Amino acid dipepetide frequency for Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / CCUG 43107 / 12-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.92AlaAla: 13.92 ± 0.245
2.082AlaCys: 2.082 ± 0.079
6.879AlaAsp: 6.879 ± 0.138
6.145AlaGlu: 6.145 ± 0.143
4.161AlaPhe: 4.161 ± 0.092
8.949AlaGly: 8.949 ± 0.156
2.604AlaHis: 2.604 ± 0.086
6.096AlaIle: 6.096 ± 0.12
3.629AlaLys: 3.629 ± 0.103
11.567AlaLeu: 11.567 ± 0.175
2.493AlaMet: 2.493 ± 0.069
2.92AlaAsn: 2.92 ± 0.093
3.803AlaPro: 3.803 ± 0.1
5.014AlaGln: 5.014 ± 0.12
6.947AlaArg: 6.947 ± 0.181
7.466AlaSer: 7.466 ± 0.178
5.947AlaThr: 5.947 ± 0.141
8.202AlaVal: 8.202 ± 0.179
1.125AlaTrp: 1.125 ± 0.054
2.806AlaTyr: 2.806 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.708CysAla: 1.708 ± 0.061
0.268CysCys: 0.268 ± 0.024
0.961CysAsp: 0.961 ± 0.038
0.834CysGlu: 0.834 ± 0.041
0.513CysPhe: 0.513 ± 0.039
1.572CysGly: 1.572 ± 0.071
0.366CysHis: 0.366 ± 0.03
0.902CysIle: 0.902 ± 0.051
0.455CysLys: 0.455 ± 0.033
1.357CysLeu: 1.357 ± 0.057
0.362CysMet: 0.362 ± 0.029
0.404CysAsn: 0.404 ± 0.03
0.808CysPro: 0.808 ± 0.052
0.411CysGln: 0.411 ± 0.032
0.764CysArg: 0.764 ± 0.036
0.827CysSer: 0.827 ± 0.047
0.887CysThr: 0.887 ± 0.042
1.14CysVal: 1.14 ± 0.052
0.115CysTrp: 0.115 ± 0.014
0.374CysTyr: 0.374 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
7.281AspAla: 7.281 ± 0.162
0.713AspCys: 0.713 ± 0.041
3.79AspAsp: 3.79 ± 0.104
4.814AspGlu: 4.814 ± 0.109
2.221AspPhe: 2.221 ± 0.071
4.667AspGly: 4.667 ± 0.121
1.102AspHis: 1.102 ± 0.047
3.769AspIle: 3.769 ± 0.094
2.319AspLys: 2.319 ± 0.077
5.288AspLeu: 5.288 ± 0.123
1.625AspMet: 1.625 ± 0.062
1.853AspAsn: 1.853 ± 0.06
2.659AspPro: 2.659 ± 0.074
1.659AspGln: 1.659 ± 0.058
3.093AspArg: 3.093 ± 0.084
3.44AspSer: 3.44 ± 0.092
3.697AspThr: 3.697 ± 0.089
4.465AspVal: 4.465 ± 0.111
0.693AspTrp: 0.693 ± 0.043
1.946AspTyr: 1.946 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
7.264GluAla: 7.264 ± 0.161
0.683GluCys: 0.683 ± 0.041
3.227GluAsp: 3.227 ± 0.085
4.278GluGlu: 4.278 ± 0.117
1.904GluPhe: 1.904 ± 0.068
4.582GluGly: 4.582 ± 0.108
1.402GluHis: 1.402 ± 0.062
3.152GluIle: 3.152 ± 0.081
2.829GluLys: 2.829 ± 0.096
5.103GluLeu: 5.103 ± 0.123
1.625GluMet: 1.625 ± 0.062
2.01GluAsn: 2.01 ± 0.076
1.882GluPro: 1.882 ± 0.061
2.504GluGln: 2.504 ± 0.084
4.01GluArg: 4.01 ± 0.114
3.554GluSer: 3.554 ± 0.091
3.422GluThr: 3.422 ± 0.081
4.639GluVal: 4.639 ± 0.102
0.504GluTrp: 0.504 ± 0.032
1.619GluTyr: 1.619 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
4.022PheAla: 4.022 ± 0.099
0.67PheCys: 0.67 ± 0.043
2.733PheAsp: 2.733 ± 0.09
2.185PheGlu: 2.185 ± 0.078
1.463PhePhe: 1.463 ± 0.06
3.186PheGly: 3.186 ± 0.099
0.651PheHis: 0.651 ± 0.036
2.416PheIle: 2.416 ± 0.092
1.374PheLys: 1.374 ± 0.057
3.006PheLeu: 3.006 ± 0.101
0.961PheMet: 0.961 ± 0.044
1.238PheAsn: 1.238 ± 0.048
1.442PhePro: 1.442 ± 0.061
0.883PheGln: 0.883 ± 0.046
1.402PheArg: 1.402 ± 0.051
2.799PheSer: 2.799 ± 0.08
2.395PheThr: 2.395 ± 0.073
2.701PheVal: 2.701 ± 0.084
0.436PheTrp: 0.436 ± 0.033
1.055PheTyr: 1.055 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
7.758GlyAla: 7.758 ± 0.154
1.363GlyCys: 1.363 ± 0.064
3.969GlyAsp: 3.969 ± 0.103
4.22GlyGlu: 4.22 ± 0.086
3.15GlyPhe: 3.15 ± 0.09
5.639GlyGly: 5.639 ± 0.138
1.625GlyHis: 1.625 ± 0.059
5.337GlyIle: 5.337 ± 0.111
3.565GlyLys: 3.565 ± 0.088
6.59GlyLeu: 6.59 ± 0.138
2.265GlyMet: 2.265 ± 0.087
2.472GlyAsn: 2.472 ± 0.077
2.057GlyPro: 2.057 ± 0.072
2.523GlyGln: 2.523 ± 0.07
3.918GlyArg: 3.918 ± 0.099
5.203GlySer: 5.203 ± 0.137
4.945GlyThr: 4.945 ± 0.134
6.171GlyVal: 6.171 ± 0.127
0.995GlyTrp: 0.995 ± 0.064
2.559GlyTyr: 2.559 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
2.265HisAla: 2.265 ± 0.07
0.317HisCys: 0.317 ± 0.023
1.349HisAsp: 1.349 ± 0.053
1.332HisGlu: 1.332 ± 0.062
0.717HisPhe: 0.717 ± 0.04
1.587HisGly: 1.587 ± 0.057
0.532HisHis: 0.532 ± 0.035
1.336HisIle: 1.336 ± 0.055
0.679HisLys: 0.679 ± 0.045
1.855HisLeu: 1.855 ± 0.069
0.519HisMet: 0.519 ± 0.032
0.602HisAsn: 0.602 ± 0.035
1.191HisPro: 1.191 ± 0.053
0.657HisGln: 0.657 ± 0.039
1.24HisArg: 1.24 ± 0.05
1.2HisSer: 1.2 ± 0.053
1.327HisThr: 1.327 ± 0.055
1.538HisVal: 1.538 ± 0.061
0.204HisTrp: 0.204 ± 0.021
0.615HisTyr: 0.615 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
7.181IleAla: 7.181 ± 0.141
0.955IleCys: 0.955 ± 0.048
4.599IleAsp: 4.599 ± 0.111
4.169IleGlu: 4.169 ± 0.098
1.746IlePhe: 1.746 ± 0.069
4.584IleGly: 4.584 ± 0.106
1.034IleHis: 1.034 ± 0.042
3.214IleIle: 3.214 ± 0.102
2.031IleLys: 2.031 ± 0.067
4.407IleLeu: 4.407 ± 0.104
1.48IleMet: 1.48 ± 0.061
1.823IleAsn: 1.823 ± 0.061
2.844IlePro: 2.844 ± 0.069
1.5IleGln: 1.5 ± 0.053
2.644IleArg: 2.644 ± 0.085
3.652IleSer: 3.652 ± 0.09
3.565IleThr: 3.565 ± 0.083
4.843IleVal: 4.843 ± 0.105
0.496IleTrp: 0.496 ± 0.033
1.334IleTyr: 1.334 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
3.944LysAla: 3.944 ± 0.104
0.4LysCys: 0.4 ± 0.032
2.129LysAsp: 2.129 ± 0.06
2.282LysGlu: 2.282 ± 0.086
0.876LysPhe: 0.876 ± 0.044
2.597LysGly: 2.597 ± 0.076
0.706LysHis: 0.706 ± 0.041
1.808LysIle: 1.808 ± 0.066
2.091LysLys: 2.091 ± 0.076
3.099LysLeu: 3.099 ± 0.1
1.055LysMet: 1.055 ± 0.049
1.425LysAsn: 1.425 ± 0.056
1.712LysPro: 1.712 ± 0.066
1.697LysGln: 1.697 ± 0.061
2.738LysArg: 2.738 ± 0.09
2.159LysSer: 2.159 ± 0.072
2.512LysThr: 2.512 ± 0.074
2.906LysVal: 2.906 ± 0.077
0.387LysTrp: 0.387 ± 0.036
0.938LysTyr: 0.938 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
10.663LeuAla: 10.663 ± 0.187
1.406LeuCys: 1.406 ± 0.052
5.684LeuAsp: 5.684 ± 0.112
5.084LeuGlu: 5.084 ± 0.117
3.665LeuPhe: 3.665 ± 0.104
6.396LeuGly: 6.396 ± 0.134
1.853LeuHis: 1.853 ± 0.065
5.235LeuIle: 5.235 ± 0.127
3.146LeuLys: 3.146 ± 0.089
7.783LeuLeu: 7.783 ± 0.179
2.253LeuMet: 2.253 ± 0.085
2.616LeuAsn: 2.616 ± 0.077
4.227LeuPro: 4.227 ± 0.108
2.64LeuGln: 2.64 ± 0.07
4.952LeuArg: 4.952 ± 0.118
6.964LeuSer: 6.964 ± 0.141
4.994LeuThr: 4.994 ± 0.091
7.136LeuVal: 7.136 ± 0.143
0.759LeuTrp: 0.759 ± 0.04
2.308LeuTyr: 2.308 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.827MetAla: 2.827 ± 0.093
0.298MetCys: 0.298 ± 0.025
1.357MetAsp: 1.357 ± 0.043
1.376MetGlu: 1.376 ± 0.056
0.753MetPhe: 0.753 ± 0.047
1.97MetGly: 1.97 ± 0.069
0.517MetHis: 0.517 ± 0.029
1.238MetIle: 1.238 ± 0.053
1.234MetLys: 1.234 ± 0.047
2.297MetLeu: 2.297 ± 0.069
0.674MetMet: 0.674 ± 0.039
0.934MetAsn: 0.934 ± 0.041
1.361MetPro: 1.361 ± 0.048
1.01MetGln: 1.01 ± 0.051
1.712MetArg: 1.712 ± 0.065
1.736MetSer: 1.736 ± 0.06
1.368MetThr: 1.368 ± 0.047
1.91MetVal: 1.91 ± 0.077
0.206MetTrp: 0.206 ± 0.02
0.487MetTyr: 0.487 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.463AsnAla: 3.463 ± 0.092
0.391AsnCys: 0.391 ± 0.028
1.725AsnAsp: 1.725 ± 0.069
1.878AsnGlu: 1.878 ± 0.066
0.913AsnPhe: 0.913 ± 0.042
2.387AsnGly: 2.387 ± 0.089
0.617AsnHis: 0.617 ± 0.036
1.774AsnIle: 1.774 ± 0.068
1.191AsnLys: 1.191 ± 0.056
2.631AsnLeu: 2.631 ± 0.076
0.785AsnMet: 0.785 ± 0.042
1.074AsnAsn: 1.074 ± 0.046
2.065AsnPro: 2.065 ± 0.082
1.087AsnGln: 1.087 ± 0.044
1.865AsnArg: 1.865 ± 0.065
1.838AsnSer: 1.838 ± 0.076
1.987AsnThr: 1.987 ± 0.073
2.297AsnVal: 2.297 ± 0.069
0.374AsnTrp: 0.374 ± 0.032
0.876AsnTyr: 0.876 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
4.529ProAla: 4.529 ± 0.109
0.538ProCys: 0.538 ± 0.033
2.912ProAsp: 2.912 ± 0.086
2.693ProGlu: 2.693 ± 0.083
1.778ProPhe: 1.778 ± 0.064
2.938ProGly: 2.938 ± 0.087
0.989ProHis: 0.989 ± 0.047
2.18ProIle: 2.18 ± 0.066
1.212ProLys: 1.212 ± 0.055
3.856ProLeu: 3.856 ± 0.098
0.727ProMet: 0.727 ± 0.038
1.263ProAsn: 1.263 ± 0.047
1.132ProPro: 1.132 ± 0.05
1.655ProGln: 1.655 ± 0.059
1.904ProArg: 1.904 ± 0.06
2.991ProSer: 2.991 ± 0.094
2.627ProThr: 2.627 ± 0.091
3.331ProVal: 3.331 ± 0.084
0.485ProTrp: 0.485 ± 0.032
1.319ProTyr: 1.319 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
4.497GlnAla: 4.497 ± 0.119
0.34GlnCys: 0.34 ± 0.028
1.661GlnAsp: 1.661 ± 0.063
2.031GlnGlu: 2.031 ± 0.068
1.027GlnPhe: 1.027 ± 0.044
2.438GlnGly: 2.438 ± 0.065
0.702GlnHis: 0.702 ± 0.042
1.951GlnIle: 1.951 ± 0.067
1.493GlnLys: 1.493 ± 0.052
2.821GlnLeu: 2.821 ± 0.083
0.989GlnMet: 0.989 ± 0.05
1.108GlnAsn: 1.108 ± 0.054
1.502GlnPro: 1.502 ± 0.06
1.742GlnGln: 1.742 ± 0.064
2.414GlnArg: 2.414 ± 0.078
2.255GlnSer: 2.255 ± 0.085
2.133GlnThr: 2.133 ± 0.053
3.052GlnVal: 3.052 ± 0.081
0.43GlnTrp: 0.43 ± 0.038
0.798GlnTyr: 0.798 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
6.152ArgAla: 6.152 ± 0.135
0.8ArgCys: 0.8 ± 0.04
3.116ArgAsp: 3.116 ± 0.094
3.688ArgGlu: 3.688 ± 0.103
2.338ArgPhe: 2.338 ± 0.08
3.637ArgGly: 3.637 ± 0.097
1.189ArgHis: 1.189 ± 0.049
3.873ArgIle: 3.873 ± 0.092
2.206ArgLys: 2.206 ± 0.07
5.205ArgLeu: 5.205 ± 0.13
1.734ArgMet: 1.734 ± 0.062
1.861ArgAsn: 1.861 ± 0.064
2.053ArgPro: 2.053 ± 0.076
1.995ArgGln: 1.995 ± 0.071
3.89ArgArg: 3.89 ± 0.112
3.45ArgSer: 3.45 ± 0.089
3.12ArgThr: 3.12 ± 0.087
4.088ArgVal: 4.088 ± 0.103
0.576ArgTrp: 0.576 ± 0.037
1.676ArgTyr: 1.676 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
7.053SerAla: 7.053 ± 0.18
0.938SerCys: 0.938 ± 0.055
4.173SerAsp: 4.173 ± 0.103
3.435SerGlu: 3.435 ± 0.095
2.946SerPhe: 2.946 ± 0.077
5.435SerGly: 5.435 ± 0.113
1.415SerHis: 1.415 ± 0.054
3.744SerIle: 3.744 ± 0.101
2.165SerLys: 2.165 ± 0.073
6.145SerLeu: 6.145 ± 0.123
1.744SerMet: 1.744 ± 0.065
2.102SerAsn: 2.102 ± 0.089
2.41SerPro: 2.41 ± 0.077
2.55SerGln: 2.55 ± 0.091
3.463SerArg: 3.463 ± 0.09
5.694SerSer: 5.694 ± 0.213
4.078SerThr: 4.078 ± 0.132
4.656SerVal: 4.656 ± 0.107
0.81SerTrp: 0.81 ± 0.044
1.931SerTyr: 1.931 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
6.281ThrAla: 6.281 ± 0.134
0.925ThrCys: 0.925 ± 0.05
3.512ThrAsp: 3.512 ± 0.095
3.074ThrGlu: 3.074 ± 0.094
2.255ThrPhe: 2.255 ± 0.062
5.028ThrGly: 5.028 ± 0.128
1.285ThrHis: 1.285 ± 0.054
3.565ThrIle: 3.565 ± 0.083
1.891ThrLys: 1.891 ± 0.075
5.477ThrLeu: 5.477 ± 0.13
1.161ThrMet: 1.161 ± 0.054
1.787ThrAsn: 1.787 ± 0.075
3.057ThrPro: 3.057 ± 0.1
2.008ThrGln: 2.008 ± 0.072
2.821ThrArg: 2.821 ± 0.097
4.005ThrSer: 4.005 ± 0.116
3.625ThrThr: 3.625 ± 0.1
5.105ThrVal: 5.105 ± 0.125
0.681ThrTrp: 0.681 ± 0.037
1.659ThrTyr: 1.659 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
8.194ValAla: 8.194 ± 0.163
1.321ValCys: 1.321 ± 0.056
4.871ValAsp: 4.871 ± 0.119
4.363ValGlu: 4.363 ± 0.103
3.142ValPhe: 3.142 ± 0.101
5.679ValGly: 5.679 ± 0.135
1.574ValHis: 1.574 ± 0.059
4.607ValIle: 4.607 ± 0.107
2.75ValLys: 2.75 ± 0.072
7.441ValLeu: 7.441 ± 0.184
1.942ValMet: 1.942 ± 0.065
2.374ValAsn: 2.374 ± 0.087
3.276ValPro: 3.276 ± 0.085
2.367ValGln: 2.367 ± 0.069
4.403ValArg: 4.403 ± 0.121
5.609ValSer: 5.609 ± 0.101
4.331ValThr: 4.331 ± 0.117
6.562ValVal: 6.562 ± 0.134
0.706ValTrp: 0.706 ± 0.044
2.027ValTyr: 2.027 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.906TrpAla: 0.906 ± 0.045
0.174TrpCys: 0.174 ± 0.021
0.657TrpAsp: 0.657 ± 0.037
0.627TrpGlu: 0.627 ± 0.038
0.37TrpPhe: 0.37 ± 0.029
0.874TrpGly: 0.874 ± 0.047
0.247TrpHis: 0.247 ± 0.022
0.608TrpIle: 0.608 ± 0.042
0.404TrpLys: 0.404 ± 0.027
1.032TrpLeu: 1.032 ± 0.052
0.336TrpMet: 0.336 ± 0.031
0.404TrpAsn: 0.404 ± 0.033
0.355TrpPro: 0.355 ± 0.03
0.464TrpGln: 0.464 ± 0.037
0.64TrpArg: 0.64 ± 0.038
0.517TrpSer: 0.517 ± 0.043
0.451TrpThr: 0.451 ± 0.031
0.804TrpVal: 0.804 ± 0.045
0.16TrpTrp: 0.16 ± 0.021
0.391TrpTyr: 0.391 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.848TyrAla: 2.848 ± 0.078
0.445TyrCys: 0.445 ± 0.035
1.789TyrAsp: 1.789 ± 0.067
1.685TyrGlu: 1.685 ± 0.067
1.083TyrPhe: 1.083 ± 0.053
2.18TyrGly: 2.18 ± 0.07
0.653TyrHis: 0.653 ± 0.036
1.295TyrIle: 1.295 ± 0.05
0.798TyrLys: 0.798 ± 0.041
2.804TyrLeu: 2.804 ± 0.079
0.532TyrMet: 0.532 ± 0.033
0.949TyrAsn: 0.949 ± 0.052
1.223TyrPro: 1.223 ± 0.052
1.019TyrGln: 1.019 ± 0.045
1.829TyrArg: 1.829 ± 0.067
1.529TyrSer: 1.529 ± 0.061
1.789TyrThr: 1.789 ± 0.079
1.991TyrVal: 1.991 ± 0.069
0.279TyrTrp: 0.279 ± 0.024
0.853TyrTyr: 0.853 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1355 proteins (470126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski