Amino acid dipepetide frequency for Pelagirhabdus alkalitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.977AlaAla: 3.977 ± 0.094
0.505AlaCys: 0.505 ± 0.027
3.454AlaAsp: 3.454 ± 0.077
4.145AlaGlu: 4.145 ± 0.087
3.126AlaPhe: 3.126 ± 0.063
4.377AlaGly: 4.377 ± 0.087
1.331AlaHis: 1.331 ± 0.045
5.882AlaIle: 5.882 ± 0.096
4.129AlaLys: 4.129 ± 0.084
6.957AlaLeu: 6.957 ± 0.111
1.959AlaMet: 1.959 ± 0.055
2.711AlaAsn: 2.711 ± 0.059
1.786AlaPro: 1.786 ± 0.047
2.327AlaGln: 2.327 ± 0.058
2.426AlaArg: 2.426 ± 0.061
4.162AlaSer: 4.162 ± 0.081
3.55AlaThr: 3.55 ± 0.073
4.474AlaVal: 4.474 ± 0.089
0.513AlaTrp: 0.513 ± 0.027
2.401AlaTyr: 2.401 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.022
0.052CysCys: 0.052 ± 0.008
0.384CysAsp: 0.384 ± 0.024
0.353CysGlu: 0.353 ± 0.022
0.208CysPhe: 0.208 ± 0.016
0.498CysGly: 0.498 ± 0.026
0.184CysHis: 0.184 ± 0.016
0.386CysIle: 0.386 ± 0.02
0.251CysLys: 0.251 ± 0.02
0.524CysLeu: 0.524 ± 0.028
0.13CysMet: 0.13 ± 0.014
0.197CysAsn: 0.197 ± 0.017
0.3CysPro: 0.3 ± 0.023
0.282CysGln: 0.282 ± 0.02
0.219CysArg: 0.219 ± 0.018
0.339CysSer: 0.339 ± 0.023
0.269CysThr: 0.269 ± 0.016
0.348CysVal: 0.348 ± 0.022
0.031CysTrp: 0.031 ± 0.007
0.226CysTyr: 0.226 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.846AspAla: 3.846 ± 0.069
0.353AspCys: 0.353 ± 0.023
4.151AspAsp: 4.151 ± 0.111
6.044AspGlu: 6.044 ± 0.126
2.624AspPhe: 2.624 ± 0.068
3.595AspGly: 3.595 ± 0.078
1.928AspHis: 1.928 ± 0.049
4.471AspIle: 4.471 ± 0.073
2.923AspLys: 2.923 ± 0.069
6.333AspLeu: 6.333 ± 0.097
1.687AspMet: 1.687 ± 0.051
2.146AspAsn: 2.146 ± 0.066
2.457AspPro: 2.457 ± 0.066
4.108AspGln: 4.108 ± 0.088
2.999AspArg: 2.999 ± 0.063
2.976AspSer: 2.976 ± 0.065
3.007AspThr: 3.007 ± 0.067
4.962AspVal: 4.962 ± 0.081
0.734AspTrp: 0.734 ± 0.038
2.977AspTyr: 2.977 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.883GluAla: 5.883 ± 0.096
0.292GluCys: 0.292 ± 0.022
4.96GluAsp: 4.96 ± 0.114
7.348GluGlu: 7.348 ± 0.16
2.293GluPhe: 2.293 ± 0.056
4.425GluGly: 4.425 ± 0.099
1.831GluHis: 1.831 ± 0.047
5.284GluIle: 5.284 ± 0.092
5.585GluLys: 5.585 ± 0.106
7.22GluLeu: 7.22 ± 0.107
2.24GluMet: 2.24 ± 0.053
3.49GluAsn: 3.49 ± 0.071
2.258GluPro: 2.258 ± 0.057
3.785GluGln: 3.785 ± 0.076
3.614GluArg: 3.614 ± 0.073
4.67GluSer: 4.67 ± 0.091
4.499GluThr: 4.499 ± 0.088
5.167GluVal: 5.167 ± 0.097
0.863GluTrp: 0.863 ± 0.035
2.082GluTyr: 2.082 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.533PheAla: 2.533 ± 0.066
0.227PheCys: 0.227 ± 0.017
3.036PheAsp: 3.036 ± 0.068
3.112PheGlu: 3.112 ± 0.07
2.081PhePhe: 2.081 ± 0.065
2.949PheGly: 2.949 ± 0.075
0.915PheHis: 0.915 ± 0.036
3.836PheIle: 3.836 ± 0.093
2.577PheLys: 2.577 ± 0.059
3.967PheLeu: 3.967 ± 0.075
1.173PheMet: 1.173 ± 0.041
2.28PheAsn: 2.28 ± 0.057
1.366PhePro: 1.366 ± 0.042
1.493PheGln: 1.493 ± 0.048
1.327PheArg: 1.327 ± 0.044
3.133PheSer: 3.133 ± 0.071
2.508PheThr: 2.508 ± 0.059
3.152PheVal: 3.152 ± 0.07
0.384PheTrp: 0.384 ± 0.024
1.698PheTyr: 1.698 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.373GlyAla: 4.373 ± 0.095
0.494GlyCys: 0.494 ± 0.024
3.683GlyAsp: 3.683 ± 0.071
4.486GlyGlu: 4.486 ± 0.091
3.274GlyPhe: 3.274 ± 0.072
4.155GlyGly: 4.155 ± 0.112
1.417GlyHis: 1.417 ± 0.047
5.179GlyIle: 5.179 ± 0.086
3.587GlyLys: 3.587 ± 0.077
6.222GlyLeu: 6.222 ± 0.11
1.953GlyMet: 1.953 ± 0.055
2.143GlyAsn: 2.143 ± 0.063
1.455GlyPro: 1.455 ± 0.043
2.236GlyGln: 2.236 ± 0.049
2.408GlyArg: 2.408 ± 0.062
3.704GlySer: 3.704 ± 0.076
3.497GlyThr: 3.497 ± 0.074
5.006GlyVal: 5.006 ± 0.099
0.614GlyTrp: 0.614 ± 0.027
2.843GlyTyr: 2.843 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.464HisAla: 1.464 ± 0.045
0.175HisCys: 0.175 ± 0.015
1.525HisAsp: 1.525 ± 0.047
1.509HisGlu: 1.509 ± 0.041
1.182HisPhe: 1.182 ± 0.042
1.309HisGly: 1.309 ± 0.046
0.868HisHis: 0.868 ± 0.037
1.708HisIle: 1.708 ± 0.041
1.075HisLys: 1.075 ± 0.039
2.604HisLeu: 2.604 ± 0.069
0.552HisMet: 0.552 ± 0.027
0.884HisAsn: 0.884 ± 0.035
1.17HisPro: 1.17 ± 0.039
1.205HisGln: 1.205 ± 0.042
0.893HisArg: 0.893 ± 0.039
1.19HisSer: 1.19 ± 0.037
1.163HisThr: 1.163 ± 0.037
1.679HisVal: 1.679 ± 0.05
0.192HisTrp: 0.192 ± 0.013
1.244HisTyr: 1.244 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.582IleAla: 5.582 ± 0.101
0.447IleCys: 0.447 ± 0.025
6.074IleAsp: 6.074 ± 0.105
6.766IleGlu: 6.766 ± 0.111
2.954IlePhe: 2.954 ± 0.076
5.614IleGly: 5.614 ± 0.105
1.815IleHis: 1.815 ± 0.058
5.678IleIle: 5.678 ± 0.105
4.714IleLys: 4.714 ± 0.081
6.496IleLeu: 6.496 ± 0.115
1.752IleMet: 1.752 ± 0.053
3.568IleAsn: 3.568 ± 0.079
2.958IlePro: 2.958 ± 0.067
3.153IleGln: 3.153 ± 0.063
2.893IleArg: 2.893 ± 0.067
4.716IleSer: 4.716 ± 0.08
4.358IleThr: 4.358 ± 0.078
5.429IleVal: 5.429 ± 0.095
0.586IleTrp: 0.586 ± 0.028
2.555IleTyr: 2.555 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
4.065LysAla: 4.065 ± 0.083
0.251LysCys: 0.251 ± 0.02
3.946LysAsp: 3.946 ± 0.079
5.952LysGlu: 5.952 ± 0.114
1.47LysPhe: 1.47 ± 0.046
3.752LysGly: 3.752 ± 0.083
1.462LysHis: 1.462 ± 0.045
3.546LysIle: 3.546 ± 0.068
4.953LysLys: 4.953 ± 0.099
4.761LysLeu: 4.761 ± 0.085
1.781LysMet: 1.781 ± 0.048
2.809LysAsn: 2.809 ± 0.074
2.073LysPro: 2.073 ± 0.052
3.636LysGln: 3.636 ± 0.078
3.544LysArg: 3.544 ± 0.074
3.412LysSer: 3.412 ± 0.082
3.481LysThr: 3.481 ± 0.077
3.734LysVal: 3.734 ± 0.075
0.652LysTrp: 0.652 ± 0.031
1.603LysTyr: 1.603 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
6.472LeuAla: 6.472 ± 0.094
0.427LeuCys: 0.427 ± 0.025
6.032LeuAsp: 6.032 ± 0.101
6.601LeuGlu: 6.601 ± 0.097
4.876LeuPhe: 4.876 ± 0.095
5.803LeuGly: 5.803 ± 0.094
1.744LeuHis: 1.744 ± 0.059
7.994LeuIle: 7.994 ± 0.126
6.524LeuLys: 6.524 ± 0.126
9.263LeuLeu: 9.263 ± 0.14
2.621LeuMet: 2.621 ± 0.068
5.045LeuAsn: 5.045 ± 0.089
3.669LeuPro: 3.669 ± 0.078
2.979LeuGln: 2.979 ± 0.066
3.236LeuArg: 3.236 ± 0.071
7.219LeuSer: 7.219 ± 0.124
6.344LeuThr: 6.344 ± 0.094
5.997LeuVal: 5.997 ± 0.098
0.65LeuTrp: 0.65 ± 0.033
3.121LeuTyr: 3.121 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.94MetAla: 1.94 ± 0.053
0.12MetCys: 0.12 ± 0.014
1.591MetAsp: 1.591 ± 0.042
1.713MetGlu: 1.713 ± 0.049
0.971MetPhe: 0.971 ± 0.038
1.561MetGly: 1.561 ± 0.048
0.537MetHis: 0.537 ± 0.027
2.421MetIle: 2.421 ± 0.07
2.049MetLys: 2.049 ± 0.047
2.391MetLeu: 2.391 ± 0.052
0.912MetMet: 0.912 ± 0.036
1.579MetAsn: 1.579 ± 0.043
0.951MetPro: 0.951 ± 0.037
1.002MetGln: 1.002 ± 0.037
1.221MetArg: 1.221 ± 0.039
1.81MetSer: 1.81 ± 0.051
1.845MetThr: 1.845 ± 0.054
1.888MetVal: 1.888 ± 0.049
0.152MetTrp: 0.152 ± 0.015
0.81MetTyr: 0.81 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.692AsnAla: 2.692 ± 0.069
0.242AsnCys: 0.242 ± 0.019
3.12AsnAsp: 3.12 ± 0.056
3.833AsnGlu: 3.833 ± 0.072
1.46AsnPhe: 1.46 ± 0.05
2.862AsnGly: 2.862 ± 0.065
1.256AsnHis: 1.256 ± 0.039
3.009AsnIle: 3.009 ± 0.075
2.492AsnLys: 2.492 ± 0.067
3.7AsnLeu: 3.7 ± 0.074
1.139AsnMet: 1.139 ± 0.039
1.877AsnAsn: 1.877 ± 0.062
1.931AsnPro: 1.931 ± 0.054
2.985AsnGln: 2.985 ± 0.074
2.256AsnArg: 2.256 ± 0.057
1.902AsnSer: 1.902 ± 0.055
2.159AsnThr: 2.159 ± 0.059
3.005AsnVal: 3.005 ± 0.064
0.516AsnTrp: 0.516 ± 0.03
1.671AsnTyr: 1.671 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
1.837ProAla: 1.837 ± 0.044
0.202ProCys: 0.202 ± 0.019
2.295ProAsp: 2.295 ± 0.061
2.976ProGlu: 2.976 ± 0.092
1.89ProPhe: 1.89 ± 0.046
1.98ProGly: 1.98 ± 0.055
0.818ProHis: 0.818 ± 0.03
2.984ProIle: 2.984 ± 0.063
1.905ProLys: 1.905 ± 0.059
3.22ProLeu: 3.22 ± 0.068
0.805ProMet: 0.805 ± 0.035
1.728ProAsn: 1.728 ± 0.054
0.816ProPro: 0.816 ± 0.036
0.992ProGln: 0.992 ± 0.034
0.985ProArg: 0.985 ± 0.032
2.234ProSer: 2.234 ± 0.061
2.031ProThr: 2.031 ± 0.057
2.635ProVal: 2.635 ± 0.06
0.282ProTrp: 0.282 ± 0.02
1.35ProTyr: 1.35 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.081GlnAla: 3.081 ± 0.071
0.145GlnCys: 0.145 ± 0.012
2.311GlnAsp: 2.311 ± 0.056
3.078GlnGlu: 3.078 ± 0.069
2.09GlnPhe: 2.09 ± 0.059
2.127GlnGly: 2.127 ± 0.055
1.001GlnHis: 1.001 ± 0.043
2.972GlnIle: 2.972 ± 0.068
2.549GlnLys: 2.549 ± 0.07
5.292GlnLeu: 5.292 ± 0.104
1.311GlnMet: 1.311 ± 0.043
1.802GlnAsn: 1.802 ± 0.054
1.385GlnPro: 1.385 ± 0.044
1.834GlnGln: 1.834 ± 0.057
1.454GlnArg: 1.454 ± 0.046
3.079GlnSer: 3.079 ± 0.072
2.799GlnThr: 2.799 ± 0.073
2.792GlnVal: 2.792 ± 0.066
0.383GlnTrp: 0.383 ± 0.024
1.468GlnTyr: 1.468 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.432ArgAla: 2.432 ± 0.06
0.202ArgCys: 0.202 ± 0.018
2.485ArgAsp: 2.485 ± 0.06
3.03ArgGlu: 3.03 ± 0.058
2.06ArgPhe: 2.06 ± 0.056
2.186ArgGly: 2.186 ± 0.061
0.963ArgHis: 0.963 ± 0.037
3.103ArgIle: 3.103 ± 0.07
2.5ArgLys: 2.5 ± 0.062
4.358ArgLeu: 4.358 ± 0.088
1.22ArgMet: 1.22 ± 0.041
1.583ArgAsn: 1.583 ± 0.054
1.223ArgPro: 1.223 ± 0.043
1.761ArgGln: 1.761 ± 0.052
1.792ArgArg: 1.792 ± 0.061
2.361ArgSer: 2.361 ± 0.053
2.058ArgThr: 2.058 ± 0.049
2.782ArgVal: 2.782 ± 0.062
0.347ArgTrp: 0.347 ± 0.022
1.756ArgTyr: 1.756 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.352SerAla: 3.352 ± 0.07
0.283SerCys: 0.283 ± 0.022
3.833SerAsp: 3.833 ± 0.073
4.438SerGlu: 4.438 ± 0.09
3.027SerPhe: 3.027 ± 0.068
4.358SerGly: 4.358 ± 0.087
1.452SerHis: 1.452 ± 0.043
5.608SerIle: 5.608 ± 0.088
3.384SerLys: 3.384 ± 0.071
6.085SerLeu: 6.085 ± 0.082
1.773SerMet: 1.773 ± 0.05
2.807SerAsn: 2.807 ± 0.069
1.949SerPro: 1.949 ± 0.052
2.322SerGln: 2.322 ± 0.065
2.315SerArg: 2.315 ± 0.053
3.807SerSer: 3.807 ± 0.079
3.349SerThr: 3.349 ± 0.075
4.611SerVal: 4.611 ± 0.08
0.519SerTrp: 0.519 ± 0.028
2.28SerTyr: 2.28 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
3.356ThrAla: 3.356 ± 0.076
0.34ThrCys: 0.34 ± 0.027
3.662ThrAsp: 3.662 ± 0.073
3.973ThrGlu: 3.973 ± 0.083
2.773ThrPhe: 2.773 ± 0.064
3.812ThrGly: 3.812 ± 0.079
1.362ThrHis: 1.362 ± 0.047
4.984ThrIle: 4.984 ± 0.095
3.134ThrLys: 3.134 ± 0.08
5.879ThrLeu: 5.879 ± 0.09
1.321ThrMet: 1.321 ± 0.046
2.498ThrAsn: 2.498 ± 0.055
2.201ThrPro: 2.201 ± 0.049
1.898ThrGln: 1.898 ± 0.055
1.998ThrArg: 1.998 ± 0.053
3.372ThrSer: 3.372 ± 0.068
3.159ThrThr: 3.159 ± 0.072
4.291ThrVal: 4.291 ± 0.079
0.476ThrTrp: 0.476 ± 0.028
2.105ThrTyr: 2.105 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.456ValAla: 4.456 ± 0.088
0.433ValCys: 0.433 ± 0.021
4.796ValAsp: 4.796 ± 0.087
5.377ValGlu: 5.377 ± 0.095
2.997ValPhe: 2.997 ± 0.067
4.6ValGly: 4.6 ± 0.097
1.364ValHis: 1.364 ± 0.039
5.824ValIle: 5.824 ± 0.1
4.159ValLys: 4.159 ± 0.082
6.48ValLeu: 6.48 ± 0.093
2.006ValMet: 2.006 ± 0.054
3.194ValAsn: 3.194 ± 0.069
2.338ValPro: 2.338 ± 0.058
2.331ValGln: 2.331 ± 0.056
2.57ValArg: 2.57 ± 0.057
4.931ValSer: 4.931 ± 0.095
4.122ValThr: 4.122 ± 0.088
5.335ValVal: 5.335 ± 0.099
0.523ValTrp: 0.523 ± 0.029
2.409ValTyr: 2.409 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.47TrpAla: 0.47 ± 0.026
0.059TrpCys: 0.059 ± 0.01
0.508TrpAsp: 0.508 ± 0.026
0.582TrpGlu: 0.582 ± 0.031
0.533TrpPhe: 0.533 ± 0.03
0.519TrpGly: 0.519 ± 0.026
0.216TrpHis: 0.216 ± 0.018
0.773TrpIle: 0.773 ± 0.036
0.482TrpLys: 0.482 ± 0.026
1.08TrpLeu: 1.08 ± 0.04
0.277TrpMet: 0.277 ± 0.018
0.373TrpAsn: 0.373 ± 0.023
0.288TrpPro: 0.288 ± 0.019
0.402TrpGln: 0.402 ± 0.026
0.345TrpArg: 0.345 ± 0.025
0.497TrpSer: 0.497 ± 0.028
0.433TrpThr: 0.433 ± 0.026
0.595TrpVal: 0.595 ± 0.031
0.105TrpTrp: 0.105 ± 0.012
0.341TrpTyr: 0.341 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.057TyrAla: 2.057 ± 0.05
0.255TyrCys: 0.255 ± 0.019
2.476TyrAsp: 2.476 ± 0.055
2.477TyrGlu: 2.477 ± 0.059
1.855TyrPhe: 1.855 ± 0.056
2.246TyrGly: 2.246 ± 0.06
1.126TyrHis: 1.126 ± 0.044
2.469TyrIle: 2.469 ± 0.056
1.909TyrLys: 1.909 ± 0.053
3.783TyrLeu: 3.783 ± 0.074
0.849TyrMet: 0.849 ± 0.033
1.396TyrAsn: 1.396 ± 0.046
1.392TyrPro: 1.392 ± 0.044
2.222TyrGln: 2.222 ± 0.059
1.706TyrArg: 1.706 ± 0.055
2.038TyrSer: 2.038 ± 0.046
1.963TyrThr: 1.963 ± 0.05
2.362TyrVal: 2.362 ± 0.058
0.359TyrTrp: 0.359 ± 0.022
1.614TyrTyr: 1.614 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2406 proteins (744324 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski