Amino acid dipepetide frequency for Antarcticibacterium arcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.293AlaAla: 5.293 ± 0.098
0.523AlaCys: 0.523 ± 0.026
3.105AlaAsp: 3.105 ± 0.069
4.783AlaGlu: 4.783 ± 0.088
3.341AlaPhe: 3.341 ± 0.065
5.369AlaGly: 5.369 ± 0.08
1.194AlaHis: 1.194 ± 0.034
5.197AlaIle: 5.197 ± 0.082
4.008AlaLys: 4.008 ± 0.072
6.343AlaLeu: 6.343 ± 0.096
1.618AlaMet: 1.618 ± 0.046
3.251AlaAsn: 3.251 ± 0.059
2.093AlaPro: 2.093 ± 0.048
2.589AlaGln: 2.589 ± 0.052
2.794AlaArg: 2.794 ± 0.064
3.99AlaSer: 3.99 ± 0.077
3.623AlaThr: 3.623 ± 0.087
4.625AlaVal: 4.625 ± 0.075
0.628AlaTrp: 0.628 ± 0.027
2.399AlaTyr: 2.399 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.417CysAla: 0.417 ± 0.024
0.098CysCys: 0.098 ± 0.011
0.383CysAsp: 0.383 ± 0.02
0.517CysGlu: 0.517 ± 0.027
0.335CysPhe: 0.335 ± 0.018
0.59CysGly: 0.59 ± 0.031
0.152CysHis: 0.152 ± 0.014
0.488CysIle: 0.488 ± 0.022
0.388CysLys: 0.388 ± 0.025
0.543CysLeu: 0.543 ± 0.021
0.113CysMet: 0.113 ± 0.011
0.341CysAsn: 0.341 ± 0.025
0.281CysPro: 0.281 ± 0.022
0.173CysGln: 0.173 ± 0.014
0.227CysArg: 0.227 ± 0.018
0.5CysSer: 0.5 ± 0.026
0.406CysThr: 0.406 ± 0.03
0.366CysVal: 0.366 ± 0.022
0.051CysTrp: 0.051 ± 0.009
0.245CysTyr: 0.245 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.517AspAla: 3.517 ± 0.076
0.332AspCys: 0.332 ± 0.023
2.394AspAsp: 2.394 ± 0.055
3.572AspGlu: 3.572 ± 0.06
3.362AspPhe: 3.362 ± 0.06
3.33AspGly: 3.33 ± 0.078
1.122AspHis: 1.122 ± 0.036
3.94AspIle: 3.94 ± 0.064
3.611AspLys: 3.611 ± 0.066
5.633AspLeu: 5.633 ± 0.097
1.105AspMet: 1.105 ± 0.033
2.617AspAsn: 2.617 ± 0.067
2.273AspPro: 2.273 ± 0.053
1.593AspGln: 1.593 ± 0.047
2.173AspArg: 2.173 ± 0.051
2.931AspSer: 2.931 ± 0.063
2.501AspThr: 2.501 ± 0.055
3.276AspVal: 3.276 ± 0.069
0.675AspTrp: 0.675 ± 0.03
2.554AspTyr: 2.554 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.881GluAla: 4.881 ± 0.074
0.32GluCys: 0.32 ± 0.018
4.015GluAsp: 4.015 ± 0.079
6.168GluGlu: 6.168 ± 0.091
3.331GluPhe: 3.331 ± 0.056
4.241GluGly: 4.241 ± 0.071
1.181GluHis: 1.181 ± 0.036
6.295GluIle: 6.295 ± 0.091
6.107GluLys: 6.107 ± 0.09
6.487GluLeu: 6.487 ± 0.088
1.905GluMet: 1.905 ± 0.043
5.076GluAsn: 5.076 ± 0.079
1.854GluPro: 1.854 ± 0.047
2.304GluGln: 2.304 ± 0.059
2.874GluArg: 2.874 ± 0.057
3.184GluSer: 3.184 ± 0.058
3.821GluThr: 3.821 ± 0.063
4.92GluVal: 4.92 ± 0.076
0.659GluTrp: 0.659 ± 0.028
2.472GluTyr: 2.472 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.119PheAla: 3.119 ± 0.071
0.383PheCys: 0.383 ± 0.019
2.949PheAsp: 2.949 ± 0.051
3.592PheGlu: 3.592 ± 0.061
2.798PhePhe: 2.798 ± 0.065
3.675PheGly: 3.675 ± 0.068
0.903PheHis: 0.903 ± 0.03
3.973PheIle: 3.973 ± 0.07
3.432PheLys: 3.432 ± 0.06
5.263PheLeu: 5.263 ± 0.091
1.141PheMet: 1.141 ± 0.039
3.061PheAsn: 3.061 ± 0.06
1.903PhePro: 1.903 ± 0.046
1.663PheGln: 1.663 ± 0.04
2.022PheArg: 2.022 ± 0.047
4.089PheSer: 4.089 ± 0.073
3.084PheThr: 3.084 ± 0.064
2.676PheVal: 2.676 ± 0.056
0.598PheTrp: 0.598 ± 0.026
2.097PheTyr: 2.097 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
4.373GlyAla: 4.373 ± 0.077
0.612GlyCys: 0.612 ± 0.032
3.605GlyAsp: 3.605 ± 0.065
4.539GlyGlu: 4.539 ± 0.075
3.774GlyPhe: 3.774 ± 0.066
4.75GlyGly: 4.75 ± 0.094
1.223GlyHis: 1.223 ± 0.032
5.771GlyIle: 5.771 ± 0.08
5.189GlyLys: 5.189 ± 0.082
6.078GlyLeu: 6.078 ± 0.099
1.796GlyMet: 1.796 ± 0.05
3.861GlyAsn: 3.861 ± 0.075
1.557GlyPro: 1.557 ± 0.045
1.937GlyGln: 1.937 ± 0.049
2.458GlyArg: 2.458 ± 0.055
4.001GlySer: 4.001 ± 0.074
3.969GlyThr: 3.969 ± 0.104
4.533GlyVal: 4.533 ± 0.069
0.831GlyTrp: 0.831 ± 0.031
2.792GlyTyr: 2.792 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
0.949HisAla: 0.949 ± 0.033
0.159HisCys: 0.159 ± 0.013
0.796HisAsp: 0.796 ± 0.031
1.016HisGlu: 1.016 ± 0.035
1.117HisPhe: 1.117 ± 0.034
1.126HisGly: 1.126 ± 0.035
0.491HisHis: 0.491 ± 0.024
1.392HisIle: 1.392 ± 0.041
1.2HisLys: 1.2 ± 0.042
1.976HisLeu: 1.976 ± 0.047
0.352HisMet: 0.352 ± 0.019
0.92HisAsn: 0.92 ± 0.031
1.02HisPro: 1.02 ± 0.035
0.726HisGln: 0.726 ± 0.031
0.839HisArg: 0.839 ± 0.026
1.178HisSer: 1.178 ± 0.036
0.997HisThr: 0.997 ± 0.035
0.873HisVal: 0.873 ± 0.028
0.227HisTrp: 0.227 ± 0.015
0.806HisTyr: 0.806 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.537IleAla: 5.537 ± 0.084
0.535IleCys: 0.535 ± 0.023
4.212IleAsp: 4.212 ± 0.072
5.369IleGlu: 5.369 ± 0.09
3.92IlePhe: 3.92 ± 0.085
4.9IleGly: 4.9 ± 0.076
1.354IleHis: 1.354 ± 0.041
5.871IleIle: 5.871 ± 0.104
5.281IleLys: 5.281 ± 0.085
7.696IleLeu: 7.696 ± 0.108
1.41IleMet: 1.41 ± 0.038
4.073IleAsn: 4.073 ± 0.073
3.509IlePro: 3.509 ± 0.058
2.432IleGln: 2.432 ± 0.058
2.744IleArg: 2.744 ± 0.057
5.617IleSer: 5.617 ± 0.074
4.633IleThr: 4.633 ± 0.087
4.164IleVal: 4.164 ± 0.072
0.705IleTrp: 0.705 ± 0.025
2.722IleTyr: 2.722 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.493LysAla: 4.493 ± 0.074
0.291LysCys: 0.291 ± 0.021
4.27LysAsp: 4.27 ± 0.073
6.149LysGlu: 6.149 ± 0.092
3.046LysPhe: 3.046 ± 0.058
4.289LysGly: 4.289 ± 0.074
1.192LysHis: 1.192 ± 0.032
5.699LysIle: 5.699 ± 0.082
5.91LysLys: 5.91 ± 0.096
6.268LysLeu: 6.268 ± 0.092
1.996LysMet: 1.996 ± 0.053
4.607LysAsn: 4.607 ± 0.077
2.309LysPro: 2.309 ± 0.049
2.235LysGln: 2.235 ± 0.051
2.828LysArg: 2.828 ± 0.053
3.741LysSer: 3.741 ± 0.072
3.991LysThr: 3.991 ± 0.075
4.43LysVal: 4.43 ± 0.077
0.704LysTrp: 0.704 ± 0.028
2.725LysTyr: 2.725 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.265LeuAla: 6.265 ± 0.1
0.598LeuCys: 0.598 ± 0.026
5.105LeuAsp: 5.105 ± 0.071
6.907LeuGlu: 6.907 ± 0.092
4.867LeuPhe: 4.867 ± 0.089
6.174LeuGly: 6.174 ± 0.091
1.666LeuHis: 1.666 ± 0.051
7.095LeuIle: 7.095 ± 0.127
7.607LeuLys: 7.607 ± 0.109
9.37LeuLeu: 9.37 ± 0.12
2.234LeuMet: 2.234 ± 0.047
5.495LeuAsn: 5.495 ± 0.094
3.906LeuPro: 3.906 ± 0.067
3.648LeuGln: 3.648 ± 0.063
3.859LeuArg: 3.859 ± 0.068
6.422LeuSer: 6.422 ± 0.079
5.049LeuThr: 5.049 ± 0.074
5.716LeuVal: 5.716 ± 0.084
0.867LeuTrp: 0.867 ± 0.03
3.188LeuTyr: 3.188 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.807MetAla: 1.807 ± 0.047
0.11MetCys: 0.11 ± 0.011
1.28MetAsp: 1.28 ± 0.037
1.84MetGlu: 1.84 ± 0.045
0.907MetPhe: 0.907 ± 0.033
1.637MetGly: 1.637 ± 0.043
0.419MetHis: 0.419 ± 0.022
1.525MetIle: 1.525 ± 0.042
2.164MetLys: 2.164 ± 0.05
2.021MetLeu: 2.021 ± 0.049
0.58MetMet: 0.58 ± 0.027
1.305MetAsn: 1.305 ± 0.035
0.841MetPro: 0.841 ± 0.033
0.886MetGln: 0.886 ± 0.032
0.967MetArg: 0.967 ± 0.03
1.266MetSer: 1.266 ± 0.038
1.096MetThr: 1.096 ± 0.034
1.531MetVal: 1.531 ± 0.044
0.172MetTrp: 0.172 ± 0.012
0.712MetTyr: 0.712 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.631AsnAla: 3.631 ± 0.058
0.391AsnCys: 0.391 ± 0.027
2.729AsnAsp: 2.729 ± 0.059
3.671AsnGlu: 3.671 ± 0.067
3.36AsnPhe: 3.36 ± 0.062
3.542AsnGly: 3.542 ± 0.076
0.952AsnHis: 0.952 ± 0.038
4.514AsnIle: 4.514 ± 0.072
3.66AsnLys: 3.66 ± 0.059
5.571AsnLeu: 5.571 ± 0.088
1.309AsnMet: 1.309 ± 0.039
3.381AsnAsn: 3.381 ± 0.066
2.699AsnPro: 2.699 ± 0.06
1.77AsnGln: 1.77 ± 0.049
2.439AsnArg: 2.439 ± 0.063
3.784AsnSer: 3.784 ± 0.073
3.274AsnThr: 3.274 ± 0.056
3.216AsnVal: 3.216 ± 0.062
0.727AsnTrp: 0.727 ± 0.027
2.638AsnTyr: 2.638 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.658ProAla: 2.658 ± 0.057
0.189ProCys: 0.189 ± 0.014
2.129ProAsp: 2.129 ± 0.048
3.463ProGlu: 3.463 ± 0.063
1.881ProPhe: 1.881 ± 0.042
2.826ProGly: 2.826 ± 0.062
0.712ProHis: 0.712 ± 0.032
2.218ProIle: 2.218 ± 0.05
2.106ProLys: 2.106 ± 0.052
3.333ProLeu: 3.333 ± 0.065
0.724ProMet: 0.724 ± 0.024
1.901ProAsn: 1.901 ± 0.043
1.032ProPro: 1.032 ± 0.036
1.472ProGln: 1.472 ± 0.036
1.221ProArg: 1.221 ± 0.037
2.07ProSer: 2.07 ± 0.044
1.963ProThr: 1.963 ± 0.051
3.227ProVal: 3.227 ± 0.054
0.368ProTrp: 0.368 ± 0.019
1.397ProTyr: 1.397 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.216GlnAla: 2.216 ± 0.055
0.15GlnCys: 0.15 ± 0.013
1.774GlnAsp: 1.774 ± 0.041
2.594GlnGlu: 2.594 ± 0.054
1.562GlnPhe: 1.562 ± 0.045
2.007GlnGly: 2.007 ± 0.048
0.613GlnHis: 0.613 ± 0.022
2.463GlnIle: 2.463 ± 0.05
2.69GlnLys: 2.69 ± 0.064
3.475GlnLeu: 3.475 ± 0.066
0.91GlnMet: 0.91 ± 0.031
2.096GlnAsn: 2.096 ± 0.049
1.185GlnPro: 1.185 ± 0.037
1.508GlnGln: 1.508 ± 0.045
1.475GlnArg: 1.475 ± 0.036
1.731GlnSer: 1.731 ± 0.045
1.839GlnThr: 1.839 ± 0.043
2.076GlnVal: 2.076 ± 0.041
0.353GlnTrp: 0.353 ± 0.019
1.282GlnTyr: 1.282 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.477ArgAla: 2.477 ± 0.052
0.194ArgCys: 0.194 ± 0.013
2.339ArgAsp: 2.339 ± 0.056
3.392ArgGlu: 3.392 ± 0.075
2.115ArgPhe: 2.115 ± 0.049
2.444ArgGly: 2.444 ± 0.058
0.689ArgHis: 0.689 ± 0.025
3.325ArgIle: 3.325 ± 0.053
3.071ArgLys: 3.071 ± 0.061
3.686ArgLeu: 3.686 ± 0.062
1.017ArgMet: 1.017 ± 0.033
2.498ArgAsn: 2.498 ± 0.066
1.257ArgPro: 1.257 ± 0.033
1.264ArgGln: 1.264 ± 0.036
1.652ArgArg: 1.652 ± 0.047
2.387ArgSer: 2.387 ± 0.058
1.935ArgThr: 1.935 ± 0.046
2.418ArgVal: 2.418 ± 0.045
0.399ArgTrp: 0.399 ± 0.018
1.623ArgTyr: 1.623 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
3.788SerAla: 3.788 ± 0.077
0.594SerCys: 0.594 ± 0.033
2.691SerAsp: 2.691 ± 0.052
3.77SerGlu: 3.77 ± 0.076
3.611SerPhe: 3.611 ± 0.073
4.846SerGly: 4.846 ± 0.095
1.174SerHis: 1.174 ± 0.033
4.673SerIle: 4.673 ± 0.073
3.929SerLys: 3.929 ± 0.073
6.347SerLeu: 6.347 ± 0.09
1.294SerMet: 1.294 ± 0.039
3.365SerAsn: 3.365 ± 0.064
2.424SerPro: 2.424 ± 0.051
2.215SerGln: 2.215 ± 0.045
2.805SerArg: 2.805 ± 0.054
4.14SerSer: 4.14 ± 0.076
3.331SerThr: 3.331 ± 0.07
3.687SerVal: 3.687 ± 0.069
0.715SerTrp: 0.715 ± 0.034
2.61SerTyr: 2.61 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.207ThrAla: 4.207 ± 0.094
0.337ThrCys: 0.337 ± 0.022
2.707ThrAsp: 2.707 ± 0.069
3.323ThrGlu: 3.323 ± 0.06
2.864ThrPhe: 2.864 ± 0.067
4.873ThrGly: 4.873 ± 0.081
1.016ThrHis: 1.016 ± 0.036
3.845ThrIle: 3.845 ± 0.07
2.916ThrLys: 2.916 ± 0.055
5.005ThrLeu: 5.005 ± 0.087
1.012ThrMet: 1.012 ± 0.035
2.83ThrAsn: 2.83 ± 0.06
2.621ThrPro: 2.621 ± 0.061
1.834ThrGln: 1.834 ± 0.048
2.238ThrArg: 2.238 ± 0.046
3.623ThrSer: 3.623 ± 0.067
3.259ThrThr: 3.259 ± 0.082
3.678ThrVal: 3.678 ± 0.125
0.549ThrTrp: 0.549 ± 0.028
2.218ThrTyr: 2.218 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.269ValAla: 4.269 ± 0.073
0.443ValCys: 0.443 ± 0.026
3.309ValAsp: 3.309 ± 0.07
4.211ValGlu: 4.211 ± 0.067
3.257ValPhe: 3.257 ± 0.055
3.771ValGly: 3.771 ± 0.063
1.104ValHis: 1.104 ± 0.039
5.13ValIle: 5.13 ± 0.077
4.38ValLys: 4.38 ± 0.074
6.036ValLeu: 6.036 ± 0.08
1.504ValMet: 1.504 ± 0.044
3.467ValAsn: 3.467 ± 0.064
2.38ValPro: 2.38 ± 0.047
2.002ValGln: 2.002 ± 0.042
2.292ValArg: 2.292 ± 0.057
4.162ValSer: 4.162 ± 0.081
3.522ValThr: 3.522 ± 0.11
4.176ValVal: 4.176 ± 0.085
0.553ValTrp: 0.553 ± 0.025
2.293ValTyr: 2.293 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.657TrpAla: 0.657 ± 0.027
0.078TrpCys: 0.078 ± 0.01
0.589TrpAsp: 0.589 ± 0.024
0.771TrpGlu: 0.771 ± 0.029
0.576TrpPhe: 0.576 ± 0.026
0.638TrpGly: 0.638 ± 0.029
0.227TrpHis: 0.227 ± 0.014
0.725TrpIle: 0.725 ± 0.028
0.803TrpLys: 0.803 ± 0.033
0.989TrpLeu: 0.989 ± 0.034
0.329TrpMet: 0.329 ± 0.018
0.666TrpAsn: 0.666 ± 0.025
0.285TrpPro: 0.285 ± 0.018
0.354TrpGln: 0.354 ± 0.02
0.39TrpArg: 0.39 ± 0.019
0.57TrpSer: 0.57 ± 0.028
0.493TrpThr: 0.493 ± 0.027
0.647TrpVal: 0.647 ± 0.024
0.162TrpTrp: 0.162 ± 0.013
0.444TrpTyr: 0.444 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.214TyrAla: 2.214 ± 0.048
0.277TyrCys: 0.277 ± 0.018
2.129TyrAsp: 2.129 ± 0.058
2.447TyrGlu: 2.447 ± 0.054
2.396TyrPhe: 2.396 ± 0.059
2.621TyrGly: 2.621 ± 0.06
0.776TyrHis: 0.776 ± 0.03
2.548TyrIle: 2.548 ± 0.054
2.724TyrLys: 2.724 ± 0.053
3.916TyrLeu: 3.916 ± 0.08
0.714TyrMet: 0.714 ± 0.027
2.446TyrAsn: 2.446 ± 0.061
1.459TyrPro: 1.459 ± 0.037
1.395TyrGln: 1.395 ± 0.042
1.882TyrArg: 1.882 ± 0.042
2.623TyrSer: 2.623 ± 0.061
2.171TyrThr: 2.171 ± 0.059
2.028TyrVal: 2.028 ± 0.048
0.449TyrTrp: 0.449 ± 0.025
1.651TyrTyr: 1.651 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2941 proteins (981175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski