Amino acid dipepetide frequency for Streptococcus phage Javan139

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.984AlaAla: 3.984 ± 0.648
0.453AlaCys: 0.453 ± 0.197
5.071AlaAsp: 5.071 ± 0.706
5.705AlaGlu: 5.705 ± 0.845
2.898AlaPhe: 2.898 ± 0.469
4.166AlaGly: 4.166 ± 0.886
0.815AlaHis: 0.815 ± 0.26
5.524AlaIle: 5.524 ± 0.76
7.426AlaLys: 7.426 ± 0.649
6.339AlaLeu: 6.339 ± 0.74
2.626AlaMet: 2.626 ± 0.461
3.169AlaAsn: 3.169 ± 0.726
1.358AlaPro: 1.358 ± 0.416
2.445AlaGln: 2.445 ± 0.493
2.626AlaArg: 2.626 ± 0.443
3.894AlaSer: 3.894 ± 0.718
2.988AlaThr: 2.988 ± 0.546
4.709AlaVal: 4.709 ± 0.69
0.815AlaTrp: 0.815 ± 0.303
1.902AlaTyr: 1.902 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.272CysAla: 0.272 ± 0.135
0.0CysCys: 0.0 ± 0.0
0.453CysAsp: 0.453 ± 0.196
0.724CysGlu: 0.724 ± 0.326
0.181CysPhe: 0.181 ± 0.128
0.362CysGly: 0.362 ± 0.208
0.181CysHis: 0.181 ± 0.119
0.453CysIle: 0.453 ± 0.246
0.362CysLys: 0.362 ± 0.172
0.091CysLeu: 0.091 ± 0.095
0.272CysMet: 0.272 ± 0.175
0.272CysAsn: 0.272 ± 0.158
0.272CysPro: 0.272 ± 0.154
0.181CysGln: 0.181 ± 0.128
0.181CysArg: 0.181 ± 0.132
0.362CysSer: 0.362 ± 0.209
0.181CysThr: 0.181 ± 0.138
0.181CysVal: 0.181 ± 0.129
0.181CysTrp: 0.181 ± 0.099
0.453CysTyr: 0.453 ± 0.219
0.0CysXaa: 0.0 ± 0.0
Asp
3.713AspAla: 3.713 ± 0.575
0.362AspCys: 0.362 ± 0.231
5.071AspAsp: 5.071 ± 0.813
5.343AspGlu: 5.343 ± 0.661
3.26AspPhe: 3.26 ± 0.478
5.071AspGly: 5.071 ± 0.904
0.453AspHis: 0.453 ± 0.202
5.252AspIle: 5.252 ± 0.851
5.796AspLys: 5.796 ± 0.756
6.339AspLeu: 6.339 ± 0.853
1.811AspMet: 1.811 ± 0.41
3.169AspAsn: 3.169 ± 0.566
1.268AspPro: 1.268 ± 0.368
1.449AspGln: 1.449 ± 0.285
1.721AspArg: 1.721 ± 0.485
4.799AspSer: 4.799 ± 0.638
3.169AspThr: 3.169 ± 0.479
3.713AspVal: 3.713 ± 0.627
0.996AspTrp: 0.996 ± 0.245
3.803AspTyr: 3.803 ± 0.7
0.0AspXaa: 0.0 ± 0.0
Glu
4.799GluAla: 4.799 ± 0.759
0.543GluCys: 0.543 ± 0.238
4.166GluAsp: 4.166 ± 0.649
6.158GluGlu: 6.158 ± 0.82
2.988GluPhe: 2.988 ± 0.503
3.532GluGly: 3.532 ± 0.435
0.906GluHis: 0.906 ± 0.305
6.701GluIle: 6.701 ± 0.728
6.248GluLys: 6.248 ± 0.784
8.059GluLeu: 8.059 ± 0.938
2.264GluMet: 2.264 ± 0.552
3.894GluAsn: 3.894 ± 0.702
1.63GluPro: 1.63 ± 0.365
3.079GluGln: 3.079 ± 0.499
4.256GluArg: 4.256 ± 0.54
4.166GluSer: 4.166 ± 0.694
3.622GluThr: 3.622 ± 0.507
5.614GluVal: 5.614 ± 0.824
1.177GluTrp: 1.177 ± 0.302
3.079GluTyr: 3.079 ± 0.555
0.0GluXaa: 0.0 ± 0.0
Phe
1.992PheAla: 1.992 ± 0.456
0.091PheCys: 0.091 ± 0.103
3.984PheAsp: 3.984 ± 0.84
3.26PheGlu: 3.26 ± 0.491
1.358PhePhe: 1.358 ± 0.391
2.807PheGly: 2.807 ± 0.466
0.453PheHis: 0.453 ± 0.174
2.354PheIle: 2.354 ± 0.449
3.351PheLys: 3.351 ± 0.438
2.626PheLeu: 2.626 ± 0.5
1.177PheMet: 1.177 ± 0.26
2.807PheAsn: 2.807 ± 0.41
1.087PhePro: 1.087 ± 0.313
1.087PheGln: 1.087 ± 0.397
1.992PheArg: 1.992 ± 0.404
2.807PheSer: 2.807 ± 0.561
2.354PheThr: 2.354 ± 0.403
1.811PheVal: 1.811 ± 0.461
0.272PheTrp: 0.272 ± 0.156
1.358PheTyr: 1.358 ± 0.473
0.0PheXaa: 0.0 ± 0.0
Gly
4.075GlyAla: 4.075 ± 0.829
0.453GlyCys: 0.453 ± 0.19
3.622GlyAsp: 3.622 ± 0.799
4.618GlyGlu: 4.618 ± 0.652
2.898GlyPhe: 2.898 ± 0.53
2.898GlyGly: 2.898 ± 0.487
0.906GlyHis: 0.906 ± 0.257
5.252GlyIle: 5.252 ± 0.964
4.89GlyLys: 4.89 ± 0.586
5.343GlyLeu: 5.343 ± 0.622
1.63GlyMet: 1.63 ± 0.319
4.347GlyAsn: 4.347 ± 0.699
0.815GlyPro: 0.815 ± 0.228
2.807GlyGln: 2.807 ± 0.592
2.445GlyArg: 2.445 ± 0.441
3.441GlySer: 3.441 ± 0.666
3.26GlyThr: 3.26 ± 0.684
2.988GlyVal: 2.988 ± 0.54
0.724GlyTrp: 0.724 ± 0.312
2.536GlyTyr: 2.536 ± 0.606
0.0GlyXaa: 0.0 ± 0.0
His
0.724HisAla: 0.724 ± 0.208
0.0HisCys: 0.0 ± 0.0
0.906HisAsp: 0.906 ± 0.265
1.087HisGlu: 1.087 ± 0.334
0.906HisPhe: 0.906 ± 0.333
0.906HisGly: 0.906 ± 0.24
0.634HisHis: 0.634 ± 0.265
1.449HisIle: 1.449 ± 0.427
0.996HisLys: 0.996 ± 0.357
0.906HisLeu: 0.906 ± 0.253
0.181HisMet: 0.181 ± 0.135
0.996HisAsn: 0.996 ± 0.3
0.815HisPro: 0.815 ± 0.293
0.634HisGln: 0.634 ± 0.227
0.453HisArg: 0.453 ± 0.202
0.634HisSer: 0.634 ± 0.224
0.815HisThr: 0.815 ± 0.246
0.906HisVal: 0.906 ± 0.33
0.181HisTrp: 0.181 ± 0.122
0.996HisTyr: 0.996 ± 0.386
0.0HisXaa: 0.0 ± 0.0
Ile
6.429IleAla: 6.429 ± 0.889
0.453IleCys: 0.453 ± 0.231
5.796IleAsp: 5.796 ± 0.756
6.429IleGlu: 6.429 ± 0.901
2.173IlePhe: 2.173 ± 0.393
4.981IleGly: 4.981 ± 0.63
1.358IleHis: 1.358 ± 0.329
5.705IleIle: 5.705 ± 0.821
7.607IleLys: 7.607 ± 0.921
4.528IleLeu: 4.528 ± 0.551
1.992IleMet: 1.992 ± 0.379
5.071IleAsn: 5.071 ± 0.693
2.354IlePro: 2.354 ± 0.434
2.626IleGln: 2.626 ± 0.474
3.532IleArg: 3.532 ± 0.529
5.343IleSer: 5.343 ± 0.851
4.256IleThr: 4.256 ± 0.523
4.709IleVal: 4.709 ± 0.672
0.996IleTrp: 0.996 ± 0.367
2.717IleTyr: 2.717 ± 0.597
0.0IleXaa: 0.0 ± 0.0
Lys
6.429LysAla: 6.429 ± 0.641
0.272LysCys: 0.272 ± 0.15
5.071LysAsp: 5.071 ± 0.724
6.701LysGlu: 6.701 ± 0.768
2.445LysPhe: 2.445 ± 0.331
5.614LysGly: 5.614 ± 0.919
1.177LysHis: 1.177 ± 0.308
7.154LysIle: 7.154 ± 0.91
6.882LysLys: 6.882 ± 1.356
9.056LysLeu: 9.056 ± 0.89
1.992LysMet: 1.992 ± 0.477
6.158LysAsn: 6.158 ± 0.692
2.536LysPro: 2.536 ± 0.491
3.713LysGln: 3.713 ± 0.648
3.713LysArg: 3.713 ± 0.575
4.528LysSer: 4.528 ± 0.522
4.799LysThr: 4.799 ± 0.633
5.614LysVal: 5.614 ± 0.761
0.453LysTrp: 0.453 ± 0.189
3.169LysTyr: 3.169 ± 0.567
0.0LysXaa: 0.0 ± 0.0
Leu
8.059LeuAla: 8.059 ± 0.994
0.906LeuCys: 0.906 ± 0.292
6.429LeuAsp: 6.429 ± 0.963
6.248LeuGlu: 6.248 ± 0.695
3.169LeuPhe: 3.169 ± 0.657
4.89LeuGly: 4.89 ± 0.751
1.358LeuHis: 1.358 ± 0.329
5.162LeuIle: 5.162 ± 0.762
7.154LeuLys: 7.154 ± 0.789
4.981LeuLeu: 4.981 ± 0.598
1.539LeuMet: 1.539 ± 0.371
4.981LeuAsn: 4.981 ± 0.66
2.807LeuPro: 2.807 ± 0.526
3.169LeuGln: 3.169 ± 0.503
4.075LeuArg: 4.075 ± 0.536
6.339LeuSer: 6.339 ± 0.78
6.701LeuThr: 6.701 ± 0.778
4.075LeuVal: 4.075 ± 0.505
0.815LeuTrp: 0.815 ± 0.252
2.264LeuTyr: 2.264 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
1.63MetAla: 1.63 ± 0.345
0.091MetCys: 0.091 ± 0.096
1.087MetAsp: 1.087 ± 0.254
2.354MetGlu: 2.354 ± 0.452
1.449MetPhe: 1.449 ± 0.346
0.906MetGly: 0.906 ± 0.254
0.091MetHis: 0.091 ± 0.103
2.445MetIle: 2.445 ± 0.401
1.449MetLys: 1.449 ± 0.366
1.992MetLeu: 1.992 ± 0.484
0.634MetMet: 0.634 ± 0.238
1.177MetAsn: 1.177 ± 0.284
0.724MetPro: 0.724 ± 0.222
0.815MetGln: 0.815 ± 0.259
1.177MetArg: 1.177 ± 0.301
2.445MetSer: 2.445 ± 0.37
1.811MetThr: 1.811 ± 0.42
0.996MetVal: 0.996 ± 0.251
0.543MetTrp: 0.543 ± 0.181
0.272MetTyr: 0.272 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
4.256AsnAla: 4.256 ± 0.644
0.181AsnCys: 0.181 ± 0.137
3.622AsnAsp: 3.622 ± 0.635
3.169AsnGlu: 3.169 ± 0.559
2.626AsnPhe: 2.626 ± 0.528
4.528AsnGly: 4.528 ± 0.62
0.724AsnHis: 0.724 ± 0.214
3.984AsnIle: 3.984 ± 0.639
4.709AsnLys: 4.709 ± 0.529
4.618AsnLeu: 4.618 ± 0.675
1.449AsnMet: 1.449 ± 0.289
3.079AsnAsn: 3.079 ± 0.637
2.898AsnPro: 2.898 ± 0.471
2.083AsnGln: 2.083 ± 0.385
1.992AsnArg: 1.992 ± 0.497
3.079AsnSer: 3.079 ± 0.521
3.169AsnThr: 3.169 ± 0.447
3.441AsnVal: 3.441 ± 0.718
0.634AsnTrp: 0.634 ± 0.288
2.898AsnTyr: 2.898 ± 0.513
0.0AsnXaa: 0.0 ± 0.0
Pro
1.268ProAla: 1.268 ± 0.3
0.091ProCys: 0.091 ± 0.084
1.177ProAsp: 1.177 ± 0.387
2.988ProGlu: 2.988 ± 0.554
0.724ProPhe: 0.724 ± 0.289
0.634ProGly: 0.634 ± 0.236
0.634ProHis: 0.634 ± 0.251
2.807ProIle: 2.807 ± 0.517
2.536ProLys: 2.536 ± 0.638
2.083ProLeu: 2.083 ± 0.514
0.634ProMet: 0.634 ± 0.248
1.449ProAsn: 1.449 ± 0.307
0.543ProPro: 0.543 ± 0.207
1.539ProGln: 1.539 ± 0.334
0.634ProArg: 0.634 ± 0.303
1.63ProSer: 1.63 ± 0.383
1.63ProThr: 1.63 ± 0.275
1.902ProVal: 1.902 ± 0.399
0.272ProTrp: 0.272 ± 0.163
0.906ProTyr: 0.906 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
3.079GlnAla: 3.079 ± 0.474
0.272GlnCys: 0.272 ± 0.152
1.902GlnAsp: 1.902 ± 0.338
2.626GlnGlu: 2.626 ± 0.435
1.811GlnPhe: 1.811 ± 0.431
2.173GlnGly: 2.173 ± 0.342
0.453GlnHis: 0.453 ± 0.202
3.532GlnIle: 3.532 ± 0.43
3.894GlnLys: 3.894 ± 0.589
5.071GlnLeu: 5.071 ± 0.731
0.815GlnMet: 0.815 ± 0.301
1.721GlnAsn: 1.721 ± 0.351
0.362GlnPro: 0.362 ± 0.151
1.449GlnGln: 1.449 ± 0.406
1.358GlnArg: 1.358 ± 0.324
2.626GlnSer: 2.626 ± 0.532
2.445GlnThr: 2.445 ± 0.435
1.811GlnVal: 1.811 ± 0.378
0.181GlnTrp: 0.181 ± 0.107
1.087GlnTyr: 1.087 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
3.26ArgAla: 3.26 ± 0.428
0.362ArgCys: 0.362 ± 0.181
2.445ArgAsp: 2.445 ± 0.518
2.717ArgGlu: 2.717 ± 0.583
1.268ArgPhe: 1.268 ± 0.33
1.811ArgGly: 1.811 ± 0.553
0.724ArgHis: 0.724 ± 0.243
3.622ArgIle: 3.622 ± 0.682
2.807ArgLys: 2.807 ± 0.505
3.622ArgLeu: 3.622 ± 0.716
1.63ArgMet: 1.63 ± 0.268
1.902ArgAsn: 1.902 ± 0.4
1.63ArgPro: 1.63 ± 0.359
1.902ArgGln: 1.902 ± 0.415
2.173ArgArg: 2.173 ± 0.442
2.354ArgSer: 2.354 ± 0.496
2.264ArgThr: 2.264 ± 0.501
2.264ArgVal: 2.264 ± 0.516
0.272ArgTrp: 0.272 ± 0.156
2.354ArgTyr: 2.354 ± 0.527
0.0ArgXaa: 0.0 ± 0.0
Ser
4.709SerAla: 4.709 ± 0.84
0.272SerCys: 0.272 ± 0.169
4.528SerAsp: 4.528 ± 0.549
5.252SerGlu: 5.252 ± 0.816
1.992SerPhe: 1.992 ± 0.397
3.713SerGly: 3.713 ± 0.713
0.906SerHis: 0.906 ± 0.386
4.256SerIle: 4.256 ± 0.692
5.433SerLys: 5.433 ± 0.791
5.977SerLeu: 5.977 ± 0.878
0.724SerMet: 0.724 ± 0.221
3.441SerAsn: 3.441 ± 0.635
0.996SerPro: 0.996 ± 0.349
2.536SerGln: 2.536 ± 0.447
2.264SerArg: 2.264 ± 0.462
3.984SerSer: 3.984 ± 0.689
3.169SerThr: 3.169 ± 0.867
3.803SerVal: 3.803 ± 0.535
0.634SerTrp: 0.634 ± 0.237
2.536SerTyr: 2.536 ± 0.542
0.0SerXaa: 0.0 ± 0.0
Thr
3.441ThrAla: 3.441 ± 0.668
0.272ThrCys: 0.272 ± 0.155
3.079ThrAsp: 3.079 ± 0.569
3.803ThrGlu: 3.803 ± 0.567
2.536ThrPhe: 2.536 ± 0.598
4.528ThrGly: 4.528 ± 0.638
1.268ThrHis: 1.268 ± 0.264
5.796ThrIle: 5.796 ± 0.787
5.071ThrLys: 5.071 ± 0.58
4.528ThrLeu: 4.528 ± 0.53
0.634ThrMet: 0.634 ± 0.226
2.445ThrAsn: 2.445 ± 0.47
1.358ThrPro: 1.358 ± 0.36
2.717ThrGln: 2.717 ± 0.41
2.083ThrArg: 2.083 ± 0.433
3.169ThrSer: 3.169 ± 0.535
4.618ThrThr: 4.618 ± 0.864
3.803ThrVal: 3.803 ± 0.631
0.815ThrTrp: 0.815 ± 0.298
2.083ThrTyr: 2.083 ± 0.526
0.0ThrXaa: 0.0 ± 0.0
Val
4.347ValAla: 4.347 ± 0.832
0.272ValCys: 0.272 ± 0.14
4.347ValAsp: 4.347 ± 0.889
4.256ValGlu: 4.256 ± 0.599
2.354ValPhe: 2.354 ± 0.453
2.898ValGly: 2.898 ± 0.439
0.815ValHis: 0.815 ± 0.283
4.89ValIle: 4.89 ± 0.864
5.614ValLys: 5.614 ± 0.758
3.894ValLeu: 3.894 ± 0.561
1.358ValMet: 1.358 ± 0.308
3.26ValAsn: 3.26 ± 0.535
1.177ValPro: 1.177 ± 0.277
1.721ValGln: 1.721 ± 0.426
2.807ValArg: 2.807 ± 0.483
3.803ValSer: 3.803 ± 0.572
4.618ValThr: 4.618 ± 0.708
3.622ValVal: 3.622 ± 0.537
1.177ValTrp: 1.177 ± 0.325
2.083ValTyr: 2.083 ± 0.431
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.201
0.091TrpCys: 0.091 ± 0.08
0.724TrpAsp: 0.724 ± 0.224
0.543TrpGlu: 0.543 ± 0.248
0.543TrpPhe: 0.543 ± 0.191
0.453TrpGly: 0.453 ± 0.178
0.181TrpHis: 0.181 ± 0.153
0.815TrpIle: 0.815 ± 0.276
1.358TrpLys: 1.358 ± 0.46
1.358TrpLeu: 1.358 ± 0.304
0.181TrpMet: 0.181 ± 0.128
1.721TrpAsn: 1.721 ± 0.637
0.091TrpPro: 0.091 ± 0.07
0.815TrpGln: 0.815 ± 0.281
0.362TrpArg: 0.362 ± 0.19
0.543TrpSer: 0.543 ± 0.192
0.543TrpThr: 0.543 ± 0.24
0.453TrpVal: 0.453 ± 0.179
0.091TrpTrp: 0.091 ± 0.093
0.362TrpTyr: 0.362 ± 0.138
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.902TyrAla: 1.902 ± 0.33
0.181TyrCys: 0.181 ± 0.127
3.079TyrAsp: 3.079 ± 0.631
2.898TyrGlu: 2.898 ± 0.47
1.449TyrPhe: 1.449 ± 0.457
3.079TyrGly: 3.079 ± 0.491
1.087TyrHis: 1.087 ± 0.331
1.902TyrIle: 1.902 ± 0.624
3.984TyrLys: 3.984 ± 0.824
3.713TyrLeu: 3.713 ± 0.66
0.453TyrMet: 0.453 ± 0.201
2.083TyrAsn: 2.083 ± 0.54
1.358TyrPro: 1.358 ± 0.374
1.902TyrGln: 1.902 ± 0.373
1.539TyrArg: 1.539 ± 0.379
1.177TyrSer: 1.177 ± 0.334
1.63TyrThr: 1.63 ± 0.342
2.898TyrVal: 2.898 ± 0.608
0.543TyrTrp: 0.543 ± 0.191
1.811TyrTyr: 1.811 ± 0.445
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski