Amino acid dipepetide frequency for Streptococcus phage CHPC930

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.237AlaAla: 3.237 ± 0.938
0.27AlaCys: 0.27 ± 0.141
4.496AlaAsp: 4.496 ± 0.698
4.136AlaGlu: 4.136 ± 0.402
2.068AlaPhe: 2.068 ± 0.618
3.866AlaGly: 3.866 ± 0.873
0.629AlaHis: 0.629 ± 0.235
4.945AlaIle: 4.945 ± 0.737
5.305AlaLys: 5.305 ± 0.895
5.664AlaLeu: 5.664 ± 0.707
1.529AlaMet: 1.529 ± 0.387
4.226AlaAsn: 4.226 ± 0.684
1.888AlaPro: 1.888 ± 0.4
2.967AlaGln: 2.967 ± 0.384
3.417AlaArg: 3.417 ± 0.476
3.776AlaSer: 3.776 ± 0.771
4.226AlaThr: 4.226 ± 0.763
3.776AlaVal: 3.776 ± 0.668
1.079AlaTrp: 1.079 ± 0.282
2.607AlaTyr: 2.607 ± 0.481
0.0AlaXaa: 0.0 ± 0.0
Cys
0.09CysAla: 0.09 ± 0.086
0.0CysCys: 0.0 ± 0.0
0.629CysAsp: 0.629 ± 0.274
0.629CysGlu: 0.629 ± 0.238
0.27CysPhe: 0.27 ± 0.175
0.27CysGly: 0.27 ± 0.175
0.09CysHis: 0.09 ± 0.089
0.09CysIle: 0.09 ± 0.087
0.45CysLys: 0.45 ± 0.199
0.629CysLeu: 0.629 ± 0.311
0.0CysMet: 0.0 ± 0.0
0.36CysAsn: 0.36 ± 0.2
0.09CysPro: 0.09 ± 0.098
0.09CysGln: 0.09 ± 0.094
0.36CysArg: 0.36 ± 0.234
0.36CysSer: 0.36 ± 0.205
0.36CysThr: 0.36 ± 0.179
0.45CysVal: 0.45 ± 0.134
0.18CysTrp: 0.18 ± 0.116
0.09CysTyr: 0.09 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
3.237AspAla: 3.237 ± 0.477
0.36AspCys: 0.36 ± 0.198
4.586AspAsp: 4.586 ± 0.822
4.406AspGlu: 4.406 ± 0.692
4.046AspPhe: 4.046 ± 0.546
6.833AspGly: 6.833 ± 1.704
1.079AspHis: 1.079 ± 0.336
4.675AspIle: 4.675 ± 0.64
5.125AspLys: 5.125 ± 0.593
4.316AspLeu: 4.316 ± 0.617
2.158AspMet: 2.158 ± 0.465
4.496AspAsn: 4.496 ± 0.712
2.428AspPro: 2.428 ± 0.477
1.169AspGln: 1.169 ± 0.252
2.607AspArg: 2.607 ± 0.399
4.136AspSer: 4.136 ± 0.788
3.956AspThr: 3.956 ± 0.556
3.776AspVal: 3.776 ± 0.724
1.169AspTrp: 1.169 ± 0.281
2.697AspTyr: 2.697 ± 0.498
0.0AspXaa: 0.0 ± 0.0
Glu
3.956GluAla: 3.956 ± 0.685
0.27GluCys: 0.27 ± 0.133
3.596GluAsp: 3.596 ± 0.458
5.035GluGlu: 5.035 ± 1.037
1.888GluPhe: 1.888 ± 0.364
3.057GluGly: 3.057 ± 0.426
1.529GluHis: 1.529 ± 0.417
5.934GluIle: 5.934 ± 0.816
3.147GluLys: 3.147 ± 0.662
6.294GluLeu: 6.294 ± 0.897
2.338GluMet: 2.338 ± 0.477
3.776GluAsn: 3.776 ± 0.704
1.798GluPro: 1.798 ± 0.458
3.776GluGln: 3.776 ± 0.568
2.967GluArg: 2.967 ± 0.506
3.147GluSer: 3.147 ± 0.494
3.417GluThr: 3.417 ± 0.551
4.945GluVal: 4.945 ± 0.73
1.349GluTrp: 1.349 ± 0.32
3.507GluTyr: 3.507 ± 0.457
0.0GluXaa: 0.0 ± 0.0
Phe
2.967PheAla: 2.967 ± 0.548
0.09PheCys: 0.09 ± 0.076
3.596PheAsp: 3.596 ± 0.688
2.518PheGlu: 2.518 ± 0.561
1.798PhePhe: 1.798 ± 0.386
3.147PheGly: 3.147 ± 0.592
0.539PheHis: 0.539 ± 0.143
2.428PheIle: 2.428 ± 0.498
5.035PheLys: 5.035 ± 0.738
2.607PheLeu: 2.607 ± 0.605
0.36PheMet: 0.36 ± 0.16
3.596PheAsn: 3.596 ± 0.642
0.36PhePro: 0.36 ± 0.185
1.708PheGln: 1.708 ± 0.355
1.169PheArg: 1.169 ± 0.278
3.237PheSer: 3.237 ± 0.529
2.338PheThr: 2.338 ± 0.553
2.518PheVal: 2.518 ± 0.495
0.629PheTrp: 0.629 ± 0.236
1.798PheTyr: 1.798 ± 0.399
0.0PheXaa: 0.0 ± 0.0
Gly
3.147GlyAla: 3.147 ± 0.62
0.36GlyCys: 0.36 ± 0.2
4.675GlyAsp: 4.675 ± 0.542
3.686GlyGlu: 3.686 ± 0.57
2.877GlyPhe: 2.877 ± 0.432
3.596GlyGly: 3.596 ± 0.763
1.169GlyHis: 1.169 ± 0.362
5.035GlyIle: 5.035 ± 0.642
6.474GlyLys: 6.474 ± 0.795
6.294GlyLeu: 6.294 ± 0.668
1.798GlyMet: 1.798 ± 0.486
3.866GlyAsn: 3.866 ± 0.714
1.259GlyPro: 1.259 ± 0.355
3.327GlyGln: 3.327 ± 0.545
2.787GlyArg: 2.787 ± 0.545
4.586GlySer: 4.586 ± 0.769
4.226GlyThr: 4.226 ± 0.746
3.866GlyVal: 3.866 ± 0.647
1.349GlyTrp: 1.349 ± 0.383
3.686GlyTyr: 3.686 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
0.629HisAla: 0.629 ± 0.181
0.18HisCys: 0.18 ± 0.118
0.899HisAsp: 0.899 ± 0.261
0.539HisGlu: 0.539 ± 0.284
0.45HisPhe: 0.45 ± 0.14
1.079HisGly: 1.079 ± 0.328
0.27HisHis: 0.27 ± 0.135
0.989HisIle: 0.989 ± 0.306
0.899HisLys: 0.899 ± 0.265
0.989HisLeu: 0.989 ± 0.321
0.45HisMet: 0.45 ± 0.239
0.989HisAsn: 0.989 ± 0.292
0.629HisPro: 0.629 ± 0.182
0.809HisGln: 0.809 ± 0.26
0.719HisArg: 0.719 ± 0.226
0.809HisSer: 0.809 ± 0.25
0.809HisThr: 0.809 ± 0.261
1.259HisVal: 1.259 ± 0.26
0.0HisTrp: 0.0 ± 0.0
1.079HisTyr: 1.079 ± 0.383
0.0HisXaa: 0.0 ± 0.0
Ile
5.035IleAla: 5.035 ± 0.636
0.45IleCys: 0.45 ± 0.186
4.945IleAsp: 4.945 ± 0.605
4.675IleGlu: 4.675 ± 0.662
1.798IlePhe: 1.798 ± 0.475
4.496IleGly: 4.496 ± 0.628
0.809IleHis: 0.809 ± 0.214
3.057IleIle: 3.057 ± 0.488
6.474IleLys: 6.474 ± 0.639
4.406IleLeu: 4.406 ± 0.803
1.888IleMet: 1.888 ± 0.5
4.406IleAsn: 4.406 ± 0.59
3.057IlePro: 3.057 ± 0.491
2.338IleGln: 2.338 ± 0.35
2.787IleArg: 2.787 ± 0.425
4.046IleSer: 4.046 ± 0.652
3.866IleThr: 3.866 ± 0.562
3.596IleVal: 3.596 ± 0.479
0.989IleTrp: 0.989 ± 0.264
1.798IleTyr: 1.798 ± 0.417
0.0IleXaa: 0.0 ± 0.0
Lys
5.215LysAla: 5.215 ± 0.6
0.45LysCys: 0.45 ± 0.24
5.305LysAsp: 5.305 ± 0.843
6.743LysGlu: 6.743 ± 0.805
3.507LysPhe: 3.507 ± 0.833
5.485LysGly: 5.485 ± 0.638
1.529LysHis: 1.529 ± 0.422
5.305LysIle: 5.305 ± 0.717
5.664LysLys: 5.664 ± 0.875
7.013LysLeu: 7.013 ± 0.961
2.068LysMet: 2.068 ± 0.472
4.945LysAsn: 4.945 ± 0.586
2.607LysPro: 2.607 ± 0.404
3.596LysGln: 3.596 ± 0.632
4.226LysArg: 4.226 ± 0.722
4.226LysSer: 4.226 ± 0.621
5.035LysThr: 5.035 ± 0.644
4.046LysVal: 4.046 ± 0.641
0.989LysTrp: 0.989 ± 0.29
3.507LysTyr: 3.507 ± 0.621
0.0LysXaa: 0.0 ± 0.0
Leu
6.923LeuAla: 6.923 ± 0.718
0.539LeuCys: 0.539 ± 0.225
5.035LeuAsp: 5.035 ± 0.782
6.743LeuGlu: 6.743 ± 0.938
2.877LeuPhe: 2.877 ± 0.488
6.294LeuGly: 6.294 ± 0.881
1.079LeuHis: 1.079 ± 0.289
4.046LeuIle: 4.046 ± 0.469
7.553LeuLys: 7.553 ± 0.597
6.024LeuLeu: 6.024 ± 0.753
2.428LeuMet: 2.428 ± 0.359
5.035LeuAsn: 5.035 ± 0.567
2.697LeuPro: 2.697 ± 0.492
2.248LeuGln: 2.248 ± 0.408
2.607LeuArg: 2.607 ± 0.507
5.305LeuSer: 5.305 ± 0.753
5.844LeuThr: 5.844 ± 0.821
3.686LeuVal: 3.686 ± 0.64
0.539LeuTrp: 0.539 ± 0.235
2.607LeuTyr: 2.607 ± 0.687
0.0LeuXaa: 0.0 ± 0.0
Met
1.529MetAla: 1.529 ± 0.438
0.0MetCys: 0.0 ± 0.0
1.349MetAsp: 1.349 ± 0.359
0.989MetGlu: 0.989 ± 0.299
1.349MetPhe: 1.349 ± 0.249
1.169MetGly: 1.169 ± 0.257
0.27MetHis: 0.27 ± 0.158
1.978MetIle: 1.978 ± 0.367
2.967MetLys: 2.967 ± 0.634
1.888MetLeu: 1.888 ± 0.346
0.539MetMet: 0.539 ± 0.272
1.259MetAsn: 1.259 ± 0.285
0.989MetPro: 0.989 ± 0.263
0.809MetGln: 0.809 ± 0.236
0.809MetArg: 0.809 ± 0.204
2.068MetSer: 2.068 ± 0.557
2.248MetThr: 2.248 ± 0.39
1.529MetVal: 1.529 ± 0.367
0.18MetTrp: 0.18 ± 0.112
0.809MetTyr: 0.809 ± 0.23
0.0MetXaa: 0.0 ± 0.0
Asn
5.125AsnAla: 5.125 ± 0.962
0.18AsnCys: 0.18 ± 0.113
3.327AsnAsp: 3.327 ± 0.496
3.596AsnGlu: 3.596 ± 0.751
3.237AsnPhe: 3.237 ± 0.474
6.743AsnGly: 6.743 ± 1.068
0.899AsnHis: 0.899 ± 0.302
3.866AsnIle: 3.866 ± 0.563
4.046AsnLys: 4.046 ± 0.614
4.496AsnLeu: 4.496 ± 0.525
0.989AsnMet: 0.989 ± 0.257
4.226AsnAsn: 4.226 ± 0.597
2.428AsnPro: 2.428 ± 0.4
2.697AsnGln: 2.697 ± 0.397
2.158AsnArg: 2.158 ± 0.439
3.507AsnSer: 3.507 ± 0.494
3.237AsnThr: 3.237 ± 0.562
3.866AsnVal: 3.866 ± 0.712
1.529AsnTrp: 1.529 ± 0.439
2.428AsnTyr: 2.428 ± 0.475
0.0AsnXaa: 0.0 ± 0.0
Pro
1.978ProAla: 1.978 ± 0.334
0.0ProCys: 0.0 ± 0.0
1.259ProAsp: 1.259 ± 0.317
1.978ProGlu: 1.978 ± 0.493
1.259ProPhe: 1.259 ± 0.362
1.079ProGly: 1.079 ± 0.422
0.36ProHis: 0.36 ± 0.156
1.618ProIle: 1.618 ± 0.338
3.507ProLys: 3.507 ± 0.51
2.248ProLeu: 2.248 ± 0.364
0.27ProMet: 0.27 ± 0.133
2.787ProAsn: 2.787 ± 0.473
0.539ProPro: 0.539 ± 0.265
1.708ProGln: 1.708 ± 0.292
1.349ProArg: 1.349 ± 0.391
2.248ProSer: 2.248 ± 0.552
2.068ProThr: 2.068 ± 0.539
1.439ProVal: 1.439 ± 0.351
0.539ProTrp: 0.539 ± 0.159
1.259ProTyr: 1.259 ± 0.391
0.0ProXaa: 0.0 ± 0.0
Gln
3.147GlnAla: 3.147 ± 0.692
0.18GlnCys: 0.18 ± 0.12
2.338GlnAsp: 2.338 ± 0.364
3.057GlnGlu: 3.057 ± 0.687
1.529GlnPhe: 1.529 ± 0.412
2.967GlnGly: 2.967 ± 0.676
0.539GlnHis: 0.539 ± 0.195
2.068GlnIle: 2.068 ± 0.516
3.596GlnLys: 3.596 ± 0.463
4.496GlnLeu: 4.496 ± 0.529
1.618GlnMet: 1.618 ± 0.313
1.888GlnAsn: 1.888 ± 0.403
0.989GlnPro: 0.989 ± 0.441
2.787GlnGln: 2.787 ± 0.524
1.708GlnArg: 1.708 ± 0.368
1.888GlnSer: 1.888 ± 0.401
3.057GlnThr: 3.057 ± 0.494
2.428GlnVal: 2.428 ± 0.575
0.629GlnTrp: 0.629 ± 0.343
2.248GlnTyr: 2.248 ± 0.321
0.0GlnXaa: 0.0 ± 0.0
Arg
1.978ArgAla: 1.978 ± 0.339
0.09ArgCys: 0.09 ± 0.094
3.327ArgAsp: 3.327 ± 0.57
2.338ArgGlu: 2.338 ± 0.448
2.248ArgPhe: 2.248 ± 0.393
2.428ArgGly: 2.428 ± 0.482
0.629ArgHis: 0.629 ± 0.23
2.607ArgIle: 2.607 ± 0.553
2.607ArgLys: 2.607 ± 0.476
3.057ArgLeu: 3.057 ± 0.542
0.899ArgMet: 0.899 ± 0.339
2.428ArgAsn: 2.428 ± 0.421
1.079ArgPro: 1.079 ± 0.245
2.248ArgGln: 2.248 ± 0.411
1.079ArgArg: 1.079 ± 0.286
2.068ArgSer: 2.068 ± 0.414
3.147ArgThr: 3.147 ± 0.714
2.607ArgVal: 2.607 ± 0.465
1.079ArgTrp: 1.079 ± 0.272
2.428ArgTyr: 2.428 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
3.327SerAla: 3.327 ± 0.599
0.539SerCys: 0.539 ± 0.254
4.675SerAsp: 4.675 ± 0.418
3.686SerGlu: 3.686 ± 0.582
2.967SerPhe: 2.967 ± 0.55
4.586SerGly: 4.586 ± 0.543
0.539SerHis: 0.539 ± 0.197
5.395SerIle: 5.395 ± 0.607
5.125SerLys: 5.125 ± 0.742
5.035SerLeu: 5.035 ± 0.599
1.529SerMet: 1.529 ± 0.277
4.136SerAsn: 4.136 ± 0.713
1.529SerPro: 1.529 ± 0.406
2.967SerGln: 2.967 ± 0.519
3.057SerArg: 3.057 ± 0.745
3.956SerSer: 3.956 ± 0.515
3.866SerThr: 3.866 ± 0.647
3.776SerVal: 3.776 ± 0.674
0.629SerTrp: 0.629 ± 0.276
2.248SerTyr: 2.248 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
4.586ThrAla: 4.586 ± 0.672
0.36ThrCys: 0.36 ± 0.198
4.765ThrAsp: 4.765 ± 0.689
3.776ThrGlu: 3.776 ± 0.558
2.787ThrPhe: 2.787 ± 0.52
3.866ThrGly: 3.866 ± 0.557
0.809ThrHis: 0.809 ± 0.305
4.765ThrIle: 4.765 ± 1.1
4.316ThrLys: 4.316 ± 0.648
6.743ThrLeu: 6.743 ± 0.65
1.079ThrMet: 1.079 ± 0.314
4.136ThrAsn: 4.136 ± 0.871
1.529ThrPro: 1.529 ± 0.437
2.877ThrGln: 2.877 ± 0.68
1.888ThrArg: 1.888 ± 0.337
4.046ThrSer: 4.046 ± 0.486
3.237ThrThr: 3.237 ± 0.698
4.136ThrVal: 4.136 ± 0.725
0.989ThrTrp: 0.989 ± 0.243
3.507ThrTyr: 3.507 ± 0.851
0.0ThrXaa: 0.0 ± 0.0
Val
4.316ValAla: 4.316 ± 0.611
0.18ValCys: 0.18 ± 0.118
4.855ValAsp: 4.855 ± 0.546
3.956ValGlu: 3.956 ± 0.702
2.607ValPhe: 2.607 ± 0.434
4.136ValGly: 4.136 ± 0.603
0.539ValHis: 0.539 ± 0.175
2.967ValIle: 2.967 ± 0.453
4.855ValLys: 4.855 ± 0.634
3.327ValLeu: 3.327 ± 0.463
1.169ValMet: 1.169 ± 0.374
3.057ValAsn: 3.057 ± 0.566
2.428ValPro: 2.428 ± 0.403
1.888ValGln: 1.888 ± 0.476
2.068ValArg: 2.068 ± 0.498
5.035ValSer: 5.035 ± 0.67
5.485ValThr: 5.485 ± 0.805
3.686ValVal: 3.686 ± 0.677
1.079ValTrp: 1.079 ± 0.353
2.158ValTyr: 2.158 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
0.539TrpAla: 0.539 ± 0.234
0.09TrpCys: 0.09 ± 0.091
0.989TrpAsp: 0.989 ± 0.268
0.809TrpGlu: 0.809 ± 0.186
0.539TrpPhe: 0.539 ± 0.218
0.45TrpGly: 0.45 ± 0.202
0.18TrpHis: 0.18 ± 0.103
0.989TrpIle: 0.989 ± 0.3
1.169TrpLys: 1.169 ± 0.396
1.259TrpLeu: 1.259 ± 0.375
0.36TrpMet: 0.36 ± 0.156
1.079TrpAsn: 1.079 ± 0.486
0.09TrpPro: 0.09 ± 0.086
1.079TrpGln: 1.079 ± 0.383
0.539TrpArg: 0.539 ± 0.184
1.978TrpSer: 1.978 ± 0.523
1.349TrpThr: 1.349 ± 0.555
1.259TrpVal: 1.259 ± 0.232
0.27TrpTrp: 0.27 ± 0.177
0.27TrpTyr: 0.27 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.147TyrAla: 3.147 ± 0.524
0.899TyrCys: 0.899 ± 0.356
2.607TyrAsp: 2.607 ± 0.49
2.518TyrGlu: 2.518 ± 0.471
2.338TyrPhe: 2.338 ± 0.467
2.518TyrGly: 2.518 ± 0.578
0.989TyrHis: 0.989 ± 0.331
2.158TyrIle: 2.158 ± 0.404
3.147TyrLys: 3.147 ± 0.524
3.327TyrLeu: 3.327 ± 0.381
1.169TyrMet: 1.169 ± 0.347
1.888TyrAsn: 1.888 ± 0.395
1.079TyrPro: 1.079 ± 0.343
2.068TyrGln: 2.068 ± 0.297
2.068TyrArg: 2.068 ± 0.366
3.147TyrSer: 3.147 ± 0.682
2.428TyrThr: 2.428 ± 0.787
3.147TyrVal: 3.147 ± 0.587
0.09TyrTrp: 0.09 ± 0.09
2.068TyrTyr: 2.068 ± 0.711
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski