Amino acid dipepetide frequency for Rickettsia bellii (strain RML369-C)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.756AlaAla: 4.756 ± 0.136
0.715AlaCys: 0.715 ± 0.047
2.908AlaAsp: 2.908 ± 0.084
4.278AlaGlu: 4.278 ± 0.11
2.508AlaPhe: 2.508 ± 0.093
3.899AlaGly: 3.899 ± 0.114
1.012AlaHis: 1.012 ± 0.051
5.89AlaIle: 5.89 ± 0.121
5.716AlaLys: 5.716 ± 0.132
6.254AlaLeu: 6.254 ± 0.12
1.339AlaMet: 1.339 ± 0.061
3.614AlaAsn: 3.614 ± 0.109
1.762AlaPro: 1.762 ± 0.08
1.777AlaGln: 1.777 ± 0.067
2.325AlaArg: 2.325 ± 0.081
4.127AlaSer: 4.127 ± 0.114
3.191AlaThr: 3.191 ± 0.096
3.739AlaVal: 3.739 ± 0.1
0.421AlaTrp: 0.421 ± 0.03
2.111AlaTyr: 2.111 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.466CysAla: 0.466 ± 0.036
0.146CysCys: 0.146 ± 0.021
0.494CysAsp: 0.494 ± 0.036
0.553CysGlu: 0.553 ± 0.041
0.532CysPhe: 0.532 ± 0.033
0.692CysGly: 0.692 ± 0.045
0.259CysHis: 0.259 ± 0.026
0.84CysIle: 0.84 ± 0.045
0.659CysLys: 0.659 ± 0.046
1.024CysLeu: 1.024 ± 0.053
0.169CysMet: 0.169 ± 0.018
0.6CysAsn: 0.6 ± 0.044
0.346CysPro: 0.346 ± 0.032
0.282CysGln: 0.282 ± 0.022
0.348CysArg: 0.348 ± 0.029
0.861CysSer: 0.861 ± 0.048
0.464CysThr: 0.464 ± 0.034
0.485CysVal: 0.485 ± 0.04
0.08CysTrp: 0.08 ± 0.014
0.456CysTyr: 0.456 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
2.544AspAla: 2.544 ± 0.084
0.525AspCys: 0.525 ± 0.042
2.407AspAsp: 2.407 ± 0.077
3.365AspGlu: 3.365 ± 0.097
2.734AspPhe: 2.734 ± 0.085
2.36AspGly: 2.36 ± 0.103
0.979AspHis: 0.979 ± 0.055
5.523AspIle: 5.523 ± 0.117
5.174AspLys: 5.174 ± 0.128
5.438AspLeu: 5.438 ± 0.137
0.991AspMet: 0.991 ± 0.053
3.668AspAsn: 3.668 ± 0.098
1.635AspPro: 1.635 ± 0.066
1.664AspGln: 1.664 ± 0.066
1.581AspArg: 1.581 ± 0.065
3.384AspSer: 3.384 ± 0.074
2.167AspThr: 2.167 ± 0.077
2.459AspVal: 2.459 ± 0.077
0.4AspTrp: 0.4 ± 0.028
2.266AspTyr: 2.266 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.339GluAla: 4.339 ± 0.123
0.445GluCys: 0.445 ± 0.033
3.012GluAsp: 3.012 ± 0.115
5.447GluGlu: 5.447 ± 0.143
2.913GluPhe: 2.913 ± 0.088
2.355GluGly: 2.355 ± 0.08
1.252GluHis: 1.252 ± 0.057
6.767GluIle: 6.767 ± 0.143
6.438GluLys: 6.438 ± 0.163
6.819GluLeu: 6.819 ± 0.123
1.398GluMet: 1.398 ± 0.061
4.603GluAsn: 4.603 ± 0.114
1.532GluPro: 1.532 ± 0.062
2.805GluGln: 2.805 ± 0.102
2.325GluArg: 2.325 ± 0.083
3.464GluSer: 3.464 ± 0.086
2.48GluThr: 2.48 ± 0.088
4.01GluVal: 4.01 ± 0.108
0.478GluTrp: 0.478 ± 0.037
2.586GluTyr: 2.586 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
3.292PheAla: 3.292 ± 0.111
0.642PheCys: 0.642 ± 0.04
2.584PheAsp: 2.584 ± 0.09
2.784PheGlu: 2.784 ± 0.082
2.473PhePhe: 2.473 ± 0.099
2.675PheGly: 2.675 ± 0.095
0.769PheHis: 0.769 ± 0.05
4.828PheIle: 4.828 ± 0.134
3.574PheLys: 3.574 ± 0.095
4.607PheLeu: 4.607 ± 0.127
1.012PheMet: 1.012 ± 0.044
3.012PheAsn: 3.012 ± 0.089
1.391PhePro: 1.391 ± 0.062
1.04PheGln: 1.04 ± 0.045
1.273PheArg: 1.273 ± 0.049
3.595PheSer: 3.595 ± 0.117
2.772PheThr: 2.772 ± 0.09
2.65PheVal: 2.65 ± 0.089
0.445PheTrp: 0.445 ± 0.038
1.913PheTyr: 1.913 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.259GlyAla: 3.259 ± 0.107
0.548GlyCys: 0.548 ± 0.038
2.494GlyAsp: 2.494 ± 0.087
2.922GlyGlu: 2.922 ± 0.1
2.805GlyPhe: 2.805 ± 0.088
3.727GlyGly: 3.727 ± 0.16
1.012GlyHis: 1.012 ± 0.051
5.184GlyIle: 5.184 ± 0.134
4.664GlyLys: 4.664 ± 0.106
4.913GlyLeu: 4.913 ± 0.139
1.297GlyMet: 1.297 ± 0.056
3.235GlyAsn: 3.235 ± 0.155
1.042GlyPro: 1.042 ± 0.058
1.631GlyGln: 1.631 ± 0.082
1.899GlyArg: 1.899 ± 0.072
3.605GlySer: 3.605 ± 0.119
2.88GlyThr: 2.88 ± 0.139
3.379GlyVal: 3.379 ± 0.09
0.541GlyTrp: 0.541 ± 0.039
2.242GlyTyr: 2.242 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.937HisAla: 0.937 ± 0.053
0.207HisCys: 0.207 ± 0.02
0.934HisAsp: 0.934 ± 0.05
1.104HisGlu: 1.104 ± 0.051
0.948HisPhe: 0.948 ± 0.052
0.953HisGly: 0.953 ± 0.046
0.447HisHis: 0.447 ± 0.034
1.645HisIle: 1.645 ± 0.068
1.541HisLys: 1.541 ± 0.063
1.798HisLeu: 1.798 ± 0.074
0.296HisMet: 0.296 ± 0.028
1.315HisAsn: 1.315 ± 0.063
0.835HisPro: 0.835 ± 0.044
0.595HisGln: 0.595 ± 0.031
0.635HisArg: 0.635 ± 0.036
1.148HisSer: 1.148 ± 0.058
0.802HisThr: 0.802 ± 0.051
0.784HisVal: 0.784 ± 0.048
0.136HisTrp: 0.136 ± 0.019
0.817HisTyr: 0.817 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.923IleAla: 6.923 ± 0.141
1.122IleCys: 1.122 ± 0.056
5.539IleAsp: 5.539 ± 0.117
6.327IleGlu: 6.327 ± 0.146
4.732IlePhe: 4.732 ± 0.158
5.483IleGly: 5.483 ± 0.13
1.36IleHis: 1.36 ± 0.055
9.878IleIle: 9.878 ± 0.189
8.269IleLys: 8.269 ± 0.16
9.266IleLeu: 9.266 ± 0.17
1.927IleMet: 1.927 ± 0.07
6.666IleAsn: 6.666 ± 0.142
3.191IlePro: 3.191 ± 0.099
2.259IleGln: 2.259 ± 0.069
2.861IleArg: 2.861 ± 0.078
7.16IleSer: 7.16 ± 0.141
5.652IleThr: 5.652 ± 0.126
5.181IleVal: 5.181 ± 0.112
0.671IleTrp: 0.671 ± 0.039
3.424IleTyr: 3.424 ± 0.114
0.0IleXaa: 0.0 ± 0.0
Lys
5.69LysAla: 5.69 ± 0.144
0.555LysCys: 0.555 ± 0.041
4.904LysAsp: 4.904 ± 0.117
6.746LysGlu: 6.746 ± 0.16
3.671LysPhe: 3.671 ± 0.095
3.791LysGly: 3.791 ± 0.107
1.6LysHis: 1.6 ± 0.07
8.979LysIle: 8.979 ± 0.162
6.923LysLys: 6.923 ± 0.16
9.189LysLeu: 9.189 ± 0.17
1.847LysMet: 1.847 ± 0.064
6.377LysAsn: 6.377 ± 0.147
2.685LysPro: 2.685 ± 0.082
3.266LysGln: 3.266 ± 0.109
2.617LysArg: 2.617 ± 0.085
5.139LysSer: 5.139 ± 0.105
4.351LysThr: 4.351 ± 0.112
4.732LysVal: 4.732 ± 0.109
0.602LysTrp: 0.602 ± 0.037
3.685LysTyr: 3.685 ± 0.097
0.0LysXaa: 0.0 ± 0.0
Leu
6.577LeuAla: 6.577 ± 0.122
0.946LeuCys: 0.946 ± 0.047
5.196LeuAsp: 5.196 ± 0.127
6.864LeuGlu: 6.864 ± 0.161
4.525LeuPhe: 4.525 ± 0.145
5.228LeuGly: 5.228 ± 0.128
1.725LeuHis: 1.725 ± 0.073
8.812LeuIle: 8.812 ± 0.158
9.104LeuLys: 9.104 ± 0.173
10.144LeuLeu: 10.144 ± 0.188
2.146LeuMet: 2.146 ± 0.081
6.292LeuAsn: 6.292 ± 0.14
4.054LeuPro: 4.054 ± 0.094
3.603LeuGln: 3.603 ± 0.093
3.264LeuArg: 3.264 ± 0.086
7.624LeuSer: 7.624 ± 0.134
5.266LeuThr: 5.266 ± 0.116
5.421LeuVal: 5.421 ± 0.115
0.784LeuTrp: 0.784 ± 0.043
3.337LeuTyr: 3.337 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.294MetAla: 1.294 ± 0.059
0.146MetCys: 0.146 ± 0.018
0.88MetAsp: 0.88 ± 0.043
0.962MetGlu: 0.962 ± 0.047
0.88MetPhe: 0.88 ± 0.044
0.995MetGly: 0.995 ± 0.053
0.487MetHis: 0.487 ± 0.037
1.817MetIle: 1.817 ± 0.067
1.657MetLys: 1.657 ± 0.065
2.482MetLeu: 2.482 ± 0.081
0.494MetMet: 0.494 ± 0.035
1.226MetAsn: 1.226 ± 0.054
1.012MetPro: 1.012 ± 0.052
1.129MetGln: 1.129 ± 0.057
0.826MetArg: 0.826 ± 0.048
1.497MetSer: 1.497 ± 0.056
1.144MetThr: 1.144 ± 0.044
1.146MetVal: 1.146 ± 0.056
0.136MetTrp: 0.136 ± 0.019
0.645MetTyr: 0.645 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.24AsnAla: 3.24 ± 0.102
0.642AsnCys: 0.642 ± 0.041
3.412AsnAsp: 3.412 ± 0.093
3.565AsnGlu: 3.565 ± 0.092
3.666AsnPhe: 3.666 ± 0.103
2.826AsnGly: 2.826 ± 0.118
1.177AsnHis: 1.177 ± 0.054
7.974AsnIle: 7.974 ± 0.18
6.177AsnLys: 6.177 ± 0.14
6.963AsnLeu: 6.963 ± 0.15
1.365AsnMet: 1.365 ± 0.056
5.951AsnAsn: 5.951 ± 0.158
2.553AsnPro: 2.553 ± 0.092
2.134AsnGln: 2.134 ± 0.076
1.906AsnArg: 1.906 ± 0.076
4.673AsnSer: 4.673 ± 0.134
3.228AsnThr: 3.228 ± 0.107
3.118AsnVal: 3.118 ± 0.096
0.551AsnTrp: 0.551 ± 0.035
3.038AsnTyr: 3.038 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
1.93ProAla: 1.93 ± 0.076
0.308ProCys: 0.308 ± 0.027
1.826ProAsp: 1.826 ± 0.07
2.647ProGlu: 2.647 ± 0.096
1.405ProPhe: 1.405 ± 0.061
1.337ProGly: 1.337 ± 0.061
0.671ProHis: 0.671 ± 0.042
3.146ProIle: 3.146 ± 0.084
2.84ProLys: 2.84 ± 0.085
3.172ProLeu: 3.172 ± 0.092
0.605ProMet: 0.605 ± 0.038
2.235ProAsn: 2.235 ± 0.085
1.235ProPro: 1.235 ± 0.115
1.094ProGln: 1.094 ± 0.054
0.864ProArg: 0.864 ± 0.048
2.052ProSer: 2.052 ± 0.106
1.793ProThr: 1.793 ± 0.076
2.108ProVal: 2.108 ± 0.072
0.275ProTrp: 0.275 ± 0.024
1.273ProTyr: 1.273 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
2.188GlnAla: 2.188 ± 0.08
0.214GlnCys: 0.214 ± 0.022
1.845GlnAsp: 1.845 ± 0.068
2.657GlnGlu: 2.657 ± 0.093
1.245GlnPhe: 1.245 ± 0.05
1.819GlnGly: 1.819 ± 0.068
0.562GlnHis: 0.562 ± 0.041
3.268GlnIle: 3.268 ± 0.099
3.139GlnLys: 3.139 ± 0.089
2.939GlnLeu: 2.939 ± 0.089
0.675GlnMet: 0.675 ± 0.037
2.642GlnAsn: 2.642 ± 0.072
0.922GlnPro: 0.922 ± 0.056
1.454GlnGln: 1.454 ± 0.073
1.066GlnArg: 1.066 ± 0.056
1.751GlnSer: 1.751 ± 0.068
1.569GlnThr: 1.569 ± 0.063
1.791GlnVal: 1.791 ± 0.066
0.16GlnTrp: 0.16 ± 0.018
1.094GlnTyr: 1.094 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
1.948ArgAla: 1.948 ± 0.07
0.296ArgCys: 0.296 ± 0.027
1.729ArgAsp: 1.729 ± 0.066
2.21ArgGlu: 2.21 ± 0.07
1.565ArgPhe: 1.565 ± 0.052
1.758ArgGly: 1.758 ± 0.077
0.628ArgHis: 0.628 ± 0.039
3.064ArgIle: 3.064 ± 0.09
2.777ArgLys: 2.777 ± 0.091
3.285ArgLeu: 3.285 ± 0.091
0.802ArgMet: 0.802 ± 0.05
1.948ArgAsn: 1.948 ± 0.058
0.955ArgPro: 0.955 ± 0.051
1.167ArgGln: 1.167 ± 0.063
1.306ArgArg: 1.306 ± 0.069
2.059ArgSer: 2.059 ± 0.078
1.457ArgThr: 1.457 ± 0.063
1.788ArgVal: 1.788 ± 0.07
0.264ArgTrp: 0.264 ± 0.027
1.198ArgTyr: 1.198 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.499SerAla: 3.499 ± 0.093
0.762SerCys: 0.762 ± 0.044
3.405SerAsp: 3.405 ± 0.09
3.984SerGlu: 3.984 ± 0.108
3.713SerPhe: 3.713 ± 0.114
4.36SerGly: 4.36 ± 0.126
1.198SerHis: 1.198 ± 0.061
5.88SerIle: 5.88 ± 0.141
5.8SerLys: 5.8 ± 0.117
7.299SerLeu: 7.299 ± 0.129
1.372SerMet: 1.372 ± 0.052
4.713SerAsn: 4.713 ± 0.132
2.045SerPro: 2.045 ± 0.082
1.939SerGln: 1.939 ± 0.067
2.068SerArg: 2.068 ± 0.064
5.478SerSer: 5.478 ± 0.126
3.28SerThr: 3.28 ± 0.1
3.777SerVal: 3.777 ± 0.098
0.529SerTrp: 0.529 ± 0.035
2.965SerTyr: 2.965 ± 0.096
0.0SerXaa: 0.0 ± 0.0
Thr
3.358ThrAla: 3.358 ± 0.11
0.416ThrCys: 0.416 ± 0.038
2.562ThrAsp: 2.562 ± 0.092
3.144ThrGlu: 3.144 ± 0.087
2.045ThrPhe: 2.045 ± 0.079
3.137ThrGly: 3.137 ± 0.15
0.913ThrHis: 0.913 ± 0.046
4.894ThrIle: 4.894 ± 0.114
4.275ThrLys: 4.275 ± 0.095
5.031ThrLeu: 5.031 ± 0.115
0.892ThrMet: 0.892 ± 0.052
3.257ThrAsn: 3.257 ± 0.101
2.273ThrPro: 2.273 ± 0.089
1.595ThrGln: 1.595 ± 0.066
1.661ThrArg: 1.661 ± 0.061
3.699ThrSer: 3.699 ± 0.11
2.984ThrThr: 2.984 ± 0.098
2.635ThrVal: 2.635 ± 0.095
0.294ThrTrp: 0.294 ± 0.029
1.619ThrTyr: 1.619 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
3.525ValAla: 3.525 ± 0.103
0.534ValCys: 0.534 ± 0.042
2.69ValAsp: 2.69 ± 0.084
3.508ValGlu: 3.508 ± 0.089
2.454ValPhe: 2.454 ± 0.078
3.247ValGly: 3.247 ± 0.103
0.842ValHis: 0.842 ± 0.047
5.669ValIle: 5.669 ± 0.125
4.927ValLys: 4.927 ± 0.116
4.901ValLeu: 4.901 ± 0.11
1.308ValMet: 1.308 ± 0.06
3.468ValAsn: 3.468 ± 0.082
1.93ValPro: 1.93 ± 0.062
1.758ValGln: 1.758 ± 0.058
1.732ValArg: 1.732 ± 0.064
3.584ValSer: 3.584 ± 0.098
3.233ValThr: 3.233 ± 0.095
3.351ValVal: 3.351 ± 0.11
0.386ValTrp: 0.386 ± 0.032
1.706ValTyr: 1.706 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.395TrpAla: 0.395 ± 0.031
0.089TrpCys: 0.089 ± 0.016
0.405TrpAsp: 0.405 ± 0.036
0.36TrpGlu: 0.36 ± 0.03
0.449TrpPhe: 0.449 ± 0.035
0.473TrpGly: 0.473 ± 0.036
0.228TrpHis: 0.228 ± 0.022
0.504TrpIle: 0.504 ± 0.036
0.449TrpLys: 0.449 ± 0.032
0.995TrpLeu: 0.995 ± 0.051
0.151TrpMet: 0.151 ± 0.02
0.4TrpAsn: 0.4 ± 0.029
0.151TrpPro: 0.151 ± 0.019
0.536TrpGln: 0.536 ± 0.038
0.322TrpArg: 0.322 ± 0.024
0.576TrpSer: 0.576 ± 0.04
0.266TrpThr: 0.266 ± 0.025
0.4TrpVal: 0.4 ± 0.031
0.12TrpTrp: 0.12 ± 0.017
0.334TrpTyr: 0.334 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.184TyrAla: 2.184 ± 0.067
0.494TyrCys: 0.494 ± 0.031
2.038TyrAsp: 2.038 ± 0.06
2.04TyrGlu: 2.04 ± 0.057
2.068TyrPhe: 2.068 ± 0.071
2.165TyrGly: 2.165 ± 0.076
0.758TyrHis: 0.758 ± 0.042
3.332TyrIle: 3.332 ± 0.094
3.245TyrLys: 3.245 ± 0.103
4.391TyrLeu: 4.391 ± 0.108
0.767TyrMet: 0.767 ± 0.043
2.934TyrAsn: 2.934 ± 0.09
1.266TyrPro: 1.266 ± 0.054
1.273TyrGln: 1.273 ± 0.056
1.325TyrArg: 1.325 ± 0.054
2.591TyrSer: 2.591 ± 0.077
1.706TyrThr: 1.706 ± 0.062
1.8TyrVal: 1.8 ± 0.066
0.332TyrTrp: 0.332 ± 0.026
1.68TyrTyr: 1.68 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1400 proteins (424981 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski