117 ± 0.038
0.224CysMet: 0.224 ± 0.016
0.26CysAsn: 0.26 ± 0.017
0.554CysPro: 0.554 ± 0.024
0.338CysGln: 0.338 ± 0.021
0.731CysArg: 0.731 ± 0.026
0.624CysSer: 0.624 ± 0.026
0.522CysThr: 0.522 ± 0.025
0.733CysVal: 0.733 ± 0.031
0.148CysTrp: 0.148 ± 0.013
0.211CysTyr: 0.211 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.238AspAla: 6.238 ± 0.09
0.563AspCys: 0.563 ± 0.028
2.902AspAsp: 2.902 ± 0.069
3.018AspGlu: 3.018 ± 0.064
2.021AspPhe: 2.021 ± 0.051
5.118AspGly: 5.118 ± 0.097
1.441AspHis: 1.441 ± 0.045
3.103AspIle: 3.103 ± 0.06
1.132AspLys: 1.132 ± 0.038
6.007AspLeu: 6.007 ± 0.092
1.545AspMet: 1.545 ± 0.045
1.326AspAsn: 1.326 ± 0.037
3.472AspPro: 3.472 ± 0.065
1.776AspGln: 1.776 ± 0.055
4.289AspArg: 4.289 ± 0.076
2.526AspSer: 2.526 ± 0.058
2.805AspThr: 2.805 ± 0.059
4.279AspVal: 4.279 ± 0.076
1.026AspTrp: 1.026 ± 0.04
1.397AspTyr: 1.397 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
6.475GluAla: 6.475 ± 0.108
0.365GluCys: 0.365 ± 0.021
3.048GluAsp: 3.048 ± 0.064
3.142GluGlu: 3.142 ± 0.073
1.362GluPhe: 1.362 ± 0.043
4.183GluGly: 4.183 ± 0.077
1.257GluHis: 1.257 ± 0.04
3.052GluIle: 3.052 ± 0.069
2.476GluLys: 2.476 ± 0.059
4.525GluLeu: 4.525 ± 0.079
1.37GluMet: 1.37 ± 0.041
2.015GluAsn: 2.015 ± 0.053
2.175GluPro: 2.175 ± 0.054
2.352GluGln: 2.352 ± 0.048
4.517GluArg: 4.517 ± 0.095
2.41GluSer: 2.41 ± 0.054
3.834GluThr: 3.834 ± 0.076
3.053GluVal: 3.053 ± 0.064
0.691GluTrp: 0.691 ± 0.027
0.941GluTyr: 0.941 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.616PheAla: 3.616 ± 0.065
0.526PheCys: 0.526 ± 0.025
2.178PheAsp: 2.178 ± 0.061
1.771PheGlu: 1.771 ± 0.052
1.347PhePhe: 1.347 ± 0.052
3.44PheGly: 3.44 ± 0.07
0.983PheHis: 0.983 ± 0.037
1.516PheIle: 1.516 ± 0.039
0.7PheLys: 0.7 ± 0.027
3.713PheLeu: 3.713 ± 0.07
0.919PheMet: 0.919 ± 0.032
1.017PheAsn: 1.017 ± 0.038
1.828PhePro: 1.828 ± 0.045
1.194PheGln: 1.194 ± 0.045
2.552PheArg: 2.552 ± 0.053
2.605PheSer: 2.605 ± 0.051
1.917PheThr: 1.917 ± 0.048
2.417PheVal: 2.417 ± 0.049
0.56PheTrp: 0.56 ± 0.03
0.87PheTyr: 0.87 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
8.068GlyAla: 8.068 ± 0.111
0.93GlyCys: 0.93 ± 0.037
3.968GlyAsp: 3.968 ± 0.08
4.166GlyGlu: 4.166 ± 0.064
3.354GlyPhe: 3.354 ± 0.062
7.148GlyGly: 7.148 ± 0.132
2.319GlyHis: 2.319 ± 0.054
4.487GlyIle: 4.487 ± 0.088
3.027GlyLys: 3.027 ± 0.065
8.962GlyLeu: 8.962 ± 0.117
2.47GlyMet: 2.47 ± 0.058
2.444GlyAsn: 2.444 ± 0.066
3.546GlyPro: 3.546 ± 0.065
3.4GlyGln: 3.4 ± 0.063
6.214GlyArg: 6.214 ± 0.099
4.904GlySer: 4.904 ± 0.086
5.209GlyThr: 5.209 ± 0.086
5.828GlyVal: 5.828 ± 0.083
1.508GlyTrp: 1.508 ± 0.052
2.21GlyTyr: 2.21 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.611HisAla: 2.611 ± 0.054
0.271HisCys: 0.271 ± 0.017
1.634HisAsp: 1.634 ± 0.045
1.199HisGlu: 1.199 ± 0.041
0.961HisPhe: 0.961 ± 0.039
2.264HisGly: 2.264 ± 0.052
0.827HisHis: 0.827 ± 0.038
1.139HisIle: 1.139 ± 0.037
0.497HisLys: 0.497 ± 0.028
2.58HisLeu: 2.58 ± 0.062
0.574HisMet: 0.574 ± 0.028
0.651HisAsn: 0.651 ± 0.028
1.677HisPro: 1.677 ± 0.045
0.788HisGln: 0.788 ± 0.029
1.679HisArg: 1.679 ± 0.045
1.178HisSer: 1.178 ± 0.039
1.103HisThr: 1.103 ± 0.038
1.91HisVal: 1.91 ± 0.051
0.412HisTrp: 0.412 ± 0.02
0.714HisTyr: 0.714 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.796IleAla: 5.796 ± 0.099
0.597IleCys: 0.597 ± 0.03
2.928IleAsp: 2.928 ± 0.062
2.901IleGlu: 2.901 ± 0.062
1.637IlePhe: 1.637 ± 0.045
4.612IleGly: 4.612 ± 0.087
1.135IleHis: 1.135 ± 0.034
2.212IleIle: 2.212 ± 0.053
1.002IleLys: 1.002 ± 0.037
4.938IleLeu: 4.938 ± 0.087
1.115IleMet: 1.115 ± 0.034
1.367IleAsn: 1.367 ± 0.048
2.668IlePro: 2.668 ± 0.06
1.56IleGln: 1.56 ± 0.051
3.829IleArg: 3.829 ± 0.064
3.231IleSer: 3.231 ± 0.069
2.835IleThr: 2.835 ± 0.051
3.777IleVal: 3.777 ± 0.067
0.625IleTrp: 0.625 ± 0.025
0.942IleTyr: 0.942 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.635LysAla: 3.635 ± 0.077
0.175LysCys: 0.175 ± 0.013
1.673LysAsp: 1.673 ± 0.043
1.456LysGlu: 1.456 ± 0.05
0.714LysPhe: 0.714 ± 0.03
2.432LysGly: 2.432 ± 0.051
0.56LysHis: 0.56 ± 0.024
1.648LysIle: 1.648 ± 0.054
1.207LysLys: 1.207 ± 0.048
2.758LysLeu: 2.758 ± 0.059
0.676LysMet: 0.676 ± 0.031
0.955LysAsn: 0.955 ± 0.035
1.761LysPro: 1.761 ± 0.05
0.965LysGln: 0.965 ± 0.031
2.058LysArg: 2.058 ± 0.051
1.676LysSer: 1.676 ± 0.045
1.98LysThr: 1.98 ± 0.046
1.906LysVal: 1.906 ± 0.059
0.308LysTrp: 0.308 ± 0.02
0.596LysTyr: 0.596 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
11.887LeuAla: 11.887 ± 0.145
1.198LeuCys: 1.198 ± 0.041
5.997LeuAsp: 5.997 ± 0.082
5.388LeuGlu: 5.388 ± 0.1
3.723LeuPhe: 3.723 ± 0.079
7.889LeuGly: 7.889 ± 0.115
2.621LeuHis: 2.621 ± 0.068
4.573LeuIle: 4.573 ± 0.096
3.446LeuLys: 3.446 ± 0.067
10.581LeuLeu: 10.581 ± 0.17
2.514LeuMet: 2.514 ± 0.059
2.849LeuAsn: 2.849 ± 0.061
6.776LeuPro: 6.776 ± 0.1
3.289LeuGln: 3.289 ± 0.073
7.749LeuArg: 7.749 ± 0.113
7.346LeuSer: 7.346 ± 0.092
6.517LeuThr: 6.517 ± 0.095
6.776LeuVal: 6.776 ± 0.1
1.25LeuTrp: 1.25 ± 0.045
2.271LeuTyr: 2.271 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.913MetAla: 2.913 ± 0.064
0.199MetCys: 0.199 ± 0.015
1.253MetAsp: 1.253 ± 0.038
1.302MetGlu: 1.302 ± 0.039
0.739MetPhe: 0.739 ± 0.029
1.989MetGly: 1.989 ± 0.051
0.506MetHis: 0.506 ± 0.024
1.32MetIle: 1.32 ± 0.041
1.019MetLys: 1.019 ± 0.036
2.563MetLeu: 2.563 ± 0.061
0.774MetMet: 0.774 ± 0.034
0.799MetAsn: 0.799 ± 0.034
1.593MetPro: 1.593 ± 0.051
0.92MetGln: 0.92 ± 0.035
1.758MetArg: 1.758 ± 0.05
1.778MetSer: 1.778 ± 0.04
2.176MetThr: 2.176 ± 0.055
1.699MetVal: 1.699 ± 0.044
0.198MetTrp: 0.198 ± 0.015
0.306MetTyr: 0.306 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.175AsnAla: 3.175 ± 0.054
0.271AsnCys: 0.271 ± 0.018
1.462AsnAsp: 1.462 ± 0.051
1.199AsnGlu: 1.199 ± 0.036
0.972AsnPhe: 0.972 ± 0.044
2.909AsnGly: 2.909 ± 0.082
0.618AsnHis: 0.618 ± 0.029
1.459AsnIle: 1.459 ± 0.045
0.536AsnLys: 0.536 ± 0.026
2.592AsnLeu: 2.592 ± 0.067
0.672AsnMet: 0.672 ± 0.028
0.737AsnAsn: 0.737 ± 0.036
1.878AsnPro: 1.878 ± 0.055
0.882AsnGln: 0.882 ± 0.038
2.084AsnArg: 2.084 ± 0.049
1.491AsnSer: 1.491 ± 0.05
1.608AsnThr: 1.608 ± 0.049
1.987AsnVal: 1.987 ± 0.054
0.489AsnTrp: 0.489 ± 0.026
0.708AsnTyr: 0.708 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
6.382ProAla: 6.382 ± 0.104
0.443ProCys: 0.443 ± 0.02
4.325ProAsp: 4.325 ± 0.077
3.917ProGlu: 3.917 ± 0.07
2.1ProPhe: 2.1 ± 0.059
4.703ProGly: 4.703 ± 0.073
1.377ProHis: 1.377 ± 0.043
2.1ProIle: 2.1 ± 0.057
1.505ProLys: 1.505 ± 0.045
5.182ProLeu: 5.182 ± 0.096
1.313ProMet: 1.313 ± 0.044
1.33ProAsn: 1.33 ± 0.039
2.986ProPro: 2.986 ± 0.095
1.988ProGln: 1.988 ± 0.055
2.972ProArg: 2.972 ± 0.061
3.527ProSer: 3.527 ± 0.064
2.641ProThr: 2.641 ± 0.058
4.948ProVal: 4.948 ± 0.082
0.76ProTrp: 0.76 ± 0.03
1.334ProTyr: 1.334 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.461GlnAla: 4.461 ± 0.092
0.246GlnCys: 0.246 ± 0.015
2.215GlnAsp: 2.215 ± 0.049
1.934GlnGlu: 1.934 ± 0.046
1.121GlnPhe: 1.121 ± 0.037
2.688GlnGly: 2.688 ± 0.058
0.743GlnHis: 0.743 ± 0.036
2.104GlnIle: 2.104 ± 0.048
1.419GlnLys: 1.419 ± 0.047
2.844GlnLeu: 2.844 ± 0.067
0.971GlnMet: 0.971 ± 0.033
1.189GlnAsn: 1.189 ± 0.044
2.038GlnPro: 2.038 ± 0.053
1.475GlnGln: 1.475 ± 0.051
2.271GlnArg: 2.271 ± 0.057
2.048GlnSer: 2.048 ± 0.056
2.436GlnThr: 2.436 ± 0.06
2.441GlnVal: 2.441 ± 0.053
0.427GlnTrp: 0.427 ± 0.025
0.761GlnTyr: 0.761 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
7.067ArgAla: 7.067 ± 0.106
0.613ArgCys: 0.613 ± 0.028
3.931ArgAsp: 3.931 ± 0.077
3.993ArgGlu: 3.993 ± 0.081
2.947ArgPhe: 2.947 ± 0.067
4.521ArgGly: 4.521 ± 0.068
2.163ArgHis: 2.163 ± 0.046
4.045ArgIle: 4.045 ± 0.074
2.435ArgLys: 2.435 ± 0.064
8.467ArgLeu: 8.467 ± 0.113
1.885ArgMet: 1.885 ± 0.05
2.264ArgAsn: 2.264 ± 0.054
3.865ArgPro: 3.865 ± 0.066
3.13ArgGln: 3.13 ± 0.066
5.837ArgArg: 5.837 ± 0.103
4.026ArgSer: 4.026 ± 0.065
3.912ArgThr: 3.912 ± 0.076
4.455ArgVal: 4.455 ± 0.08
1.019ArgTrp: 1.019 ± 0.039
1.812ArgTyr: 1.812 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.311SerAla: 6.311 ± 0.092
0.624SerCys: 0.624 ± 0.027
3.208SerAsp: 3.208 ± 0.058
2.887SerGlu: 2.887 ± 0.052
2.449SerPhe: 2.449 ± 0.055
6.041SerGly: 6.041 ± 0.099
1.425SerHis: 1.425 ± 0.04
2.828SerIle: 2.828 ± 0.069
1.307SerLys: 1.307 ± 0.046
6.315SerLeu: 6.315 ± 0.086
1.609SerMet: 1.609 ± 0.039
1.459SerAsn: 1.459 ± 0.056
3.551SerPro: 3.551 ± 0.072
1.957SerGln: 1.957 ± 0.056
4.356SerArg: 4.356 ± 0.077
3.891SerSer: 3.891 ± 0.097
3.135SerThr: 3.135 ± 0.067
4.474SerVal: 4.474 ± 0.075
0.841SerTrp: 0.841 ± 0.029
1.5SerTyr: 1.5 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
6.244ThrAla: 6.244 ± 0.09
0.515ThrCys: 0.515 ± 0.027
3.317ThrAsp: 3.317 ± 0.066
2.842ThrGlu: 2.842 ± 0.072
1.995ThrPhe: 1.995 ± 0.054
5.546ThrGly: 5.546 ± 0.08
1.329ThrHis: 1.329 ± 0.043
2.98ThrIle: 2.98 ± 0.064
1.42ThrLys: 1.42 ± 0.041
6.839ThrLeu: 6.839 ± 0.091
1.307ThrMet: 1.307 ± 0.041
1.456ThrAsn: 1.456 ± 0.05
3.855ThrPro: 3.855 ± 0.084
1.86ThrGln: 1.86 ± 0.05
3.437ThrArg: 3.437 ± 0.064
3.288ThrSer: 3.288 ± 0.071
3.198ThrThr: 3.198 ± 0.069
4.764ThrVal: 4.764 ± 0.075
0.693ThrTrp: 0.693 ± 0.027
1.274ThrTyr: 1.274 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
7.559ValAla: 7.559 ± 0.108
0.792ValCys: 0.792 ± 0.033
3.465ValAsp: 3.465 ± 0.063
3.777ValGlu: 3.777 ± 0.076
2.576ValPhe: 2.576 ± 0.053
4.907ValGly: 4.907 ± 0.084
1.562ValHis: 1.562 ± 0.043
3.593ValIle: 3.593 ± 0.069
1.777ValLys: 1.777 ± 0.053
7.901ValLeu: 7.901 ± 0.108
1.994ValMet: 1.994 ± 0.051
1.841ValAsn: 1.841 ± 0.051
4.046ValPro: 4.046 ± 0.073
2.46ValGln: 2.46 ± 0.06
4.982ValArg: 4.982 ± 0.076
4.961ValSer: 4.961 ± 0.086
4.668ValThr: 4.668 ± 0.078
5.083ValVal: 5.083 ± 0.099
0.963ValTrp: 0.963 ± 0.036
1.322ValTyr: 1.322 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.126TrpAla: 1.126 ± 0.036
0.173TrpCys: 0.173 ± 0.015
0.682TrpAsp: 0.682 ± 0.03
0.627TrpGlu: 0.627 ± 0.03
0.493TrpPhe: 0.493 ± 0.022
0.926TrpGly: 0.926 ± 0.035
0.447TrpHis: 0.447 ± 0.026
0.723TrpIle: 0.723 ± 0.03
0.588TrpLys: 0.588 ± 0.024
1.698TrpLeu: 1.698 ± 0.046
0.392TrpMet: 0.392 ± 0.024
0.493TrpAsn: 0.493 ± 0.027
0.697TrpPro: 0.697 ± 0.03
0.661TrpGln: 0.661 ± 0.031
1.163TrpArg: 1.163 ± 0.039
0.852TrpSer: 0.852 ± 0.033
0.795TrpThr: 0.795 ± 0.033
0.759TrpVal: 0.759 ± 0.034
0.227TrpTrp: 0.227 ± 0.017
0.323TrpTyr: 0.323 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.369TyrAla: 2.369 ± 0.058
0.278TyrCys: 0.278 ± 0.016
1.504TyrAsp: 1.504 ± 0.04
1.158TyrGlu: 1.158 ± 0.041
0.798TyrPhe: 0.798 ± 0.034
2.317TyrGly: 2.317 ± 0.059
0.568TyrHis: 0.568 ± 0.025
0.88TyrIle: 0.88 ± 0.032
0.499TyrLys: 0.499 ± 0.028
2.142TyrLeu: 2.142 ± 0.056
0.426TyrMet: 0.426 ± 0.023
0.737TyrAsn: 0.737 ± 0.037
1.216TyrPro: 1.216 ± 0.037
0.801TyrGln: 0.801 ± 0.03
1.81TyrArg: 1.81 ± 0.058
1.174TyrSer: 1.174 ± 0.047
1.165TyrThr: 1.165 ± 0.041
1.595TyrVal: 1.595 ± 0.046
0.316TyrTrp: 0.316 ± 0.019
0.62TyrTyr: 0.62 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2846 proteins (857605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski