Amino acid dipepetide frequency for bacterium 1XD21-70

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.291AlaAla: 9.291 ± 0.132	1.322AlaCys: 1.322 ± 0.039	4.637AlaAsp: 4.637 ± 0.062	6.006AlaGlu: 6.006 ± 0.085	3.291AlaPhe: 3.291 ± 0.062	7.794AlaGly: 7.794 ± 0.102	1.11AlaHis: 1.11 ± 0.033	4.7AlaIle: 4.7 ± 0.083	4.521AlaLys: 4.521 ± 0.068	7.306AlaLeu: 7.306 ± 0.083	2.753AlaMet: 2.753 ± 0.049	2.542AlaAsn: 2.542 ± 0.046	2.379AlaPro: 2.379 ± 0.051	2.49AlaGln: 2.49 ± 0.05	3.936AlaArg: 3.936 ± 0.057	4.257AlaSer: 4.257 ± 0.066	2.963AlaThr: 2.963 ± 0.061	6.907AlaVal: 6.907 ± 0.086	0.883AlaTrp: 0.883 ± 0.029	2.826AlaTyr: 2.826 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.033	0.329CysCys: 0.329 ± 0.016	0.759CysAsp: 0.759 ± 0.028	0.862CysGlu: 0.862 ± 0.024	0.72CysPhe: 0.72 ± 0.025	1.656CysGly: 1.656 ± 0.039	0.366CysHis: 0.366 ± 0.018	0.979CysIle: 0.979 ± 0.028	0.701CysLys: 0.701 ± 0.024	1.386CysLeu: 1.386 ± 0.033	0.459CysMet: 0.459 ± 0.022	0.536CysAsn: 0.536 ± 0.02	0.716CysPro: 0.716 ± 0.026	0.514CysGln: 0.514 ± 0.022	1.086CysArg: 1.086 ± 0.031	0.949CysSer: 0.949 ± 0.028	0.733CysThr: 0.733 ± 0.023	1.011CysVal: 1.011 ± 0.031	0.144CysTrp: 0.144 ± 0.013	0.634CysTyr: 0.634 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.891AspAla: 3.891 ± 0.066	0.837AspCys: 0.837 ± 0.023	2.416AspAsp: 2.416 ± 0.062	4.003AspGlu: 4.003 ± 0.063	2.615AspPhe: 2.615 ± 0.045	5.024AspGly: 5.024 ± 0.099	0.818AspHis: 0.818 ± 0.028	3.983AspIle: 3.983 ± 0.063	3.009AspLys: 3.009 ± 0.055	4.318AspLeu: 4.318 ± 0.07	1.768AspMet: 1.768 ± 0.038	1.914AspAsn: 1.914 ± 0.047	1.995AspPro: 1.995 ± 0.048	1.362AspGln: 1.362 ± 0.037	2.649AspArg: 2.649 ± 0.05	3.0AspSer: 3.0 ± 0.058	2.756AspThr: 2.756 ± 0.051	3.443AspVal: 3.443 ± 0.055	0.639AspTrp: 0.639 ± 0.025	2.608AspTyr: 2.608 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.548GluAla: 6.548 ± 0.094	0.884GluCys: 0.884 ± 0.027	4.382GluAsp: 4.382 ± 0.067	7.817GluGlu: 7.817 ± 0.134	2.457GluPhe: 2.457 ± 0.047	5.424GluGly: 5.424 ± 0.089	1.331GluHis: 1.331 ± 0.033	5.145GluIle: 5.145 ± 0.074	5.991GluLys: 5.991 ± 0.081	6.598GluLeu: 6.598 ± 0.083	2.429GluMet: 2.429 ± 0.04	3.676GluAsn: 3.676 ± 0.065	2.355GluPro: 2.355 ± 0.06	3.056GluGln: 3.056 ± 0.053	4.21GluArg: 4.21 ± 0.067	3.385GluSer: 3.385 ± 0.061	3.403GluThr: 3.403 ± 0.073	4.466GluVal: 4.466 ± 0.061	0.756GluTrp: 0.756 ± 0.023	3.072GluTyr: 3.072 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.183PheAla: 3.183 ± 0.055	0.9PheCys: 0.9 ± 0.028	2.259PheAsp: 2.259 ± 0.043	2.415PheGlu: 2.415 ± 0.051	1.872PhePhe: 1.872 ± 0.05	3.334PheGly: 3.334 ± 0.061	0.874PheHis: 0.874 ± 0.025	2.335PheIle: 2.335 ± 0.051	1.681PheLys: 1.681 ± 0.039	4.164PheLeu: 4.164 ± 0.072	1.147PheMet: 1.147 ± 0.033	1.273PheAsn: 1.273 ± 0.035	1.564PhePro: 1.564 ± 0.036	1.325PheGln: 1.325 ± 0.034	2.007PheArg: 2.007 ± 0.039	2.875PheSer: 2.875 ± 0.048	2.087PheThr: 2.087 ± 0.047	2.715PheVal: 2.715 ± 0.053	0.512PheTrp: 0.512 ± 0.022	1.714PheTyr: 1.714 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.869GlyAla: 5.869 ± 0.081	1.437GlyCys: 1.437 ± 0.037	3.775GlyAsp: 3.775 ± 0.063	5.802GlyGlu: 5.802 ± 0.07	3.351GlyPhe: 3.351 ± 0.061	6.332GlyGly: 6.332 ± 0.137	1.491GlyHis: 1.491 ± 0.041	6.35GlyIle: 6.35 ± 0.089	5.671GlyLys: 5.671 ± 0.072	6.461GlyLeu: 6.461 ± 0.082	2.951GlyMet: 2.951 ± 0.05	3.319GlyAsn: 3.319 ± 0.066	1.398GlyPro: 1.398 ± 0.045	2.93GlyGln: 2.93 ± 0.049	4.451GlyArg: 4.451 ± 0.083	4.818GlySer: 4.818 ± 0.09	4.26GlyThr: 4.26 ± 0.072	5.195GlyVal: 5.195 ± 0.067	0.963GlyTrp: 0.963 ± 0.033	3.426GlyTyr: 3.426 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.246HisAla: 1.246 ± 0.031	0.327HisCys: 0.327 ± 0.017	0.867HisAsp: 0.867 ± 0.023	1.059HisGlu: 1.059 ± 0.032	0.855HisPhe: 0.855 ± 0.028	1.493HisGly: 1.493 ± 0.035	0.417HisHis: 0.417 ± 0.019	1.307HisIle: 1.307 ± 0.032	0.93HisLys: 0.93 ± 0.027	1.559HisLeu: 1.559 ± 0.036	0.56HisMet: 0.56 ± 0.022	0.673HisAsn: 0.673 ± 0.023	0.91HisPro: 0.91 ± 0.03	0.581HisGln: 0.581 ± 0.022	0.939HisArg: 0.939 ± 0.03	0.979HisSer: 0.979 ± 0.028	0.911HisThr: 0.911 ± 0.027	1.153HisVal: 1.153 ± 0.029	0.208HisTrp: 0.208 ± 0.012	0.791HisTyr: 0.791 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.193IleAla: 5.193 ± 0.077	1.19IleCys: 1.19 ± 0.032	3.375IleAsp: 3.375 ± 0.051	4.117IleGlu: 4.117 ± 0.059	2.545IlePhe: 2.545 ± 0.053	4.79IleGly: 4.79 ± 0.071	1.393IleHis: 1.393 ± 0.034	4.03IleIle: 4.03 ± 0.076	3.191IleLys: 3.191 ± 0.055	6.448IleLeu: 6.448 ± 0.09	1.712IleMet: 1.712 ± 0.042	2.339IleAsn: 2.339 ± 0.047	2.943IlePro: 2.943 ± 0.049	2.295IleGln: 2.295 ± 0.045	4.296IleArg: 4.296 ± 0.068	4.17IleSer: 4.17 ± 0.065	3.466IleThr: 3.466 ± 0.055	4.132IleVal: 4.132 ± 0.067	0.626IleTrp: 0.626 ± 0.023	2.511IleTyr: 2.511 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.963LysAla: 4.963 ± 0.071	0.652LysCys: 0.652 ± 0.023	3.362LysAsp: 3.362 ± 0.061	5.873LysGlu: 5.873 ± 0.077	1.572LysPhe: 1.572 ± 0.037	4.268LysGly: 4.268 ± 0.059	0.951LysHis: 0.951 ± 0.028	3.867LysIle: 3.867 ± 0.066	5.153LysLys: 5.153 ± 0.075	4.838LysLeu: 4.838 ± 0.071	1.762LysMet: 1.762 ± 0.036	2.964LysAsn: 2.964 ± 0.054	2.033LysPro: 2.033 ± 0.045	2.135LysGln: 2.135 ± 0.046	3.39LysArg: 3.39 ± 0.064	3.0LysSer: 3.0 ± 0.049	3.092LysThr: 3.092 ± 0.056	3.727LysVal: 3.727 ± 0.064	0.562LysTrp: 0.562 ± 0.021	2.352LysTyr: 2.352 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	7.993LeuAla: 7.993 ± 0.093	1.569LeuCys: 1.569 ± 0.039	4.958LeuAsp: 4.958 ± 0.082	6.946LeuGlu: 6.946 ± 0.103	3.784LeuPhe: 3.784 ± 0.081	6.536LeuGly: 6.536 ± 0.074	1.553LeuHis: 1.553 ± 0.035	4.969LeuIle: 4.969 ± 0.08	5.643LeuLys: 5.643 ± 0.079	8.993LeuLeu: 8.993 ± 0.136	2.694LeuMet: 2.694 ± 0.053	3.342LeuAsn: 3.342 ± 0.052	3.832LeuPro: 3.832 ± 0.056	3.011LeuGln: 3.011 ± 0.054	4.292LeuArg: 4.292 ± 0.075	5.943LeuSer: 5.943 ± 0.071	4.484LeuThr: 4.484 ± 0.056	5.97LeuVal: 5.97 ± 0.083	0.895LeuTrp: 0.895 ± 0.028	3.39LeuTyr: 3.39 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	3.025MetAla: 3.025 ± 0.052	0.376MetCys: 0.376 ± 0.016	1.914MetAsp: 1.914 ± 0.044	2.884MetGlu: 2.884 ± 0.053	0.985MetPhe: 0.985 ± 0.028	2.414MetGly: 2.414 ± 0.048	0.394MetHis: 0.394 ± 0.016	1.821MetIle: 1.821 ± 0.043	2.155MetLys: 2.155 ± 0.041	2.663MetLeu: 2.663 ± 0.049	0.964MetMet: 0.964 ± 0.03	1.368MetAsn: 1.368 ± 0.041	1.268MetPro: 1.268 ± 0.03	1.015MetGln: 1.015 ± 0.029	1.473MetArg: 1.473 ± 0.031	1.729MetSer: 1.729 ± 0.04	1.462MetThr: 1.462 ± 0.033	2.331MetVal: 2.331 ± 0.04	0.223MetTrp: 0.223 ± 0.012	0.851MetTyr: 0.851 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.844AsnAla: 2.844 ± 0.052	0.574AsnCys: 0.574 ± 0.023	1.73AsnAsp: 1.73 ± 0.038	2.414AsnGlu: 2.414 ± 0.05	1.433AsnPhe: 1.433 ± 0.038	3.383AsnGly: 3.383 ± 0.061	0.799AsnHis: 0.799 ± 0.029	2.874AsnIle: 2.874 ± 0.051	1.911AsnLys: 1.911 ± 0.048	3.417AsnLeu: 3.417 ± 0.056	1.154AsnMet: 1.154 ± 0.033	1.489AsnAsn: 1.489 ± 0.043	1.977AsnPro: 1.977 ± 0.04	1.505AsnGln: 1.505 ± 0.039	2.267AsnArg: 2.267 ± 0.038	2.015AsnSer: 2.015 ± 0.046	2.035AsnThr: 2.035 ± 0.043	2.475AsnVal: 2.475 ± 0.041	0.419AsnTrp: 0.419 ± 0.017	1.652AsnTyr: 1.652 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.952ProAla: 2.952 ± 0.058	0.509ProCys: 0.509 ± 0.019	2.382ProAsp: 2.382 ± 0.043	3.577ProGlu: 3.577 ± 0.067	1.573ProPhe: 1.573 ± 0.035	3.277ProGly: 3.277 ± 0.051	0.62ProHis: 0.62 ± 0.023	1.769ProIle: 1.769 ± 0.038	1.853ProLys: 1.853 ± 0.038	2.985ProLeu: 2.985 ± 0.045	0.998ProMet: 0.998 ± 0.032	1.126ProAsn: 1.126 ± 0.028	1.028ProPro: 1.028 ± 0.031	1.317ProGln: 1.317 ± 0.035	1.282ProArg: 1.282 ± 0.034	1.916ProSer: 1.916 ± 0.039	1.408ProThr: 1.408 ± 0.039	3.356ProVal: 3.356 ± 0.055	0.361ProTrp: 0.361 ± 0.018	1.573ProTyr: 1.573 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.1GlnAla: 3.1 ± 0.055	0.364GlnCys: 0.364 ± 0.017	1.744GlnAsp: 1.744 ± 0.04	3.312GlnGlu: 3.312 ± 0.063	1.115GlnPhe: 1.115 ± 0.028	2.489GlnGly: 2.489 ± 0.049	0.52GlnHis: 0.52 ± 0.019	2.385GlnIle: 2.385 ± 0.039	2.661GlnLys: 2.661 ± 0.05	2.868GlnLeu: 2.868 ± 0.049	1.312GlnMet: 1.312 ± 0.032	1.463GlnAsn: 1.463 ± 0.037	1.077GlnPro: 1.077 ± 0.031	1.312GlnGln: 1.312 ± 0.039	1.683GlnArg: 1.683 ± 0.044	1.596GlnSer: 1.596 ± 0.035	1.527GlnThr: 1.527 ± 0.033	2.648GlnVal: 2.648 ± 0.052	0.374GlnTrp: 0.374 ± 0.017	1.441GlnTyr: 1.441 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.356ArgAla: 3.356 ± 0.055	0.763ArgCys: 0.763 ± 0.025	2.579ArgAsp: 2.579 ± 0.047	4.826ArgGlu: 4.826 ± 0.084	2.246ArgPhe: 2.246 ± 0.044	3.221ArgGly: 3.221 ± 0.055	1.066ArgHis: 1.066 ± 0.031	3.907ArgIle: 3.907 ± 0.063	3.561ArgLys: 3.561 ± 0.061	5.189ArgLeu: 5.189 ± 0.083	1.956ArgMet: 1.956 ± 0.04	2.064ArgAsn: 2.064 ± 0.042	1.729ArgPro: 1.729 ± 0.037	2.57ArgGln: 2.57 ± 0.055	3.175ArgArg: 3.175 ± 0.061	2.323ArgSer: 2.323 ± 0.049	2.45ArgThr: 2.45 ± 0.041	3.258ArgVal: 3.258 ± 0.058	0.528ArgTrp: 0.528 ± 0.021	2.242ArgTyr: 2.242 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.377SerAla: 4.377 ± 0.056	0.841SerCys: 0.841 ± 0.025	2.808SerAsp: 2.808 ± 0.055	3.538SerGlu: 3.538 ± 0.065	2.551SerPhe: 2.551 ± 0.045	5.48SerGly: 5.48 ± 0.092	1.127SerHis: 1.127 ± 0.032	3.408SerIle: 3.408 ± 0.055	2.749SerLys: 2.749 ± 0.046	5.36SerLeu: 5.36 ± 0.079	1.77SerMet: 1.77 ± 0.037	1.928SerAsn: 1.928 ± 0.042	1.988SerPro: 1.988 ± 0.042	1.976SerGln: 1.976 ± 0.039	3.328SerArg: 3.328 ± 0.057	3.333SerSer: 3.333 ± 0.068	2.436SerThr: 2.436 ± 0.051	4.112SerVal: 4.112 ± 0.062	0.662SerTrp: 0.662 ± 0.022	2.302SerTyr: 2.302 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.276ThrAla: 4.276 ± 0.069	0.588ThrCys: 0.588 ± 0.022	2.731ThrAsp: 2.731 ± 0.055	3.587ThrGlu: 3.587 ± 0.068	1.807ThrPhe: 1.807 ± 0.044	4.631ThrGly: 4.631 ± 0.077	0.763ThrHis: 0.763 ± 0.023	3.169ThrIle: 3.169 ± 0.049	2.45ThrLys: 2.45 ± 0.046	4.137ThrLeu: 4.137 ± 0.054	1.364ThrMet: 1.364 ± 0.033	1.694ThrAsn: 1.694 ± 0.037	2.015ThrPro: 2.015 ± 0.047	1.307ThrGln: 1.307 ± 0.041	2.155ThrArg: 2.155 ± 0.039	2.515ThrSer: 2.515 ± 0.04	2.381ThrThr: 2.381 ± 0.049	4.197ThrVal: 4.197 ± 0.073	0.514ThrTrp: 0.514 ± 0.019	1.716ThrTyr: 1.716 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.353ValAla: 5.353 ± 0.073	1.283ValCys: 1.283 ± 0.033	3.594ValAsp: 3.594 ± 0.055	4.572ValGlu: 4.572 ± 0.065	3.195ValPhe: 3.195 ± 0.057	4.539ValGly: 4.539 ± 0.073	1.094ValHis: 1.094 ± 0.034	4.609ValIle: 4.609 ± 0.074	3.985ValLys: 3.985 ± 0.055	7.056ValLeu: 7.056 ± 0.087	2.167ValMet: 2.167 ± 0.043	2.585ValAsn: 2.585 ± 0.046	2.851ValPro: 2.851 ± 0.051	2.068ValGln: 2.068 ± 0.044	3.524ValArg: 3.524 ± 0.058	4.58ValSer: 4.58 ± 0.064	3.805ValThr: 3.805 ± 0.07	5.217ValVal: 5.217 ± 0.078	0.695ValTrp: 0.695 ± 0.027	2.67ValTyr: 2.67 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.615TrpAla: 0.615 ± 0.023	0.155TrpCys: 0.155 ± 0.011	0.596TrpAsp: 0.596 ± 0.021	0.891TrpGlu: 0.891 ± 0.026	0.438TrpPhe: 0.438 ± 0.02	0.795TrpGly: 0.795 ± 0.026	0.193TrpHis: 0.193 ± 0.013	0.68TrpIle: 0.68 ± 0.025	0.783TrpLys: 0.783 ± 0.026	1.061TrpLeu: 1.061 ± 0.031	0.36TrpMet: 0.36 ± 0.019	0.544TrpAsn: 0.544 ± 0.023	0.259TrpPro: 0.259 ± 0.015	0.483TrpGln: 0.483 ± 0.022	0.488TrpArg: 0.488 ± 0.021	0.487TrpSer: 0.487 ± 0.02	0.401TrpThr: 0.401 ± 0.019	0.624TrpVal: 0.624 ± 0.024	0.146TrpTrp: 0.146 ± 0.012	0.492TrpTyr: 0.492 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.749TyrAla: 2.749 ± 0.058	0.73TyrCys: 0.73 ± 0.025	2.18TyrAsp: 2.18 ± 0.041	2.883TyrGlu: 2.883 ± 0.05	1.832TyrPhe: 1.832 ± 0.038	3.371TyrGly: 3.371 ± 0.051	0.882TyrHis: 0.882 ± 0.029	2.474TyrIle: 2.474 ± 0.047	1.916TyrLys: 1.916 ± 0.041	3.989TyrLeu: 3.989 ± 0.058	1.037TyrMet: 1.037 ± 0.03	1.528TyrAsn: 1.528 ± 0.034	1.545TyrPro: 1.545 ± 0.034	1.738TyrGln: 1.738 ± 0.039	2.383TyrArg: 2.383 ± 0.046	2.203TyrSer: 2.203 ± 0.047	1.939TyrThr: 1.939 ± 0.043	2.505TyrVal: 2.505 ± 0.046	0.382TyrTrp: 0.382 ± 0.021	1.879TyrTyr: 1.879 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3860 proteins (1250839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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