Amino acid dipepetide frequency for Aspergillus tamarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.949AlaAla: 7.949 ± 0.052	1.155AlaCys: 1.155 ± 0.017	3.96AlaAsp: 3.96 ± 0.026	4.715AlaGlu: 4.715 ± 0.036	3.227AlaPhe: 3.227 ± 0.023	5.495AlaGly: 5.495 ± 0.034	1.786AlaHis: 1.786 ± 0.019	4.431AlaIle: 4.431 ± 0.028	3.653AlaLys: 3.653 ± 0.028	7.771AlaLeu: 7.771 ± 0.039	1.969AlaMet: 1.969 ± 0.018	2.853AlaAsn: 2.853 ± 0.022	4.259AlaPro: 4.259 ± 0.032	3.199AlaGln: 3.199 ± 0.025	4.559AlaArg: 4.559 ± 0.03	6.863AlaSer: 6.863 ± 0.042	5.061AlaThr: 5.061 ± 0.031	5.413AlaVal: 5.413 ± 0.035	1.183AlaTrp: 1.183 ± 0.017	2.279AlaTyr: 2.279 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.03CysAla: 1.03 ± 0.014	0.283CysCys: 0.283 ± 0.008	0.743CysAsp: 0.743 ± 0.012	0.65CysGlu: 0.65 ± 0.01	0.61CysPhe: 0.61 ± 0.01	0.988CysGly: 0.988 ± 0.014	0.387CysHis: 0.387 ± 0.009	0.823CysIle: 0.823 ± 0.013	0.525CysLys: 0.525 ± 0.011	1.455CysLeu: 1.455 ± 0.018	0.325CysMet: 0.325 ± 0.008	0.484CysAsn: 0.484 ± 0.01	0.723CysPro: 0.723 ± 0.014	0.53CysGln: 0.53 ± 0.009	0.866CysArg: 0.866 ± 0.013	1.067CysSer: 1.067 ± 0.015	0.775CysThr: 0.775 ± 0.013	0.898CysVal: 0.898 ± 0.013	0.224CysTrp: 0.224 ± 0.007	0.415CysTyr: 0.415 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.332AspAla: 4.332 ± 0.03	0.659AspCys: 0.659 ± 0.012	3.676AspAsp: 3.676 ± 0.035	4.014AspGlu: 4.014 ± 0.029	2.126AspPhe: 2.126 ± 0.02	3.898AspGly: 3.898 ± 0.028	1.28AspHis: 1.28 ± 0.015	3.263AspIle: 3.263 ± 0.025	2.251AspLys: 2.251 ± 0.023	5.069AspLeu: 5.069 ± 0.03	1.271AspMet: 1.271 ± 0.014	1.945AspAsn: 1.945 ± 0.018	3.29AspPro: 3.29 ± 0.026	1.923AspGln: 1.923 ± 0.018	3.032AspArg: 3.032 ± 0.025	4.075AspSer: 4.075 ± 0.028	2.989AspThr: 2.989 ± 0.022	3.59AspVal: 3.59 ± 0.028	0.885AspTrp: 0.885 ± 0.013	1.666AspTyr: 1.666 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.963GluAla: 4.963 ± 0.033	0.691GluCys: 0.691 ± 0.01	3.877GluAsp: 3.877 ± 0.03	5.011GluGlu: 5.011 ± 0.05	1.95GluPhe: 1.95 ± 0.019	3.626GluGly: 3.626 ± 0.027	1.39GluHis: 1.39 ± 0.015	3.066GluIle: 3.066 ± 0.023	3.485GluLys: 3.485 ± 0.032	5.147GluLeu: 5.147 ± 0.031	1.387GluMet: 1.387 ± 0.017	2.358GluAsn: 2.358 ± 0.019	2.718GluPro: 2.718 ± 0.045	2.446GluGln: 2.446 ± 0.022	3.777GluArg: 3.777 ± 0.029	4.324GluSer: 4.324 ± 0.028	3.487GluThr: 3.487 ± 0.028	3.483GluVal: 3.483 ± 0.026	0.881GluTrp: 0.881 ± 0.014	1.753GluTyr: 1.753 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.057PheAla: 3.057 ± 0.025	0.648PheCys: 0.648 ± 0.012	2.249PheAsp: 2.249 ± 0.016	2.07PheGlu: 2.07 ± 0.019	1.796PhePhe: 1.796 ± 0.021	2.879PheGly: 2.879 ± 0.026	1.011PheHis: 1.011 ± 0.012	2.016PheIle: 2.016 ± 0.019	1.439PheLys: 1.439 ± 0.015	3.799PheLeu: 3.799 ± 0.029	0.824PheMet: 0.824 ± 0.01	1.495PheAsn: 1.495 ± 0.016	2.083PhePro: 2.083 ± 0.021	1.498PheGln: 1.498 ± 0.015	2.021PheArg: 2.021 ± 0.019	3.145PheSer: 3.145 ± 0.023	2.281PheThr: 2.281 ± 0.02	2.492PheVal: 2.492 ± 0.021	0.708PheTrp: 0.708 ± 0.012	1.227PheTyr: 1.227 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.082GlyAla: 5.082 ± 0.034	0.981GlyCys: 0.981 ± 0.015	3.532GlyAsp: 3.532 ± 0.025	3.521GlyGlu: 3.521 ± 0.029	2.903GlyPhe: 2.903 ± 0.028	5.286GlyGly: 5.286 ± 0.047	1.691GlyHis: 1.691 ± 0.019	3.8GlyIle: 3.8 ± 0.028	3.281GlyLys: 3.281 ± 0.029	6.323GlyLeu: 6.323 ± 0.036	1.558GlyMet: 1.558 ± 0.018	2.586GlyAsn: 2.586 ± 0.02	3.289GlyPro: 3.289 ± 0.027	2.591GlyGln: 2.591 ± 0.023	3.954GlyArg: 3.954 ± 0.029	5.634GlySer: 5.634 ± 0.029	3.973GlyThr: 3.973 ± 0.029	4.483GlyVal: 4.483 ± 0.029	1.216GlyTrp: 1.216 ± 0.015	2.303GlyTyr: 2.303 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.831HisAla: 1.831 ± 0.019	0.389HisCys: 0.389 ± 0.009	1.335HisAsp: 1.335 ± 0.017	1.338HisGlu: 1.338 ± 0.014	0.949HisPhe: 0.949 ± 0.012	1.767HisGly: 1.767 ± 0.017	0.859HisHis: 0.859 ± 0.014	1.349HisIle: 1.349 ± 0.016	0.892HisLys: 0.892 ± 0.013	2.368HisLeu: 2.368 ± 0.02	0.523HisMet: 0.523 ± 0.01	0.907HisAsn: 0.907 ± 0.013	1.678HisPro: 1.678 ± 0.016	0.971HisGln: 0.971 ± 0.014	1.567HisArg: 1.567 ± 0.018	1.941HisSer: 1.941 ± 0.021	1.314HisThr: 1.314 ± 0.017	1.458HisVal: 1.458 ± 0.015	0.392HisTrp: 0.392 ± 0.009	0.765HisTyr: 0.765 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.334IleAla: 4.334 ± 0.031	0.874IleCys: 0.874 ± 0.012	2.896IleAsp: 2.896 ± 0.025	2.909IleGlu: 2.909 ± 0.021	2.214IlePhe: 2.214 ± 0.023	3.44IleGly: 3.44 ± 0.028	1.334IleHis: 1.334 ± 0.014	2.791IleIle: 2.791 ± 0.025	2.074IleLys: 2.074 ± 0.022	5.021IleLeu: 5.021 ± 0.032	1.09IleMet: 1.09 ± 0.011	1.9IleAsn: 1.9 ± 0.015	3.301IlePro: 3.301 ± 0.022	2.065IleGln: 2.065 ± 0.019	2.898IleArg: 2.898 ± 0.025	4.174IleSer: 4.174 ± 0.031	2.998IleThr: 2.998 ± 0.024	3.412IleVal: 3.412 ± 0.023	0.784IleTrp: 0.784 ± 0.012	1.63IleTyr: 1.63 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.92LysAla: 3.92 ± 0.03	0.571LysCys: 0.571 ± 0.011	2.669LysAsp: 2.669 ± 0.02	3.182LysGlu: 3.182 ± 0.03	1.387LysPhe: 1.387 ± 0.015	2.88LysGly: 2.88 ± 0.023	1.094LysHis: 1.094 ± 0.014	2.162LysIle: 2.162 ± 0.02	2.819LysLys: 2.819 ± 0.038	3.946LysLeu: 3.946 ± 0.031	0.919LysMet: 0.919 ± 0.011	1.703LysAsn: 1.703 ± 0.017	2.537LysPro: 2.537 ± 0.023	1.795LysGln: 1.795 ± 0.019	3.14LysArg: 3.14 ± 0.026	3.318LysSer: 3.318 ± 0.023	2.594LysThr: 2.594 ± 0.02	2.764LysVal: 2.764 ± 0.021	0.657LysTrp: 0.657 ± 0.01	1.384LysTyr: 1.384 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.75LeuAla: 7.75 ± 0.042	1.376LeuCys: 1.376 ± 0.016	5.164LeuAsp: 5.164 ± 0.03	5.483LeuGlu: 5.483 ± 0.031	3.647LeuPhe: 3.647 ± 0.028	6.193LeuGly: 6.193 ± 0.036	2.382LeuHis: 2.382 ± 0.019	4.291LeuIle: 4.291 ± 0.032	4.041LeuLys: 4.041 ± 0.028	8.917LeuLeu: 8.917 ± 0.048	1.913LeuMet: 1.913 ± 0.017	3.345LeuAsn: 3.345 ± 0.021	5.555LeuPro: 5.555 ± 0.028	3.965LeuGln: 3.965 ± 0.028	5.828LeuArg: 5.828 ± 0.039	7.806LeuSer: 7.806 ± 0.037	5.011LeuThr: 5.011 ± 0.035	5.74LeuVal: 5.74 ± 0.036	1.302LeuTrp: 1.302 ± 0.015	2.661LeuTyr: 2.661 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.143MetAla: 2.143 ± 0.018	0.278MetCys: 0.278 ± 0.006	1.226MetAsp: 1.226 ± 0.014	1.296MetGlu: 1.296 ± 0.014	0.769MetPhe: 0.769 ± 0.012	1.514MetGly: 1.514 ± 0.017	0.497MetHis: 0.497 ± 0.009	1.098MetIle: 1.098 ± 0.015	1.005MetLys: 1.005 ± 0.014	1.926MetLeu: 1.926 ± 0.019	0.564MetMet: 0.564 ± 0.01	0.838MetAsn: 0.838 ± 0.011	1.189MetPro: 1.189 ± 0.013	0.866MetGln: 0.866 ± 0.012	1.227MetArg: 1.227 ± 0.014	1.874MetSer: 1.874 ± 0.017	1.347MetThr: 1.347 ± 0.014	1.424MetVal: 1.424 ± 0.016	0.278MetTrp: 0.278 ± 0.007	0.566MetTyr: 0.566 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.066AsnAla: 3.066 ± 0.022	0.516AsnCys: 0.516 ± 0.009	1.984AsnAsp: 1.984 ± 0.019	2.068AsnGlu: 2.068 ± 0.02	1.383AsnPhe: 1.383 ± 0.015	2.972AsnGly: 2.972 ± 0.026	0.903AsnHis: 0.903 ± 0.014	2.223AsnIle: 2.223 ± 0.019	1.515AsnLys: 1.515 ± 0.017	3.337AsnLeu: 3.337 ± 0.025	0.88AsnMet: 0.88 ± 0.013	1.52AsnAsn: 1.52 ± 0.02	2.484AsnPro: 2.484 ± 0.023	1.378AsnGln: 1.378 ± 0.016	1.999AsnArg: 1.999 ± 0.016	2.781AsnSer: 2.781 ± 0.025	2.272AsnThr: 2.272 ± 0.02	2.45AsnVal: 2.45 ± 0.019	0.606AsnTrp: 0.606 ± 0.011	1.145AsnTyr: 1.145 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.603ProAla: 4.603 ± 0.034	0.61ProCys: 0.61 ± 0.012	3.145ProAsp: 3.145 ± 0.026	3.834ProGlu: 3.834 ± 0.036	2.156ProPhe: 2.156 ± 0.018	3.833ProGly: 3.833 ± 0.029	1.315ProHis: 1.315 ± 0.017	2.612ProIle: 2.612 ± 0.02	2.493ProLys: 2.493 ± 0.024	4.774ProLeu: 4.774 ± 0.029	1.089ProMet: 1.089 ± 0.014	2.205ProAsn: 2.205 ± 0.021	4.375ProPro: 4.375 ± 0.058	2.372ProGln: 2.372 ± 0.025	3.269ProArg: 3.269 ± 0.031	5.847ProSer: 5.847 ± 0.043	3.894ProThr: 3.894 ± 0.03	3.609ProVal: 3.609 ± 0.033	0.803ProTrp: 0.803 ± 0.013	1.591ProTyr: 1.591 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.296GlnAla: 3.296 ± 0.026	0.527GlnCys: 0.527 ± 0.01	2.037GlnAsp: 2.037 ± 0.017	2.452GlnGlu: 2.452 ± 0.025	1.343GlnPhe: 1.343 ± 0.017	2.469GlnGly: 2.469 ± 0.023	1.044GlnHis: 1.044 ± 0.012	1.986GlnIle: 1.986 ± 0.018	1.97GlnLys: 1.97 ± 0.018	3.593GlnLeu: 3.593 ± 0.027	0.887GlnMet: 0.887 ± 0.013	1.604GlnAsn: 1.604 ± 0.019	2.444GlnPro: 2.444 ± 0.026	2.212GlnGln: 2.212 ± 0.043	2.594GlnArg: 2.594 ± 0.022	3.212GlnSer: 3.212 ± 0.025	2.322GlnThr: 2.322 ± 0.019	2.249GlnVal: 2.249 ± 0.022	0.619GlnTrp: 0.619 ± 0.011	1.24GlnTyr: 1.24 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.414ArgAla: 4.414 ± 0.033	0.799ArgCys: 0.799 ± 0.013	3.233ArgAsp: 3.233 ± 0.026	3.655ArgGlu: 3.655 ± 0.029	2.214ArgPhe: 2.214 ± 0.019	3.552ArgGly: 3.552 ± 0.031	1.578ArgHis: 1.578 ± 0.019	2.961ArgIle: 2.961 ± 0.023	3.251ArgLys: 3.251 ± 0.026	5.638ArgLeu: 5.638 ± 0.03	1.312ArgMet: 1.312 ± 0.014	2.26ArgAsn: 2.26 ± 0.02	3.32ArgPro: 3.32 ± 0.027	2.571ArgGln: 2.571 ± 0.021	4.822ArgArg: 4.822 ± 0.041	4.713ArgSer: 4.713 ± 0.04	3.227ArgThr: 3.227 ± 0.022	3.458ArgVal: 3.458 ± 0.024	0.984ArgTrp: 0.984 ± 0.014	1.794ArgTyr: 1.794 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.389SerAla: 6.389 ± 0.036	1.029SerCys: 1.029 ± 0.013	4.238SerAsp: 4.238 ± 0.03	4.193SerGlu: 4.193 ± 0.028	3.249SerPhe: 3.249 ± 0.024	5.516SerGly: 5.516 ± 0.034	2.041SerHis: 2.041 ± 0.02	4.278SerIle: 4.278 ± 0.031	3.558SerLys: 3.558 ± 0.024	7.642SerLeu: 7.642 ± 0.043	1.749SerMet: 1.749 ± 0.02	3.072SerAsn: 3.072 ± 0.024	5.236SerPro: 5.236 ± 0.046	3.371SerGln: 3.371 ± 0.027	4.947SerArg: 4.947 ± 0.038	8.59SerSer: 8.59 ± 0.061	5.512SerThr: 5.512 ± 0.037	4.795SerVal: 4.795 ± 0.029	1.212SerTrp: 1.212 ± 0.013	2.229SerTyr: 2.229 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.032ThrAla: 5.032 ± 0.027	0.818ThrCys: 0.818 ± 0.013	2.914ThrAsp: 2.914 ± 0.021	3.203ThrGlu: 3.203 ± 0.024	2.309ThrPhe: 2.309 ± 0.022	4.292ThrGly: 4.292 ± 0.032	1.324ThrHis: 1.324 ± 0.014	3.259ThrIle: 3.259 ± 0.027	2.491ThrLys: 2.491 ± 0.021	5.4ThrLeu: 5.4 ± 0.03	1.227ThrMet: 1.227 ± 0.015	2.143ThrAsn: 2.143 ± 0.017	4.065ThrPro: 4.065 ± 0.037	2.094ThrGln: 2.094 ± 0.019	3.025ThrArg: 3.025 ± 0.024	5.21ThrSer: 5.21 ± 0.036	4.099ThrThr: 4.099 ± 0.037	3.964ThrVal: 3.964 ± 0.03	0.931ThrTrp: 0.931 ± 0.013	1.751ThrTyr: 1.751 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.176ValAla: 5.176 ± 0.035	0.926ValCys: 0.926 ± 0.013	3.725ValAsp: 3.725 ± 0.026	3.767ValGlu: 3.767 ± 0.028	2.624ValPhe: 2.624 ± 0.022	4.159ValGly: 4.159 ± 0.034	1.469ValHis: 1.469 ± 0.015	3.242ValIle: 3.242 ± 0.025	2.747ValLys: 2.747 ± 0.022	5.829ValLeu: 5.829 ± 0.036	1.371ValMet: 1.371 ± 0.017	2.365ValAsn: 2.365 ± 0.017	3.617ValPro: 3.617 ± 0.029	2.457ValGln: 2.457 ± 0.02	3.469ValArg: 3.469 ± 0.023	4.949ValSer: 4.949 ± 0.03	3.678ValThr: 3.678 ± 0.025	4.382ValVal: 4.382 ± 0.035	0.917ValTrp: 0.917 ± 0.016	1.916ValTyr: 1.916 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.015	0.213TrpCys: 0.213 ± 0.005	0.928TrpAsp: 0.928 ± 0.012	0.867TrpGlu: 0.867 ± 0.013	0.585TrpPhe: 0.585 ± 0.011	0.992TrpGly: 0.992 ± 0.014	0.381TrpHis: 0.381 ± 0.008	0.845TrpIle: 0.845 ± 0.013	0.844TrpLys: 0.844 ± 0.012	1.474TrpLeu: 1.474 ± 0.017	0.393TrpMet: 0.393 ± 0.008	0.684TrpAsn: 0.684 ± 0.012	0.638TrpPro: 0.638 ± 0.01	0.593TrpGln: 0.593 ± 0.011	0.981TrpArg: 0.981 ± 0.015	1.114TrpSer: 1.114 ± 0.014	0.968TrpThr: 0.968 ± 0.013	0.946TrpVal: 0.946 ± 0.013	0.3TrpTrp: 0.3 ± 0.007	0.475TrpTyr: 0.475 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.249TyrAla: 2.249 ± 0.019	0.455TyrCys: 0.455 ± 0.009	1.703TyrAsp: 1.703 ± 0.02	1.592TyrGlu: 1.592 ± 0.017	1.298TyrPhe: 1.298 ± 0.016	2.236TyrGly: 2.236 ± 0.024	0.827TyrHis: 0.827 ± 0.012	1.643TyrIle: 1.643 ± 0.018	1.109TyrLys: 1.109 ± 0.015	2.94TyrLeu: 2.94 ± 0.024	0.673TyrMet: 0.673 ± 0.011	1.214TyrAsn: 1.214 ± 0.014	1.63TyrPro: 1.63 ± 0.016	1.204TyrGln: 1.204 ± 0.014	1.784TyrArg: 1.784 ± 0.019	2.208TyrSer: 2.208 ± 0.018	1.748TyrThr: 1.748 ± 0.017	1.774TyrVal: 1.774 ± 0.018	0.502TyrTrp: 0.502 ± 0.011	1.053TyrTyr: 1.053 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13330 proteins (6167100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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