Amino acid dipepetide frequency for Streptococcus phage Javan326

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.009AlaAla: 3.009 ± 0.749
0.344AlaCys: 0.344 ± 0.179
4.728AlaAsp: 4.728 ± 0.634
5.931AlaGlu: 5.931 ± 0.773
3.181AlaPhe: 3.181 ± 0.724
4.9AlaGly: 4.9 ± 0.73
0.86AlaHis: 0.86 ± 0.375
6.103AlaIle: 6.103 ± 1.047
6.705AlaLys: 6.705 ± 0.776
7.135AlaLeu: 7.135 ± 1.118
1.891AlaMet: 1.891 ± 0.558
3.696AlaAsn: 3.696 ± 0.501
1.461AlaPro: 1.461 ± 0.292
2.149AlaGln: 2.149 ± 0.432
3.438AlaArg: 3.438 ± 0.63
2.235AlaSer: 2.235 ± 0.463
4.212AlaThr: 4.212 ± 0.64
4.986AlaVal: 4.986 ± 0.537
1.032AlaTrp: 1.032 ± 0.295
1.805AlaTyr: 1.805 ± 0.407
0.0AlaXaa: 0.0 ± 0.0
Cys
0.258CysAla: 0.258 ± 0.126
0.086CysCys: 0.086 ± 0.094
0.258CysAsp: 0.258 ± 0.147
0.344CysGlu: 0.344 ± 0.189
0.258CysPhe: 0.258 ± 0.132
0.344CysGly: 0.344 ± 0.173
0.172CysHis: 0.172 ± 0.126
0.172CysIle: 0.172 ± 0.133
0.602CysLys: 0.602 ± 0.233
0.516CysLeu: 0.516 ± 0.262
0.0CysMet: 0.0 ± 0.0
0.086CysAsn: 0.086 ± 0.081
0.43CysPro: 0.43 ± 0.207
0.602CysGln: 0.602 ± 0.193
0.344CysArg: 0.344 ± 0.178
0.258CysSer: 0.258 ± 0.167
0.086CysThr: 0.086 ± 0.083
0.172CysVal: 0.172 ± 0.132
0.0CysTrp: 0.0 ± 0.0
0.172CysTyr: 0.172 ± 0.106
0.0CysXaa: 0.0 ± 0.0
Asp
5.33AspAla: 5.33 ± 1.004
0.516AspCys: 0.516 ± 0.235
3.267AspAsp: 3.267 ± 0.539
4.814AspGlu: 4.814 ± 0.806
3.524AspPhe: 3.524 ± 0.899
4.986AspGly: 4.986 ± 0.904
0.258AspHis: 0.258 ± 0.176
5.072AspIle: 5.072 ± 0.62
5.244AspLys: 5.244 ± 0.694
4.728AspLeu: 4.728 ± 0.711
1.977AspMet: 1.977 ± 0.357
3.438AspAsn: 3.438 ± 0.552
1.805AspPro: 1.805 ± 0.376
1.375AspGln: 1.375 ± 0.298
2.751AspArg: 2.751 ± 0.423
4.04AspSer: 4.04 ± 0.46
3.353AspThr: 3.353 ± 0.488
3.61AspVal: 3.61 ± 0.658
1.032AspTrp: 1.032 ± 0.276
2.837AspTyr: 2.837 ± 0.562
0.0AspXaa: 0.0 ± 0.0
Glu
5.588GluAla: 5.588 ± 0.666
0.086GluCys: 0.086 ± 0.081
3.868GluAsp: 3.868 ± 0.621
7.737GluGlu: 7.737 ± 1.277
3.954GluPhe: 3.954 ± 0.655
3.095GluGly: 3.095 ± 0.546
2.149GluHis: 2.149 ± 0.444
5.416GluIle: 5.416 ± 0.57
7.049GluLys: 7.049 ± 0.937
9.714GluLeu: 9.714 ± 1.251
2.063GluMet: 2.063 ± 0.472
2.751GluAsn: 2.751 ± 0.561
2.923GluPro: 2.923 ± 0.639
4.814GluGln: 4.814 ± 0.715
4.642GluArg: 4.642 ± 0.539
4.384GluSer: 4.384 ± 0.541
3.782GluThr: 3.782 ± 0.74
5.759GluVal: 5.759 ± 0.612
0.43GluTrp: 0.43 ± 0.183
2.321GluTyr: 2.321 ± 0.617
0.0GluXaa: 0.0 ± 0.0
Phe
3.267PheAla: 3.267 ± 0.574
0.258PheCys: 0.258 ± 0.218
3.181PheAsp: 3.181 ± 0.482
3.954PheGlu: 3.954 ± 0.59
1.891PhePhe: 1.891 ± 0.351
3.095PheGly: 3.095 ± 0.758
0.344PheHis: 0.344 ± 0.18
2.235PheIle: 2.235 ± 0.49
3.181PheLys: 3.181 ± 0.598
2.407PheLeu: 2.407 ± 0.492
1.289PheMet: 1.289 ± 0.316
2.493PheAsn: 2.493 ± 0.431
1.032PhePro: 1.032 ± 0.321
2.235PheGln: 2.235 ± 0.408
1.977PheArg: 1.977 ± 0.399
2.665PheSer: 2.665 ± 0.742
2.579PheThr: 2.579 ± 0.568
2.407PheVal: 2.407 ± 0.465
0.774PheTrp: 0.774 ± 0.319
1.719PheTyr: 1.719 ± 0.412
0.0PheXaa: 0.0 ± 0.0
Gly
3.954GlyAla: 3.954 ± 0.626
0.172GlyCys: 0.172 ± 0.125
5.244GlyAsp: 5.244 ± 0.837
5.588GlyGlu: 5.588 ± 0.565
2.923GlyPhe: 2.923 ± 0.434
5.502GlyGly: 5.502 ± 1.156
0.774GlyHis: 0.774 ± 0.255
4.642GlyIle: 4.642 ± 0.682
4.212GlyLys: 4.212 ± 0.702
5.759GlyLeu: 5.759 ± 0.825
1.719GlyMet: 1.719 ± 0.44
3.524GlyAsn: 3.524 ± 0.662
1.118GlyPro: 1.118 ± 0.473
3.353GlyGln: 3.353 ± 0.637
3.095GlyArg: 3.095 ± 0.408
4.04GlySer: 4.04 ± 0.822
2.923GlyThr: 2.923 ± 0.61
5.33GlyVal: 5.33 ± 0.67
1.547GlyTrp: 1.547 ± 0.629
2.579GlyTyr: 2.579 ± 0.459
0.0GlyXaa: 0.0 ± 0.0
His
0.86HisAla: 0.86 ± 0.237
0.0HisCys: 0.0 ± 0.0
0.774HisAsp: 0.774 ± 0.256
1.032HisGlu: 1.032 ± 0.269
1.203HisPhe: 1.203 ± 0.28
1.118HisGly: 1.118 ± 0.313
0.172HisHis: 0.172 ± 0.123
1.203HisIle: 1.203 ± 0.292
1.289HisLys: 1.289 ± 0.419
1.375HisLeu: 1.375 ± 0.363
0.344HisMet: 0.344 ± 0.137
0.946HisAsn: 0.946 ± 0.253
0.774HisPro: 0.774 ± 0.24
0.688HisGln: 0.688 ± 0.24
0.344HisArg: 0.344 ± 0.173
0.946HisSer: 0.946 ± 0.369
0.602HisThr: 0.602 ± 0.222
0.688HisVal: 0.688 ± 0.229
0.344HisTrp: 0.344 ± 0.173
0.774HisTyr: 0.774 ± 0.322
0.0HisXaa: 0.0 ± 0.0
Ile
4.9IleAla: 4.9 ± 1.054
0.516IleCys: 0.516 ± 0.184
5.33IleAsp: 5.33 ± 0.697
5.674IleGlu: 5.674 ± 0.753
2.751IlePhe: 2.751 ± 0.554
4.556IleGly: 4.556 ± 1.208
0.516IleHis: 0.516 ± 0.184
3.438IleIle: 3.438 ± 0.581
5.759IleLys: 5.759 ± 0.741
5.416IleLeu: 5.416 ± 0.72
1.289IleMet: 1.289 ± 0.36
3.009IleAsn: 3.009 ± 0.456
1.032IlePro: 1.032 ± 0.3
2.923IleGln: 2.923 ± 0.555
3.782IleArg: 3.782 ± 0.61
4.986IleSer: 4.986 ± 0.587
3.524IleThr: 3.524 ± 0.47
3.267IleVal: 3.267 ± 0.49
0.344IleTrp: 0.344 ± 0.187
1.547IleTyr: 1.547 ± 0.523
0.0IleXaa: 0.0 ± 0.0
Lys
4.642LysAla: 4.642 ± 0.66
0.086LysCys: 0.086 ± 0.1
4.728LysAsp: 4.728 ± 0.737
7.994LysGlu: 7.994 ± 0.754
3.009LysPhe: 3.009 ± 0.547
5.33LysGly: 5.33 ± 0.799
1.633LysHis: 1.633 ± 0.463
6.017LysIle: 6.017 ± 0.703
7.221LysLys: 7.221 ± 0.843
7.909LysLeu: 7.909 ± 0.918
2.235LysMet: 2.235 ± 0.409
4.212LysAsn: 4.212 ± 0.503
2.493LysPro: 2.493 ± 0.583
3.438LysGln: 3.438 ± 0.56
3.696LysArg: 3.696 ± 0.664
4.04LysSer: 4.04 ± 0.692
4.298LysThr: 4.298 ± 0.494
6.447LysVal: 6.447 ± 0.748
1.118LysTrp: 1.118 ± 0.253
3.095LysTyr: 3.095 ± 0.447
0.0LysXaa: 0.0 ± 0.0
Leu
6.963LeuAla: 6.963 ± 0.856
0.344LeuCys: 0.344 ± 0.14
6.447LeuAsp: 6.447 ± 0.649
8.252LeuGlu: 8.252 ± 1.082
2.493LeuPhe: 2.493 ± 0.519
6.361LeuGly: 6.361 ± 1.201
1.375LeuHis: 1.375 ± 0.39
3.696LeuIle: 3.696 ± 0.593
7.651LeuLys: 7.651 ± 0.785
7.221LeuLeu: 7.221 ± 0.918
2.751LeuMet: 2.751 ± 0.396
3.438LeuAsn: 3.438 ± 0.534
2.493LeuPro: 2.493 ± 0.444
3.696LeuGln: 3.696 ± 0.614
3.353LeuArg: 3.353 ± 0.593
5.072LeuSer: 5.072 ± 0.611
5.845LeuThr: 5.845 ± 0.735
3.696LeuVal: 3.696 ± 0.59
0.774LeuTrp: 0.774 ± 0.247
2.321LeuTyr: 2.321 ± 0.458
0.0LeuXaa: 0.0 ± 0.0
Met
2.149MetAla: 2.149 ± 0.353
0.086MetCys: 0.086 ± 0.097
1.719MetAsp: 1.719 ± 0.319
1.461MetGlu: 1.461 ± 0.347
0.86MetPhe: 0.86 ± 0.259
1.547MetGly: 1.547 ± 0.426
0.516MetHis: 0.516 ± 0.209
2.063MetIle: 2.063 ± 0.339
3.009MetLys: 3.009 ± 0.392
1.289MetLeu: 1.289 ± 0.307
0.602MetMet: 0.602 ± 0.242
1.375MetAsn: 1.375 ± 0.36
1.289MetPro: 1.289 ± 0.357
0.688MetGln: 0.688 ± 0.256
0.86MetArg: 0.86 ± 0.277
1.891MetSer: 1.891 ± 0.471
1.891MetThr: 1.891 ± 0.422
1.375MetVal: 1.375 ± 0.336
0.258MetTrp: 0.258 ± 0.156
1.203MetTyr: 1.203 ± 0.271
0.0MetXaa: 0.0 ± 0.0
Asn
3.524AsnAla: 3.524 ± 0.802
0.43AsnCys: 0.43 ± 0.182
3.438AsnAsp: 3.438 ± 0.466
2.923AsnGlu: 2.923 ± 0.556
1.289AsnPhe: 1.289 ± 0.391
3.524AsnGly: 3.524 ± 0.529
1.375AsnHis: 1.375 ± 0.329
2.923AsnIle: 2.923 ± 0.616
3.61AsnLys: 3.61 ± 0.565
4.212AsnLeu: 4.212 ± 0.604
1.547AsnMet: 1.547 ± 0.318
2.407AsnAsn: 2.407 ± 0.506
1.805AsnPro: 1.805 ± 0.309
2.407AsnGln: 2.407 ± 0.405
2.751AsnArg: 2.751 ± 0.435
2.235AsnSer: 2.235 ± 0.377
2.923AsnThr: 2.923 ± 0.44
3.009AsnVal: 3.009 ± 0.546
0.688AsnTrp: 0.688 ± 0.266
2.063AsnTyr: 2.063 ± 0.456
0.0AsnXaa: 0.0 ± 0.0
Pro
2.321ProAla: 2.321 ± 0.344
0.344ProCys: 0.344 ± 0.222
1.719ProAsp: 1.719 ± 0.479
3.438ProGlu: 3.438 ± 0.529
1.032ProPhe: 1.032 ± 0.381
1.633ProGly: 1.633 ± 0.445
0.344ProHis: 0.344 ± 0.165
1.375ProIle: 1.375 ± 0.374
2.923ProLys: 2.923 ± 0.476
1.633ProLeu: 1.633 ± 0.363
0.602ProMet: 0.602 ± 0.228
1.203ProAsn: 1.203 ± 0.423
1.032ProPro: 1.032 ± 0.345
0.86ProGln: 0.86 ± 0.303
1.461ProArg: 1.461 ± 0.318
1.203ProSer: 1.203 ± 0.356
1.977ProThr: 1.977 ± 0.445
2.579ProVal: 2.579 ± 0.443
0.43ProTrp: 0.43 ± 0.2
0.774ProTyr: 0.774 ± 0.303
0.0ProXaa: 0.0 ± 0.0
Gln
4.126GlnAla: 4.126 ± 0.736
0.516GlnCys: 0.516 ± 0.215
1.633GlnAsp: 1.633 ± 0.414
3.954GlnGlu: 3.954 ± 0.753
1.805GlnPhe: 1.805 ± 0.367
2.579GlnGly: 2.579 ± 0.485
0.43GlnHis: 0.43 ± 0.179
2.923GlnIle: 2.923 ± 0.502
3.181GlnLys: 3.181 ± 0.655
3.267GlnLeu: 3.267 ± 0.669
0.688GlnMet: 0.688 ± 0.259
3.009GlnAsn: 3.009 ± 0.489
0.86GlnPro: 0.86 ± 0.293
1.891GlnGln: 1.891 ± 0.385
1.891GlnArg: 1.891 ± 0.39
2.407GlnSer: 2.407 ± 0.474
2.235GlnThr: 2.235 ± 0.403
3.267GlnVal: 3.267 ± 0.49
0.688GlnTrp: 0.688 ± 0.224
1.118GlnTyr: 1.118 ± 0.343
0.0GlnXaa: 0.0 ± 0.0
Arg
1.977ArgAla: 1.977 ± 0.354
0.258ArgCys: 0.258 ± 0.15
3.267ArgAsp: 3.267 ± 0.651
3.353ArgGlu: 3.353 ± 0.621
1.891ArgPhe: 1.891 ± 0.392
2.321ArgGly: 2.321 ± 0.511
0.86ArgHis: 0.86 ± 0.254
3.181ArgIle: 3.181 ± 0.47
3.954ArgLys: 3.954 ± 0.73
3.696ArgLeu: 3.696 ± 0.59
1.891ArgMet: 1.891 ± 0.459
1.977ArgAsn: 1.977 ± 0.453
1.375ArgPro: 1.375 ± 0.301
1.461ArgGln: 1.461 ± 0.351
2.321ArgArg: 2.321 ± 0.466
2.493ArgSer: 2.493 ± 0.432
2.751ArgThr: 2.751 ± 0.541
3.524ArgVal: 3.524 ± 0.503
0.43ArgTrp: 0.43 ± 0.276
1.977ArgTyr: 1.977 ± 0.429
0.0ArgXaa: 0.0 ± 0.0
Ser
4.212SerAla: 4.212 ± 0.925
0.172SerCys: 0.172 ± 0.122
3.524SerAsp: 3.524 ± 0.643
3.868SerGlu: 3.868 ± 0.672
1.891SerPhe: 1.891 ± 0.467
4.47SerGly: 4.47 ± 0.639
0.86SerHis: 0.86 ± 0.281
4.298SerIle: 4.298 ± 0.671
4.384SerLys: 4.384 ± 0.608
4.556SerLeu: 4.556 ± 0.494
1.805SerMet: 1.805 ± 0.466
2.493SerAsn: 2.493 ± 0.515
1.805SerPro: 1.805 ± 0.339
2.149SerGln: 2.149 ± 0.413
1.719SerArg: 1.719 ± 0.312
3.61SerSer: 3.61 ± 0.651
3.524SerThr: 3.524 ± 0.518
3.438SerVal: 3.438 ± 0.67
1.203SerTrp: 1.203 ± 0.584
2.665SerTyr: 2.665 ± 0.695
0.0SerXaa: 0.0 ± 0.0
Thr
4.642ThrAla: 4.642 ± 0.588
0.258ThrCys: 0.258 ± 0.249
3.524ThrAsp: 3.524 ± 0.491
4.04ThrGlu: 4.04 ± 0.657
3.009ThrPhe: 3.009 ± 0.551
4.728ThrGly: 4.728 ± 0.903
1.032ThrHis: 1.032 ± 0.333
3.954ThrIle: 3.954 ± 0.651
3.954ThrLys: 3.954 ± 0.611
4.728ThrLeu: 4.728 ± 0.712
0.86ThrMet: 0.86 ± 0.23
2.407ThrAsn: 2.407 ± 0.405
1.633ThrPro: 1.633 ± 0.344
3.181ThrGln: 3.181 ± 0.554
1.461ThrArg: 1.461 ± 0.318
3.438ThrSer: 3.438 ± 0.539
3.696ThrThr: 3.696 ± 0.56
3.61ThrVal: 3.61 ± 0.585
1.032ThrTrp: 1.032 ± 0.339
2.063ThrTyr: 2.063 ± 0.459
0.0ThrXaa: 0.0 ± 0.0
Val
4.642ValAla: 4.642 ± 0.788
0.258ValCys: 0.258 ± 0.158
3.61ValAsp: 3.61 ± 0.622
5.072ValGlu: 5.072 ± 0.711
2.665ValPhe: 2.665 ± 0.485
3.954ValGly: 3.954 ± 0.695
0.86ValHis: 0.86 ± 0.251
2.751ValIle: 2.751 ± 0.509
4.728ValLys: 4.728 ± 0.489
5.502ValLeu: 5.502 ± 0.559
1.891ValMet: 1.891 ± 0.352
3.696ValAsn: 3.696 ± 0.569
2.235ValPro: 2.235 ± 0.469
2.149ValGln: 2.149 ± 0.446
3.095ValArg: 3.095 ± 0.554
4.728ValSer: 4.728 ± 0.662
4.556ValThr: 4.556 ± 0.665
4.212ValVal: 4.212 ± 0.574
0.258ValTrp: 0.258 ± 0.126
3.267ValTyr: 3.267 ± 0.501
0.0ValXaa: 0.0 ± 0.0
Trp
1.032TrpAla: 1.032 ± 0.293
0.172TrpCys: 0.172 ± 0.104
0.946TrpAsp: 0.946 ± 0.368
0.602TrpGlu: 0.602 ± 0.215
1.203TrpPhe: 1.203 ± 0.649
0.688TrpGly: 0.688 ± 0.258
0.086TrpHis: 0.086 ± 0.09
0.688TrpIle: 0.688 ± 0.201
1.289TrpLys: 1.289 ± 0.381
1.032TrpLeu: 1.032 ± 0.312
0.086TrpMet: 0.086 ± 0.091
0.86TrpAsn: 0.86 ± 0.226
0.172TrpPro: 0.172 ± 0.126
0.43TrpGln: 0.43 ± 0.201
0.344TrpArg: 0.344 ± 0.218
0.602TrpSer: 0.602 ± 0.17
0.43TrpThr: 0.43 ± 0.178
0.946TrpVal: 0.946 ± 0.319
0.258TrpTrp: 0.258 ± 0.185
1.203TrpTyr: 1.203 ± 0.496
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.407TyrAla: 2.407 ± 0.385
0.258TyrCys: 0.258 ± 0.137
2.751TyrAsp: 2.751 ± 0.515
2.493TyrGlu: 2.493 ± 0.495
2.149TyrPhe: 2.149 ± 0.439
3.267TyrGly: 3.267 ± 0.649
0.86TyrHis: 0.86 ± 0.303
2.407TyrIle: 2.407 ± 0.642
3.782TyrLys: 3.782 ± 0.684
2.149TyrLeu: 2.149 ± 0.441
0.516TyrMet: 0.516 ± 0.202
2.063TyrAsn: 2.063 ± 0.363
1.118TyrPro: 1.118 ± 0.311
1.977TyrGln: 1.977 ± 0.4
1.633TyrArg: 1.633 ± 0.429
1.375TyrSer: 1.375 ± 0.469
2.063TyrThr: 2.063 ± 0.446
1.805TyrVal: 1.805 ± 0.43
0.43TyrTrp: 0.43 ± 0.247
1.547TyrTyr: 1.547 ± 0.465
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (11634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski