Amino acid dipepetide frequency for Candidatus Brocadia fulgida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.524AlaAla: 5.524 ± 0.091	1.072AlaCys: 1.072 ± 0.039	3.697AlaAsp: 3.697 ± 0.061	4.708AlaGlu: 4.708 ± 0.073	3.318AlaPhe: 3.318 ± 0.058	5.492AlaGly: 5.492 ± 0.078	1.559AlaHis: 1.559 ± 0.041	5.823AlaIle: 5.823 ± 0.088	4.488AlaLys: 4.488 ± 0.072	7.274AlaLeu: 7.274 ± 0.092	1.969AlaMet: 1.969 ± 0.045	2.496AlaAsn: 2.496 ± 0.048	2.27AlaPro: 2.27 ± 0.056	2.324AlaGln: 2.324 ± 0.057	3.924AlaArg: 3.924 ± 0.065	4.437AlaSer: 4.437 ± 0.072	3.629AlaThr: 3.629 ± 0.082	5.172AlaVal: 5.172 ± 0.082	0.76AlaTrp: 0.76 ± 0.038	2.368AlaTyr: 2.368 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.034	0.256CysCys: 0.256 ± 0.019	0.678CysAsp: 0.678 ± 0.024	0.736CysGlu: 0.736 ± 0.027	0.623CysPhe: 0.623 ± 0.022	1.162CysGly: 1.162 ± 0.041	0.59CysHis: 0.59 ± 0.045	0.941CysIle: 0.941 ± 0.033	0.768CysLys: 0.768 ± 0.031	1.312CysLeu: 1.312 ± 0.037	0.336CysMet: 0.336 ± 0.023	0.588CysAsn: 0.588 ± 0.029	0.709CysPro: 0.709 ± 0.035	0.401CysGln: 0.401 ± 0.018	0.715CysArg: 0.715 ± 0.03	0.832CysSer: 0.832 ± 0.033	0.677CysThr: 0.677 ± 0.027	0.9CysVal: 0.9 ± 0.033	0.135CysTrp: 0.135 ± 0.012	0.482CysTyr: 0.482 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.392AspAla: 4.392 ± 0.072	0.643AspCys: 0.643 ± 0.027	2.631AspAsp: 2.631 ± 0.062	3.763AspGlu: 3.763 ± 0.066	2.476AspPhe: 2.476 ± 0.053	3.691AspGly: 3.691 ± 0.085	0.982AspHis: 0.982 ± 0.036	4.59AspIle: 4.59 ± 0.076	3.487AspLys: 3.487 ± 0.061	4.716AspLeu: 4.716 ± 0.073	1.291AspMet: 1.291 ± 0.036	1.965AspAsn: 1.965 ± 0.044	2.1AspPro: 2.1 ± 0.048	1.298AspGln: 1.298 ± 0.036	2.536AspArg: 2.536 ± 0.048	2.623AspSer: 2.623 ± 0.057	2.983AspThr: 2.983 ± 0.059	3.669AspVal: 3.669 ± 0.063	0.688AspTrp: 0.688 ± 0.031	2.064AspTyr: 2.064 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.76GluAla: 4.76 ± 0.079	0.682GluCys: 0.682 ± 0.026	3.274GluAsp: 3.274 ± 0.059	5.071GluGlu: 5.071 ± 0.099	2.494GluPhe: 2.494 ± 0.054	4.279GluGly: 4.279 ± 0.067	1.359GluHis: 1.359 ± 0.038	5.908GluIle: 5.908 ± 0.083	6.228GluLys: 6.228 ± 0.093	5.729GluLeu: 5.729 ± 0.086	1.884GluMet: 1.884 ± 0.045	2.944GluAsn: 2.944 ± 0.059	1.87GluPro: 1.87 ± 0.049	2.217GluGln: 2.217 ± 0.048	3.992GluArg: 3.992 ± 0.071	3.352GluSer: 3.352 ± 0.053	3.588GluThr: 3.588 ± 0.055	4.297GluVal: 4.297 ± 0.072	0.697GluTrp: 0.697 ± 0.028	2.12GluTyr: 2.12 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.907PheAla: 2.907 ± 0.052	0.767PheCys: 0.767 ± 0.031	2.576PheAsp: 2.576 ± 0.057	2.503PheGlu: 2.503 ± 0.053	2.312PhePhe: 2.312 ± 0.062	3.154PheGly: 3.154 ± 0.062	1.175PheHis: 1.175 ± 0.039	3.149PheIle: 3.149 ± 0.063	2.312PheLys: 2.312 ± 0.05	4.674PheLeu: 4.674 ± 0.088	1.031PheMet: 1.031 ± 0.032	1.72PheAsn: 1.72 ± 0.044	1.823PhePro: 1.823 ± 0.045	1.631PheGln: 1.631 ± 0.04	2.258PheArg: 2.258 ± 0.048	3.139PheSer: 3.139 ± 0.064	2.453PheThr: 2.453 ± 0.054	2.976PheVal: 2.976 ± 0.062	0.493PheTrp: 0.493 ± 0.022	1.604PheTyr: 1.604 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.794GlyAla: 4.794 ± 0.086	1.127GlyCys: 1.127 ± 0.037	3.328GlyAsp: 3.328 ± 0.072	4.262GlyGlu: 4.262 ± 0.066	3.302GlyPhe: 3.302 ± 0.067	4.808GlyGly: 4.808 ± 0.099	1.473GlyHis: 1.473 ± 0.038	6.299GlyIle: 6.299 ± 0.08	5.517GlyLys: 5.517 ± 0.082	6.119GlyLeu: 6.119 ± 0.09	2.113GlyMet: 2.113 ± 0.044	3.306GlyAsn: 3.306 ± 0.065	1.714GlyPro: 1.714 ± 0.052	1.934GlyGln: 1.934 ± 0.048	3.546GlyArg: 3.546 ± 0.061	4.047GlySer: 4.047 ± 0.077	3.879GlyThr: 3.879 ± 0.076	4.824GlyVal: 4.824 ± 0.076	0.835GlyTrp: 0.835 ± 0.031	2.671GlyTyr: 2.671 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.776HisAla: 1.776 ± 0.049	0.349HisCys: 0.349 ± 0.02	1.172HisAsp: 1.172 ± 0.036	1.423HisGlu: 1.423 ± 0.043	1.042HisPhe: 1.042 ± 0.032	1.694HisGly: 1.694 ± 0.038	0.658HisHis: 0.658 ± 0.028	1.653HisIle: 1.653 ± 0.037	1.286HisLys: 1.286 ± 0.036	2.183HisLeu: 2.183 ± 0.054	0.518HisMet: 0.518 ± 0.025	0.906HisAsn: 0.906 ± 0.031	1.196HisPro: 1.196 ± 0.038	0.706HisGln: 0.706 ± 0.026	1.127HisArg: 1.127 ± 0.03	1.163HisSer: 1.163 ± 0.033	1.271HisThr: 1.271 ± 0.037	1.462HisVal: 1.462 ± 0.042	0.27HisTrp: 0.27 ± 0.017	0.89HisTyr: 0.89 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.166IleAla: 6.166 ± 0.082	1.007IleCys: 1.007 ± 0.034	4.197IleAsp: 4.197 ± 0.072	4.889IleGlu: 4.889 ± 0.075	3.213IlePhe: 3.213 ± 0.071	4.983IleGly: 4.983 ± 0.086	1.77IleHis: 1.77 ± 0.045	5.487IleIle: 5.487 ± 0.085	4.799IleLys: 4.799 ± 0.073	6.947IleLeu: 6.947 ± 0.109	1.657IleMet: 1.657 ± 0.044	2.973IleAsn: 2.973 ± 0.054	3.791IlePro: 3.791 ± 0.06	2.538IleGln: 2.538 ± 0.048	4.135IleArg: 4.135 ± 0.066	5.107IleSer: 5.107 ± 0.073	4.638IleThr: 4.638 ± 0.071	5.206IleVal: 5.206 ± 0.077	0.635IleTrp: 0.635 ± 0.026	2.167IleTyr: 2.167 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.771LysAla: 4.771 ± 0.087	0.686LysCys: 0.686 ± 0.032	3.967LysAsp: 3.967 ± 0.067	5.88LysGlu: 5.88 ± 0.074	2.135LysPhe: 2.135 ± 0.047	4.759LysGly: 4.759 ± 0.07	1.347LysHis: 1.347 ± 0.031	5.459LysIle: 5.459 ± 0.089	6.299LysLys: 6.299 ± 0.099	5.442LysLeu: 5.442 ± 0.078	1.847LysMet: 1.847 ± 0.041	3.524LysAsn: 3.524 ± 0.067	2.551LysPro: 2.551 ± 0.053	2.222LysGln: 2.222 ± 0.058	3.923LysArg: 3.923 ± 0.067	3.496LysSer: 3.496 ± 0.059	4.11LysThr: 4.11 ± 0.073	4.257LysVal: 4.257 ± 0.065	0.582LysTrp: 0.582 ± 0.028	2.368LysTyr: 2.368 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.809LeuAla: 6.809 ± 0.093	1.347LeuCys: 1.347 ± 0.036	4.631LeuAsp: 4.631 ± 0.075	6.032LeuGlu: 6.032 ± 0.089	4.402LeuPhe: 4.402 ± 0.082	6.118LeuGly: 6.118 ± 0.084	2.018LeuHis: 2.018 ± 0.042	6.321LeuIle: 6.321 ± 0.086	6.799LeuLys: 6.799 ± 0.089	8.92LeuLeu: 8.92 ± 0.108	2.16LeuMet: 2.16 ± 0.042	3.736LeuAsn: 3.736 ± 0.062	4.264LeuPro: 4.264 ± 0.067	3.239LeuGln: 3.239 ± 0.061	5.264LeuArg: 5.264 ± 0.079	6.783LeuSer: 6.783 ± 0.089	4.936LeuThr: 4.936 ± 0.06	5.699LeuVal: 5.699 ± 0.075	1.006LeuTrp: 1.006 ± 0.038	2.875LeuTyr: 2.875 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.95MetAla: 1.95 ± 0.048	0.284MetCys: 0.284 ± 0.018	1.271MetAsp: 1.271 ± 0.036	1.604MetGlu: 1.604 ± 0.038	0.79MetPhe: 0.79 ± 0.026	1.821MetGly: 1.821 ± 0.04	0.548MetHis: 0.548 ± 0.022	1.729MetIle: 1.729 ± 0.047	2.244MetLys: 2.244 ± 0.047	2.168MetLeu: 2.168 ± 0.048	0.627MetMet: 0.627 ± 0.026	1.163MetAsn: 1.163 ± 0.032	1.116MetPro: 1.116 ± 0.036	0.866MetGln: 0.866 ± 0.027	1.351MetArg: 1.351 ± 0.034	1.532MetSer: 1.532 ± 0.04	1.302MetThr: 1.302 ± 0.036	1.713MetVal: 1.713 ± 0.043	0.202MetTrp: 0.202 ± 0.015	0.636MetTyr: 0.636 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.032AsnAla: 3.032 ± 0.061	0.516AsnCys: 0.516 ± 0.027	2.267AsnAsp: 2.267 ± 0.055	2.522AsnGlu: 2.522 ± 0.048	1.698AsnPhe: 1.698 ± 0.039	2.605AsnGly: 2.605 ± 0.062	0.899AsnHis: 0.899 ± 0.029	3.34AsnIle: 3.34 ± 0.058	2.618AsnLys: 2.618 ± 0.061	4.031AsnLeu: 4.031 ± 0.062	0.888AsnMet: 0.888 ± 0.03	1.903AsnAsn: 1.903 ± 0.054	2.291AsnPro: 2.291 ± 0.059	1.327AsnGln: 1.327 ± 0.043	2.141AsnArg: 2.141 ± 0.046	2.144AsnSer: 2.144 ± 0.052	2.403AsnThr: 2.403 ± 0.058	2.711AsnVal: 2.711 ± 0.054	0.458AsnTrp: 0.458 ± 0.022	1.518AsnTyr: 1.518 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.973ProAla: 2.973 ± 0.063	0.567ProCys: 0.567 ± 0.023	2.589ProAsp: 2.589 ± 0.052	3.223ProGlu: 3.223 ± 0.062	2.061ProPhe: 2.061 ± 0.045	2.892ProGly: 2.892 ± 0.057	1.018ProHis: 1.018 ± 0.034	2.42ProIle: 2.42 ± 0.053	2.223ProLys: 2.223 ± 0.05	3.862ProLeu: 3.862 ± 0.067	0.879ProMet: 0.879 ± 0.032	1.41ProAsn: 1.41 ± 0.039	1.652ProPro: 1.652 ± 0.044	1.296ProGln: 1.296 ± 0.033	1.793ProArg: 1.793 ± 0.042	2.357ProSer: 2.357 ± 0.055	1.937ProThr: 1.937 ± 0.052	3.297ProVal: 3.297 ± 0.065	0.491ProTrp: 0.491 ± 0.023	1.465ProTyr: 1.465 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	2.308GlnAla: 2.308 ± 0.048	0.401GlnCys: 0.401 ± 0.022	1.549GlnAsp: 1.549 ± 0.039	2.364GlnGlu: 2.364 ± 0.054	1.263GlnPhe: 1.263 ± 0.037	2.209GlnGly: 2.209 ± 0.053	0.721GlnHis: 0.721 ± 0.028	2.433GlnIle: 2.433 ± 0.052	2.749GlnLys: 2.749 ± 0.05	2.629GlnLeu: 2.629 ± 0.057	0.871GlnMet: 0.871 ± 0.028	1.384GlnAsn: 1.384 ± 0.039	1.24GlnPro: 1.24 ± 0.037	1.302GlnGln: 1.302 ± 0.045	1.966GlnArg: 1.966 ± 0.044	1.736GlnSer: 1.736 ± 0.045	1.688GlnThr: 1.688 ± 0.041	1.961GlnVal: 1.961 ± 0.048	0.393GlnTrp: 0.393 ± 0.021	1.11GlnTyr: 1.11 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.247ArgAla: 3.247 ± 0.058	0.766ArgCys: 0.766 ± 0.033	2.819ArgAsp: 2.819 ± 0.05	4.062ArgGlu: 4.062 ± 0.073	2.552ArgPhe: 2.552 ± 0.055	3.192ArgGly: 3.192 ± 0.059	1.357ArgHis: 1.357 ± 0.038	4.349ArgIle: 4.349 ± 0.076	3.868ArgLys: 3.868 ± 0.067	5.124ArgLeu: 5.124 ± 0.091	1.534ArgMet: 1.534 ± 0.041	2.427ArgAsn: 2.427 ± 0.045	1.841ArgPro: 1.841 ± 0.044	1.926ArgGln: 1.926 ± 0.045	3.016ArgArg: 3.016 ± 0.064	2.753ArgSer: 2.753 ± 0.054	2.523ArgThr: 2.523 ± 0.049	3.345ArgVal: 3.345 ± 0.063	0.645ArgTrp: 0.645 ± 0.027	2.187ArgTyr: 2.187 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.152SerAla: 4.152 ± 0.065	0.807SerCys: 0.807 ± 0.032	3.1SerAsp: 3.1 ± 0.057	3.562SerGlu: 3.562 ± 0.068	3.031SerPhe: 3.031 ± 0.05	4.89SerGly: 4.89 ± 0.093	1.292SerHis: 1.292 ± 0.034	4.294SerIle: 4.294 ± 0.07	3.382SerLys: 3.382 ± 0.065	6.261SerLeu: 6.261 ± 0.091	1.468SerMet: 1.468 ± 0.037	2.144SerAsn: 2.144 ± 0.052	2.743SerPro: 2.743 ± 0.065	1.907SerGln: 1.907 ± 0.038	3.104SerArg: 3.104 ± 0.06	3.68SerSer: 3.68 ± 0.076	2.801SerThr: 2.801 ± 0.05	4.154SerVal: 4.154 ± 0.07	0.697SerTrp: 0.697 ± 0.029	1.933SerTyr: 1.933 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.044ThrAla: 4.044 ± 0.066	0.717ThrCys: 0.717 ± 0.028	2.747ThrAsp: 2.747 ± 0.054	3.159ThrGlu: 3.159 ± 0.062	2.376ThrPhe: 2.376 ± 0.053	4.52ThrGly: 4.52 ± 0.074	1.225ThrHis: 1.225 ± 0.037	4.267ThrIle: 4.267 ± 0.074	3.076ThrLys: 3.076 ± 0.062	5.185ThrLeu: 5.185 ± 0.075	1.267ThrMet: 1.267 ± 0.037	2.046ThrAsn: 2.046 ± 0.053	2.639ThrPro: 2.639 ± 0.061	1.556ThrGln: 1.556 ± 0.041	2.633ThrArg: 2.633 ± 0.051	3.03ThrSer: 3.03 ± 0.058	3.103ThrThr: 3.103 ± 0.073	4.012ThrVal: 4.012 ± 0.077	0.574ThrTrp: 0.574 ± 0.025	1.729ThrTyr: 1.729 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.79ValAla: 4.79 ± 0.08	1.109ValCys: 1.109 ± 0.029	3.503ValAsp: 3.503 ± 0.062	4.091ValGlu: 4.091 ± 0.078	3.345ValPhe: 3.345 ± 0.065	4.438ValGly: 4.438 ± 0.079	1.492ValHis: 1.492 ± 0.044	5.142ValIle: 5.142 ± 0.084	4.543ValLys: 4.543 ± 0.082	6.143ValLeu: 6.143 ± 0.083	1.716ValMet: 1.716 ± 0.038	2.764ValAsn: 2.764 ± 0.047	2.627ValPro: 2.627 ± 0.062	1.856ValGln: 1.856 ± 0.046	3.433ValArg: 3.433 ± 0.067	4.748ValSer: 4.748 ± 0.081	3.801ValThr: 3.801 ± 0.073	5.05ValVal: 5.05 ± 0.084	0.711ValTrp: 0.711 ± 0.032	2.073ValTyr: 2.073 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.629TrpAla: 0.629 ± 0.027	0.166TrpCys: 0.166 ± 0.012	0.617TrpAsp: 0.617 ± 0.027	0.747TrpGlu: 0.747 ± 0.031	0.527TrpPhe: 0.527 ± 0.025	0.713TrpGly: 0.713 ± 0.027	0.292TrpHis: 0.292 ± 0.017	0.771TrpIle: 0.771 ± 0.028	0.802TrpLys: 0.802 ± 0.028	1.111TrpLeu: 1.111 ± 0.039	0.31TrpMet: 0.31 ± 0.018	0.526TrpAsn: 0.526 ± 0.024	0.358TrpPro: 0.358 ± 0.02	0.44TrpGln: 0.44 ± 0.023	0.624TrpArg: 0.624 ± 0.026	0.548TrpSer: 0.548 ± 0.025	0.5TrpThr: 0.5 ± 0.019	0.638TrpVal: 0.638 ± 0.028	0.164TrpTrp: 0.164 ± 0.014	0.366TrpTyr: 0.366 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.315TyrAla: 2.315 ± 0.049	0.542TyrCys: 0.542 ± 0.026	1.973TyrAsp: 1.973 ± 0.05	2.147TyrGlu: 2.147 ± 0.047	1.696TyrPhe: 1.696 ± 0.046	2.478TyrGly: 2.478 ± 0.06	0.971TyrHis: 0.971 ± 0.036	1.931TyrIle: 1.931 ± 0.042	2.133TyrLys: 2.133 ± 0.042	3.529TyrLeu: 3.529 ± 0.069	0.551TyrMet: 0.551 ± 0.025	1.383TyrAsn: 1.383 ± 0.041	1.612TyrPro: 1.612 ± 0.043	1.292TyrGln: 1.292 ± 0.038	2.05TyrArg: 2.05 ± 0.048	1.895TyrSer: 1.895 ± 0.051	1.683TyrThr: 1.683 ± 0.041	2.034TyrVal: 2.034 ± 0.045	0.411TyrTrp: 0.411 ± 0.023	1.363TyrTyr: 1.363 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3391 proteins (980976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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