Amino acid dipepetide frequency for Sphingopyxis lindanitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.532AlaAla: 21.532 ± 0.219	1.037AlaCys: 1.037 ± 0.03	8.594AlaAsp: 8.594 ± 0.096	7.679AlaGlu: 7.679 ± 0.093	4.549AlaPhe: 4.549 ± 0.064	11.82AlaGly: 11.82 ± 0.116	2.414AlaHis: 2.414 ± 0.049	7.344AlaIle: 7.344 ± 0.077	4.471AlaLys: 4.471 ± 0.068	13.914AlaLeu: 13.914 ± 0.126	4.085AlaMet: 4.085 ± 0.058	3.256AlaAsn: 3.256 ± 0.061	6.765AlaPro: 6.765 ± 0.082	4.066AlaGln: 4.066 ± 0.06	9.914AlaArg: 9.914 ± 0.106	6.838AlaSer: 6.838 ± 0.079	6.779AlaThr: 6.779 ± 0.093	8.686AlaVal: 8.686 ± 0.101	1.712AlaTrp: 1.712 ± 0.045	2.636AlaTyr: 2.636 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.029	0.106CysCys: 0.106 ± 0.01	0.542CysAsp: 0.542 ± 0.022	0.405CysGlu: 0.405 ± 0.017	0.286CysPhe: 0.286 ± 0.015	0.841CysGly: 0.841 ± 0.026	0.241CysHis: 0.241 ± 0.016	0.389CysIle: 0.389 ± 0.019	0.161CysLys: 0.161 ± 0.011	0.661CysLeu: 0.661 ± 0.025	0.157CysMet: 0.157 ± 0.012	0.223CysAsn: 0.223 ± 0.012	0.446CysPro: 0.446 ± 0.022	0.198CysGln: 0.198 ± 0.011	0.591CysArg: 0.591 ± 0.025	0.45CysSer: 0.45 ± 0.021	0.368CysThr: 0.368 ± 0.016	0.519CysVal: 0.519 ± 0.021	0.114CysTrp: 0.114 ± 0.009	0.186CysTyr: 0.186 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.533AspAla: 8.533 ± 0.085	0.502AspCys: 0.502 ± 0.022	3.629AspAsp: 3.629 ± 0.057	3.428AspGlu: 3.428 ± 0.054	2.258AspPhe: 2.258 ± 0.043	5.891AspGly: 5.891 ± 0.078	1.426AspHis: 1.426 ± 0.037	3.224AspIle: 3.224 ± 0.048	1.748AspLys: 1.748 ± 0.039	5.889AspLeu: 5.889 ± 0.07	1.492AspMet: 1.492 ± 0.042	1.349AspAsn: 1.349 ± 0.039	3.896AspPro: 3.896 ± 0.052	1.71AspGln: 1.71 ± 0.04	5.148AspArg: 5.148 ± 0.078	2.411AspSer: 2.411 ± 0.05	2.66AspThr: 2.66 ± 0.045	4.045AspVal: 4.045 ± 0.058	1.202AspTrp: 1.202 ± 0.033	1.812AspTyr: 1.812 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.756GluAla: 7.756 ± 0.095	0.333GluCys: 0.333 ± 0.018	2.48GluAsp: 2.48 ± 0.05	2.654GluGlu: 2.654 ± 0.057	1.471GluPhe: 1.471 ± 0.037	4.375GluGly: 4.375 ± 0.056	1.011GluHis: 1.011 ± 0.03	2.934GluIle: 2.934 ± 0.051	1.9GluLys: 1.9 ± 0.041	4.862GluLeu: 4.862 ± 0.072	1.383GluMet: 1.383 ± 0.032	1.297GluAsn: 1.297 ± 0.035	2.455GluPro: 2.455 ± 0.051	1.88GluGln: 1.88 ± 0.037	4.825GluArg: 4.825 ± 0.075	2.272GluSer: 2.272 ± 0.04	2.987GluThr: 2.987 ± 0.05	3.386GluVal: 3.386 ± 0.059	0.76GluTrp: 0.76 ± 0.024	1.023GluTyr: 1.023 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	5.134PheAla: 5.134 ± 0.056	0.332PheCys: 0.332 ± 0.015	2.801PheAsp: 2.801 ± 0.043	1.97PheGlu: 1.97 ± 0.044	1.291PhePhe: 1.291 ± 0.037	3.783PheGly: 3.783 ± 0.06	0.753PheHis: 0.753 ± 0.029	1.428PheIle: 1.428 ± 0.033	0.844PheLys: 0.844 ± 0.029	3.105PheLeu: 3.105 ± 0.052	0.701PheMet: 0.701 ± 0.025	1.051PheAsn: 1.051 ± 0.033	1.571PhePro: 1.571 ± 0.034	0.915PheGln: 0.915 ± 0.029	2.239PheArg: 2.239 ± 0.046	1.996PheSer: 1.996 ± 0.044	1.934PheThr: 1.934 ± 0.044	2.543PheVal: 2.543 ± 0.044	0.51PheTrp: 0.51 ± 0.021	0.876PheTyr: 0.876 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.769GlyAla: 10.769 ± 0.114	0.828GlyCys: 0.828 ± 0.028	5.446GlyAsp: 5.446 ± 0.071	4.986GlyGlu: 4.986 ± 0.068	3.681GlyPhe: 3.681 ± 0.056	8.697GlyGly: 8.697 ± 0.159	1.895GlyHis: 1.895 ± 0.042	4.594GlyIle: 4.594 ± 0.063	3.32GlyLys: 3.32 ± 0.06	8.735GlyLeu: 8.735 ± 0.093	2.31GlyMet: 2.31 ± 0.045	2.18GlyAsn: 2.18 ± 0.06	3.738GlyPro: 3.738 ± 0.061	2.993GlyGln: 2.993 ± 0.047	6.579GlyArg: 6.579 ± 0.084	4.832GlySer: 4.832 ± 0.08	4.753GlyThr: 4.753 ± 0.096	6.226GlyVal: 6.226 ± 0.083	1.664GlyTrp: 1.664 ± 0.036	2.344GlyTyr: 2.344 ± 0.05	0.001GlyXaa: 0.001 ± 0.001
His	2.388HisAla: 2.388 ± 0.051	0.261HisCys: 0.261 ± 0.016	1.269HisAsp: 1.269 ± 0.038	0.962HisGlu: 0.962 ± 0.028	0.863HisPhe: 0.863 ± 0.029	2.011HisGly: 2.011 ± 0.043	0.597HisHis: 0.597 ± 0.023	1.069HisIle: 1.069 ± 0.029	0.456HisLys: 0.456 ± 0.019	1.867HisLeu: 1.867 ± 0.042	0.491HisMet: 0.491 ± 0.02	0.445HisAsn: 0.445 ± 0.018	1.323HisPro: 1.323 ± 0.037	0.554HisGln: 0.554 ± 0.019	1.525HisArg: 1.525 ± 0.032	0.982HisSer: 0.982 ± 0.031	0.633HisThr: 0.633 ± 0.024	1.453HisVal: 1.453 ± 0.04	0.388HisTrp: 0.388 ± 0.02	0.581HisTyr: 0.581 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	8.35IleAla: 8.35 ± 0.09	0.439IleCys: 0.439 ± 0.02	4.357IleAsp: 4.357 ± 0.064	3.473IleGlu: 3.473 ± 0.064	1.775IlePhe: 1.775 ± 0.04	5.212IleGly: 5.212 ± 0.066	0.932IleHis: 0.932 ± 0.028	2.217IleIle: 2.217 ± 0.046	1.211IleLys: 1.211 ± 0.036	4.312IleLeu: 4.312 ± 0.069	0.863IleMet: 0.863 ± 0.025	1.284IleAsn: 1.284 ± 0.032	2.28IlePro: 2.28 ± 0.038	1.081IleGln: 1.081 ± 0.03	3.214IleArg: 3.214 ± 0.049	2.551IleSer: 2.551 ± 0.047	2.403IleThr: 2.403 ± 0.047	4.206IleVal: 4.206 ± 0.06	0.694IleTrp: 0.694 ± 0.024	1.039IleTyr: 1.039 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.261LysAla: 4.261 ± 0.075	0.155LysCys: 0.155 ± 0.011	1.59LysAsp: 1.59 ± 0.042	1.237LysGlu: 1.237 ± 0.034	0.849LysPhe: 0.849 ± 0.025	2.687LysGly: 2.687 ± 0.048	0.524LysHis: 0.524 ± 0.022	1.529LysIle: 1.529 ± 0.037	1.106LysLys: 1.106 ± 0.041	3.098LysLeu: 3.098 ± 0.053	0.753LysMet: 0.753 ± 0.03	0.71LysAsn: 0.71 ± 0.027	1.975LysPro: 1.975 ± 0.039	0.935LysGln: 0.935 ± 0.026	2.234LysArg: 2.234 ± 0.043	1.601LysSer: 1.601 ± 0.035	1.623LysThr: 1.623 ± 0.039	2.086LysVal: 2.086 ± 0.047	0.406LysTrp: 0.406 ± 0.019	0.605LysTyr: 0.605 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.487LeuAla: 14.487 ± 0.135	0.776LeuCys: 0.776 ± 0.026	6.107LeuAsp: 6.107 ± 0.072	4.154LeuGlu: 4.154 ± 0.056	3.757LeuPhe: 3.757 ± 0.062	8.342LeuGly: 8.342 ± 0.084	1.819LeuHis: 1.819 ± 0.041	4.928LeuIle: 4.928 ± 0.072	2.883LeuLys: 2.883 ± 0.052	9.356LeuLeu: 9.356 ± 0.127	2.083LeuMet: 2.083 ± 0.037	2.3LeuAsn: 2.3 ± 0.046	5.443LeuPro: 5.443 ± 0.063	2.302LeuGln: 2.302 ± 0.043	6.611LeuArg: 6.611 ± 0.079	5.753LeuSer: 5.753 ± 0.081	5.472LeuThr: 5.472 ± 0.069	7.116LeuVal: 7.116 ± 0.07	1.288LeuTrp: 1.288 ± 0.035	2.019LeuTyr: 2.019 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.423MetAla: 3.423 ± 0.052	0.167MetCys: 0.167 ± 0.012	1.094MetAsp: 1.094 ± 0.031	1.061MetGlu: 1.061 ± 0.034	0.685MetPhe: 0.685 ± 0.025	1.886MetGly: 1.886 ± 0.039	0.414MetHis: 0.414 ± 0.018	1.435MetIle: 1.435 ± 0.035	0.865MetLys: 0.865 ± 0.025	2.609MetLeu: 2.609 ± 0.042	0.675MetMet: 0.675 ± 0.03	0.65MetAsn: 0.65 ± 0.025	1.422MetPro: 1.422 ± 0.032	0.741MetGln: 0.741 ± 0.026	1.848MetArg: 1.848 ± 0.04	1.417MetSer: 1.417 ± 0.039	1.866MetThr: 1.866 ± 0.038	1.599MetVal: 1.599 ± 0.036	0.237MetTrp: 0.237 ± 0.013	0.252MetTyr: 0.252 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.13AsnAla: 3.13 ± 0.056	0.246AsnCys: 0.246 ± 0.014	1.367AsnAsp: 1.367 ± 0.032	1.085AsnGlu: 1.085 ± 0.034	1.031AsnPhe: 1.031 ± 0.03	2.406AsnGly: 2.406 ± 0.055	0.447AsnHis: 0.447 ± 0.017	1.453AsnIle: 1.453 ± 0.039	0.65AsnLys: 0.65 ± 0.022	2.358AsnLeu: 2.358 ± 0.054	0.579AsnMet: 0.579 ± 0.022	0.663AsnAsn: 0.663 ± 0.026	1.764AsnPro: 1.764 ± 0.041	0.713AsnGln: 0.713 ± 0.023	1.88AsnArg: 1.88 ± 0.037	1.277AsnSer: 1.277 ± 0.041	0.989AsnThr: 0.989 ± 0.033	1.658AsnVal: 1.658 ± 0.041	0.422AsnTrp: 0.422 ± 0.017	0.71AsnTyr: 0.71 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.226ProAla: 7.226 ± 0.095	0.332ProCys: 0.332 ± 0.015	3.948ProAsp: 3.948 ± 0.053	3.164ProGlu: 3.164 ± 0.047	1.864ProPhe: 1.864 ± 0.044	5.002ProGly: 5.002 ± 0.063	1.081ProHis: 1.081 ± 0.03	2.468ProIle: 2.468 ± 0.044	1.557ProLys: 1.557 ± 0.041	5.031ProLeu: 5.031 ± 0.065	1.275ProMet: 1.275 ± 0.029	1.265ProAsn: 1.265 ± 0.034	2.975ProPro: 2.975 ± 0.072	1.63ProGln: 1.63 ± 0.039	3.172ProArg: 3.172 ± 0.057	2.674ProSer: 2.674 ± 0.048	2.661ProThr: 2.661 ± 0.05	4.275ProVal: 4.275 ± 0.065	0.699ProTrp: 0.699 ± 0.026	1.105ProTyr: 1.105 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.943GlnAla: 3.943 ± 0.067	0.205GlnCys: 0.205 ± 0.011	1.447GlnAsp: 1.447 ± 0.034	1.152GlnGlu: 1.152 ± 0.033	1.085GlnPhe: 1.085 ± 0.031	2.404GlnGly: 2.404 ± 0.043	0.589GlnHis: 0.589 ± 0.023	1.769GlnIle: 1.769 ± 0.039	0.899GlnLys: 0.899 ± 0.027	2.979GlnLeu: 2.979 ± 0.046	0.778GlnMet: 0.778 ± 0.023	0.741GlnAsn: 0.741 ± 0.025	1.737GlnPro: 1.737 ± 0.034	1.108GlnGln: 1.108 ± 0.032	2.391GlnArg: 2.391 ± 0.042	1.665GlnSer: 1.665 ± 0.036	1.488GlnThr: 1.488 ± 0.036	1.994GlnVal: 1.994 ± 0.04	0.467GlnTrp: 0.467 ± 0.019	0.639GlnTyr: 0.639 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.22ArgAla: 9.22 ± 0.102	0.535ArgCys: 0.535 ± 0.021	4.489ArgAsp: 4.489 ± 0.074	3.918ArgGlu: 3.918 ± 0.076	3.054ArgPhe: 3.054 ± 0.054	5.362ArgGly: 5.362 ± 0.067	1.805ArgHis: 1.805 ± 0.04	4.268ArgIle: 4.268 ± 0.063	2.072ArgLys: 2.072 ± 0.041	7.952ArgLeu: 7.952 ± 0.09	1.976ArgMet: 1.976 ± 0.04	1.724ArgAsn: 1.724 ± 0.036	3.726ArgPro: 3.726 ± 0.059	2.454ArgGln: 2.454 ± 0.04	5.728ArgArg: 5.728 ± 0.088	3.604ArgSer: 3.604 ± 0.054	3.481ArgThr: 3.481 ± 0.05	4.782ArgVal: 4.782 ± 0.057	1.294ArgTrp: 1.294 ± 0.033	1.831ArgTyr: 1.831 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.418SerAla: 6.418 ± 0.075	0.397SerCys: 0.397 ± 0.02	3.353SerAsp: 3.353 ± 0.052	2.504SerGlu: 2.504 ± 0.043	2.25SerPhe: 2.25 ± 0.043	5.432SerGly: 5.432 ± 0.079	0.991SerHis: 0.991 ± 0.031	2.759SerIle: 2.759 ± 0.053	1.389SerLys: 1.389 ± 0.038	5.122SerLeu: 5.122 ± 0.071	1.145SerMet: 1.145 ± 0.029	1.348SerAsn: 1.348 ± 0.033	2.782SerPro: 2.782 ± 0.045	1.489SerGln: 1.489 ± 0.039	3.426SerArg: 3.426 ± 0.05	2.706SerSer: 2.706 ± 0.056	2.359SerThr: 2.359 ± 0.046	3.584SerVal: 3.584 ± 0.056	0.788SerTrp: 0.788 ± 0.026	1.36SerTyr: 1.36 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.461ThrAla: 6.461 ± 0.09	0.363ThrCys: 0.363 ± 0.016	2.956ThrAsp: 2.956 ± 0.05	2.216ThrGlu: 2.216 ± 0.041	1.612ThrPhe: 1.612 ± 0.039	5.314ThrGly: 5.314 ± 0.087	1.01ThrHis: 1.01 ± 0.029	3.027ThrIle: 3.027 ± 0.051	1.307ThrLys: 1.307 ± 0.032	5.662ThrLeu: 5.662 ± 0.075	1.223ThrMet: 1.223 ± 0.031	1.292ThrAsn: 1.292 ± 0.04	3.44ThrPro: 3.44 ± 0.051	1.328ThrGln: 1.328 ± 0.034	3.403ThrArg: 3.403 ± 0.05	2.626ThrSer: 2.626 ± 0.047	2.52ThrThr: 2.52 ± 0.059	3.757ThrVal: 3.757 ± 0.065	0.581ThrTrp: 0.581 ± 0.02	1.076ThrTyr: 1.076 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.833ValAla: 9.833 ± 0.111	0.509ValCys: 0.509 ± 0.021	4.382ValAsp: 4.382 ± 0.053	4.311ValGlu: 4.311 ± 0.069	1.998ValPhe: 1.998 ± 0.047	5.948ValGly: 5.948 ± 0.076	1.307ValHis: 1.307 ± 0.033	3.442ValIle: 3.442 ± 0.055	2.05ValLys: 2.05 ± 0.048	5.628ValLeu: 5.628 ± 0.07	1.608ValMet: 1.608 ± 0.034	1.952ValAsn: 1.952 ± 0.044	3.848ValPro: 3.848 ± 0.057	2.002ValGln: 2.002 ± 0.043	5.175ValArg: 5.175 ± 0.07	3.789ValSer: 3.789 ± 0.06	4.343ValThr: 4.343 ± 0.064	4.924ValVal: 4.924 ± 0.071	0.821ValTrp: 0.821 ± 0.029	1.323ValTyr: 1.323 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.463TrpAla: 1.463 ± 0.039	0.144TrpCys: 0.144 ± 0.01	0.824TrpAsp: 0.824 ± 0.028	0.59TrpGlu: 0.59 ± 0.024	0.568TrpPhe: 0.568 ± 0.024	0.93TrpGly: 0.93 ± 0.03	0.358TrpHis: 0.358 ± 0.016	0.729TrpIle: 0.729 ± 0.027	0.486TrpLys: 0.486 ± 0.022	1.782TrpLeu: 1.782 ± 0.037	0.355TrpMet: 0.355 ± 0.017	0.471TrpAsn: 0.471 ± 0.02	0.725TrpPro: 0.725 ± 0.024	0.652TrpGln: 0.652 ± 0.022	1.384TrpArg: 1.384 ± 0.037	0.923TrpSer: 0.923 ± 0.029	0.892TrpThr: 0.892 ± 0.03	0.856TrpVal: 0.856 ± 0.029	0.257TrpTrp: 0.257 ± 0.016	0.297TrpTyr: 0.297 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.738TyrAla: 2.738 ± 0.044	0.245TyrCys: 0.245 ± 0.016	1.574TyrAsp: 1.574 ± 0.038	1.095TyrGlu: 1.095 ± 0.031	0.851TyrPhe: 0.851 ± 0.024	2.23TyrGly: 2.23 ± 0.045	0.505TyrHis: 0.505 ± 0.022	0.883TyrIle: 0.883 ± 0.03	0.588TyrLys: 0.588 ± 0.026	2.074TyrLeu: 2.074 ± 0.04	0.411TyrMet: 0.411 ± 0.02	0.629TyrAsn: 0.629 ± 0.025	1.096TyrPro: 1.096 ± 0.03	0.73TyrGln: 0.73 ± 0.029	1.989TyrArg: 1.989 ± 0.043	1.234TyrSer: 1.234 ± 0.033	0.964TyrThr: 0.964 ± 0.029	1.494TyrVal: 1.494 ± 0.036	0.384TyrTrp: 0.384 ± 0.016	0.685TyrTyr: 0.685 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4026 proteins (1288095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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