Amino acid dipepetide frequency for Haloarcula hispanica pleomorphic virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.913AlaAla: 8.913 ± 2.142
0.594AlaCys: 0.594 ± 0.509
7.427AlaAsp: 7.427 ± 1.691
7.724AlaGlu: 7.724 ± 1.882
1.783AlaPhe: 1.783 ± 0.916
8.021AlaGly: 8.021 ± 1.679
1.485AlaHis: 1.485 ± 0.801
4.753AlaIle: 4.753 ± 1.308
4.159AlaLys: 4.159 ± 1.035
4.456AlaLeu: 4.456 ± 1.72
2.377AlaMet: 2.377 ± 0.911
3.268AlaAsn: 3.268 ± 0.948
3.268AlaPro: 3.268 ± 0.93
3.565AlaGln: 3.565 ± 1.33
5.051AlaArg: 5.051 ± 1.232
3.268AlaSer: 3.268 ± 1.618
5.348AlaThr: 5.348 ± 1.292
5.348AlaVal: 5.348 ± 1.74
1.485AlaTrp: 1.485 ± 0.559
3.268AlaTyr: 3.268 ± 1.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.594CysAla: 0.594 ± 0.377
0.0CysCys: 0.0 ± 0.0
0.297CysAsp: 0.297 ± 0.319
0.0CysGlu: 0.0 ± 0.0
0.594CysPhe: 0.594 ± 0.36
0.594CysGly: 0.594 ± 0.36
0.297CysHis: 0.297 ± 0.252
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.891CysLeu: 0.891 ± 0.415
0.0CysMet: 0.0 ± 0.0
0.297CysAsn: 0.297 ± 0.378
0.891CysPro: 0.891 ± 0.532
0.297CysGln: 0.297 ± 0.274
0.297CysArg: 0.297 ± 0.252
0.891CysSer: 0.891 ± 0.524
0.0CysThr: 0.0 ± 0.0
0.891CysVal: 0.891 ± 0.42
0.0CysTrp: 0.0 ± 0.0
0.594CysTyr: 0.594 ± 0.411
0.0CysXaa: 0.0 ± 0.0
Asp
7.13AspAla: 7.13 ± 1.154
0.594AspCys: 0.594 ± 0.427
6.833AspAsp: 6.833 ± 1.614
5.645AspGlu: 5.645 ± 1.615
2.377AspPhe: 2.377 ± 0.879
7.13AspGly: 7.13 ± 1.666
0.594AspHis: 0.594 ± 0.429
3.565AspIle: 3.565 ± 1.227
0.891AspLys: 0.891 ± 0.465
6.833AspLeu: 6.833 ± 1.302
1.485AspMet: 1.485 ± 0.59
2.674AspAsn: 2.674 ± 0.851
4.753AspPro: 4.753 ± 1.441
3.565AspGln: 3.565 ± 0.84
4.753AspArg: 4.753 ± 1.01
4.753AspSer: 4.753 ± 0.946
4.456AspThr: 4.456 ± 1.261
3.862AspVal: 3.862 ± 1.305
1.485AspTrp: 1.485 ± 0.647
3.565AspTyr: 3.565 ± 0.788
0.0AspXaa: 0.0 ± 0.0
Glu
3.862GluAla: 3.862 ± 0.838
0.594GluCys: 0.594 ± 0.36
6.833GluAsp: 6.833 ± 1.553
3.862GluGlu: 3.862 ± 1.39
2.08GluPhe: 2.08 ± 0.66
5.051GluGly: 5.051 ± 1.075
1.188GluHis: 1.188 ± 0.579
6.833GluIle: 6.833 ± 1.411
4.159GluLys: 4.159 ± 0.738
5.645GluLeu: 5.645 ± 1.496
1.783GluMet: 1.783 ± 0.913
2.674GluAsn: 2.674 ± 1.015
3.268GluPro: 3.268 ± 1.077
4.456GluGln: 4.456 ± 1.175
3.862GluArg: 3.862 ± 1.252
4.159GluSer: 4.159 ± 1.692
7.427GluThr: 7.427 ± 1.415
6.536GluVal: 6.536 ± 2.084
2.674GluTrp: 2.674 ± 1.249
4.159GluTyr: 4.159 ± 1.011
0.0GluXaa: 0.0 ± 0.0
Phe
1.188PheAla: 1.188 ± 0.56
0.297PheCys: 0.297 ± 0.305
2.971PheAsp: 2.971 ± 0.854
2.377PheGlu: 2.377 ± 1.111
0.297PhePhe: 0.297 ± 0.305
2.08PheGly: 2.08 ± 0.896
0.0PheHis: 0.0 ± 0.0
0.594PheIle: 0.594 ± 0.429
0.594PheLys: 0.594 ± 0.41
0.891PheLeu: 0.891 ± 0.518
0.297PheMet: 0.297 ± 0.33
1.485PheAsn: 1.485 ± 0.799
0.297PhePro: 0.297 ± 0.305
1.485PheGln: 1.485 ± 0.559
1.188PheArg: 1.188 ± 0.397
1.188PheSer: 1.188 ± 0.539
2.674PheThr: 2.674 ± 1.102
2.674PheVal: 2.674 ± 0.684
0.594PheTrp: 0.594 ± 0.427
1.485PheTyr: 1.485 ± 0.687
0.0PheXaa: 0.0 ± 0.0
Gly
2.674GlyAla: 2.674 ± 1.01
0.891GlyCys: 0.891 ± 0.458
6.239GlyAsp: 6.239 ± 1.614
5.348GlyGlu: 5.348 ± 1.185
0.891GlyPhe: 0.891 ± 0.499
8.021GlyGly: 8.021 ± 1.734
1.188GlyHis: 1.188 ± 0.573
5.051GlyIle: 5.051 ± 1.03
3.862GlyLys: 3.862 ± 0.946
5.645GlyLeu: 5.645 ± 1.163
1.188GlyMet: 1.188 ± 0.586
2.08GlyAsn: 2.08 ± 0.933
3.862GlyPro: 3.862 ± 0.791
4.159GlyGln: 4.159 ± 1.3
5.051GlyArg: 5.051 ± 1.32
5.051GlySer: 5.051 ± 1.251
5.348GlyThr: 5.348 ± 1.665
5.051GlyVal: 5.051 ± 0.588
1.783GlyTrp: 1.783 ± 0.682
3.862GlyTyr: 3.862 ± 0.966
0.0GlyXaa: 0.0 ± 0.0
His
1.188HisAla: 1.188 ± 0.681
0.297HisCys: 0.297 ± 0.319
0.891HisAsp: 0.891 ± 0.481
1.783HisGlu: 1.783 ± 0.727
0.891HisPhe: 0.891 ± 0.412
0.891HisGly: 0.891 ± 0.482
0.594HisHis: 0.594 ± 0.379
0.594HisIle: 0.594 ± 0.334
0.891HisLys: 0.891 ± 0.426
1.188HisLeu: 1.188 ± 0.387
0.0HisMet: 0.0 ± 0.0
0.594HisAsn: 0.594 ± 0.429
1.783HisPro: 1.783 ± 0.915
0.891HisGln: 0.891 ± 0.54
3.565HisArg: 3.565 ± 1.252
0.891HisSer: 0.891 ± 0.461
1.783HisThr: 1.783 ± 0.715
1.188HisVal: 1.188 ± 0.554
0.297HisTrp: 0.297 ± 0.375
1.188HisTyr: 1.188 ± 0.57
0.0HisXaa: 0.0 ± 0.0
Ile
5.051IleAla: 5.051 ± 1.3
0.0IleCys: 0.0 ± 0.0
4.753IleAsp: 4.753 ± 1.446
4.456IleGlu: 4.456 ± 0.846
1.783IlePhe: 1.783 ± 0.956
4.456IleGly: 4.456 ± 1.136
0.891IleHis: 0.891 ± 0.648
2.377IleIle: 2.377 ± 0.961
2.08IleLys: 2.08 ± 0.607
2.674IleLeu: 2.674 ± 0.685
0.594IleMet: 0.594 ± 0.377
1.188IleAsn: 1.188 ± 0.481
2.377IlePro: 2.377 ± 0.876
2.674IleGln: 2.674 ± 1.246
5.051IleArg: 5.051 ± 1.119
3.862IleSer: 3.862 ± 1.248
3.565IleThr: 3.565 ± 1.051
3.268IleVal: 3.268 ± 1.226
0.0IleTrp: 0.0 ± 0.0
1.188IleTyr: 1.188 ± 0.51
0.0IleXaa: 0.0 ± 0.0
Lys
3.565LysAla: 3.565 ± 0.994
0.297LysCys: 0.297 ± 0.252
1.485LysAsp: 1.485 ± 0.429
3.862LysGlu: 3.862 ± 1.546
0.891LysPhe: 0.891 ± 0.486
3.268LysGly: 3.268 ± 0.497
1.783LysHis: 1.783 ± 0.778
2.674LysIle: 2.674 ± 0.619
1.783LysLys: 1.783 ± 0.686
4.456LysLeu: 4.456 ± 1.443
0.594LysMet: 0.594 ± 0.431
1.188LysAsn: 1.188 ± 0.603
1.783LysPro: 1.783 ± 0.844
2.377LysGln: 2.377 ± 0.936
2.08LysArg: 2.08 ± 1.112
2.08LysSer: 2.08 ± 0.74
3.268LysThr: 3.268 ± 0.885
1.783LysVal: 1.783 ± 0.73
0.0LysTrp: 0.0 ± 0.0
1.188LysTyr: 1.188 ± 0.775
0.0LysXaa: 0.0 ± 0.0
Leu
7.724LeuAla: 7.724 ± 2.163
0.297LeuCys: 0.297 ± 0.321
4.456LeuAsp: 4.456 ± 1.168
4.159LeuGlu: 4.159 ± 0.977
2.377LeuPhe: 2.377 ± 0.77
3.862LeuGly: 3.862 ± 1.491
0.891LeuHis: 0.891 ± 0.399
4.159LeuIle: 4.159 ± 1.267
4.159LeuLys: 4.159 ± 1.339
4.753LeuLeu: 4.753 ± 0.99
2.674LeuMet: 2.674 ± 1.148
3.565LeuAsn: 3.565 ± 1.056
2.971LeuPro: 2.971 ± 0.929
1.783LeuGln: 1.783 ± 0.851
4.159LeuArg: 4.159 ± 1.336
4.753LeuSer: 4.753 ± 1.248
5.051LeuThr: 5.051 ± 1.208
5.645LeuVal: 5.645 ± 1.672
1.188LeuTrp: 1.188 ± 0.483
2.08LeuTyr: 2.08 ± 0.726
0.0LeuXaa: 0.0 ± 0.0
Met
1.485MetAla: 1.485 ± 0.955
0.0MetCys: 0.0 ± 0.0
1.188MetAsp: 1.188 ± 0.517
1.188MetGlu: 1.188 ± 0.787
0.594MetPhe: 0.594 ± 0.476
1.485MetGly: 1.485 ± 0.715
0.891MetHis: 0.891 ± 0.491
0.891MetIle: 0.891 ± 0.471
0.594MetLys: 0.594 ± 0.419
0.297MetLeu: 0.297 ± 0.274
0.297MetMet: 0.297 ± 0.371
0.297MetAsn: 0.297 ± 0.26
0.891MetPro: 0.891 ± 0.417
0.891MetGln: 0.891 ± 0.401
1.783MetArg: 1.783 ± 0.947
2.08MetSer: 2.08 ± 0.688
2.377MetThr: 2.377 ± 0.682
0.297MetVal: 0.297 ± 0.305
0.297MetTrp: 0.297 ± 0.33
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.08AsnAla: 2.08 ± 0.609
0.594AsnCys: 0.594 ± 0.377
1.485AsnAsp: 1.485 ± 0.503
2.674AsnGlu: 2.674 ± 0.935
1.188AsnPhe: 1.188 ± 0.689
3.268AsnGly: 3.268 ± 1.044
1.485AsnHis: 1.485 ± 0.535
2.377AsnIle: 2.377 ± 0.642
1.485AsnLys: 1.485 ± 0.709
2.08AsnLeu: 2.08 ± 0.64
0.297AsnMet: 0.297 ± 0.258
2.08AsnAsn: 2.08 ± 1.04
2.08AsnPro: 2.08 ± 0.724
1.188AsnGln: 1.188 ± 0.825
2.377AsnArg: 2.377 ± 0.91
2.674AsnSer: 2.674 ± 1.794
2.971AsnThr: 2.971 ± 1.248
2.08AsnVal: 2.08 ± 0.701
0.297AsnTrp: 0.297 ± 0.274
2.377AsnTyr: 2.377 ± 0.906
0.0AsnXaa: 0.0 ± 0.0
Pro
4.753ProAla: 4.753 ± 0.85
0.297ProCys: 0.297 ± 0.274
5.645ProAsp: 5.645 ± 1.324
2.971ProGlu: 2.971 ± 1.12
0.594ProPhe: 0.594 ± 0.394
3.862ProGly: 3.862 ± 0.589
1.783ProHis: 1.783 ± 0.695
0.891ProIle: 0.891 ± 0.504
2.08ProLys: 2.08 ± 0.512
2.971ProLeu: 2.971 ± 1.046
1.188ProMet: 1.188 ± 0.886
2.377ProAsn: 2.377 ± 0.694
1.188ProPro: 1.188 ± 0.387
1.485ProGln: 1.485 ± 0.75
1.783ProArg: 1.783 ± 0.565
1.485ProSer: 1.485 ± 0.771
4.456ProThr: 4.456 ± 1.479
3.268ProVal: 3.268 ± 1.068
0.0ProTrp: 0.0 ± 0.0
2.377ProTyr: 2.377 ± 0.581
0.0ProXaa: 0.0 ± 0.0
Gln
4.456GlnAla: 4.456 ± 1.206
0.297GlnCys: 0.297 ± 0.252
3.862GlnAsp: 3.862 ± 1.512
2.971GlnGlu: 2.971 ± 0.968
1.783GlnPhe: 1.783 ± 0.57
2.377GlnGly: 2.377 ± 0.772
0.297GlnHis: 0.297 ± 0.319
1.783GlnIle: 1.783 ± 1.004
2.674GlnLys: 2.674 ± 0.968
3.268GlnLeu: 3.268 ± 0.857
1.485GlnMet: 1.485 ± 0.659
3.268GlnAsn: 3.268 ± 1.96
2.377GlnPro: 2.377 ± 0.92
2.377GlnGln: 2.377 ± 0.454
1.188GlnArg: 1.188 ± 0.939
3.862GlnSer: 3.862 ± 1.575
2.674GlnThr: 2.674 ± 1.043
1.783GlnVal: 1.783 ± 0.539
0.297GlnTrp: 0.297 ± 0.26
2.08GlnTyr: 2.08 ± 0.798
0.0GlnXaa: 0.0 ± 0.0
Arg
5.051ArgAla: 5.051 ± 0.729
1.188ArgCys: 1.188 ± 0.632
4.753ArgAsp: 4.753 ± 1.7
7.13ArgGlu: 7.13 ± 2.018
1.485ArgPhe: 1.485 ± 0.749
2.674ArgGly: 2.674 ± 1.151
1.188ArgHis: 1.188 ± 0.698
3.862ArgIle: 3.862 ± 1.285
2.674ArgLys: 2.674 ± 1.22
2.971ArgLeu: 2.971 ± 1.128
0.891ArgMet: 0.891 ± 0.587
2.971ArgAsn: 2.971 ± 0.837
2.674ArgPro: 2.674 ± 1.12
1.188ArgGln: 1.188 ± 0.718
3.565ArgArg: 3.565 ± 1.274
4.456ArgSer: 4.456 ± 1.141
2.971ArgThr: 2.971 ± 0.727
4.159ArgVal: 4.159 ± 1.53
2.377ArgTrp: 2.377 ± 1.07
3.565ArgTyr: 3.565 ± 1.269
0.0ArgXaa: 0.0 ± 0.0
Ser
7.13SerAla: 7.13 ± 1.849
0.0SerCys: 0.0 ± 0.0
3.268SerAsp: 3.268 ± 1.199
5.051SerGlu: 5.051 ± 1.563
0.891SerPhe: 0.891 ± 0.545
6.833SerGly: 6.833 ± 1.801
1.188SerHis: 1.188 ± 0.409
1.783SerIle: 1.783 ± 1.193
2.08SerLys: 2.08 ± 0.605
4.456SerLeu: 4.456 ± 0.901
0.594SerMet: 0.594 ± 0.357
2.377SerAsn: 2.377 ± 0.936
3.268SerPro: 3.268 ± 0.966
2.377SerGln: 2.377 ± 1.096
4.159SerArg: 4.159 ± 1.209
5.645SerSer: 5.645 ± 1.481
2.08SerThr: 2.08 ± 1.012
4.753SerVal: 4.753 ± 1.37
1.188SerTrp: 1.188 ± 0.596
2.08SerTyr: 2.08 ± 0.642
0.0SerXaa: 0.0 ± 0.0
Thr
8.913ThrAla: 8.913 ± 2.109
0.297ThrCys: 0.297 ± 0.252
5.051ThrAsp: 5.051 ± 1.239
6.833ThrGlu: 6.833 ± 1.725
2.08ThrPhe: 2.08 ± 0.73
3.862ThrGly: 3.862 ± 0.985
0.594ThrHis: 0.594 ± 0.344
3.862ThrIle: 3.862 ± 1.184
2.377ThrLys: 2.377 ± 0.681
6.239ThrLeu: 6.239 ± 1.653
0.594ThrMet: 0.594 ± 0.433
1.485ThrAsn: 1.485 ± 0.974
3.565ThrPro: 3.565 ± 0.935
2.08ThrGln: 2.08 ± 0.899
1.188ThrArg: 1.188 ± 0.461
3.268ThrSer: 3.268 ± 0.937
3.862ThrThr: 3.862 ± 1.215
6.833ThrVal: 6.833 ± 1.78
1.188ThrTrp: 1.188 ± 0.469
3.862ThrTyr: 3.862 ± 1.355
0.0ThrXaa: 0.0 ± 0.0
Val
5.051ValAla: 5.051 ± 1.716
0.594ValCys: 0.594 ± 0.344
4.159ValAsp: 4.159 ± 0.955
7.13ValGlu: 7.13 ± 1.665
1.188ValPhe: 1.188 ± 0.435
4.456ValGly: 4.456 ± 1.224
3.268ValHis: 3.268 ± 0.982
4.753ValIle: 4.753 ± 1.417
1.783ValLys: 1.783 ± 0.547
4.456ValLeu: 4.456 ± 1.341
0.594ValMet: 0.594 ± 0.504
1.783ValAsn: 1.783 ± 0.687
3.268ValPro: 3.268 ± 0.881
3.565ValGln: 3.565 ± 1.131
6.536ValArg: 6.536 ± 2.075
4.456ValSer: 4.456 ± 1.0
4.159ValThr: 4.159 ± 0.985
4.753ValVal: 4.753 ± 1.195
0.297ValTrp: 0.297 ± 0.274
1.188ValTyr: 1.188 ± 0.711
0.0ValXaa: 0.0 ± 0.0
Trp
1.188TrpAla: 1.188 ± 0.554
0.297TrpCys: 0.297 ± 0.252
0.891TrpAsp: 0.891 ± 0.59
1.188TrpGlu: 1.188 ± 0.527
0.297TrpPhe: 0.297 ± 0.322
0.891TrpGly: 0.891 ± 0.587
0.594TrpHis: 0.594 ± 0.632
0.594TrpIle: 0.594 ± 0.419
0.594TrpLys: 0.594 ± 0.448
2.377TrpLeu: 2.377 ± 1.177
0.297TrpMet: 0.297 ± 0.33
0.594TrpAsn: 0.594 ± 0.365
0.297TrpPro: 0.297 ± 0.252
0.297TrpGln: 0.297 ± 0.26
1.783TrpArg: 1.783 ± 0.672
1.188TrpSer: 1.188 ± 0.695
1.188TrpThr: 1.188 ± 0.588
0.594TrpVal: 0.594 ± 0.376
0.0TrpTrp: 0.0 ± 0.0
0.297TrpTyr: 0.297 ± 0.316
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.565TyrAla: 3.565 ± 1.018
0.0TyrCys: 0.0 ± 0.0
4.456TyrAsp: 4.456 ± 1.324
4.753TyrGlu: 4.753 ± 0.87
0.594TyrPhe: 0.594 ± 0.504
4.159TyrGly: 4.159 ± 1.284
1.188TyrHis: 1.188 ± 0.497
0.891TyrIle: 0.891 ± 0.322
1.485TyrLys: 1.485 ± 0.594
4.159TyrLeu: 4.159 ± 1.001
0.297TyrMet: 0.297 ± 0.302
0.891TyrAsn: 0.891 ± 0.49
0.594TyrPro: 0.594 ± 0.355
4.456TyrGln: 4.456 ± 1.113
2.674TyrArg: 2.674 ± 0.806
1.188TyrSer: 1.188 ± 0.397
2.377TyrThr: 2.377 ± 0.771
2.674TyrVal: 2.674 ± 0.625
0.0TyrTrp: 0.0 ± 0.0
2.377TyrTyr: 2.377 ± 1.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (3367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski