Amino acid dipepetide frequency for Nonomuraea pusilla

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.818AlaAla: 22.818 ± 0.167	1.214AlaCys: 1.214 ± 0.022	7.602AlaAsp: 7.602 ± 0.057	8.639AlaGlu: 8.639 ± 0.074	3.838AlaPhe: 3.838 ± 0.044	14.174AlaGly: 14.174 ± 0.101	2.647AlaHis: 2.647 ± 0.036	3.712AlaIle: 3.712 ± 0.043	2.469AlaLys: 2.469 ± 0.04	15.205AlaLeu: 15.205 ± 0.104	2.803AlaMet: 2.803 ± 0.033	1.768AlaAsn: 1.768 ± 0.027	6.931AlaPro: 6.931 ± 0.068	3.428AlaGln: 3.428 ± 0.042	11.247AlaArg: 11.247 ± 0.089	5.835AlaSer: 5.835 ± 0.045	6.673AlaThr: 6.673 ± 0.055	12.729AlaVal: 12.729 ± 0.089	2.099AlaTrp: 2.099 ± 0.028	2.838AlaTyr: 2.838 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.021	0.101CysCys: 0.101 ± 0.007	0.493CysAsp: 0.493 ± 0.014	0.382CysGlu: 0.382 ± 0.01	0.219CysPhe: 0.219 ± 0.01	0.999CysGly: 0.999 ± 0.025	0.22CysHis: 0.22 ± 0.009	0.113CysIle: 0.113 ± 0.006	0.099CysLys: 0.099 ± 0.006	0.789CysLeu: 0.789 ± 0.02	0.123CysMet: 0.123 ± 0.006	0.112CysAsn: 0.112 ± 0.006	0.51CysPro: 0.51 ± 0.015	0.161CysGln: 0.161 ± 0.007	0.634CysArg: 0.634 ± 0.016	0.414CysSer: 0.414 ± 0.015	0.402CysThr: 0.402 ± 0.012	0.706CysVal: 0.706 ± 0.015	0.117CysTrp: 0.117 ± 0.007	0.179CysTyr: 0.179 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.029AspAla: 7.029 ± 0.062	0.353AspCys: 0.353 ± 0.011	3.527AspAsp: 3.527 ± 0.042	3.599AspGlu: 3.599 ± 0.039	1.441AspPhe: 1.441 ± 0.024	6.116AspGly: 6.116 ± 0.056	1.326AspHis: 1.326 ± 0.027	1.535AspIle: 1.535 ± 0.026	0.941AspLys: 0.941 ± 0.019	6.606AspLeu: 6.606 ± 0.062	0.771AspMet: 0.771 ± 0.016	0.794AspAsn: 0.794 ± 0.018	4.534AspPro: 4.534 ± 0.049	1.424AspGln: 1.424 ± 0.024	4.811AspArg: 4.811 ± 0.041	1.974AspSer: 1.974 ± 0.031	2.482AspThr: 2.482 ± 0.034	5.239AspVal: 5.239 ± 0.045	0.909AspTrp: 0.909 ± 0.017	1.1AspTyr: 1.1 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.157GluAla: 7.157 ± 0.063	0.347GluCys: 0.347 ± 0.012	2.477GluAsp: 2.477 ± 0.031	3.643GluGlu: 3.643 ± 0.041	1.363GluPhe: 1.363 ± 0.024	4.239GluGly: 4.239 ± 0.042	1.549GluHis: 1.549 ± 0.028	2.352GluIle: 2.352 ± 0.035	1.079GluLys: 1.079 ± 0.023	6.909GluLeu: 6.909 ± 0.056	0.863GluMet: 0.863 ± 0.02	0.843GluAsn: 0.843 ± 0.018	3.678GluPro: 3.678 ± 0.042	2.143GluGln: 2.143 ± 0.028	5.956GluArg: 5.956 ± 0.057	2.481GluSer: 2.481 ± 0.027	2.77GluThr: 2.77 ± 0.034	4.606GluVal: 4.606 ± 0.051	0.77GluTrp: 0.77 ± 0.02	1.02GluTyr: 1.02 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.891PheAla: 3.891 ± 0.036	0.259PheCys: 0.259 ± 0.01	1.964PheAsp: 1.964 ± 0.026	1.412PheGlu: 1.412 ± 0.021	0.872PhePhe: 0.872 ± 0.02	2.995PheGly: 2.995 ± 0.036	0.632PheHis: 0.632 ± 0.015	0.677PheIle: 0.677 ± 0.017	0.475PheLys: 0.475 ± 0.014	2.724PheLeu: 2.724 ± 0.036	0.434PheMet: 0.434 ± 0.013	0.517PheAsn: 0.517 ± 0.014	1.435PhePro: 1.435 ± 0.026	0.7PheGln: 0.7 ± 0.017	1.839PheArg: 1.839 ± 0.027	1.445PheSer: 1.445 ± 0.026	2.003PheThr: 2.003 ± 0.027	2.325PheVal: 2.325 ± 0.032	0.463PheTrp: 0.463 ± 0.013	0.573PheTyr: 0.573 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.23GlyAla: 11.23 ± 0.095	0.854GlyCys: 0.854 ± 0.02	5.309GlyAsp: 5.309 ± 0.045	5.467GlyGlu: 5.467 ± 0.051	2.981GlyPhe: 2.981 ± 0.035	9.499GlyGly: 9.499 ± 0.093	2.354GlyHis: 2.354 ± 0.033	2.88GlyIle: 2.88 ± 0.033	2.102GlyLys: 2.102 ± 0.035	10.247GlyLeu: 10.247 ± 0.078	2.067GlyMet: 2.067 ± 0.029	1.501GlyAsn: 1.501 ± 0.03	5.515GlyPro: 5.515 ± 0.055	2.742GlyGln: 2.742 ± 0.045	8.579GlyArg: 8.579 ± 0.066	4.811GlySer: 4.811 ± 0.053	5.569GlyThr: 5.569 ± 0.061	8.549GlyVal: 8.549 ± 0.067	1.78GlyTrp: 1.78 ± 0.029	2.335GlyTyr: 2.335 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.782HisAla: 2.782 ± 0.037	0.203HisCys: 0.203 ± 0.009	1.409HisAsp: 1.409 ± 0.026	1.171HisGlu: 1.171 ± 0.021	0.557HisPhe: 0.557 ± 0.015	2.35HisGly: 2.35 ± 0.034	0.633HisHis: 0.633 ± 0.016	0.536HisIle: 0.536 ± 0.016	0.295HisLys: 0.295 ± 0.008	2.483HisLeu: 2.483 ± 0.032	0.324HisMet: 0.324 ± 0.012	0.301HisAsn: 0.301 ± 0.011	1.772HisPro: 1.772 ± 0.026	0.566HisGln: 0.566 ± 0.014	1.987HisArg: 1.987 ± 0.028	0.836HisSer: 0.836 ± 0.018	1.052HisThr: 1.052 ± 0.02	1.852HisVal: 1.852 ± 0.028	0.352HisTrp: 0.352 ± 0.012	0.476HisTyr: 0.476 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.637IleAla: 4.637 ± 0.048	0.273IleCys: 0.273 ± 0.009	2.192IleAsp: 2.192 ± 0.03	1.927IleGlu: 1.927 ± 0.03	0.729IlePhe: 0.729 ± 0.019	3.306IleGly: 3.306 ± 0.042	0.568IleHis: 0.568 ± 0.016	0.874IleIle: 0.874 ± 0.019	0.665IleLys: 0.665 ± 0.019	2.384IleLeu: 2.384 ± 0.036	0.512IleMet: 0.512 ± 0.015	0.604IleAsn: 0.604 ± 0.017	1.659IlePro: 1.659 ± 0.025	0.664IleGln: 0.664 ± 0.016	2.287IleArg: 2.287 ± 0.033	1.626IleSer: 1.626 ± 0.025	2.111IleThr: 2.111 ± 0.031	2.904IleVal: 2.904 ± 0.034	0.387IleTrp: 0.387 ± 0.012	0.517IleTyr: 0.517 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.518LysAla: 2.518 ± 0.039	0.105LysCys: 0.105 ± 0.007	1.113LysAsp: 1.113 ± 0.026	1.15LysGlu: 1.15 ± 0.023	0.368LysPhe: 0.368 ± 0.012	1.705LysGly: 1.705 ± 0.035	0.375LysHis: 0.375 ± 0.014	0.812LysIle: 0.812 ± 0.021	0.588LysLys: 0.588 ± 0.021	1.836LysLeu: 1.836 ± 0.028	0.319LysMet: 0.319 ± 0.012	0.395LysAsn: 0.395 ± 0.013	1.247LysPro: 1.247 ± 0.026	0.575LysGln: 0.575 ± 0.017	1.271LysArg: 1.271 ± 0.024	0.898LysSer: 0.898 ± 0.02	1.089LysThr: 1.089 ± 0.024	1.813LysVal: 1.813 ± 0.031	0.232LysTrp: 0.232 ± 0.009	0.365LysTyr: 0.365 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	16.708LeuAla: 16.708 ± 0.11	0.789LeuCys: 0.789 ± 0.017	6.837LeuAsp: 6.837 ± 0.061	4.818LeuGlu: 4.818 ± 0.048	2.753LeuPhe: 2.753 ± 0.035	9.863LeuGly: 9.863 ± 0.074	2.134LeuHis: 2.134 ± 0.028	3.289LeuIle: 3.289 ± 0.047	1.852LeuLys: 1.852 ± 0.03	11.914LeuLeu: 11.914 ± 0.093	1.786LeuMet: 1.786 ± 0.031	1.614LeuAsn: 1.614 ± 0.026	6.836LeuPro: 6.836 ± 0.051	2.079LeuGln: 2.079 ± 0.031	9.45LeuArg: 9.45 ± 0.07	5.516LeuSer: 5.516 ± 0.048	6.661LeuThr: 6.661 ± 0.053	9.601LeuVal: 9.601 ± 0.07	1.364LeuTrp: 1.364 ± 0.023	1.891LeuTyr: 1.891 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.434MetAla: 2.434 ± 0.034	0.128MetCys: 0.128 ± 0.007	0.87MetAsp: 0.87 ± 0.018	0.804MetGlu: 0.804 ± 0.017	0.473MetPhe: 0.473 ± 0.014	1.349MetGly: 1.349 ± 0.023	0.323MetHis: 0.323 ± 0.011	0.804MetIle: 0.804 ± 0.017	0.445MetLys: 0.445 ± 0.012	1.887MetLeu: 1.887 ± 0.028	0.322MetMet: 0.322 ± 0.012	0.434MetAsn: 0.434 ± 0.014	1.186MetPro: 1.186 ± 0.024	0.386MetGln: 0.386 ± 0.012	1.741MetArg: 1.741 ± 0.025	1.324MetSer: 1.324 ± 0.023	1.574MetThr: 1.574 ± 0.027	1.328MetVal: 1.328 ± 0.023	0.22MetTrp: 0.22 ± 0.009	0.304MetTyr: 0.304 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.036AsnAla: 2.036 ± 0.026	0.146AsnCys: 0.146 ± 0.008	0.836AsnAsp: 0.836 ± 0.018	0.718AsnGlu: 0.718 ± 0.019	0.404AsnPhe: 0.404 ± 0.013	1.612AsnGly: 1.612 ± 0.03	0.346AsnHis: 0.346 ± 0.012	0.52AsnIle: 0.52 ± 0.016	0.328AsnLys: 0.328 ± 0.013	1.67AsnLeu: 1.67 ± 0.026	0.247AsnMet: 0.247 ± 0.01	0.319AsnAsn: 0.319 ± 0.013	1.325AsnPro: 1.325 ± 0.023	0.454AsnGln: 0.454 ± 0.015	1.221AsnArg: 1.221 ± 0.02	0.682AsnSer: 0.682 ± 0.014	0.885AsnThr: 0.885 ± 0.023	1.385AsnVal: 1.385 ± 0.022	0.264AsnTrp: 0.264 ± 0.011	0.364AsnTyr: 0.364 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.933ProAla: 8.933 ± 0.076	0.379ProCys: 0.379 ± 0.013	4.258ProAsp: 4.258 ± 0.044	4.27ProGlu: 4.27 ± 0.041	1.657ProPhe: 1.657 ± 0.027	7.447ProGly: 7.447 ± 0.067	1.292ProHis: 1.292 ± 0.025	1.498ProIle: 1.498 ± 0.026	1.113ProLys: 1.113 ± 0.023	5.613ProLeu: 5.613 ± 0.047	1.15ProMet: 1.15 ± 0.019	0.875ProAsn: 0.875 ± 0.02	4.241ProPro: 4.241 ± 0.059	1.567ProGln: 1.567 ± 0.029	4.318ProArg: 4.318 ± 0.042	3.451ProSer: 3.451 ± 0.045	2.863ProThr: 2.863 ± 0.038	5.567ProVal: 5.567 ± 0.049	1.003ProTrp: 1.003 ± 0.02	1.521ProTyr: 1.521 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.964GlnAla: 3.964 ± 0.043	0.15GlnCys: 0.15 ± 0.008	1.255GlnAsp: 1.255 ± 0.022	1.461GlnGlu: 1.461 ± 0.025	0.601GlnPhe: 0.601 ± 0.015	2.216GlnGly: 2.216 ± 0.042	0.507GlnHis: 0.507 ± 0.013	1.031GlnIle: 1.031 ± 0.018	0.509GlnLys: 0.509 ± 0.016	2.534GlnLeu: 2.534 ± 0.037	0.442GlnMet: 0.442 ± 0.014	0.428GlnAsn: 0.428 ± 0.014	1.722GlnPro: 1.722 ± 0.036	0.969GlnGln: 0.969 ± 0.03	2.174GlnArg: 2.174 ± 0.034	1.07GlnSer: 1.07 ± 0.024	1.216GlnThr: 1.216 ± 0.023	2.512GlnVal: 2.512 ± 0.031	0.433GlnTrp: 0.433 ± 0.014	0.493GlnTyr: 0.493 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.664ArgAla: 10.664 ± 0.084	0.645ArgCys: 0.645 ± 0.017	4.559ArgAsp: 4.559 ± 0.045	4.948ArgGlu: 4.948 ± 0.05	2.489ArgPhe: 2.489 ± 0.028	6.232ArgGly: 6.232 ± 0.052	2.299ArgHis: 2.299 ± 0.031	2.851ArgIle: 2.851 ± 0.033	1.463ArgLys: 1.463 ± 0.027	10.179ArgLeu: 10.179 ± 0.075	1.913ArgMet: 1.913 ± 0.029	1.252ArgAsn: 1.252 ± 0.025	5.588ArgPro: 5.588 ± 0.06	2.396ArgGln: 2.396 ± 0.032	8.783ArgArg: 8.783 ± 0.081	3.917ArgSer: 3.917 ± 0.041	4.688ArgThr: 4.688 ± 0.04	6.845ArgVal: 6.845 ± 0.059	1.524ArgTrp: 1.524 ± 0.028	1.895ArgTyr: 1.895 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.329SerAla: 6.329 ± 0.054	0.407SerCys: 0.407 ± 0.012	2.464SerAsp: 2.464 ± 0.03	2.245SerGlu: 2.245 ± 0.032	1.527SerPhe: 1.527 ± 0.022	5.919SerGly: 5.919 ± 0.062	0.945SerHis: 0.945 ± 0.018	1.512SerIle: 1.512 ± 0.024	0.931SerLys: 0.931 ± 0.02	4.627SerLeu: 4.627 ± 0.043	1.097SerMet: 1.097 ± 0.02	0.755SerAsn: 0.755 ± 0.019	3.193SerPro: 3.193 ± 0.033	1.155SerGln: 1.155 ± 0.024	3.785SerArg: 3.785 ± 0.042	2.604SerSer: 2.604 ± 0.04	2.633SerThr: 2.633 ± 0.037	3.947SerVal: 3.947 ± 0.045	0.951SerTrp: 0.951 ± 0.02	1.122SerTyr: 1.122 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	7.715ThrAla: 7.715 ± 0.056	0.416ThrCys: 0.416 ± 0.014	2.677ThrAsp: 2.677 ± 0.034	2.552ThrGlu: 2.552 ± 0.031	1.681ThrPhe: 1.681 ± 0.025	6.346ThrGly: 6.346 ± 0.059	1.064ThrHis: 1.064 ± 0.018	1.78ThrIle: 1.78 ± 0.027	0.966ThrLys: 0.966 ± 0.023	5.82ThrLeu: 5.82 ± 0.049	1.043ThrMet: 1.043 ± 0.019	0.808ThrAsn: 0.808 ± 0.017	4.06ThrPro: 4.06 ± 0.044	1.219ThrGln: 1.219 ± 0.022	4.072ThrArg: 4.072 ± 0.035	2.928ThrSer: 2.928 ± 0.036	3.191ThrThr: 3.191 ± 0.042	5.494ThrVal: 5.494 ± 0.051	0.923ThrTrp: 0.923 ± 0.021	1.245ThrTyr: 1.245 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	12.285ValAla: 12.285 ± 0.083	0.732ValCys: 0.732 ± 0.017	4.479ValAsp: 4.479 ± 0.038	5.098ValGlu: 5.098 ± 0.051	2.561ValPhe: 2.561 ± 0.033	6.631ValGly: 6.631 ± 0.053	1.873ValHis: 1.873 ± 0.028	3.037ValIle: 3.037 ± 0.035	1.784ValLys: 1.784 ± 0.031	10.074ValLeu: 10.074 ± 0.076	1.547ValMet: 1.547 ± 0.027	1.713ValAsn: 1.713 ± 0.029	5.59ValPro: 5.59 ± 0.049	1.911ValGln: 1.911 ± 0.03	7.569ValArg: 7.569 ± 0.058	4.528ValSer: 4.528 ± 0.043	6.037ValThr: 6.037 ± 0.053	8.632ValVal: 8.632 ± 0.077	1.198ValTrp: 1.198 ± 0.022	1.666ValTyr: 1.666 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.698TrpAla: 1.698 ± 0.027	0.163TrpCys: 0.163 ± 0.007	0.818TrpAsp: 0.818 ± 0.019	0.747TrpGlu: 0.747 ± 0.017	0.507TrpPhe: 0.507 ± 0.015	1.096TrpGly: 1.096 ± 0.022	0.412TrpHis: 0.412 ± 0.015	0.576TrpIle: 0.576 ± 0.015	0.333TrpLys: 0.333 ± 0.012	1.96TrpLeu: 1.96 ± 0.025	0.313TrpMet: 0.313 ± 0.011	0.386TrpAsn: 0.386 ± 0.013	0.885TrpPro: 0.885 ± 0.021	0.581TrpGln: 0.581 ± 0.019	1.52TrpArg: 1.52 ± 0.022	0.919TrpSer: 0.919 ± 0.018	0.993TrpThr: 0.993 ± 0.019	1.049TrpVal: 1.049 ± 0.021	0.368TrpTrp: 0.368 ± 0.013	0.368TrpTyr: 0.368 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.769TyrAla: 2.769 ± 0.03	0.18TyrCys: 0.18 ± 0.008	1.373TyrAsp: 1.373 ± 0.029	1.195TyrGlu: 1.195 ± 0.021	0.617TyrPhe: 0.617 ± 0.017	2.276TyrGly: 2.276 ± 0.035	0.436TyrHis: 0.436 ± 0.012	0.439TyrIle: 0.439 ± 0.013	0.337TyrLys: 0.337 ± 0.012	2.296TyrLeu: 2.296 ± 0.032	0.259TyrMet: 0.259 ± 0.011	0.344TyrAsn: 0.344 ± 0.014	1.107TyrPro: 1.107 ± 0.02	0.566TyrGln: 0.566 ± 0.016	1.886TyrArg: 1.886 ± 0.025	0.889TyrSer: 0.889 ± 0.016	1.106TyrThr: 1.106 ± 0.022	1.862TyrVal: 1.862 ± 0.027	0.333TyrTrp: 0.333 ± 0.01	0.443TyrTyr: 0.443 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8486 proteins (2733672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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