Amino acid dipepetide frequency for Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.029AlaAla: 22.029 ± 1.781
2.658AlaCys: 2.658 ± 0.249
6.772AlaAsp: 6.772 ± 0.479
6.287AlaGlu: 6.287 ± 0.521
4.293AlaPhe: 4.293 ± 0.287
10.785AlaGly: 10.785 ± 0.67
3.552AlaHis: 3.552 ± 0.277
3.271AlaIle: 3.271 ± 0.232
1.84AlaLys: 1.84 ± 0.254
13.161AlaLeu: 13.161 ± 0.885
1.84AlaMet: 1.84 ± 0.174
2.274AlaAsn: 2.274 ± 0.323
13.085AlaPro: 13.085 ± 0.999
3.654AlaGln: 3.654 ± 0.318
11.628AlaArg: 11.628 ± 0.654
8.74AlaSer: 8.74 ± 0.496
7.002AlaThr: 7.002 ± 0.531
9.635AlaVal: 9.635 ± 0.551
1.636AlaTrp: 1.636 ± 0.205
2.632AlaTyr: 2.632 ± 0.258
0.0AlaXaa: 0.0 ± 0.0
Cys
2.3CysAla: 2.3 ± 0.279
0.383CysCys: 0.383 ± 0.107
0.92CysAsp: 0.92 ± 0.188
0.869CysGlu: 0.869 ± 0.131
0.741CysPhe: 0.741 ± 0.13
1.15CysGly: 1.15 ± 0.143
0.307CysHis: 0.307 ± 0.094
0.537CysIle: 0.537 ± 0.125
0.281CysLys: 0.281 ± 0.084
2.274CysLeu: 2.274 ± 0.276
0.486CysMet: 0.486 ± 0.126
0.511CysAsn: 0.511 ± 0.122
1.329CysPro: 1.329 ± 0.211
0.46CysGln: 0.46 ± 0.118
1.533CysArg: 1.533 ± 0.207
0.767CysSer: 0.767 ± 0.147
0.869CysThr: 0.869 ± 0.161
1.584CysVal: 1.584 ± 0.202
0.153CysTrp: 0.153 ± 0.06
0.46CysTyr: 0.46 ± 0.108
0.0CysXaa: 0.0 ± 0.0
Asp
7.795AspAla: 7.795 ± 0.677
0.946AspCys: 0.946 ± 0.139
4.319AspAsp: 4.319 ± 0.677
2.99AspGlu: 2.99 ± 0.298
1.431AspPhe: 1.431 ± 0.193
3.859AspGly: 3.859 ± 0.348
1.227AspHis: 1.227 ± 0.18
1.661AspIle: 1.661 ± 0.251
0.664AspLys: 0.664 ± 0.189
4.856AspLeu: 4.856 ± 0.408
0.741AspMet: 0.741 ± 0.129
0.843AspAsn: 0.843 ± 0.173
5.009AspPro: 5.009 ± 0.386
0.997AspGln: 0.997 ± 0.166
3.348AspArg: 3.348 ± 0.325
3.424AspSer: 3.424 ± 0.404
2.607AspThr: 2.607 ± 0.253
4.012AspVal: 4.012 ± 0.29
0.741AspTrp: 0.741 ± 0.131
0.997AspTyr: 0.997 ± 0.136
0.0AspXaa: 0.0 ± 0.0
Glu
7.309GluAla: 7.309 ± 0.456
0.818GluCys: 0.818 ± 0.178
3.092GluAsp: 3.092 ± 0.253
2.888GluGlu: 2.888 ± 0.267
1.789GluPhe: 1.789 ± 0.329
3.45GluGly: 3.45 ± 0.347
1.303GluHis: 1.303 ± 0.168
1.38GluIle: 1.38 ± 0.171
0.716GluLys: 0.716 ± 0.15
5.265GluLeu: 5.265 ± 0.515
0.971GluMet: 0.971 ± 0.141
1.303GluAsn: 1.303 ± 0.199
2.99GluPro: 2.99 ± 0.332
1.814GluGln: 1.814 ± 0.208
3.961GluArg: 3.961 ± 0.284
2.607GluSer: 2.607 ± 0.298
2.939GluThr: 2.939 ± 0.236
2.811GluVal: 2.811 ± 0.227
0.511GluTrp: 0.511 ± 0.095
1.15GluTyr: 1.15 ± 0.139
0.0GluXaa: 0.0 ± 0.0
Phe
3.731PheAla: 3.731 ± 0.322
0.894PheCys: 0.894 ± 0.146
2.044PheAsp: 2.044 ± 0.244
1.891PheGlu: 1.891 ± 0.233
1.431PhePhe: 1.431 ± 0.208
2.556PheGly: 2.556 ± 0.267
0.869PheHis: 0.869 ± 0.136
1.227PheIle: 1.227 ± 0.22
0.818PheLys: 0.818 ± 0.207
3.782PheLeu: 3.782 ± 0.37
0.537PheMet: 0.537 ± 0.126
0.843PheAsn: 0.843 ± 0.171
2.096PhePro: 2.096 ± 0.211
0.613PheGln: 0.613 ± 0.121
2.3PheArg: 2.3 ± 0.263
2.172PheSer: 2.172 ± 0.269
1.227PheThr: 1.227 ± 0.224
3.297PheVal: 3.297 ± 0.341
0.486PheTrp: 0.486 ± 0.109
0.971PheTyr: 0.971 ± 0.162
0.0PheXaa: 0.0 ± 0.0
Gly
10.912GlyAla: 10.912 ± 0.636
0.869GlyCys: 0.869 ± 0.168
5.009GlyAsp: 5.009 ± 0.335
3.936GlyGlu: 3.936 ± 0.298
2.581GlyPhe: 2.581 ± 0.319
8.485GlyGly: 8.485 ± 0.658
1.763GlyHis: 1.763 ± 0.174
1.712GlyIle: 1.712 ± 0.187
0.997GlyLys: 0.997 ± 0.141
7.028GlyLeu: 7.028 ± 0.4
1.048GlyMet: 1.048 ± 0.156
1.099GlyAsn: 1.099 ± 0.195
8.178GlyPro: 8.178 ± 0.697
1.968GlyGln: 1.968 ± 0.264
6.645GlyArg: 6.645 ± 0.479
4.523GlySer: 4.523 ± 0.388
3.706GlyThr: 3.706 ± 0.315
5.111GlyVal: 5.111 ± 0.321
0.92GlyTrp: 0.92 ± 0.149
1.431GlyTyr: 1.431 ± 0.205
0.0GlyXaa: 0.0 ± 0.0
His
3.552HisAla: 3.552 ± 0.248
0.46HisCys: 0.46 ± 0.16
0.843HisAsp: 0.843 ± 0.184
1.303HisGlu: 1.303 ± 0.195
0.767HisPhe: 0.767 ± 0.188
2.019HisGly: 2.019 ± 0.216
0.971HisHis: 0.971 ± 0.187
0.792HisIle: 0.792 ± 0.131
0.332HisLys: 0.332 ± 0.105
2.3HisLeu: 2.3 ± 0.271
0.46HisMet: 0.46 ± 0.113
0.613HisAsn: 0.613 ± 0.159
2.607HisPro: 2.607 ± 0.314
0.741HisGln: 0.741 ± 0.162
2.479HisArg: 2.479 ± 0.242
1.252HisSer: 1.252 ± 0.195
1.661HisThr: 1.661 ± 0.181
1.763HisVal: 1.763 ± 0.205
0.23HisTrp: 0.23 ± 0.083
0.767HisTyr: 0.767 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
3.22IleAla: 3.22 ± 0.312
0.562IleCys: 0.562 ± 0.134
1.533IleAsp: 1.533 ± 0.229
1.227IleGlu: 1.227 ± 0.205
0.997IlePhe: 0.997 ± 0.17
1.354IleGly: 1.354 ± 0.205
0.971IleHis: 0.971 ± 0.185
1.15IleIle: 1.15 ± 0.202
0.716IleLys: 0.716 ± 0.194
2.658IleLeu: 2.658 ± 0.329
0.434IleMet: 0.434 ± 0.117
1.099IleAsn: 1.099 ± 0.168
1.763IlePro: 1.763 ± 0.254
0.894IleGln: 0.894 ± 0.168
2.172IleArg: 2.172 ± 0.262
1.533IleSer: 1.533 ± 0.19
2.249IleThr: 2.249 ± 0.359
1.738IleVal: 1.738 ± 0.236
0.332IleTrp: 0.332 ± 0.085
0.843IleTyr: 0.843 ± 0.174
0.0IleXaa: 0.0 ± 0.0
Lys
1.508LysAla: 1.508 ± 0.248
0.179LysCys: 0.179 ± 0.061
0.69LysAsp: 0.69 ± 0.15
0.486LysGlu: 0.486 ± 0.109
0.741LysPhe: 0.741 ± 0.149
0.562LysGly: 0.562 ± 0.112
0.383LysHis: 0.383 ± 0.086
0.716LysIle: 0.716 ± 0.177
0.562LysLys: 0.562 ± 0.165
1.278LysLeu: 1.278 ± 0.242
0.588LysMet: 0.588 ± 0.101
0.332LysAsn: 0.332 ± 0.078
1.073LysPro: 1.073 ± 0.194
0.588LysGln: 0.588 ± 0.134
2.198LysArg: 2.198 ± 0.278
0.869LysSer: 0.869 ± 0.119
1.508LysThr: 1.508 ± 0.222
1.15LysVal: 1.15 ± 0.21
0.077LysTrp: 0.077 ± 0.04
0.588LysTyr: 0.588 ± 0.17
0.0LysXaa: 0.0 ± 0.0
Leu
12.778LeuAla: 12.778 ± 0.768
2.3LeuCys: 2.3 ± 0.272
4.498LeuAsp: 4.498 ± 0.404
5.265LeuGlu: 5.265 ± 0.41
4.063LeuPhe: 4.063 ± 0.269
7.156LeuGly: 7.156 ± 0.425
2.326LeuHis: 2.326 ± 0.226
2.453LeuIle: 2.453 ± 0.244
1.457LeuLys: 1.457 ± 0.218
9.788LeuLeu: 9.788 ± 0.609
1.942LeuMet: 1.942 ± 0.284
1.968LeuAsn: 1.968 ± 0.311
6.415LeuPro: 6.415 ± 0.623
3.016LeuGln: 3.016 ± 0.266
9.277LeuArg: 9.277 ± 0.559
5.086LeuSer: 5.086 ± 0.401
5.316LeuThr: 5.316 ± 0.345
7.411LeuVal: 7.411 ± 0.553
1.329LeuTrp: 1.329 ± 0.233
2.683LeuTyr: 2.683 ± 0.271
0.0LeuXaa: 0.0 ± 0.0
Met
2.607MetAla: 2.607 ± 0.265
0.23MetCys: 0.23 ± 0.079
0.946MetAsp: 0.946 ± 0.141
0.69MetGlu: 0.69 ± 0.151
0.767MetPhe: 0.767 ± 0.121
1.38MetGly: 1.38 ± 0.168
0.332MetHis: 0.332 ± 0.096
0.434MetIle: 0.434 ± 0.11
0.383MetLys: 0.383 ± 0.103
1.559MetLeu: 1.559 ± 0.223
0.281MetMet: 0.281 ± 0.091
0.486MetAsn: 0.486 ± 0.123
0.639MetPro: 0.639 ± 0.147
0.562MetGln: 0.562 ± 0.159
1.636MetArg: 1.636 ± 0.197
1.099MetSer: 1.099 ± 0.168
0.894MetThr: 0.894 ± 0.151
0.843MetVal: 0.843 ± 0.124
0.179MetTrp: 0.179 ± 0.06
0.562MetTyr: 0.562 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.067AsnAla: 3.067 ± 0.319
0.358AsnCys: 0.358 ± 0.091
0.894AsnAsp: 0.894 ± 0.138
0.664AsnGlu: 0.664 ± 0.114
0.894AsnPhe: 0.894 ± 0.164
1.201AsnGly: 1.201 ± 0.212
0.562AsnHis: 0.562 ± 0.145
0.792AsnIle: 0.792 ± 0.191
0.409AsnLys: 0.409 ± 0.102
1.814AsnLeu: 1.814 ± 0.294
0.358AsnMet: 0.358 ± 0.107
0.843AsnAsn: 0.843 ± 0.181
1.789AsnPro: 1.789 ± 0.193
0.664AsnGln: 0.664 ± 0.134
1.124AsnArg: 1.124 ± 0.175
1.073AsnSer: 1.073 ± 0.156
1.917AsnThr: 1.917 ± 0.212
1.457AsnVal: 1.457 ± 0.219
0.153AsnTrp: 0.153 ± 0.059
0.716AsnTyr: 0.716 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
12.931ProAla: 12.931 ± 1.018
1.073ProCys: 1.073 ± 0.134
4.447ProAsp: 4.447 ± 0.423
5.009ProGlu: 5.009 ± 0.37
1.533ProPhe: 1.533 ± 0.171
8.74ProGly: 8.74 ± 0.598
2.223ProHis: 2.223 ± 0.225
1.559ProIle: 1.559 ± 0.213
1.482ProLys: 1.482 ± 0.176
6.849ProLeu: 6.849 ± 0.618
1.15ProMet: 1.15 ± 0.18
1.584ProAsn: 1.584 ± 0.229
13.315ProPro: 13.315 ± 1.526
2.683ProGln: 2.683 ± 0.378
8.485ProArg: 8.485 ± 0.93
5.443ProSer: 5.443 ± 0.407
4.728ProThr: 4.728 ± 0.507
4.779ProVal: 4.779 ± 0.374
0.792ProTrp: 0.792 ± 0.143
1.457ProTyr: 1.457 ± 0.228
0.0ProXaa: 0.0 ± 0.0
Gln
3.552GlnAla: 3.552 ± 0.349
0.562GlnCys: 0.562 ± 0.085
1.201GlnAsp: 1.201 ± 0.18
1.176GlnGlu: 1.176 ± 0.197
0.971GlnPhe: 0.971 ± 0.145
1.584GlnGly: 1.584 ± 0.193
0.792GlnHis: 0.792 ± 0.167
1.099GlnIle: 1.099 ± 0.158
0.486GlnLys: 0.486 ± 0.119
3.45GlnLeu: 3.45 ± 0.329
0.537GlnMet: 0.537 ± 0.127
0.46GlnAsn: 0.46 ± 0.117
2.53GlnPro: 2.53 ± 0.281
1.329GlnGln: 1.329 ± 0.22
2.837GlnArg: 2.837 ± 0.271
1.354GlnSer: 1.354 ± 0.166
1.993GlnThr: 1.993 ± 0.214
1.38GlnVal: 1.38 ± 0.248
0.332GlnTrp: 0.332 ± 0.09
1.022GlnTyr: 1.022 ± 0.11
0.0GlnXaa: 0.0 ± 0.0
Arg
11.5ArgAla: 11.5 ± 0.785
1.431ArgCys: 1.431 ± 0.246
4.83ArgAsp: 4.83 ± 0.377
4.804ArgGlu: 4.804 ± 0.359
3.143ArgPhe: 3.143 ± 0.331
7.079ArgGly: 7.079 ± 0.464
2.453ArgHis: 2.453 ± 0.221
1.84ArgIle: 1.84 ± 0.206
1.176ArgLys: 1.176 ± 0.256
8.178ArgLeu: 8.178 ± 0.438
1.252ArgMet: 1.252 ± 0.194
1.61ArgAsn: 1.61 ± 0.219
7.437ArgPro: 7.437 ± 0.453
2.504ArgGln: 2.504 ± 0.256
9.865ArgArg: 9.865 ± 0.752
4.677ArgSer: 4.677 ± 0.438
4.472ArgThr: 4.472 ± 0.387
5.725ArgVal: 5.725 ± 0.417
0.792ArgTrp: 0.792 ± 0.14
2.326ArgTyr: 2.326 ± 0.242
0.0ArgXaa: 0.0 ± 0.0
Ser
7.82SerAla: 7.82 ± 0.696
0.869SerCys: 0.869 ± 0.157
2.964SerAsp: 2.964 ± 0.351
2.939SerGlu: 2.939 ± 0.325
1.687SerPhe: 1.687 ± 0.204
5.29SerGly: 5.29 ± 0.447
1.431SerHis: 1.431 ± 0.219
1.38SerIle: 1.38 ± 0.256
0.92SerLys: 0.92 ± 0.168
6.031SerLeu: 6.031 ± 0.44
1.022SerMet: 1.022 ± 0.177
0.767SerAsn: 0.767 ± 0.178
6.44SerPro: 6.44 ± 0.538
1.584SerGln: 1.584 ± 0.225
4.396SerArg: 4.396 ± 0.382
6.031SerSer: 6.031 ± 0.92
3.22SerThr: 3.22 ± 0.331
4.166SerVal: 4.166 ± 0.413
0.716SerTrp: 0.716 ± 0.177
1.073SerTyr: 1.073 ± 0.188
0.0SerXaa: 0.0 ± 0.0
Thr
7.105ThrAla: 7.105 ± 0.522
0.894ThrCys: 0.894 ± 0.151
2.581ThrAsp: 2.581 ± 0.254
2.402ThrGlu: 2.402 ± 0.249
1.891ThrPhe: 1.891 ± 0.239
3.399ThrGly: 3.399 ± 0.267
1.993ThrHis: 1.993 ± 0.24
1.891ThrIle: 1.891 ± 0.257
1.022ThrLys: 1.022 ± 0.169
4.651ThrLeu: 4.651 ± 0.334
0.716ThrMet: 0.716 ± 0.146
1.661ThrAsn: 1.661 ± 0.204
5.878ThrPro: 5.878 ± 0.648
1.891ThrGln: 1.891 ± 0.224
4.779ThrArg: 4.779 ± 0.38
3.399ThrSer: 3.399 ± 0.271
4.038ThrThr: 4.038 ± 0.333
3.169ThrVal: 3.169 ± 0.348
0.818ThrTrp: 0.818 ± 0.113
1.789ThrTyr: 1.789 ± 0.247
0.0ThrXaa: 0.0 ± 0.0
Val
8.485ValAla: 8.485 ± 0.424
1.687ValCys: 1.687 ± 0.249
3.067ValAsp: 3.067 ± 0.238
2.913ValGlu: 2.913 ± 0.229
2.786ValPhe: 2.786 ± 0.293
5.009ValGly: 5.009 ± 0.407
1.482ValHis: 1.482 ± 0.176
2.351ValIle: 2.351 ± 0.268
1.176ValLys: 1.176 ± 0.196
7.539ValLeu: 7.539 ± 0.426
1.329ValMet: 1.329 ± 0.192
1.661ValAsn: 1.661 ± 0.23
5.367ValPro: 5.367 ± 0.364
1.84ValGln: 1.84 ± 0.182
5.546ValArg: 5.546 ± 0.37
4.753ValSer: 4.753 ± 0.372
3.552ValThr: 3.552 ± 0.314
5.955ValVal: 5.955 ± 0.433
0.818ValTrp: 0.818 ± 0.147
2.121ValTyr: 2.121 ± 0.242
0.0ValXaa: 0.0 ± 0.0
Trp
1.406TrpAla: 1.406 ± 0.208
0.179TrpCys: 0.179 ± 0.077
0.434TrpAsp: 0.434 ± 0.093
0.486TrpGlu: 0.486 ± 0.134
0.409TrpPhe: 0.409 ± 0.105
1.15TrpGly: 1.15 ± 0.197
0.307TrpHis: 0.307 ± 0.102
0.332TrpIle: 0.332 ± 0.098
0.204TrpLys: 0.204 ± 0.072
1.354TrpLeu: 1.354 ± 0.186
0.307TrpMet: 0.307 ± 0.095
0.153TrpAsn: 0.153 ± 0.061
0.664TrpPro: 0.664 ± 0.136
0.256TrpGln: 0.256 ± 0.085
1.124TrpArg: 1.124 ± 0.19
0.639TrpSer: 0.639 ± 0.152
0.818TrpThr: 0.818 ± 0.173
0.92TrpVal: 0.92 ± 0.127
0.256TrpTrp: 0.256 ± 0.081
0.23TrpTyr: 0.23 ± 0.07
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.169TyrAla: 3.169 ± 0.302
0.562TyrCys: 0.562 ± 0.118
1.38TyrAsp: 1.38 ± 0.264
0.843TyrGlu: 0.843 ± 0.179
0.869TyrPhe: 0.869 ± 0.175
1.712TyrGly: 1.712 ± 0.243
0.664TyrHis: 0.664 ± 0.118
0.869TyrIle: 0.869 ± 0.181
0.434TyrLys: 0.434 ± 0.138
2.709TyrLeu: 2.709 ± 0.238
0.486TyrMet: 0.486 ± 0.111
0.664TyrAsn: 0.664 ± 0.136
1.661TyrPro: 1.661 ± 0.285
0.588TyrGln: 0.588 ± 0.11
1.763TyrArg: 1.763 ± 0.222
1.303TyrSer: 1.303 ± 0.202
1.252TyrThr: 1.252 ± 0.169
2.53TyrVal: 2.53 ± 0.235
0.358TyrTrp: 0.358 ± 0.1
1.252TyrTyr: 1.252 ± 0.236
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (39131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski