Amino acid dipepetide frequency for Immundisolibacter cernigliae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.752AlaAla: 19.752 ± 0.239	1.369AlaCys: 1.369 ± 0.043	7.891AlaAsp: 7.891 ± 0.11	6.773AlaGlu: 6.773 ± 0.109	3.798AlaPhe: 3.798 ± 0.066	12.687AlaGly: 12.687 ± 0.16	2.758AlaHis: 2.758 ± 0.057	5.047AlaIle: 5.047 ± 0.078	2.505AlaLys: 2.505 ± 0.062	16.021AlaLeu: 16.021 ± 0.187	3.052AlaMet: 3.052 ± 0.06	2.386AlaAsn: 2.386 ± 0.052	6.422AlaPro: 6.422 ± 0.107	5.87AlaGln: 5.87 ± 0.1	10.491AlaArg: 10.491 ± 0.125	5.59AlaSer: 5.59 ± 0.075	5.672AlaThr: 5.672 ± 0.088	9.772AlaVal: 9.772 ± 0.114	1.984AlaTrp: 1.984 ± 0.057	2.731AlaTyr: 2.731 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.174CysAla: 1.174 ± 0.036	0.13CysCys: 0.13 ± 0.013	0.528CysAsp: 0.528 ± 0.023	0.531CysGlu: 0.531 ± 0.025	0.357CysPhe: 0.357 ± 0.018	1.101CysGly: 1.101 ± 0.038	0.323CysHis: 0.323 ± 0.018	0.367CysIle: 0.367 ± 0.021	0.19CysLys: 0.19 ± 0.015	1.025CysLeu: 1.025 ± 0.037	0.173CysMet: 0.173 ± 0.014	0.242CysAsn: 0.242 ± 0.015	0.594CysPro: 0.594 ± 0.028	0.338CysGln: 0.338 ± 0.018	0.825CysArg: 0.825 ± 0.031	0.45CysSer: 0.45 ± 0.024	0.476CysThr: 0.476 ± 0.022	0.685CysVal: 0.685 ± 0.031	0.13CysTrp: 0.13 ± 0.012	0.247CysTyr: 0.247 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.661AspAla: 7.661 ± 0.104	0.614AspCys: 0.614 ± 0.027	3.191AspAsp: 3.191 ± 0.067	3.254AspGlu: 3.254 ± 0.069	2.209AspPhe: 2.209 ± 0.06	5.439AspGly: 5.439 ± 0.099	1.235AspHis: 1.235 ± 0.038	2.592AspIle: 2.592 ± 0.053	1.334AspLys: 1.334 ± 0.043	6.392AspLeu: 6.392 ± 0.083	1.192AspMet: 1.192 ± 0.035	1.107AspAsn: 1.107 ± 0.037	3.592AspPro: 3.592 ± 0.074	1.828AspGln: 1.828 ± 0.048	4.078AspArg: 4.078 ± 0.074	2.331AspSer: 2.331 ± 0.058	2.766AspThr: 2.766 ± 0.063	3.955AspVal: 3.955 ± 0.061	1.092AspTrp: 1.092 ± 0.037	1.681AspTyr: 1.681 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.73GluAla: 6.73 ± 0.11	0.413GluCys: 0.413 ± 0.024	2.251GluAsp: 2.251 ± 0.051	2.062GluGlu: 2.062 ± 0.054	1.947GluPhe: 1.947 ± 0.058	3.524GluGly: 3.524 ± 0.066	1.587GluHis: 1.587 ± 0.047	2.357GluIle: 2.357 ± 0.057	1.35GluLys: 1.35 ± 0.045	6.671GluLeu: 6.671 ± 0.105	1.03GluMet: 1.03 ± 0.038	1.168GluAsn: 1.168 ± 0.039	2.744GluPro: 2.744 ± 0.049	2.702GluGln: 2.702 ± 0.056	5.107GluArg: 5.107 ± 0.08	2.138GluSer: 2.138 ± 0.045	2.575GluThr: 2.575 ± 0.057	4.008GluVal: 4.008 ± 0.064	0.577GluTrp: 0.577 ± 0.026	1.148GluTyr: 1.148 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.127PheAla: 4.127 ± 0.068	0.406PheCys: 0.406 ± 0.022	2.515PheAsp: 2.515 ± 0.048	2.133PheGlu: 2.133 ± 0.052	1.287PhePhe: 1.287 ± 0.045	3.525PheGly: 3.525 ± 0.071	0.831PheHis: 0.831 ± 0.033	1.28PheIle: 1.28 ± 0.036	0.762PheLys: 0.762 ± 0.034	3.122PheLeu: 3.122 ± 0.063	0.76PheMet: 0.76 ± 0.03	0.94PheAsn: 0.94 ± 0.034	1.483PhePro: 1.483 ± 0.041	0.918PheGln: 0.918 ± 0.029	2.013PheArg: 2.013 ± 0.045	1.644PheSer: 1.644 ± 0.045	1.716PheThr: 1.716 ± 0.047	2.588PheVal: 2.588 ± 0.054	0.49PheTrp: 0.49 ± 0.025	0.959PheTyr: 0.959 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.011GlyAla: 10.011 ± 0.128	0.946GlyCys: 0.946 ± 0.038	4.718GlyAsp: 4.718 ± 0.094	4.982GlyGlu: 4.982 ± 0.081	3.354GlyPhe: 3.354 ± 0.068	7.597GlyGly: 7.597 ± 0.12	2.164GlyHis: 2.164 ± 0.049	3.933GlyIle: 3.933 ± 0.067	2.668GlyLys: 2.668 ± 0.068	9.865GlyLeu: 9.865 ± 0.126	2.316GlyMet: 2.316 ± 0.05	2.1GlyAsn: 2.1 ± 0.047	3.743GlyPro: 3.743 ± 0.07	3.631GlyGln: 3.631 ± 0.069	6.863GlyArg: 6.863 ± 0.103	4.274GlySer: 4.274 ± 0.08	4.116GlyThr: 4.116 ± 0.071	6.902GlyVal: 6.902 ± 0.083	1.495GlyTrp: 1.495 ± 0.038	2.556GlyTyr: 2.556 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.88HisAla: 2.88 ± 0.063	0.294HisCys: 0.294 ± 0.016	1.27HisAsp: 1.27 ± 0.038	1.08HisGlu: 1.08 ± 0.034	0.842HisPhe: 0.842 ± 0.032	2.495HisGly: 2.495 ± 0.06	0.722HisHis: 0.722 ± 0.031	0.932HisIle: 0.932 ± 0.033	0.474HisLys: 0.474 ± 0.023	2.667HisLeu: 2.667 ± 0.048	0.445HisMet: 0.445 ± 0.021	0.521HisAsn: 0.521 ± 0.024	1.535HisPro: 1.535 ± 0.046	0.668HisGln: 0.668 ± 0.031	1.855HisArg: 1.855 ± 0.047	1.028HisSer: 1.028 ± 0.033	1.075HisThr: 1.075 ± 0.036	1.686HisVal: 1.686 ± 0.043	0.449HisTrp: 0.449 ± 0.023	0.763HisTyr: 0.763 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.585IleAla: 5.585 ± 0.083	0.384IleCys: 0.384 ± 0.021	3.282IleAsp: 3.282 ± 0.062	2.99IleGlu: 2.99 ± 0.066	1.085IlePhe: 1.085 ± 0.04	4.35IleGly: 4.35 ± 0.072	0.927IleHis: 0.927 ± 0.035	1.436IleIle: 1.436 ± 0.042	1.08IleLys: 1.08 ± 0.038	3.204IleLeu: 3.204 ± 0.062	0.629IleMet: 0.629 ± 0.029	1.222IleAsn: 1.222 ± 0.037	1.99IlePro: 1.99 ± 0.049	1.029IleGln: 1.029 ± 0.033	2.787IleArg: 2.787 ± 0.063	1.899IleSer: 1.899 ± 0.052	2.212IleThr: 2.212 ± 0.053	2.997IleVal: 2.997 ± 0.065	0.388IleTrp: 0.388 ± 0.019	0.975IleTyr: 0.975 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.048LysAla: 3.048 ± 0.073	0.148LysCys: 0.148 ± 0.015	1.253LysAsp: 1.253 ± 0.042	0.994LysGlu: 0.994 ± 0.035	0.647LysPhe: 0.647 ± 0.028	1.704LysGly: 1.704 ± 0.042	0.519LysHis: 0.519 ± 0.024	1.001LysIle: 1.001 ± 0.034	0.791LysLys: 0.791 ± 0.037	2.606LysLeu: 2.606 ± 0.061	0.487LysMet: 0.487 ± 0.025	0.603LysAsn: 0.603 ± 0.023	1.508LysPro: 1.508 ± 0.043	0.905LysGln: 0.905 ± 0.032	1.732LysArg: 1.732 ± 0.045	1.138LysSer: 1.138 ± 0.039	1.414LysThr: 1.414 ± 0.047	1.894LysVal: 1.894 ± 0.053	0.244LysTrp: 0.244 ± 0.018	0.511LysTyr: 0.511 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	17.468LeuAla: 17.468 ± 0.205	1.151LeuCys: 1.151 ± 0.041	6.951LeuAsp: 6.951 ± 0.09	5.756LeuGlu: 5.756 ± 0.088	3.365LeuPhe: 3.365 ± 0.067	9.959LeuGly: 9.959 ± 0.133	2.549LeuHis: 2.549 ± 0.05	4.367LeuIle: 4.367 ± 0.076	2.79LeuLys: 2.79 ± 0.064	13.563LeuLeu: 13.563 ± 0.245	2.111LeuMet: 2.111 ± 0.05	2.406LeuAsn: 2.406 ± 0.053	7.247LeuPro: 7.247 ± 0.108	3.566LeuGln: 3.566 ± 0.059	9.681LeuArg: 9.681 ± 0.14	5.294LeuSer: 5.294 ± 0.079	5.915LeuThr: 5.915 ± 0.091	7.876LeuVal: 7.876 ± 0.109	1.44LeuTrp: 1.44 ± 0.048	2.362LeuTyr: 2.362 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.775MetAla: 2.775 ± 0.056	0.139MetCys: 0.139 ± 0.01	1.11MetAsp: 1.11 ± 0.036	0.905MetGlu: 0.905 ± 0.032	0.604MetPhe: 0.604 ± 0.025	1.532MetGly: 1.532 ± 0.043	0.46MetHis: 0.46 ± 0.022	0.852MetIle: 0.852 ± 0.031	0.684MetLys: 0.684 ± 0.03	2.281MetLeu: 2.281 ± 0.052	0.424MetMet: 0.424 ± 0.024	0.73MetAsn: 0.73 ± 0.029	1.338MetPro: 1.338 ± 0.041	0.892MetGln: 0.892 ± 0.031	1.508MetArg: 1.508 ± 0.042	1.321MetSer: 1.321 ± 0.037	1.272MetThr: 1.272 ± 0.037	1.369MetVal: 1.369 ± 0.039	0.196MetTrp: 0.196 ± 0.017	0.354MetTyr: 0.354 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.745AsnAla: 2.745 ± 0.072	0.24AsnCys: 0.24 ± 0.016	1.172AsnAsp: 1.172 ± 0.041	0.962AsnGlu: 0.962 ± 0.034	0.87AsnPhe: 0.87 ± 0.034	1.886AsnGly: 1.886 ± 0.053	0.496AsnHis: 0.496 ± 0.024	1.087AsnIle: 1.087 ± 0.034	0.5AsnLys: 0.5 ± 0.023	2.526AsnLeu: 2.526 ± 0.048	0.456AsnMet: 0.456 ± 0.023	0.519AsnAsn: 0.519 ± 0.028	1.723AsnPro: 1.723 ± 0.047	0.71AsnGln: 0.71 ± 0.03	1.696AsnArg: 1.696 ± 0.044	0.877AsnSer: 0.877 ± 0.032	1.177AsnThr: 1.177 ± 0.041	1.746AsnVal: 1.746 ± 0.052	0.396AsnTrp: 0.396 ± 0.023	0.61AsnTyr: 0.61 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.185ProAla: 8.185 ± 0.116	0.396ProCys: 0.396 ± 0.02	3.795ProAsp: 3.795 ± 0.076	2.953ProGlu: 2.953 ± 0.058	1.738ProPhe: 1.738 ± 0.041	5.516ProGly: 5.516 ± 0.079	1.184ProHis: 1.184 ± 0.038	1.825ProIle: 1.825 ± 0.045	1.122ProLys: 1.122 ± 0.035	6.202ProLeu: 6.202 ± 0.102	1.151ProMet: 1.151 ± 0.035	1.194ProAsn: 1.194 ± 0.038	3.35ProPro: 3.35 ± 0.088	2.505ProGln: 2.505 ± 0.054	3.452ProArg: 3.452 ± 0.059	2.186ProSer: 2.186 ± 0.053	2.489ProThr: 2.489 ± 0.049	4.542ProVal: 4.542 ± 0.073	0.774ProTrp: 0.774 ± 0.027	1.273ProTyr: 1.273 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.953GlnAla: 5.953 ± 0.089	0.321GlnCys: 0.321 ± 0.02	1.814GlnAsp: 1.814 ± 0.042	1.658GlnGlu: 1.658 ± 0.042	1.281GlnPhe: 1.281 ± 0.036	2.708GlnGly: 2.708 ± 0.052	0.977GlnHis: 0.977 ± 0.029	1.763GlnIle: 1.763 ± 0.048	0.826GlnLys: 0.826 ± 0.034	3.942GlnLeu: 3.942 ± 0.076	0.841GlnMet: 0.841 ± 0.031	0.689GlnAsn: 0.689 ± 0.032	2.316GlnPro: 2.316 ± 0.047	1.682GlnGln: 1.682 ± 0.049	3.834GlnArg: 3.834 ± 0.077	1.459GlnSer: 1.459 ± 0.041	1.788GlnThr: 1.788 ± 0.046	3.387GlnVal: 3.387 ± 0.066	0.55GlnTrp: 0.55 ± 0.023	0.783GlnTyr: 0.783 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.164ArgAla: 9.164 ± 0.114	0.747ArgCys: 0.747 ± 0.026	4.062ArgAsp: 4.062 ± 0.068	4.71ArgGlu: 4.71 ± 0.074	2.921ArgPhe: 2.921 ± 0.061	5.83ArgGly: 5.83 ± 0.081	2.181ArgHis: 2.181 ± 0.047	3.478ArgIle: 3.478 ± 0.06	1.68ArgLys: 1.68 ± 0.044	10.268ArgLeu: 10.268 ± 0.148	1.654ArgMet: 1.654 ± 0.038	1.54ArgAsn: 1.54 ± 0.045	4.165ArgPro: 4.165 ± 0.07	3.502ArgGln: 3.502 ± 0.081	6.954ArgArg: 6.954 ± 0.107	3.423ArgSer: 3.423 ± 0.064	3.216ArgThr: 3.216 ± 0.061	5.832ArgVal: 5.832 ± 0.084	1.252ArgTrp: 1.252 ± 0.038	2.196ArgTyr: 2.196 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.596SerAla: 5.596 ± 0.09	0.447SerCys: 0.447 ± 0.023	2.28SerAsp: 2.28 ± 0.057	2.127SerGlu: 2.127 ± 0.049	1.689SerPhe: 1.689 ± 0.042	4.797SerGly: 4.797 ± 0.072	1.005SerHis: 1.005 ± 0.035	1.814SerIle: 1.814 ± 0.051	0.986SerLys: 0.986 ± 0.032	4.977SerLeu: 4.977 ± 0.082	0.939SerMet: 0.939 ± 0.032	1.059SerAsn: 1.059 ± 0.038	2.491SerPro: 2.491 ± 0.045	1.471SerGln: 1.471 ± 0.036	3.351SerArg: 3.351 ± 0.063	2.088SerSer: 2.088 ± 0.058	2.18SerThr: 2.18 ± 0.051	3.485SerVal: 3.485 ± 0.067	0.604SerTrp: 0.604 ± 0.029	1.124SerTyr: 1.124 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.284ThrAla: 6.284 ± 0.1	0.483ThrCys: 0.483 ± 0.024	2.826ThrAsp: 2.826 ± 0.055	2.281ThrGlu: 2.281 ± 0.05	1.531ThrPhe: 1.531 ± 0.045	4.661ThrGly: 4.661 ± 0.091	1.101ThrHis: 1.101 ± 0.037	1.704ThrIle: 1.704 ± 0.053	0.796ThrLys: 0.796 ± 0.032	6.517ThrLeu: 6.517 ± 0.093	0.698ThrMet: 0.698 ± 0.026	0.906ThrAsn: 0.906 ± 0.033	3.404ThrPro: 3.404 ± 0.064	1.633ThrGln: 1.633 ± 0.052	3.373ThrArg: 3.373 ± 0.064	1.803ThrSer: 1.803 ± 0.048	2.36ThrThr: 2.36 ± 0.069	4.185ThrVal: 4.185 ± 0.072	0.639ThrTrp: 0.639 ± 0.027	1.11ThrTyr: 1.11 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	9.267ValAla: 9.267 ± 0.109	0.828ValCys: 0.828 ± 0.032	4.578ValAsp: 4.578 ± 0.08	4.213ValGlu: 4.213 ± 0.072	2.595ValPhe: 2.595 ± 0.059	5.835ValGly: 5.835 ± 0.094	1.625ValHis: 1.625 ± 0.041	3.316ValIle: 3.316 ± 0.059	1.727ValLys: 1.727 ± 0.048	8.848ValLeu: 8.848 ± 0.127	1.711ValMet: 1.711 ± 0.047	2.004ValAsn: 2.004 ± 0.061	4.088ValPro: 4.088 ± 0.075	2.76ValGln: 2.76 ± 0.06	5.439ValArg: 5.439 ± 0.081	3.911ValSer: 3.911 ± 0.067	4.072ValThr: 4.072 ± 0.099	5.929ValVal: 5.929 ± 0.104	1.004ValTrp: 1.004 ± 0.035	1.766ValTyr: 1.766 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.317TrpAla: 1.317 ± 0.045	0.165TrpCys: 0.165 ± 0.014	0.62TrpAsp: 0.62 ± 0.029	0.532TrpGlu: 0.532 ± 0.024	0.492TrpPhe: 0.492 ± 0.026	0.885TrpGly: 0.885 ± 0.031	0.386TrpHis: 0.386 ± 0.019	0.518TrpIle: 0.518 ± 0.026	0.361TrpLys: 0.361 ± 0.023	2.211TrpLeu: 2.211 ± 0.056	0.288TrpMet: 0.288 ± 0.017	0.414TrpAsn: 0.414 ± 0.024	0.818TrpPro: 0.818 ± 0.035	0.998TrpGln: 0.998 ± 0.037	1.356TrpArg: 1.356 ± 0.036	0.648TrpSer: 0.648 ± 0.024	0.689TrpThr: 0.689 ± 0.031	0.969TrpVal: 0.969 ± 0.031	0.225TrpTrp: 0.225 ± 0.02	0.375TrpTyr: 0.375 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.845TyrAla: 2.845 ± 0.051	0.264TyrCys: 0.264 ± 0.02	1.438TyrAsp: 1.438 ± 0.051	1.196TyrGlu: 1.196 ± 0.042	0.89TyrPhe: 0.89 ± 0.034	2.201TyrGly: 2.201 ± 0.052	0.651TyrHis: 0.651 ± 0.029	0.783TyrIle: 0.783 ± 0.028	0.521TyrLys: 0.521 ± 0.027	2.91TyrLeu: 2.91 ± 0.055	0.387TyrMet: 0.387 ± 0.022	0.642TyrAsn: 0.642 ± 0.025	1.279TyrPro: 1.279 ± 0.045	0.964TyrGln: 0.964 ± 0.035	2.38TyrArg: 2.38 ± 0.057	1.008TyrSer: 1.008 ± 0.036	1.113TyrThr: 1.113 ± 0.039	1.712TyrVal: 1.712 ± 0.042	0.34TyrTrp: 0.34 ± 0.02	0.658TyrTyr: 0.658 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2904 proteins (932638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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