Amino acid dipepetide frequency for Oleiphilus sp. HI0066

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.681AlaAla: 7.681 ± 0.115	1.056AlaCys: 1.056 ± 0.034	4.71AlaAsp: 4.71 ± 0.069	5.962AlaGlu: 5.962 ± 0.085	3.585AlaPhe: 3.585 ± 0.061	6.083AlaGly: 6.083 ± 0.091	1.797AlaHis: 1.797 ± 0.045	5.672AlaIle: 5.672 ± 0.076	4.861AlaLys: 4.861 ± 0.072	10.274AlaLeu: 10.274 ± 0.11	2.566AlaMet: 2.566 ± 0.05	3.575AlaAsn: 3.575 ± 0.06	3.023AlaPro: 3.023 ± 0.053	3.842AlaGln: 3.842 ± 0.07	4.086AlaArg: 4.086 ± 0.064	6.284AlaSer: 6.284 ± 0.084	4.085AlaThr: 4.085 ± 0.064	5.655AlaVal: 5.655 ± 0.08	1.01AlaTrp: 1.01 ± 0.03	2.58AlaTyr: 2.58 ± 0.05	0.005AlaXaa: 0.005 ± 0.002
Cys	0.889CysAla: 0.889 ± 0.031	0.143CysCys: 0.143 ± 0.012	0.646CysAsp: 0.646 ± 0.025	0.628CysGlu: 0.628 ± 0.027	0.493CysPhe: 0.493 ± 0.024	0.909CysGly: 0.909 ± 0.031	0.251CysHis: 0.251 ± 0.015	0.637CysIle: 0.637 ± 0.022	0.396CysLys: 0.396 ± 0.019	1.021CysLeu: 1.021 ± 0.029	0.212CysMet: 0.212 ± 0.013	0.331CysAsn: 0.331 ± 0.02	0.431CysPro: 0.431 ± 0.022	0.347CysGln: 0.347 ± 0.017	0.436CysArg: 0.436 ± 0.02	0.788CysSer: 0.788 ± 0.031	0.495CysThr: 0.495 ± 0.024	0.664CysVal: 0.664 ± 0.025	0.113CysTrp: 0.113 ± 0.01	0.267CysTyr: 0.267 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.373AspAla: 5.373 ± 0.069	0.57AspCys: 0.57 ± 0.022	3.346AspAsp: 3.346 ± 0.074	4.198AspGlu: 4.198 ± 0.067	2.57AspPhe: 2.57 ± 0.059	4.118AspGly: 4.118 ± 0.111	1.159AspHis: 1.159 ± 0.039	4.067AspIle: 4.067 ± 0.07	3.023AspLys: 3.023 ± 0.054	6.028AspLeu: 6.028 ± 0.075	1.47AspMet: 1.47 ± 0.035	2.127AspAsn: 2.127 ± 0.047	2.246AspPro: 2.246 ± 0.056	2.643AspGln: 2.643 ± 0.058	2.613AspArg: 2.613 ± 0.046	3.561AspSer: 3.561 ± 0.079	2.798AspThr: 2.798 ± 0.071	4.258AspVal: 4.258 ± 0.065	0.771AspTrp: 0.771 ± 0.027	1.964AspTyr: 1.964 ± 0.048	0.003AspXaa: 0.003 ± 0.002
Glu	5.835GluAla: 5.835 ± 0.073	0.543GluCys: 0.543 ± 0.022	3.51GluAsp: 3.51 ± 0.064	4.482GluGlu: 4.482 ± 0.089	2.594GluPhe: 2.594 ± 0.045	4.099GluGly: 4.099 ± 0.062	1.665GluHis: 1.665 ± 0.051	4.125GluIle: 4.125 ± 0.054	3.792GluLys: 3.792 ± 0.077	7.636GluLeu: 7.636 ± 0.093	1.563GluMet: 1.563 ± 0.037	2.834GluAsn: 2.834 ± 0.053	2.11GluPro: 2.11 ± 0.055	3.962GluGln: 3.962 ± 0.077	3.866GluArg: 3.866 ± 0.06	4.485GluSer: 4.485 ± 0.07	3.349GluThr: 3.349 ± 0.052	4.379GluVal: 4.379 ± 0.07	0.681GluTrp: 0.681 ± 0.03	1.883GluTyr: 1.883 ± 0.038	0.005GluXaa: 0.005 ± 0.002
Phe	3.52PheAla: 3.52 ± 0.064	0.45PheCys: 0.45 ± 0.02	3.041PheAsp: 3.041 ± 0.054	2.922PheGlu: 2.922 ± 0.05	1.796PhePhe: 1.796 ± 0.047	3.316PheGly: 3.316 ± 0.054	0.768PheHis: 0.768 ± 0.029	2.669PheIle: 2.669 ± 0.049	2.085PheLys: 2.085 ± 0.047	3.743PheLeu: 3.743 ± 0.074	0.98PheMet: 0.98 ± 0.033	1.797PheAsn: 1.797 ± 0.045	1.492PhePro: 1.492 ± 0.039	1.302PheGln: 1.302 ± 0.035	1.591PheArg: 1.591 ± 0.04	3.406PheSer: 3.406 ± 0.066	2.09PheThr: 2.09 ± 0.045	3.056PheVal: 3.056 ± 0.056	0.464PheTrp: 0.464 ± 0.023	1.361PheTyr: 1.361 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.794GlyAla: 5.794 ± 0.077	0.794GlyCys: 0.794 ± 0.029	3.84GlyAsp: 3.84 ± 0.076	4.301GlyGlu: 4.301 ± 0.073	3.408GlyPhe: 3.408 ± 0.053	4.881GlyGly: 4.881 ± 0.079	1.519GlyHis: 1.519 ± 0.038	4.505GlyIle: 4.505 ± 0.071	3.808GlyLys: 3.808 ± 0.065	7.444GlyLeu: 7.444 ± 0.107	1.916GlyMet: 1.916 ± 0.042	2.447GlyAsn: 2.447 ± 0.056	1.764GlyPro: 1.764 ± 0.044	2.693GlyGln: 2.693 ± 0.073	3.11GlyArg: 3.11 ± 0.057	4.421GlySer: 4.421 ± 0.069	3.518GlyThr: 3.518 ± 0.091	5.353GlyVal: 5.353 ± 0.078	0.785GlyTrp: 0.785 ± 0.03	2.331GlyTyr: 2.331 ± 0.037	0.003GlyXaa: 0.003 ± 0.002
His	1.772HisAla: 1.772 ± 0.041	0.326HisCys: 0.326 ± 0.017	1.162HisAsp: 1.162 ± 0.042	1.297HisGlu: 1.297 ± 0.039	1.027HisPhe: 1.027 ± 0.038	1.592HisGly: 1.592 ± 0.039	0.629HisHis: 0.629 ± 0.027	1.346HisIle: 1.346 ± 0.039	0.976HisLys: 0.976 ± 0.028	2.056HisLeu: 2.056 ± 0.052	0.527HisMet: 0.527 ± 0.026	0.765HisAsn: 0.765 ± 0.026	1.088HisPro: 1.088 ± 0.034	0.938HisGln: 0.938 ± 0.034	1.037HisArg: 1.037 ± 0.035	1.399HisSer: 1.399 ± 0.043	1.028HisThr: 1.028 ± 0.032	1.392HisVal: 1.392 ± 0.043	0.258HisTrp: 0.258 ± 0.015	0.78HisTyr: 0.78 ± 0.031	0.001HisXaa: 0.001 ± 0.001
Ile	6.328IleAla: 6.328 ± 0.093	0.652IleCys: 0.652 ± 0.026	4.58IleAsp: 4.58 ± 0.07	4.979IleGlu: 4.979 ± 0.075	2.177IlePhe: 2.177 ± 0.053	4.477IleGly: 4.477 ± 0.065	1.205IleHis: 1.205 ± 0.038	3.391IleIle: 3.391 ± 0.061	3.291IleLys: 3.291 ± 0.053	5.257IleLeu: 5.257 ± 0.084	1.202IleMet: 1.202 ± 0.037	2.913IleAsn: 2.913 ± 0.063	2.68IlePro: 2.68 ± 0.057	2.364IleGln: 2.364 ± 0.046	2.722IleArg: 2.722 ± 0.048	4.745IleSer: 4.745 ± 0.066	3.267IleThr: 3.267 ± 0.056	4.281IleVal: 4.281 ± 0.059	0.543IleTrp: 0.543 ± 0.021	1.653IleTyr: 1.653 ± 0.042	0.003IleXaa: 0.003 ± 0.002
Lys	4.953LysAla: 4.953 ± 0.088	0.337LysCys: 0.337 ± 0.019	2.886LysAsp: 2.886 ± 0.05	3.51LysGlu: 3.51 ± 0.066	1.528LysPhe: 1.528 ± 0.038	3.405LysGly: 3.405 ± 0.049	1.305LysHis: 1.305 ± 0.035	2.821LysIle: 2.821 ± 0.049	2.974LysLys: 2.974 ± 0.08	5.477LysLeu: 5.477 ± 0.08	1.191LysMet: 1.191 ± 0.034	2.145LysAsn: 2.145 ± 0.044	2.267LysPro: 2.267 ± 0.047	2.647LysGln: 2.647 ± 0.056	2.851LysArg: 2.851 ± 0.058	3.37LysSer: 3.37 ± 0.064	2.844LysThr: 2.844 ± 0.053	3.604LysVal: 3.604 ± 0.051	0.489LysTrp: 0.489 ± 0.025	1.344LysTyr: 1.344 ± 0.04	0.005LysXaa: 0.005 ± 0.002
Leu	9.518LeuAla: 9.518 ± 0.112	1.113LeuCys: 1.113 ± 0.033	6.182LeuAsp: 6.182 ± 0.071	6.711LeuGlu: 6.711 ± 0.093	4.139LeuPhe: 4.139 ± 0.072	7.251LeuGly: 7.251 ± 0.094	2.03LeuHis: 2.03 ± 0.044	6.431LeuIle: 6.431 ± 0.096	5.67LeuLys: 5.67 ± 0.078	10.014LeuLeu: 10.014 ± 0.121	2.52LeuMet: 2.52 ± 0.045	4.753LeuAsn: 4.753 ± 0.073	4.368LeuPro: 4.368 ± 0.071	3.452LeuGln: 3.452 ± 0.059	4.769LeuArg: 4.769 ± 0.07	8.656LeuSer: 8.656 ± 0.087	5.16LeuThr: 5.16 ± 0.079	7.239LeuVal: 7.239 ± 0.089	0.974LeuTrp: 0.974 ± 0.03	2.529LeuTyr: 2.529 ± 0.051	0.005LeuXaa: 0.005 ± 0.002
Met	2.242MetAla: 2.242 ± 0.048	0.204MetCys: 0.204 ± 0.014	1.225MetAsp: 1.225 ± 0.032	1.191MetGlu: 1.191 ± 0.029	0.907MetPhe: 0.907 ± 0.031	1.66MetGly: 1.66 ± 0.042	0.56MetHis: 0.56 ± 0.023	1.444MetIle: 1.444 ± 0.038	1.284MetLys: 1.284 ± 0.032	2.608MetLeu: 2.608 ± 0.051	0.655MetMet: 0.655 ± 0.022	1.111MetAsn: 1.111 ± 0.03	1.22MetPro: 1.22 ± 0.032	1.079MetGln: 1.079 ± 0.031	1.333MetArg: 1.333 ± 0.04	2.048MetSer: 2.048 ± 0.046	1.428MetThr: 1.428 ± 0.035	1.497MetVal: 1.497 ± 0.039	0.213MetTrp: 0.213 ± 0.015	0.545MetTyr: 0.545 ± 0.023	0.001MetXaa: 0.001 ± 0.001
Asn	3.814AsnAla: 3.814 ± 0.069	0.372AsnCys: 0.372 ± 0.02	2.59AsnAsp: 2.59 ± 0.061	2.751AsnGlu: 2.751 ± 0.049	1.584AsnPhe: 1.584 ± 0.036	2.809AsnGly: 2.809 ± 0.06	0.8AsnHis: 0.8 ± 0.025	2.839AsnIle: 2.839 ± 0.053	2.154AsnLys: 2.154 ± 0.048	3.831AsnLeu: 3.831 ± 0.063	0.994AsnMet: 0.994 ± 0.027	1.747AsnAsn: 1.747 ± 0.048	2.038AsnPro: 2.038 ± 0.043	1.765AsnGln: 1.765 ± 0.038	1.816AsnArg: 1.816 ± 0.042	2.645AsnSer: 2.645 ± 0.059	2.242AsnThr: 2.242 ± 0.049	2.683AsnVal: 2.683 ± 0.058	0.497AsnTrp: 0.497 ± 0.021	1.313AsnTyr: 1.313 ± 0.037	0.002AsnXaa: 0.002 ± 0.001
Pro	2.984ProAla: 2.984 ± 0.064	0.31ProCys: 0.31 ± 0.016	2.34ProAsp: 2.34 ± 0.045	3.34ProGlu: 3.34 ± 0.061	1.738ProPhe: 1.738 ± 0.042	2.317ProGly: 2.317 ± 0.054	0.802ProHis: 0.802 ± 0.031	2.413ProIle: 2.413 ± 0.046	2.108ProLys: 2.108 ± 0.052	3.604ProLeu: 3.604 ± 0.063	0.908ProMet: 0.908 ± 0.033	1.861ProAsn: 1.861 ± 0.045	1.1ProPro: 1.1 ± 0.034	1.349ProGln: 1.349 ± 0.036	1.401ProArg: 1.401 ± 0.04	2.96ProSer: 2.96 ± 0.062	1.949ProThr: 1.949 ± 0.041	2.967ProVal: 2.967 ± 0.047	0.465ProTrp: 0.465 ± 0.021	1.208ProTyr: 1.208 ± 0.037	0.004ProXaa: 0.004 ± 0.002
Gln	4.112GlnAla: 4.112 ± 0.073	0.397GlnCys: 0.397 ± 0.02	2.13GlnAsp: 2.13 ± 0.045	2.671GlnGlu: 2.671 ± 0.06	1.629GlnPhe: 1.629 ± 0.039	2.723GlnGly: 2.723 ± 0.055	1.009GlnHis: 1.009 ± 0.033	2.474GlnIle: 2.474 ± 0.054	1.979GlnLys: 1.979 ± 0.05	4.364GlnLeu: 4.364 ± 0.071	0.945GlnMet: 0.945 ± 0.029	1.698GlnAsn: 1.698 ± 0.044	1.371GlnPro: 1.371 ± 0.032	2.075GlnGln: 2.075 ± 0.057	2.222GlnArg: 2.222 ± 0.053	2.989GlnSer: 2.989 ± 0.059	2.333GlnThr: 2.333 ± 0.053	2.814GlnVal: 2.814 ± 0.051	0.483GlnTrp: 0.483 ± 0.023	1.151GlnTyr: 1.151 ± 0.034	0.001GlnXaa: 0.001 ± 0.001
Arg	3.844ArgAla: 3.844 ± 0.068	0.478ArgCys: 0.478 ± 0.022	2.678ArgAsp: 2.678 ± 0.051	3.131ArgGlu: 3.131 ± 0.059	2.357ArgPhe: 2.357 ± 0.049	2.547ArgGly: 2.547 ± 0.05	1.055ArgHis: 1.055 ± 0.034	3.2ArgIle: 3.2 ± 0.053	2.378ArgLys: 2.378 ± 0.055	5.13ArgLeu: 5.13 ± 0.078	1.218ArgMet: 1.218 ± 0.037	1.855ArgAsn: 1.855 ± 0.046	1.656ArgPro: 1.656 ± 0.043	1.917ArgGln: 1.917 ± 0.043	2.301ArgArg: 2.301 ± 0.046	3.066ArgSer: 3.066 ± 0.054	2.163ArgThr: 2.163 ± 0.049	3.449ArgVal: 3.449 ± 0.063	0.602ArgTrp: 0.602 ± 0.026	1.863ArgTyr: 1.863 ± 0.042	0.002ArgXaa: 0.002 ± 0.001
Ser	6.138SerAla: 6.138 ± 0.078	0.621SerCys: 0.621 ± 0.027	4.417SerAsp: 4.417 ± 0.081	4.8SerGlu: 4.8 ± 0.07	3.223SerPhe: 3.223 ± 0.062	5.214SerGly: 5.214 ± 0.076	1.398SerHis: 1.398 ± 0.039	4.648SerIle: 4.648 ± 0.068	3.51SerLys: 3.51 ± 0.054	7.573SerLeu: 7.573 ± 0.11	1.787SerMet: 1.787 ± 0.043	2.993SerAsn: 2.993 ± 0.058	2.581SerPro: 2.581 ± 0.052	2.754SerGln: 2.754 ± 0.051	3.022SerArg: 3.022 ± 0.048	5.388SerSer: 5.388 ± 0.09	3.558SerThr: 3.558 ± 0.065	5.122SerVal: 5.122 ± 0.08	0.806SerTrp: 0.806 ± 0.028	2.19SerTyr: 2.19 ± 0.042	0.002SerXaa: 0.002 ± 0.001
Thr	4.129ThrAla: 4.129 ± 0.074	0.443ThrCys: 0.443 ± 0.022	2.83ThrAsp: 2.83 ± 0.068	3.076ThrGlu: 3.076 ± 0.058	2.109ThrPhe: 2.109 ± 0.048	3.877ThrGly: 3.877 ± 0.076	1.141ThrHis: 1.141 ± 0.036	3.198ThrIle: 3.198 ± 0.06	2.342ThrLys: 2.342 ± 0.051	5.728ThrLeu: 5.728 ± 0.079	1.078ThrMet: 1.078 ± 0.031	2.101ThrAsn: 2.101 ± 0.048	2.428ThrPro: 2.428 ± 0.045	2.136ThrGln: 2.136 ± 0.048	2.295ThrArg: 2.295 ± 0.049	3.373ThrSer: 3.373 ± 0.055	2.65ThrThr: 2.65 ± 0.059	3.423ThrVal: 3.423 ± 0.062	0.587ThrTrp: 0.587 ± 0.029	1.529ThrTyr: 1.529 ± 0.044	0.002ThrXaa: 0.002 ± 0.001
Val	6.186ValAla: 6.186 ± 0.087	0.814ValCys: 0.814 ± 0.028	4.456ValAsp: 4.456 ± 0.075	4.879ValGlu: 4.879 ± 0.078	3.02ValPhe: 3.02 ± 0.055	4.538ValGly: 4.538 ± 0.07	1.376ValHis: 1.376 ± 0.032	4.597ValIle: 4.597 ± 0.074	3.4ValLys: 3.4 ± 0.064	7.152ValLeu: 7.152 ± 0.077	1.794ValMet: 1.794 ± 0.04	2.804ValAsn: 2.804 ± 0.052	2.59ValPro: 2.59 ± 0.054	2.29ValGln: 2.29 ± 0.044	3.165ValArg: 3.165 ± 0.068	5.38ValSer: 5.38 ± 0.08	3.539ValThr: 3.539 ± 0.068	5.413ValVal: 5.413 ± 0.079	0.738ValTrp: 0.738 ± 0.028	1.824ValTyr: 1.824 ± 0.042	0.002ValXaa: 0.002 ± 0.001
Trp	0.796TrpAla: 0.796 ± 0.024	0.134TrpCys: 0.134 ± 0.011	0.58TrpAsp: 0.58 ± 0.024	0.634TrpGlu: 0.634 ± 0.024	0.545TrpPhe: 0.545 ± 0.024	0.725TrpGly: 0.725 ± 0.028	0.263TrpHis: 0.263 ± 0.015	0.63TrpIle: 0.63 ± 0.026	0.485TrpLys: 0.485 ± 0.022	1.403TrpLeu: 1.403 ± 0.043	0.297TrpMet: 0.297 ± 0.015	0.433TrpAsn: 0.433 ± 0.021	0.409TrpPro: 0.409 ± 0.022	0.58TrpGln: 0.58 ± 0.025	0.576TrpArg: 0.576 ± 0.024	0.761TrpSer: 0.761 ± 0.027	0.52TrpThr: 0.52 ± 0.029	0.795TrpVal: 0.795 ± 0.03	0.142TrpTrp: 0.142 ± 0.012	0.331TrpTyr: 0.331 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.482TyrAla: 2.482 ± 0.041	0.337TyrCys: 0.337 ± 0.017	1.756TyrAsp: 1.756 ± 0.039	1.931TyrGlu: 1.931 ± 0.043	1.419TyrPhe: 1.419 ± 0.032	2.089TyrGly: 2.089 ± 0.045	0.665TyrHis: 0.665 ± 0.024	1.594TyrIle: 1.594 ± 0.037	1.437TyrLys: 1.437 ± 0.037	3.134TyrLeu: 3.134 ± 0.056	0.629TyrMet: 0.629 ± 0.026	0.998TyrAsn: 0.998 ± 0.031	1.265TyrPro: 1.265 ± 0.036	1.431TyrGln: 1.431 ± 0.041	1.675TyrArg: 1.675 ± 0.039	2.019TyrSer: 2.019 ± 0.047	1.456TyrThr: 1.456 ± 0.041	1.91TyrVal: 1.91 ± 0.039	0.418TyrTrp: 0.418 ± 0.02	0.946TyrTyr: 0.946 ± 0.032	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.004XaaGlu: 0.004 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.005XaaGly: 0.005 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.004XaaIle: 0.004 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.007XaaLeu: 0.007 ± 0.003	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.003XaaGln: 0.003 ± 0.002	0.004XaaArg: 0.004 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.005XaaVal: 0.005 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3585 proteins (1085609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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