Amino acid dipepetide frequency for Bartonella tamiae Th239

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.904AlaAla: 7.904 ± 0.132
0.843AlaCys: 0.843 ± 0.044
4.472AlaAsp: 4.472 ± 0.09
4.755AlaGlu: 4.755 ± 0.095
3.866AlaPhe: 3.866 ± 0.089
5.971AlaGly: 5.971 ± 0.138
2.14AlaHis: 2.14 ± 0.052
6.544AlaIle: 6.544 ± 0.101
4.738AlaLys: 4.738 ± 0.092
10.308AlaLeu: 10.308 ± 0.167
2.61AlaMet: 2.61 ± 0.066
3.049AlaAsn: 3.049 ± 0.077
3.015AlaPro: 3.015 ± 0.076
3.923AlaGln: 3.923 ± 0.074
4.871AlaArg: 4.871 ± 0.104
5.036AlaSer: 5.036 ± 0.091
4.344AlaThr: 4.344 ± 0.106
5.42AlaVal: 5.42 ± 0.109
0.816AlaTrp: 0.816 ± 0.041
2.563AlaTyr: 2.563 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.806CysAla: 0.806 ± 0.042
0.107CysCys: 0.107 ± 0.011
0.56CysAsp: 0.56 ± 0.034
0.476CysGlu: 0.476 ± 0.031
0.48CysPhe: 0.48 ± 0.03
0.764CysGly: 0.764 ± 0.037
0.304CysHis: 0.304 ± 0.023
0.583CysIle: 0.583 ± 0.031
0.308CysLys: 0.308 ± 0.024
0.922CysLeu: 0.922 ± 0.046
0.165CysMet: 0.165 ± 0.014
0.289CysAsn: 0.289 ± 0.022
0.417CysPro: 0.417 ± 0.027
0.31CysGln: 0.31 ± 0.026
0.413CysArg: 0.413 ± 0.025
0.523CysSer: 0.523 ± 0.031
0.378CysThr: 0.378 ± 0.03
0.67CysVal: 0.67 ± 0.029
0.107CysTrp: 0.107 ± 0.014
0.245CysTyr: 0.245 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.706AspAla: 4.706 ± 0.091
0.509AspCys: 0.509 ± 0.032
3.613AspAsp: 3.613 ± 0.102
3.85AspGlu: 3.85 ± 0.087
2.592AspPhe: 2.592 ± 0.064
4.067AspGly: 4.067 ± 0.12
1.701AspHis: 1.701 ± 0.055
4.75AspIle: 4.75 ± 0.104
3.274AspLys: 3.274 ± 0.087
5.409AspLeu: 5.409 ± 0.098
1.539AspMet: 1.539 ± 0.051
2.455AspAsn: 2.455 ± 0.075
2.466AspPro: 2.466 ± 0.067
2.187AspGln: 2.187 ± 0.063
2.931AspArg: 2.931 ± 0.067
2.536AspSer: 2.536 ± 0.075
2.708AspThr: 2.708 ± 0.101
3.953AspVal: 3.953 ± 0.076
0.745AspTrp: 0.745 ± 0.034
1.949AspTyr: 1.949 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.141GluAla: 5.141 ± 0.093
0.423GluCys: 0.423 ± 0.031
3.036GluAsp: 3.036 ± 0.082
3.574GluGlu: 3.574 ± 0.103
1.817GluPhe: 1.817 ± 0.056
3.558GluGly: 3.558 ± 0.068
1.127GluHis: 1.127 ± 0.041
4.377GluIle: 4.377 ± 0.087
4.939GluLys: 4.939 ± 0.089
4.545GluLeu: 4.545 ± 0.083
1.649GluMet: 1.649 ± 0.057
3.443GluAsn: 3.443 ± 0.077
1.948GluPro: 1.948 ± 0.066
2.206GluGln: 2.206 ± 0.07
3.808GluArg: 3.808 ± 0.089
2.618GluSer: 2.618 ± 0.069
3.613GluThr: 3.613 ± 0.079
3.099GluVal: 3.099 ± 0.083
0.659GluTrp: 0.659 ± 0.033
1.227GluTyr: 1.227 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.653PheAla: 3.653 ± 0.078
0.51PheCys: 0.51 ± 0.033
2.98PheAsp: 2.98 ± 0.068
2.414PheGlu: 2.414 ± 0.064
2.385PhePhe: 2.385 ± 0.079
3.446PheGly: 3.446 ± 0.083
1.001PheHis: 1.001 ± 0.039
3.595PheIle: 3.595 ± 0.09
1.899PheLys: 1.899 ± 0.062
4.235PheLeu: 4.235 ± 0.099
1.042PheMet: 1.042 ± 0.044
1.875PheAsn: 1.875 ± 0.066
1.5PhePro: 1.5 ± 0.053
1.442PheGln: 1.442 ± 0.049
1.751PheArg: 1.751 ± 0.064
3.404PheSer: 3.404 ± 0.074
2.158PheThr: 2.158 ± 0.061
2.901PheVal: 2.901 ± 0.074
0.585PheTrp: 0.585 ± 0.029
1.445PheTyr: 1.445 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
6.148GlyAla: 6.148 ± 0.114
0.709GlyCys: 0.709 ± 0.036
3.803GlyAsp: 3.803 ± 0.095
3.834GlyGlu: 3.834 ± 0.081
3.601GlyPhe: 3.601 ± 0.086
5.333GlyGly: 5.333 ± 0.123
1.776GlyHis: 1.776 ± 0.061
4.914GlyIle: 4.914 ± 0.082
3.87GlyLys: 3.87 ± 0.093
7.274GlyLeu: 7.274 ± 0.116
1.788GlyMet: 1.788 ± 0.063
2.56GlyAsn: 2.56 ± 0.11
2.145GlyPro: 2.145 ± 0.068
2.968GlyGln: 2.968 ± 0.076
3.84GlyArg: 3.84 ± 0.081
4.12GlySer: 4.12 ± 0.099
3.76GlyThr: 3.76 ± 0.098
4.919GlyVal: 4.919 ± 0.113
0.904GlyTrp: 0.904 ± 0.041
2.261GlyTyr: 2.261 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.956HisAla: 1.956 ± 0.065
0.275HisCys: 0.275 ± 0.022
1.489HisAsp: 1.489 ± 0.051
1.378HisGlu: 1.378 ± 0.044
1.252HisPhe: 1.252 ± 0.044
1.578HisGly: 1.578 ± 0.055
0.922HisHis: 0.922 ± 0.045
1.875HisIle: 1.875 ± 0.06
1.164HisLys: 1.164 ± 0.045
2.387HisLeu: 2.387 ± 0.066
0.593HisMet: 0.593 ± 0.032
1.116HisAsn: 1.116 ± 0.042
1.155HisPro: 1.155 ± 0.044
0.84HisGln: 0.84 ± 0.038
1.132HisArg: 1.132 ± 0.049
1.355HisSer: 1.355 ± 0.052
0.937HisThr: 0.937 ± 0.035
1.513HisVal: 1.513 ± 0.049
0.344HisTrp: 0.344 ± 0.028
0.967HisTyr: 0.967 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.431IleAla: 7.431 ± 0.132
0.777IleCys: 0.777 ± 0.036
5.215IleAsp: 5.215 ± 0.108
4.764IleGlu: 4.764 ± 0.096
3.383IlePhe: 3.383 ± 0.082
6.035IleGly: 6.035 ± 0.117
1.576IleHis: 1.576 ± 0.05
5.72IleIle: 5.72 ± 0.135
3.803IleLys: 3.803 ± 0.081
7.043IleLeu: 7.043 ± 0.133
1.797IleMet: 1.797 ± 0.052
3.067IleAsn: 3.067 ± 0.078
2.859IlePro: 2.859 ± 0.067
2.192IleGln: 2.192 ± 0.071
3.435IleArg: 3.435 ± 0.085
4.685IleSer: 4.685 ± 0.094
3.732IleThr: 3.732 ± 0.09
5.186IleVal: 5.186 ± 0.103
0.74IleTrp: 0.74 ± 0.037
1.914IleTyr: 1.914 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.011LysAla: 5.011 ± 0.11
0.287LysCys: 0.287 ± 0.024
3.18LysAsp: 3.18 ± 0.08
3.17LysGlu: 3.17 ± 0.081
1.61LysPhe: 1.61 ± 0.055
3.635LysGly: 3.635 ± 0.089
1.223LysHis: 1.223 ± 0.051
4.498LysIle: 4.498 ± 0.093
4.719LysLys: 4.719 ± 0.109
4.805LysLeu: 4.805 ± 0.096
1.563LysMet: 1.563 ± 0.055
3.529LysAsn: 3.529 ± 0.08
2.494LysPro: 2.494 ± 0.062
2.106LysGln: 2.106 ± 0.061
3.506LysArg: 3.506 ± 0.081
3.204LysSer: 3.204 ± 0.078
4.021LysThr: 4.021 ± 0.087
3.02LysVal: 3.02 ± 0.075
0.575LysTrp: 0.575 ± 0.033
1.256LysTyr: 1.256 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
8.747LeuAla: 8.747 ± 0.135
0.987LeuCys: 0.987 ± 0.045
5.475LeuAsp: 5.475 ± 0.112
5.388LeuGlu: 5.388 ± 0.102
4.178LeuPhe: 4.178 ± 0.099
6.554LeuGly: 6.554 ± 0.116
2.129LeuHis: 2.129 ± 0.061
7.398LeuIle: 7.398 ± 0.144
6.211LeuLys: 6.211 ± 0.126
9.028LeuLeu: 9.028 ± 0.174
2.553LeuMet: 2.553 ± 0.06
4.507LeuAsn: 4.507 ± 0.089
4.407LeuPro: 4.407 ± 0.092
3.222LeuGln: 3.222 ± 0.075
4.966LeuArg: 4.966 ± 0.108
7.773LeuSer: 7.773 ± 0.132
5.551LeuThr: 5.551 ± 0.099
5.706LeuVal: 5.706 ± 0.111
1.022LeuTrp: 1.022 ± 0.046
2.599LeuTyr: 2.599 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.547MetAla: 2.547 ± 0.071
0.179MetCys: 0.179 ± 0.015
1.253MetAsp: 1.253 ± 0.046
1.252MetGlu: 1.252 ± 0.049
0.801MetPhe: 0.801 ± 0.038
1.773MetGly: 1.773 ± 0.056
0.536MetHis: 0.536 ± 0.028
1.957MetIle: 1.957 ± 0.063
1.562MetLys: 1.562 ± 0.046
2.297MetLeu: 2.297 ± 0.056
0.764MetMet: 0.764 ± 0.041
1.16MetAsn: 1.16 ± 0.04
1.353MetPro: 1.353 ± 0.05
0.956MetGln: 0.956 ± 0.042
1.72MetArg: 1.72 ± 0.051
1.914MetSer: 1.914 ± 0.058
1.775MetThr: 1.775 ± 0.051
1.734MetVal: 1.734 ± 0.052
0.189MetTrp: 0.189 ± 0.019
0.331MetTyr: 0.331 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.91AsnAla: 3.91 ± 0.087
0.329AsnCys: 0.329 ± 0.021
2.899AsnAsp: 2.899 ± 0.075
2.516AsnGlu: 2.516 ± 0.061
1.797AsnPhe: 1.797 ± 0.054
3.435AsnGly: 3.435 ± 0.108
1.189AsnHis: 1.189 ± 0.044
3.592AsnIle: 3.592 ± 0.089
2.251AsnLys: 2.251 ± 0.059
3.861AsnLeu: 3.861 ± 0.098
1.024AsnMet: 1.024 ± 0.041
2.224AsnAsn: 2.224 ± 0.08
2.196AsnPro: 2.196 ± 0.071
1.607AsnGln: 1.607 ± 0.058
2.151AsnArg: 2.151 ± 0.058
2.183AsnSer: 2.183 ± 0.069
2.255AsnThr: 2.255 ± 0.078
2.875AsnVal: 2.875 ± 0.073
0.539AsnTrp: 0.539 ± 0.029
1.42AsnTyr: 1.42 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.81ProAla: 2.81 ± 0.077
0.3ProCys: 0.3 ± 0.024
2.594ProAsp: 2.594 ± 0.066
2.773ProGlu: 2.773 ± 0.087
2.09ProPhe: 2.09 ± 0.065
2.34ProGly: 2.34 ± 0.064
1.066ProHis: 1.066 ± 0.045
3.012ProIle: 3.012 ± 0.075
2.225ProLys: 2.225 ± 0.061
4.142ProLeu: 4.142 ± 0.095
0.929ProMet: 0.929 ± 0.038
1.764ProAsn: 1.764 ± 0.056
1.387ProPro: 1.387 ± 0.057
1.804ProGln: 1.804 ± 0.055
1.684ProArg: 1.684 ± 0.054
2.547ProSer: 2.547 ± 0.072
2.074ProThr: 2.074 ± 0.074
2.762ProVal: 2.762 ± 0.07
0.455ProTrp: 0.455 ± 0.028
1.277ProTyr: 1.277 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.338GlnAla: 3.338 ± 0.081
0.317GlnCys: 0.317 ± 0.023
1.835GlnAsp: 1.835 ± 0.06
2.024GlnGlu: 2.024 ± 0.062
1.365GlnPhe: 1.365 ± 0.046
2.306GlnGly: 2.306 ± 0.063
0.793GlnHis: 0.793 ± 0.034
2.745GlnIle: 2.745 ± 0.069
2.996GlnLys: 2.996 ± 0.078
3.387GlnLeu: 3.387 ± 0.073
1.151GlnMet: 1.151 ± 0.043
2.334GlnAsn: 2.334 ± 0.07
1.382GlnPro: 1.382 ± 0.045
1.437GlnGln: 1.437 ± 0.059
2.114GlnArg: 2.114 ± 0.063
2.791GlnSer: 2.791 ± 0.071
2.519GlnThr: 2.519 ± 0.069
1.838GlnVal: 1.838 ± 0.063
0.536GlnTrp: 0.536 ± 0.03
0.919GlnTyr: 0.919 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
4.504ArgAla: 4.504 ± 0.099
0.347ArgCys: 0.347 ± 0.025
3.012ArgAsp: 3.012 ± 0.076
3.089ArgGlu: 3.089 ± 0.08
2.708ArgPhe: 2.708 ± 0.07
3.143ArgGly: 3.143 ± 0.077
1.412ArgHis: 1.412 ± 0.057
3.852ArgIle: 3.852 ± 0.081
2.628ArgLys: 2.628 ± 0.074
5.996ArgLeu: 5.996 ± 0.128
1.332ArgMet: 1.332 ± 0.054
2.09ArgAsn: 2.09 ± 0.057
2.009ArgPro: 2.009 ± 0.056
2.492ArgGln: 2.492 ± 0.067
3.077ArgArg: 3.077 ± 0.095
3.065ArgSer: 3.065 ± 0.078
2.188ArgThr: 2.188 ± 0.055
3.211ArgVal: 3.211 ± 0.077
0.547ArgTrp: 0.547 ± 0.034
1.639ArgTyr: 1.639 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.191SerAla: 5.191 ± 0.089
0.496SerCys: 0.496 ± 0.034
3.711SerAsp: 3.711 ± 0.101
3.311SerGlu: 3.311 ± 0.071
3.24SerPhe: 3.24 ± 0.072
5.134SerGly: 5.134 ± 0.11
1.615SerHis: 1.615 ± 0.052
4.36SerIle: 4.36 ± 0.079
3.026SerLys: 3.026 ± 0.068
6.405SerLeu: 6.405 ± 0.12
1.607SerMet: 1.607 ± 0.052
2.503SerAsn: 2.503 ± 0.07
2.284SerPro: 2.284 ± 0.072
2.471SerGln: 2.471 ± 0.062
2.98SerArg: 2.98 ± 0.079
4.062SerSer: 4.062 ± 0.104
2.931SerThr: 2.931 ± 0.08
4.173SerVal: 4.173 ± 0.085
0.766SerTrp: 0.766 ± 0.035
1.891SerTyr: 1.891 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.601ThrAla: 4.601 ± 0.092
0.409ThrCys: 0.409 ± 0.026
2.634ThrAsp: 2.634 ± 0.078
2.188ThrGlu: 2.188 ± 0.06
2.337ThrPhe: 2.337 ± 0.066
4.102ThrGly: 4.102 ± 0.099
1.286ThrHis: 1.286 ± 0.044
4.304ThrIle: 4.304 ± 0.12
2.695ThrLys: 2.695 ± 0.073
6.092ThrLeu: 6.092 ± 0.106
1.366ThrMet: 1.366 ± 0.05
2.192ThrAsn: 2.192 ± 0.08
2.736ThrPro: 2.736 ± 0.08
2.135ThrGln: 2.135 ± 0.064
2.502ThrArg: 2.502 ± 0.056
3.298ThrSer: 3.298 ± 0.072
3.033ThrThr: 3.033 ± 0.085
3.627ThrVal: 3.627 ± 0.099
0.499ThrTrp: 0.499 ± 0.03
1.478ThrTyr: 1.478 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.565ValAla: 5.565 ± 0.108
0.556ValCys: 0.556 ± 0.031
3.773ValAsp: 3.773 ± 0.087
4.034ValGlu: 4.034 ± 0.086
2.884ValPhe: 2.884 ± 0.065
4.499ValGly: 4.499 ± 0.103
1.323ValHis: 1.323 ± 0.046
4.769ValIle: 4.769 ± 0.095
3.203ValLys: 3.203 ± 0.074
6.082ValLeu: 6.082 ± 0.125
1.678ValMet: 1.678 ± 0.053
2.421ValAsn: 2.421 ± 0.066
2.615ValPro: 2.615 ± 0.065
2.04ValGln: 2.04 ± 0.056
3.067ValArg: 3.067 ± 0.072
4.591ValSer: 4.591 ± 0.093
3.622ValThr: 3.622 ± 0.088
4.393ValVal: 4.393 ± 0.104
0.63ValTrp: 0.63 ± 0.032
1.562ValTyr: 1.562 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.042
0.124TrpCys: 0.124 ± 0.016
0.526TrpAsp: 0.526 ± 0.029
0.454TrpGlu: 0.454 ± 0.028
0.539TrpPhe: 0.539 ± 0.035
0.659TrpGly: 0.659 ± 0.036
0.321TrpHis: 0.321 ± 0.02
0.733TrpIle: 0.733 ± 0.035
0.585TrpLys: 0.585 ± 0.03
1.41TrpLeu: 1.41 ± 0.056
0.287TrpMet: 0.287 ± 0.021
0.494TrpAsn: 0.494 ± 0.024
0.499TrpPro: 0.499 ± 0.028
0.577TrpGln: 0.577 ± 0.028
0.749TrpArg: 0.749 ± 0.036
0.712TrpSer: 0.712 ± 0.043
0.598TrpThr: 0.598 ± 0.039
0.644TrpVal: 0.644 ± 0.029
0.173TrpTrp: 0.173 ± 0.018
0.31TrpTyr: 0.31 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.403TyrAla: 2.403 ± 0.063
0.344TyrCys: 0.344 ± 0.024
1.878TyrAsp: 1.878 ± 0.057
1.562TyrGlu: 1.562 ± 0.053
1.295TyrPhe: 1.295 ± 0.053
2.196TyrGly: 2.196 ± 0.061
0.788TyrHis: 0.788 ± 0.038
1.775TyrIle: 1.775 ± 0.056
1.318TyrLys: 1.318 ± 0.048
2.773TyrLeu: 2.773 ± 0.068
0.614TyrMet: 0.614 ± 0.034
1.184TyrAsn: 1.184 ± 0.05
1.169TyrPro: 1.169 ± 0.045
1.213TyrGln: 1.213 ± 0.045
1.644TyrArg: 1.644 ± 0.052
1.739TyrSer: 1.739 ± 0.057
1.316TyrThr: 1.316 ± 0.055
1.662TyrVal: 1.662 ± 0.048
0.381TyrTrp: 0.381 ± 0.027
0.848TyrTyr: 0.848 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1978 proteins (619200 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski