Amino acid dipepetide frequency for Theileria annulata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.627AlaAla: 1.627 ± 0.055	0.507AlaCys: 0.507 ± 0.018	1.638AlaAsp: 1.638 ± 0.035	1.914AlaGlu: 1.914 ± 0.038	1.603AlaPhe: 1.603 ± 0.033	1.714AlaGly: 1.714 ± 0.044	0.678AlaHis: 0.678 ± 0.02	2.307AlaIle: 2.307 ± 0.046	2.66AlaLys: 2.66 ± 0.058	3.67AlaLeu: 3.67 ± 0.063	0.73AlaMet: 0.73 ± 0.02	2.214AlaAsn: 2.214 ± 0.04	1.236AlaPro: 1.236 ± 0.031	1.048AlaGln: 1.048 ± 0.028	1.255AlaArg: 1.255 ± 0.028	2.788AlaSer: 2.788 ± 0.045	2.085AlaThr: 2.085 ± 0.052	2.22AlaVal: 2.22 ± 0.042	0.235AlaTrp: 0.235 ± 0.012	1.248AlaTyr: 1.248 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.484CysAla: 0.484 ± 0.017	0.468CysCys: 0.468 ± 0.036	0.848CysAsp: 0.848 ± 0.021	0.869CysGlu: 0.869 ± 0.024	0.83CysPhe: 0.83 ± 0.024	0.845CysGly: 0.845 ± 0.025	0.333CysHis: 0.333 ± 0.013	1.323CysIle: 1.323 ± 0.03	1.436CysLys: 1.436 ± 0.032	1.642CysLeu: 1.642 ± 0.033	0.31CysMet: 0.31 ± 0.012	1.164CysAsn: 1.164 ± 0.029	0.568CysPro: 0.568 ± 0.021	0.366CysGln: 0.366 ± 0.015	0.657CysArg: 0.657 ± 0.019	1.424CysSer: 1.424 ± 0.031	1.019CysThr: 1.019 ± 0.03	1.035CysVal: 1.035 ± 0.023	0.151CysTrp: 0.151 ± 0.009	0.705CysTyr: 0.705 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	1.657AspAla: 1.657 ± 0.04	0.74AspCys: 0.74 ± 0.02	3.792AspAsp: 3.792 ± 0.079	4.583AspGlu: 4.583 ± 0.071	2.856AspPhe: 2.856 ± 0.042	2.656AspGly: 2.656 ± 0.049	1.066AspHis: 1.066 ± 0.024	4.042AspIle: 4.042 ± 0.07	4.59AspLys: 4.59 ± 0.057	5.879AspLeu: 5.879 ± 0.075	1.087AspMet: 1.087 ± 0.024	3.827AspAsn: 3.827 ± 0.057	2.371AspPro: 2.371 ± 0.039	1.757AspGln: 1.757 ± 0.035	1.916AspArg: 1.916 ± 0.039	5.238AspSer: 5.238 ± 0.061	3.195AspThr: 3.195 ± 0.057	3.426AspVal: 3.426 ± 0.058	0.436AspTrp: 0.436 ± 0.014	2.534AspTyr: 2.534 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	2.229GluAla: 2.229 ± 0.046	1.154GluCys: 1.154 ± 0.029	4.016GluAsp: 4.016 ± 0.061	5.282GluGlu: 5.282 ± 0.102	3.088GluPhe: 3.088 ± 0.042	2.509GluGly: 2.509 ± 0.039	1.232GluHis: 1.232 ± 0.025	4.481GluIle: 4.481 ± 0.059	5.005GluLys: 5.005 ± 0.065	6.716GluLeu: 6.716 ± 0.071	1.46GluMet: 1.46 ± 0.026	5.057GluAsn: 5.057 ± 0.076	2.266GluPro: 2.266 ± 0.056	2.044GluGln: 2.044 ± 0.041	2.291GluArg: 2.291 ± 0.047	5.651GluSer: 5.651 ± 0.074	3.415GluThr: 3.415 ± 0.056	3.609GluVal: 3.609 ± 0.051	0.511GluTrp: 0.511 ± 0.019	2.829GluTyr: 2.829 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	1.478PheAla: 1.478 ± 0.033	0.845PheCys: 0.845 ± 0.022	3.146PheAsp: 3.146 ± 0.044	2.946PheGlu: 2.946 ± 0.039	2.301PhePhe: 2.301 ± 0.043	2.678PheGly: 2.678 ± 0.047	1.049PheHis: 1.049 ± 0.022	3.619PheIle: 3.619 ± 0.058	4.157PheLys: 4.157 ± 0.052	4.734PheLeu: 4.734 ± 0.059	1.041PheMet: 1.041 ± 0.024	4.017PheAsn: 4.017 ± 0.058	1.56PhePro: 1.56 ± 0.027	1.37PheGln: 1.37 ± 0.028	1.841PheArg: 1.841 ± 0.032	4.282PheSer: 4.282 ± 0.056	2.813PheThr: 2.813 ± 0.051	3.014PheVal: 3.014 ± 0.047	0.433PheTrp: 0.433 ± 0.016	2.301PheTyr: 2.301 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	1.915GlyAla: 1.915 ± 0.05	0.669GlyCys: 0.669 ± 0.019	2.574GlyAsp: 2.574 ± 0.045	2.557GlyGlu: 2.557 ± 0.044	2.235GlyPhe: 2.235 ± 0.043	2.33GlyGly: 2.33 ± 0.058	0.91GlyHis: 0.91 ± 0.027	3.212GlyIle: 3.212 ± 0.049	3.415GlyLys: 3.415 ± 0.045	4.085GlyLeu: 4.085 ± 0.058	0.956GlyMet: 0.956 ± 0.026	2.967GlyAsn: 2.967 ± 0.046	1.582GlyPro: 1.582 ± 0.039	1.172GlyGln: 1.172 ± 0.038	1.698GlyArg: 1.698 ± 0.035	3.846GlySer: 3.846 ± 0.064	3.324GlyThr: 3.324 ± 0.072	2.962GlyVal: 2.962 ± 0.06	0.392GlyTrp: 0.392 ± 0.016	2.075GlyTyr: 2.075 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	0.582HisAla: 0.582 ± 0.021	0.308HisCys: 0.308 ± 0.012	1.005HisAsp: 1.005 ± 0.029	1.186HisGlu: 1.186 ± 0.023	1.156HisPhe: 1.156 ± 0.023	0.871HisGly: 0.871 ± 0.025	0.47HisHis: 0.47 ± 0.015	1.446HisIle: 1.446 ± 0.028	1.496HisLys: 1.496 ± 0.028	2.289HisLeu: 2.289 ± 0.038	0.428HisMet: 0.428 ± 0.016	1.349HisAsn: 1.349 ± 0.026	0.875HisPro: 0.875 ± 0.028	0.634HisGln: 0.634 ± 0.018	0.826HisArg: 0.826 ± 0.022	1.734HisSer: 1.734 ± 0.032	1.188HisThr: 1.188 ± 0.025	1.145HisVal: 1.145 ± 0.024	0.197HisTrp: 0.197 ± 0.012	1.024HisTyr: 1.024 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	2.312IleAla: 2.312 ± 0.042	1.278IleCys: 1.278 ± 0.026	3.795IleAsp: 3.795 ± 0.054	4.028IleGlu: 4.028 ± 0.061	3.541IlePhe: 3.541 ± 0.052	2.848IleGly: 2.848 ± 0.047	1.491IleHis: 1.491 ± 0.03	5.588IleIle: 5.588 ± 0.103	5.918IleLys: 5.918 ± 0.078	7.421IleLeu: 7.421 ± 0.104	1.363IleMet: 1.363 ± 0.029	5.931IleAsn: 5.931 ± 0.096	2.852IlePro: 2.852 ± 0.045	2.112IleGln: 2.112 ± 0.039	2.614IleArg: 2.614 ± 0.042	6.09IleSer: 6.09 ± 0.073	4.298IleThr: 4.298 ± 0.072	3.793IleVal: 3.793 ± 0.056	0.728IleTrp: 0.728 ± 0.027	3.179IleTyr: 3.179 ± 0.048	0.0IleXaa: 0.0 ± 0.001
Lys	2.737LysAla: 2.737 ± 0.061	1.545LysCys: 1.545 ± 0.035	4.473LysAsp: 4.473 ± 0.067	5.138LysGlu: 5.138 ± 0.071	4.249LysPhe: 4.249 ± 0.076	3.313LysGly: 3.313 ± 0.045	1.712LysHis: 1.712 ± 0.028	5.966LysIle: 5.966 ± 0.069	6.059LysLys: 6.059 ± 0.081	9.034LysLeu: 9.034 ± 0.08	1.759LysMet: 1.759 ± 0.031	5.652LysAsn: 5.652 ± 0.067	2.836LysPro: 2.836 ± 0.053	2.3LysGln: 2.3 ± 0.039	3.578LysArg: 3.578 ± 0.06	6.733LysSer: 6.733 ± 0.078	4.281LysThr: 4.281 ± 0.047	4.575LysVal: 4.575 ± 0.059	0.688LysTrp: 0.688 ± 0.021	3.958LysTyr: 3.958 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	3.558LeuAla: 3.558 ± 0.059	1.668LeuCys: 1.668 ± 0.035	5.862LeuAsp: 5.862 ± 0.074	6.495LeuGlu: 6.495 ± 0.092	5.142LeuPhe: 5.142 ± 0.07	4.029LeuGly: 4.029 ± 0.045	2.036LeuHis: 2.036 ± 0.036	7.052LeuIle: 7.052 ± 0.092	8.591LeuLys: 8.591 ± 0.084	10.513LeuLeu: 10.513 ± 0.107	2.203LeuMet: 2.203 ± 0.034	7.975LeuAsn: 7.975 ± 0.081	3.323LeuPro: 3.323 ± 0.051	3.066LeuGln: 3.066 ± 0.043	3.943LeuArg: 3.943 ± 0.049	8.789LeuSer: 8.789 ± 0.073	5.55LeuThr: 5.55 ± 0.061	5.957LeuVal: 5.957 ± 0.064	0.802LeuTrp: 0.802 ± 0.021	4.337LeuTyr: 4.337 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	0.92MetAla: 0.92 ± 0.021	0.453MetCys: 0.453 ± 0.014	1.408MetAsp: 1.408 ± 0.029	1.615MetGlu: 1.615 ± 0.037	1.011MetPhe: 1.011 ± 0.024	1.107MetGly: 1.107 ± 0.03	0.274MetHis: 0.274 ± 0.012	1.386MetIle: 1.386 ± 0.031	1.61MetLys: 1.61 ± 0.028	1.891MetLeu: 1.891 ± 0.037	0.496MetMet: 0.496 ± 0.016	1.542MetAsn: 1.542 ± 0.03	0.669MetPro: 0.669 ± 0.021	0.402MetGln: 0.402 ± 0.015	0.758MetArg: 0.758 ± 0.023	1.641MetSer: 1.641 ± 0.03	1.053MetThr: 1.053 ± 0.023	1.312MetVal: 1.312 ± 0.032	0.147MetTrp: 0.147 ± 0.008	0.847MetTyr: 0.847 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.067AsnAla: 2.067 ± 0.042	1.238AsnCys: 1.238 ± 0.025	3.971AsnAsp: 3.971 ± 0.058	4.802AsnGlu: 4.802 ± 0.066	3.888AsnPhe: 3.888 ± 0.05	3.151AsnGly: 3.151 ± 0.048	1.446AsnHis: 1.446 ± 0.026	5.685AsnIle: 5.685 ± 0.093	6.242AsnLys: 6.242 ± 0.082	7.739AsnLeu: 7.739 ± 0.097	1.55AsnMet: 1.55 ± 0.033	6.614AsnAsn: 6.614 ± 0.108	2.659AsnPro: 2.659 ± 0.046	2.324AsnGln: 2.324 ± 0.04	2.602AsnArg: 2.602 ± 0.039	7.222AsnSer: 7.222 ± 0.097	4.93AsnThr: 4.93 ± 0.074	4.225AsnVal: 4.225 ± 0.052	0.562AsnTrp: 0.562 ± 0.017	3.418AsnTyr: 3.418 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.178ProAla: 1.178 ± 0.039	0.423ProCys: 0.423 ± 0.018	1.929ProAsp: 1.929 ± 0.037	2.949ProGlu: 2.949 ± 0.06	1.751ProPhe: 1.751 ± 0.029	1.75ProGly: 1.75 ± 0.046	0.675ProHis: 0.675 ± 0.02	2.54ProIle: 2.54 ± 0.045	3.166ProLys: 3.166 ± 0.053	3.201ProLeu: 3.201 ± 0.049	0.696ProMet: 0.696 ± 0.025	2.847ProAsn: 2.847 ± 0.045	1.846ProPro: 1.846 ± 0.056	1.488ProGln: 1.488 ± 0.056	1.244ProArg: 1.244 ± 0.028	3.072ProSer: 3.072 ± 0.042	2.364ProThr: 2.364 ± 0.053	2.25ProVal: 2.25 ± 0.039	0.255ProTrp: 0.255 ± 0.012	1.535ProTyr: 1.535 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.079GlnAla: 1.079 ± 0.029	0.417GlnCys: 0.417 ± 0.015	1.482GlnAsp: 1.482 ± 0.026	1.892GlnGlu: 1.892 ± 0.04	1.562GlnPhe: 1.562 ± 0.03	1.15GlnGly: 1.15 ± 0.04	0.657GlnHis: 0.657 ± 0.023	2.288GlnIle: 2.288 ± 0.039	2.149GlnLys: 2.149 ± 0.037	3.432GlnLeu: 3.432 ± 0.048	0.731GlnMet: 0.731 ± 0.023	2.273GlnAsn: 2.273 ± 0.041	1.618GlnPro: 1.618 ± 0.082	1.363GlnGln: 1.363 ± 0.057	1.147GlnArg: 1.147 ± 0.027	2.441GlnSer: 2.441 ± 0.048	1.764GlnThr: 1.764 ± 0.042	1.683GlnVal: 1.683 ± 0.03	0.255GlnTrp: 0.255 ± 0.012	1.403GlnTyr: 1.403 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.344ArgAla: 1.344 ± 0.029	0.7ArgCys: 0.7 ± 0.02	2.125ArgAsp: 2.125 ± 0.041	2.361ArgGlu: 2.361 ± 0.04	2.097ArgPhe: 2.097 ± 0.035	1.628ArgGly: 1.628 ± 0.032	0.819ArgHis: 0.819 ± 0.025	2.895ArgIle: 2.895 ± 0.047	3.056ArgLys: 3.056 ± 0.046	3.958ArgLeu: 3.958 ± 0.055	0.847ArgMet: 0.847 ± 0.022	2.779ArgAsn: 2.779 ± 0.048	1.27ArgPro: 1.27 ± 0.029	1.056ArgGln: 1.056 ± 0.026	2.235ArgArg: 2.235 ± 0.046	2.895ArgSer: 2.895 ± 0.061	1.927ArgThr: 1.927 ± 0.033	2.226ArgVal: 2.226 ± 0.033	0.32ArgTrp: 0.32 ± 0.013	1.731ArgTyr: 1.731 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	2.632SerAla: 2.632 ± 0.049	1.317SerCys: 1.317 ± 0.03	5.532SerAsp: 5.532 ± 0.077	5.656SerGlu: 5.656 ± 0.064	4.181SerPhe: 4.181 ± 0.056	4.22SerGly: 4.22 ± 0.058	1.74SerHis: 1.74 ± 0.03	5.791SerIle: 5.791 ± 0.081	6.985SerLys: 6.985 ± 0.073	8.288SerLeu: 8.288 ± 0.073	1.611SerMet: 1.611 ± 0.031	6.665SerAsn: 6.665 ± 0.073	2.795SerPro: 2.795 ± 0.049	2.837SerGln: 2.837 ± 0.053	3.243SerArg: 3.243 ± 0.054	8.234SerSer: 8.234 ± 0.104	5.672SerThr: 5.672 ± 0.08	5.102SerVal: 5.102 ± 0.061	0.56SerTrp: 0.56 ± 0.018	3.25SerTyr: 3.25 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	2.141ThrAla: 2.141 ± 0.048	0.869ThrCys: 0.869 ± 0.022	3.249ThrAsp: 3.249 ± 0.06	3.71ThrGlu: 3.71 ± 0.061	2.814ThrPhe: 2.814 ± 0.04	3.029ThrGly: 3.029 ± 0.076	1.366ThrHis: 1.366 ± 0.027	4.009ThrIle: 4.009 ± 0.054	4.736ThrLys: 4.736 ± 0.063	5.617ThrLeu: 5.617 ± 0.067	1.091ThrMet: 1.091 ± 0.023	5.063ThrAsn: 5.063 ± 0.077	2.728ThrPro: 2.728 ± 0.057	2.104ThrGln: 2.104 ± 0.05	2.096ThrArg: 2.096 ± 0.035	5.115ThrSer: 5.115 ± 0.067	4.187ThrThr: 4.187 ± 0.077	3.879ThrVal: 3.879 ± 0.068	0.359ThrTrp: 0.359 ± 0.013	1.949ThrTyr: 1.949 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	1.919ValAla: 1.919 ± 0.04	0.982ValCys: 0.982 ± 0.024	3.877ValAsp: 3.877 ± 0.05	3.813ValGlu: 3.813 ± 0.056	2.774ValPhe: 2.774 ± 0.043	2.773ValGly: 2.773 ± 0.051	1.099ValHis: 1.099 ± 0.028	3.808ValIle: 3.808 ± 0.053	4.866ValLys: 4.866 ± 0.061	5.726ValLeu: 5.726 ± 0.068	1.177ValMet: 1.177 ± 0.025	4.197ValAsn: 4.197 ± 0.062	2.387ValPro: 2.387 ± 0.053	1.667ValGln: 1.667 ± 0.033	2.161ValArg: 2.161 ± 0.035	4.723ValSer: 4.723 ± 0.056	3.976ValThr: 3.976 ± 0.077	3.848ValVal: 3.848 ± 0.053	0.676ValTrp: 0.676 ± 0.036	2.646ValTyr: 2.646 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.28TrpAla: 0.28 ± 0.011	0.171TrpCys: 0.171 ± 0.011	0.468TrpAsp: 0.468 ± 0.017	0.566TrpGlu: 0.566 ± 0.026	0.333TrpPhe: 0.333 ± 0.012	0.312TrpGly: 0.312 ± 0.015	0.232TrpHis: 0.232 ± 0.012	0.608TrpIle: 0.608 ± 0.019	0.766TrpLys: 0.766 ± 0.037	0.761TrpLeu: 0.761 ± 0.022	0.15TrpMet: 0.15 ± 0.01	0.641TrpAsn: 0.641 ± 0.018	0.226TrpPro: 0.226 ± 0.012	0.218TrpGln: 0.218 ± 0.012	0.358TrpArg: 0.358 ± 0.014	0.67TrpSer: 0.67 ± 0.02	0.49TrpThr: 0.49 ± 0.02	0.484TrpVal: 0.484 ± 0.016	0.074TrpTrp: 0.074 ± 0.006	0.329TrpTyr: 0.329 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.239TyrAla: 1.239 ± 0.028	0.727TyrCys: 0.727 ± 0.022	2.458TyrAsp: 2.458 ± 0.046	2.484TyrGlu: 2.484 ± 0.038	2.21TyrPhe: 2.21 ± 0.04	1.961TyrGly: 1.961 ± 0.04	0.926TyrHis: 0.926 ± 0.021	3.13TyrIle: 3.13 ± 0.05	3.684TyrLys: 3.684 ± 0.05	4.295TyrLeu: 4.295 ± 0.051	0.856TyrMet: 0.856 ± 0.023	3.561TyrAsn: 3.561 ± 0.061	1.494TyrPro: 1.494 ± 0.035	1.456TyrGln: 1.456 ± 0.037	1.806TyrArg: 1.806 ± 0.036	3.727TyrSer: 3.727 ± 0.049	2.578TyrThr: 2.578 ± 0.044	2.351TyrVal: 2.351 ± 0.036	0.357TyrTrp: 0.357 ± 0.017	2.238TyrTyr: 2.238 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3790 proteins (2024948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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