Amino acid dipepetide frequency for [Ruminococcus] torques L2-14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.85AlaAla: 6.85 ± 0.143
1.074AlaCys: 1.074 ± 0.037
4.465AlaAsp: 4.465 ± 0.072
5.701AlaGlu: 5.701 ± 0.106
2.953AlaPhe: 2.953 ± 0.071
5.765AlaGly: 5.765 ± 0.103
1.165AlaHis: 1.165 ± 0.038
5.169AlaIle: 5.169 ± 0.096
5.12AlaLys: 5.12 ± 0.083
6.433AlaLeu: 6.433 ± 0.107
2.307AlaMet: 2.307 ± 0.057
2.474AlaAsn: 2.474 ± 0.054
1.879AlaPro: 1.879 ± 0.046
2.327AlaGln: 2.327 ± 0.055
2.758AlaArg: 2.758 ± 0.067
3.541AlaSer: 3.541 ± 0.074
3.285AlaThr: 3.285 ± 0.068
6.1AlaVal: 6.1 ± 0.094
0.587AlaTrp: 0.587 ± 0.028
2.717AlaTyr: 2.717 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.977CysAla: 0.977 ± 0.032
0.268CysCys: 0.268 ± 0.019
0.834CysAsp: 0.834 ± 0.027
0.988CysGlu: 0.988 ± 0.037
0.614CysPhe: 0.614 ± 0.025
1.511CysGly: 1.511 ± 0.05
0.293CysHis: 0.293 ± 0.018
1.083CysIle: 1.083 ± 0.04
0.92CysLys: 0.92 ± 0.038
1.113CysLeu: 1.113 ± 0.035
0.476CysMet: 0.476 ± 0.026
0.597CysAsn: 0.597 ± 0.029
0.653CysPro: 0.653 ± 0.031
0.43CysGln: 0.43 ± 0.021
0.654CysArg: 0.654 ± 0.027
0.865CysSer: 0.865 ± 0.032
0.782CysThr: 0.782 ± 0.035
1.049CysVal: 1.049 ± 0.035
0.136CysTrp: 0.136 ± 0.011
0.582CysTyr: 0.582 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.127AspAla: 4.127 ± 0.076
0.887AspCys: 0.887 ± 0.035
2.895AspAsp: 2.895 ± 0.077
4.865AspGlu: 4.865 ± 0.084
2.522AspPhe: 2.522 ± 0.061
4.228AspGly: 4.228 ± 0.075
0.912AspHis: 0.912 ± 0.039
4.281AspIle: 4.281 ± 0.071
3.553AspLys: 3.553 ± 0.072
4.773AspLeu: 4.773 ± 0.087
1.828AspMet: 1.828 ± 0.049
2.109AspAsn: 2.109 ± 0.053
1.676AspPro: 1.676 ± 0.056
1.547AspGln: 1.547 ± 0.046
2.35AspArg: 2.35 ± 0.06
3.064AspSer: 3.064 ± 0.067
3.072AspThr: 3.072 ± 0.069
3.954AspVal: 3.954 ± 0.074
0.585AspTrp: 0.585 ± 0.027
2.742AspTyr: 2.742 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.7GluAla: 5.7 ± 0.096
0.874GluCys: 0.874 ± 0.031
4.539GluAsp: 4.539 ± 0.076
7.981GluGlu: 7.981 ± 0.139
2.647GluPhe: 2.647 ± 0.054
4.364GluGly: 4.364 ± 0.077
1.476GluHis: 1.476 ± 0.042
5.96GluIle: 5.96 ± 0.096
7.574GluLys: 7.574 ± 0.111
7.296GluLeu: 7.296 ± 0.097
2.662GluMet: 2.662 ± 0.056
4.552GluAsn: 4.552 ± 0.073
1.848GluPro: 1.848 ± 0.05
3.389GluGln: 3.389 ± 0.078
3.546GluArg: 3.546 ± 0.079
3.379GluSer: 3.379 ± 0.075
3.777GluThr: 3.777 ± 0.064
4.903GluVal: 4.903 ± 0.093
0.701GluTrp: 0.701 ± 0.035
3.385GluTyr: 3.385 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.834PheAla: 2.834 ± 0.066
0.747PheCys: 0.747 ± 0.03
2.478PheAsp: 2.478 ± 0.059
2.669PheGlu: 2.669 ± 0.054
1.74PhePhe: 1.74 ± 0.053
3.105PheGly: 3.105 ± 0.065
0.865PheHis: 0.865 ± 0.031
2.784PheIle: 2.784 ± 0.063
2.117PheLys: 2.117 ± 0.052
3.809PheLeu: 3.809 ± 0.086
1.168PheMet: 1.168 ± 0.036
1.546PheAsn: 1.546 ± 0.046
1.409PhePro: 1.409 ± 0.04
1.346PheGln: 1.346 ± 0.045
1.64PheArg: 1.64 ± 0.044
2.681PheSer: 2.681 ± 0.058
2.203PheThr: 2.203 ± 0.048
2.774PheVal: 2.774 ± 0.059
0.362PheTrp: 0.362 ± 0.023
1.658PheTyr: 1.658 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.893GlyAla: 4.893 ± 0.091
1.254GlyCys: 1.254 ± 0.044
3.378GlyAsp: 3.378 ± 0.068
4.739GlyGlu: 4.739 ± 0.072
3.016GlyPhe: 3.016 ± 0.068
4.754GlyGly: 4.754 ± 0.118
1.261GlyHis: 1.261 ± 0.045
6.176GlyIle: 6.176 ± 0.088
5.838GlyLys: 5.838 ± 0.093
5.627GlyLeu: 5.627 ± 0.1
2.605GlyMet: 2.605 ± 0.063
3.299GlyAsn: 3.299 ± 0.069
1.216GlyPro: 1.216 ± 0.04
2.084GlyGln: 2.084 ± 0.052
2.951GlyArg: 2.951 ± 0.066
3.863GlySer: 3.863 ± 0.074
4.314GlyThr: 4.314 ± 0.074
5.056GlyVal: 5.056 ± 0.091
0.717GlyTrp: 0.717 ± 0.031
3.157GlyTyr: 3.157 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.13HisAla: 1.13 ± 0.035
0.329HisCys: 0.329 ± 0.019
0.909HisAsp: 0.909 ± 0.034
1.145HisGlu: 1.145 ± 0.037
0.878HisPhe: 0.878 ± 0.032
1.32HisGly: 1.32 ± 0.046
0.448HisHis: 0.448 ± 0.037
1.344HisIle: 1.344 ± 0.036
0.98HisLys: 0.98 ± 0.035
1.578HisLeu: 1.578 ± 0.048
0.5HisMet: 0.5 ± 0.024
0.779HisAsn: 0.779 ± 0.032
0.879HisPro: 0.879 ± 0.033
0.574HisGln: 0.574 ± 0.026
0.814HisArg: 0.814 ± 0.035
0.996HisSer: 0.996 ± 0.036
1.002HisThr: 1.002 ± 0.034
1.178HisVal: 1.178 ± 0.041
0.173HisTrp: 0.173 ± 0.016
0.792HisTyr: 0.792 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.737IleAla: 5.737 ± 0.095
1.348IleCys: 1.348 ± 0.046
4.216IleAsp: 4.216 ± 0.079
5.32IleGlu: 5.32 ± 0.077
2.981IlePhe: 2.981 ± 0.07
5.347IleGly: 5.347 ± 0.097
1.411IleHis: 1.411 ± 0.039
4.965IleIle: 4.965 ± 0.102
4.332IleLys: 4.332 ± 0.076
7.085IleLeu: 7.085 ± 0.108
1.958IleMet: 1.958 ± 0.049
2.912IleAsn: 2.912 ± 0.057
3.231IlePro: 3.231 ± 0.063
2.504IleGln: 2.504 ± 0.055
3.564IleArg: 3.564 ± 0.063
4.786IleSer: 4.786 ± 0.078
4.059IleThr: 4.059 ± 0.065
5.078IleVal: 5.078 ± 0.095
0.609IleTrp: 0.609 ± 0.027
2.832IleTyr: 2.832 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
5.112LysAla: 5.112 ± 0.094
0.829LysCys: 0.829 ± 0.037
4.25LysAsp: 4.25 ± 0.07
7.681LysGlu: 7.681 ± 0.121
2.056LysPhe: 2.056 ± 0.054
4.377LysGly: 4.377 ± 0.072
1.106LysHis: 1.106 ± 0.038
5.342LysIle: 5.342 ± 0.076
6.978LysLys: 6.978 ± 0.111
5.629LysLeu: 5.629 ± 0.086
2.606LysMet: 2.606 ± 0.06
3.822LysAsn: 3.822 ± 0.082
2.009LysPro: 2.009 ± 0.047
2.615LysGln: 2.615 ± 0.066
3.336LysArg: 3.336 ± 0.071
3.499LysSer: 3.499 ± 0.069
3.911LysThr: 3.911 ± 0.076
4.691LysVal: 4.691 ± 0.082
0.627LysTrp: 0.627 ± 0.031
2.943LysTyr: 2.943 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.641LeuAla: 6.641 ± 0.102
1.505LeuCys: 1.505 ± 0.04
4.881LeuAsp: 4.881 ± 0.087
6.634LeuGlu: 6.634 ± 0.113
3.678LeuPhe: 3.678 ± 0.093
5.983LeuGly: 5.983 ± 0.086
1.609LeuHis: 1.609 ± 0.048
6.279LeuIle: 6.279 ± 0.105
6.43LeuLys: 6.43 ± 0.081
8.333LeuLeu: 8.333 ± 0.136
2.714LeuMet: 2.714 ± 0.06
3.822LeuAsn: 3.822 ± 0.069
3.474LeuPro: 3.474 ± 0.065
2.925LeuGln: 2.925 ± 0.062
3.611LeuArg: 3.611 ± 0.07
5.611LeuSer: 5.611 ± 0.085
4.992LeuThr: 4.992 ± 0.086
5.409LeuVal: 5.409 ± 0.089
0.721LeuTrp: 0.721 ± 0.027
3.206LeuTyr: 3.206 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.418MetAla: 2.418 ± 0.056
0.408MetCys: 0.408 ± 0.021
1.822MetAsp: 1.822 ± 0.044
2.635MetGlu: 2.635 ± 0.063
1.049MetPhe: 1.049 ± 0.035
2.094MetGly: 2.094 ± 0.053
0.468MetHis: 0.468 ± 0.022
2.417MetIle: 2.417 ± 0.059
2.835MetLys: 2.835 ± 0.055
2.741MetLeu: 2.741 ± 0.052
1.019MetMet: 1.019 ± 0.046
1.675MetAsn: 1.675 ± 0.043
1.062MetPro: 1.062 ± 0.038
1.083MetGln: 1.083 ± 0.029
1.325MetArg: 1.325 ± 0.04
1.799MetSer: 1.799 ± 0.046
1.844MetThr: 1.844 ± 0.045
1.852MetVal: 1.852 ± 0.05
0.241MetTrp: 0.241 ± 0.017
0.938MetTyr: 0.938 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.154AsnAla: 3.154 ± 0.061
0.59AsnCys: 0.59 ± 0.028
2.13AsnAsp: 2.13 ± 0.059
3.036AsnGlu: 3.036 ± 0.056
1.593AsnPhe: 1.593 ± 0.041
3.482AsnGly: 3.482 ± 0.072
0.861AsnHis: 0.861 ± 0.036
3.36AsnIle: 3.36 ± 0.064
2.682AsnLys: 2.682 ± 0.062
3.922AsnLeu: 3.922 ± 0.064
1.396AsnMet: 1.396 ± 0.043
1.747AsnAsn: 1.747 ± 0.052
2.042AsnPro: 2.042 ± 0.049
1.626AsnGln: 1.626 ± 0.05
2.044AsnArg: 2.044 ± 0.054
2.386AsnSer: 2.386 ± 0.067
2.294AsnThr: 2.294 ± 0.054
3.062AsnVal: 3.062 ± 0.062
0.431AsnTrp: 0.431 ± 0.023
1.901AsnTyr: 1.901 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.232ProAla: 2.232 ± 0.052
0.408ProCys: 0.408 ± 0.022
2.095ProAsp: 2.095 ± 0.052
3.45ProGlu: 3.45 ± 0.069
1.452ProPhe: 1.452 ± 0.044
2.254ProGly: 2.254 ± 0.055
0.58ProHis: 0.58 ± 0.029
2.182ProIle: 2.182 ± 0.048
2.081ProLys: 2.081 ± 0.058
2.704ProLeu: 2.704 ± 0.061
0.856ProMet: 0.856 ± 0.033
1.218ProAsn: 1.218 ± 0.034
0.612ProPro: 0.612 ± 0.03
1.027ProGln: 1.027 ± 0.034
0.95ProArg: 0.95 ± 0.037
1.706ProSer: 1.706 ± 0.049
1.587ProThr: 1.587 ± 0.046
2.91ProVal: 2.91 ± 0.059
0.263ProTrp: 0.263 ± 0.017
1.385ProTyr: 1.385 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.38GlnAla: 2.38 ± 0.058
0.374GlnCys: 0.374 ± 0.022
1.579GlnAsp: 1.579 ± 0.049
2.89GlnGlu: 2.89 ± 0.076
1.201GlnPhe: 1.201 ± 0.039
1.896GlnGly: 1.896 ± 0.041
0.484GlnHis: 0.484 ± 0.025
2.993GlnIle: 2.993 ± 0.059
3.064GlnLys: 3.064 ± 0.076
2.923GlnLeu: 2.923 ± 0.069
1.262GlnMet: 1.262 ± 0.04
1.707GlnAsn: 1.707 ± 0.048
0.909GlnPro: 0.909 ± 0.039
1.278GlnGln: 1.278 ± 0.047
1.418GlnArg: 1.418 ± 0.052
1.722GlnSer: 1.722 ± 0.046
1.83GlnThr: 1.83 ± 0.055
2.162GlnVal: 2.162 ± 0.05
0.349GlnTrp: 0.349 ± 0.022
1.348GlnTyr: 1.348 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.57ArgAla: 2.57 ± 0.061
0.559ArgCys: 0.559 ± 0.025
2.139ArgAsp: 2.139 ± 0.05
3.702ArgGlu: 3.702 ± 0.076
1.815ArgPhe: 1.815 ± 0.044
2.377ArgGly: 2.377 ± 0.058
0.779ArgHis: 0.779 ± 0.03
3.319ArgIle: 3.319 ± 0.058
3.873ArgLys: 3.873 ± 0.071
3.682ArgLeu: 3.682 ± 0.076
1.602ArgMet: 1.602 ± 0.05
2.052ArgAsn: 2.052 ± 0.05
1.285ArgPro: 1.285 ± 0.043
1.716ArgGln: 1.716 ± 0.059
2.265ArgArg: 2.265 ± 0.059
2.017ArgSer: 2.017 ± 0.041
2.239ArgThr: 2.239 ± 0.051
2.576ArgVal: 2.576 ± 0.066
0.39ArgTrp: 0.39 ± 0.024
1.801ArgTyr: 1.801 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.808SerAla: 3.808 ± 0.075
0.839SerCys: 0.839 ± 0.035
3.149SerAsp: 3.149 ± 0.062
4.07SerGlu: 4.07 ± 0.076
2.454SerPhe: 2.454 ± 0.055
4.69SerGly: 4.69 ± 0.081
0.947SerHis: 0.947 ± 0.035
3.923SerIle: 3.923 ± 0.075
3.622SerLys: 3.622 ± 0.071
4.832SerLeu: 4.832 ± 0.081
1.746SerMet: 1.746 ± 0.048
2.16SerAsn: 2.16 ± 0.059
1.664SerPro: 1.664 ± 0.048
1.698SerGln: 1.698 ± 0.048
2.482SerArg: 2.482 ± 0.06
3.294SerSer: 3.294 ± 0.112
2.703SerThr: 2.703 ± 0.066
4.336SerVal: 4.336 ± 0.082
0.496SerTrp: 0.496 ± 0.029
2.324SerTyr: 2.324 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.151ThrAla: 4.151 ± 0.076
0.623ThrCys: 0.623 ± 0.03
3.237ThrAsp: 3.237 ± 0.06
4.282ThrGlu: 4.282 ± 0.077
2.156ThrPhe: 2.156 ± 0.054
4.632ThrGly: 4.632 ± 0.09
0.908ThrHis: 0.908 ± 0.03
3.916ThrIle: 3.916 ± 0.073
3.32ThrLys: 3.32 ± 0.066
4.697ThrLeu: 4.697 ± 0.075
1.427ThrMet: 1.427 ± 0.042
2.01ThrAsn: 2.01 ± 0.055
2.042ThrPro: 2.042 ± 0.05
1.528ThrGln: 1.528 ± 0.046
1.907ThrArg: 1.907 ± 0.053
2.97ThrSer: 2.97 ± 0.075
2.944ThrThr: 2.944 ± 0.077
4.473ThrVal: 4.473 ± 0.088
0.449ThrTrp: 0.449 ± 0.024
2.056ThrTyr: 2.056 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.719ValAla: 4.719 ± 0.084
1.172ValCys: 1.172 ± 0.035
3.978ValAsp: 3.978 ± 0.063
4.982ValGlu: 4.982 ± 0.085
2.997ValPhe: 2.997 ± 0.063
4.443ValGly: 4.443 ± 0.079
1.147ValHis: 1.147 ± 0.035
5.301ValIle: 5.301 ± 0.086
4.877ValLys: 4.877 ± 0.083
6.739ValLeu: 6.739 ± 0.099
2.096ValMet: 2.096 ± 0.052
2.976ValAsn: 2.976 ± 0.066
2.482ValPro: 2.482 ± 0.053
2.156ValGln: 2.156 ± 0.057
2.859ValArg: 2.859 ± 0.061
4.418ValSer: 4.418 ± 0.077
4.161ValThr: 4.161 ± 0.083
4.964ValVal: 4.964 ± 0.097
0.584ValTrp: 0.584 ± 0.03
2.556ValTyr: 2.556 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.51TrpAla: 0.51 ± 0.025
0.155TrpCys: 0.155 ± 0.016
0.493TrpAsp: 0.493 ± 0.023
0.606TrpGlu: 0.606 ± 0.028
0.37TrpPhe: 0.37 ± 0.023
0.641TrpGly: 0.641 ± 0.033
0.172TrpHis: 0.172 ± 0.016
0.717TrpIle: 0.717 ± 0.035
0.807TrpLys: 0.807 ± 0.032
0.766TrpLeu: 0.766 ± 0.03
0.358TrpMet: 0.358 ± 0.021
0.582TrpAsn: 0.582 ± 0.029
0.179TrpPro: 0.179 ± 0.017
0.327TrpGln: 0.327 ± 0.02
0.349TrpArg: 0.349 ± 0.023
0.475TrpSer: 0.475 ± 0.029
0.399TrpThr: 0.399 ± 0.022
0.479TrpVal: 0.479 ± 0.023
0.108TrpTrp: 0.108 ± 0.015
0.395TrpTyr: 0.395 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.729TyrAla: 2.729 ± 0.049
0.584TyrCys: 0.584 ± 0.025
2.502TyrAsp: 2.502 ± 0.058
3.177TyrGlu: 3.177 ± 0.068
1.761TyrPhe: 1.761 ± 0.043
2.931TyrGly: 2.931 ± 0.07
0.86TyrHis: 0.86 ± 0.031
2.763TyrIle: 2.763 ± 0.056
2.418TyrLys: 2.418 ± 0.057
3.779TyrLeu: 3.779 ± 0.071
1.135TyrMet: 1.135 ± 0.045
1.699TyrAsn: 1.699 ± 0.051
1.404TyrPro: 1.404 ± 0.037
1.587TyrGln: 1.587 ± 0.046
1.935TyrArg: 1.935 ± 0.046
2.164TyrSer: 2.164 ± 0.056
2.326TyrThr: 2.326 ± 0.051
2.603TyrVal: 2.603 ± 0.059
0.358TyrTrp: 0.358 ± 0.024
1.832TyrTyr: 1.832 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2797 proteins (851199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski