Amino acid dipepetide frequency for Pseudogymnoascus verrucosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.052AlaAla: 10.052 ± 0.072	1.06AlaCys: 1.06 ± 0.015	4.331AlaAsp: 4.331 ± 0.035	5.412AlaGlu: 5.412 ± 0.052	3.158AlaPhe: 3.158 ± 0.028	6.246AlaGly: 6.246 ± 0.039	1.727AlaHis: 1.727 ± 0.02	4.548AlaIle: 4.548 ± 0.032	4.365AlaLys: 4.365 ± 0.038	7.863AlaLeu: 7.863 ± 0.047	2.024AlaMet: 2.024 ± 0.022	3.114AlaAsn: 3.114 ± 0.029	5.24AlaPro: 5.24 ± 0.05	3.403AlaGln: 3.403 ± 0.032	4.829AlaArg: 4.829 ± 0.037	7.224AlaSer: 7.224 ± 0.038	5.625AlaThr: 5.625 ± 0.038	5.601AlaVal: 5.601 ± 0.037	1.145AlaTrp: 1.145 ± 0.017	2.231AlaTyr: 2.231 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.013	0.239CysCys: 0.239 ± 0.008	0.66CysAsp: 0.66 ± 0.012	0.578CysGlu: 0.578 ± 0.011	0.525CysPhe: 0.525 ± 0.011	0.984CysGly: 0.984 ± 0.017	0.3CysHis: 0.3 ± 0.009	0.703CysIle: 0.703 ± 0.013	0.512CysLys: 0.512 ± 0.01	1.181CysLeu: 1.181 ± 0.017	0.272CysMet: 0.272 ± 0.007	0.432CysAsn: 0.432 ± 0.011	0.609CysPro: 0.609 ± 0.013	0.408CysGln: 0.408 ± 0.009	0.675CysArg: 0.675 ± 0.012	0.875CysSer: 0.875 ± 0.016	0.689CysThr: 0.689 ± 0.013	0.773CysVal: 0.773 ± 0.013	0.2CysTrp: 0.2 ± 0.006	0.359CysTyr: 0.359 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.816AspAla: 4.816 ± 0.031	0.583AspCys: 0.583 ± 0.011	4.069AspAsp: 4.069 ± 0.04	4.441AspGlu: 4.441 ± 0.046	2.199AspPhe: 2.199 ± 0.024	4.231AspGly: 4.231 ± 0.035	1.072AspHis: 1.072 ± 0.015	3.137AspIle: 3.137 ± 0.024	2.407AspLys: 2.407 ± 0.024	4.847AspLeu: 4.847 ± 0.033	1.254AspMet: 1.254 ± 0.015	1.923AspAsn: 1.923 ± 0.02	3.03AspPro: 3.03 ± 0.023	1.672AspGln: 1.672 ± 0.019	2.806AspArg: 2.806 ± 0.027	4.021AspSer: 4.021 ± 0.031	2.967AspThr: 2.967 ± 0.026	3.689AspVal: 3.689 ± 0.029	0.849AspTrp: 0.849 ± 0.014	1.598AspTyr: 1.598 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.703GluAla: 5.703 ± 0.052	0.61GluCys: 0.61 ± 0.012	4.126GluAsp: 4.126 ± 0.039	5.842GluGlu: 5.842 ± 0.066	1.972GluPhe: 1.972 ± 0.022	4.395GluGly: 4.395 ± 0.036	1.242GluHis: 1.242 ± 0.016	3.116GluIle: 3.116 ± 0.03	3.79GluLys: 3.79 ± 0.037	5.078GluLeu: 5.078 ± 0.037	1.571GluMet: 1.571 ± 0.019	2.197GluAsn: 2.197 ± 0.02	2.634GluPro: 2.634 ± 0.034	2.255GluGln: 2.255 ± 0.027	3.974GluArg: 3.974 ± 0.038	4.226GluSer: 4.226 ± 0.029	3.447GluThr: 3.447 ± 0.029	3.946GluVal: 3.946 ± 0.034	0.896GluTrp: 0.896 ± 0.014	1.677GluTyr: 1.677 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.13PheAla: 3.13 ± 0.032	0.541PheCys: 0.541 ± 0.012	2.226PheAsp: 2.226 ± 0.02	2.189PheGlu: 2.189 ± 0.023	1.589PhePhe: 1.589 ± 0.022	3.008PheGly: 3.008 ± 0.033	0.843PheHis: 0.843 ± 0.014	1.889PheIle: 1.889 ± 0.022	1.577PheLys: 1.577 ± 0.018	3.34PheLeu: 3.34 ± 0.028	0.823PheMet: 0.823 ± 0.014	1.433PheAsn: 1.433 ± 0.018	1.894PhePro: 1.894 ± 0.021	1.351PheGln: 1.351 ± 0.02	1.807PheArg: 1.807 ± 0.019	2.907PheSer: 2.907 ± 0.024	2.154PheThr: 2.154 ± 0.021	2.377PheVal: 2.377 ± 0.022	0.623PheTrp: 0.623 ± 0.012	1.111PheTyr: 1.111 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.939GlyAla: 5.939 ± 0.041	0.913GlyCys: 0.913 ± 0.017	3.82GlyAsp: 3.82 ± 0.029	4.253GlyGlu: 4.253 ± 0.035	2.924GlyPhe: 2.924 ± 0.025	7.208GlyGly: 7.208 ± 0.081	1.625GlyHis: 1.625 ± 0.021	3.732GlyIle: 3.732 ± 0.036	3.852GlyLys: 3.852 ± 0.032	6.153GlyLeu: 6.153 ± 0.036	1.774GlyMet: 1.774 ± 0.021	2.729GlyAsn: 2.729 ± 0.023	3.354GlyPro: 3.354 ± 0.033	2.587GlyGln: 2.587 ± 0.026	4.261GlyArg: 4.261 ± 0.031	5.863GlySer: 5.863 ± 0.039	4.147GlyThr: 4.147 ± 0.035	4.81GlyVal: 4.81 ± 0.039	1.259GlyTrp: 1.259 ± 0.017	2.216GlyTyr: 2.216 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.736HisAla: 1.736 ± 0.019	0.295HisCys: 0.295 ± 0.008	1.179HisAsp: 1.179 ± 0.014	1.202HisGlu: 1.202 ± 0.016	0.868HisPhe: 0.868 ± 0.014	1.625HisGly: 1.625 ± 0.019	0.729HisHis: 0.729 ± 0.015	1.217HisIle: 1.217 ± 0.014	0.912HisLys: 0.912 ± 0.015	2.067HisLeu: 2.067 ± 0.025	0.452HisMet: 0.452 ± 0.009	0.845HisAsn: 0.845 ± 0.014	1.543HisPro: 1.543 ± 0.019	0.864HisGln: 0.864 ± 0.014	1.341HisArg: 1.341 ± 0.015	1.65HisSer: 1.65 ± 0.021	1.257HisThr: 1.257 ± 0.017	1.34HisVal: 1.34 ± 0.017	0.31HisTrp: 0.31 ± 0.008	0.675HisTyr: 0.675 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.466IleAla: 4.466 ± 0.034	0.759IleCys: 0.759 ± 0.013	2.921IleAsp: 2.921 ± 0.024	2.953IleGlu: 2.953 ± 0.028	2.066IlePhe: 2.066 ± 0.023	3.41IleGly: 3.41 ± 0.031	1.139IleHis: 1.139 ± 0.016	2.737IleIle: 2.737 ± 0.03	2.295IleLys: 2.295 ± 0.024	4.644IleLeu: 4.644 ± 0.037	1.073IleMet: 1.073 ± 0.017	1.917IleAsn: 1.917 ± 0.023	3.091IlePro: 3.091 ± 0.025	1.85IleGln: 1.85 ± 0.02	2.689IleArg: 2.689 ± 0.024	4.04IleSer: 4.04 ± 0.03	3.089IleThr: 3.089 ± 0.026	3.263IleVal: 3.263 ± 0.032	0.708IleTrp: 0.708 ± 0.014	1.501IleTyr: 1.501 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.579LysAla: 4.579 ± 0.038	0.509LysCys: 0.509 ± 0.01	2.814LysAsp: 2.814 ± 0.024	3.552LysGlu: 3.552 ± 0.034	1.533LysPhe: 1.533 ± 0.019	3.3LysGly: 3.3 ± 0.029	1.067LysHis: 1.067 ± 0.014	2.391LysIle: 2.391 ± 0.025	3.427LysLys: 3.427 ± 0.05	4.175LysLeu: 4.175 ± 0.031	1.064LysMet: 1.064 ± 0.014	1.798LysAsn: 1.798 ± 0.02	2.697LysPro: 2.697 ± 0.025	1.707LysGln: 1.707 ± 0.019	3.305LysArg: 3.305 ± 0.033	3.628LysSer: 3.628 ± 0.029	2.911LysThr: 2.911 ± 0.026	2.993LysVal: 2.993 ± 0.031	0.695LysTrp: 0.695 ± 0.012	1.419LysTyr: 1.419 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.881LeuAla: 7.881 ± 0.049	1.127LeuCys: 1.127 ± 0.015	4.974LeuAsp: 4.974 ± 0.033	5.396LeuGlu: 5.396 ± 0.04	3.235LeuPhe: 3.235 ± 0.032	6.053LeuGly: 6.053 ± 0.034	2.076LeuHis: 2.076 ± 0.022	4.023LeuIle: 4.023 ± 0.032	4.291LeuLys: 4.291 ± 0.033	8.298LeuLeu: 8.298 ± 0.065	1.784LeuMet: 1.784 ± 0.019	3.099LeuAsn: 3.099 ± 0.023	5.424LeuPro: 5.424 ± 0.035	3.556LeuGln: 3.556 ± 0.031	5.359LeuArg: 5.359 ± 0.038	7.179LeuSer: 7.179 ± 0.046	4.863LeuThr: 4.863 ± 0.031	5.278LeuVal: 5.278 ± 0.042	1.183LeuTrp: 1.183 ± 0.017	2.323LeuTyr: 2.323 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.299MetAla: 2.299 ± 0.021	0.233MetCys: 0.233 ± 0.006	1.263MetAsp: 1.263 ± 0.015	1.362MetGlu: 1.362 ± 0.016	0.771MetPhe: 0.771 ± 0.015	1.663MetGly: 1.663 ± 0.021	0.489MetHis: 0.489 ± 0.009	0.996MetIle: 0.996 ± 0.014	1.073MetLys: 1.073 ± 0.015	1.847MetLeu: 1.847 ± 0.021	0.608MetMet: 0.608 ± 0.012	0.809MetAsn: 0.809 ± 0.013	1.246MetPro: 1.246 ± 0.016	0.826MetGln: 0.826 ± 0.015	1.269MetArg: 1.269 ± 0.016	1.901MetSer: 1.901 ± 0.018	1.242MetThr: 1.242 ± 0.017	1.355MetVal: 1.355 ± 0.02	0.273MetTrp: 0.273 ± 0.007	0.526MetTyr: 0.526 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.198AsnAla: 3.198 ± 0.031	0.471AsnCys: 0.471 ± 0.01	1.941AsnAsp: 1.941 ± 0.022	2.006AsnGlu: 2.006 ± 0.023	1.421AsnPhe: 1.421 ± 0.018	3.221AsnGly: 3.221 ± 0.031	0.801AsnHis: 0.801 ± 0.013	2.169AsnIle: 2.169 ± 0.022	1.581AsnLys: 1.581 ± 0.019	3.219AsnLeu: 3.219 ± 0.026	0.867AsnMet: 0.867 ± 0.014	1.601AsnAsn: 1.601 ± 0.028	2.446AsnPro: 2.446 ± 0.024	1.295AsnGln: 1.295 ± 0.02	1.889AsnArg: 1.889 ± 0.022	2.855AsnSer: 2.855 ± 0.023	2.237AsnThr: 2.237 ± 0.025	2.283AsnVal: 2.283 ± 0.023	0.554AsnTrp: 0.554 ± 0.011	1.112AsnTyr: 1.112 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.332ProAla: 5.332 ± 0.04	0.479ProCys: 0.479 ± 0.011	2.897ProAsp: 2.897 ± 0.023	3.606ProGlu: 3.606 ± 0.028	1.959ProPhe: 1.959 ± 0.018	3.922ProGly: 3.922 ± 0.035	1.26ProHis: 1.26 ± 0.019	2.646ProIle: 2.646 ± 0.026	2.751ProLys: 2.751 ± 0.024	4.78ProLeu: 4.78 ± 0.035	1.06ProMet: 1.06 ± 0.016	2.211ProAsn: 2.211 ± 0.024	5.19ProPro: 5.19 ± 0.064	2.394ProGln: 2.394 ± 0.028	3.273ProArg: 3.273 ± 0.035	5.796ProSer: 5.796 ± 0.046	4.29ProThr: 4.29 ± 0.042	3.523ProVal: 3.523 ± 0.033	0.709ProTrp: 0.709 ± 0.012	1.493ProTyr: 1.493 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.307GlnAla: 3.307 ± 0.033	0.417GlnCys: 0.417 ± 0.01	1.858GlnAsp: 1.858 ± 0.02	2.232GlnGlu: 2.232 ± 0.025	1.252GlnPhe: 1.252 ± 0.016	2.486GlnGly: 2.486 ± 0.028	0.949GlnHis: 0.949 ± 0.014	1.844GlnIle: 1.844 ± 0.018	1.889GlnLys: 1.889 ± 0.024	3.264GlnLeu: 3.264 ± 0.026	0.856GlnMet: 0.856 ± 0.014	1.524GlnAsn: 1.524 ± 0.019	2.357GlnPro: 2.357 ± 0.026	2.47GlnGln: 2.47 ± 0.059	2.415GlnArg: 2.415 ± 0.022	2.884GlnSer: 2.884 ± 0.027	2.206GlnThr: 2.206 ± 0.022	2.034GlnVal: 2.034 ± 0.024	0.553GlnTrp: 0.553 ± 0.01	1.167GlnTyr: 1.167 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.651ArgAla: 4.651 ± 0.034	0.669ArgCys: 0.669 ± 0.012	3.231ArgAsp: 3.231 ± 0.029	3.876ArgGlu: 3.876 ± 0.04	1.975ArgPhe: 1.975 ± 0.018	3.981ArgGly: 3.981 ± 0.035	1.43ArgHis: 1.43 ± 0.017	2.808ArgIle: 2.808 ± 0.022	3.311ArgLys: 3.311 ± 0.032	5.027ArgLeu: 5.027 ± 0.037	1.281ArgMet: 1.281 ± 0.016	2.166ArgAsn: 2.166 ± 0.025	3.23ArgPro: 3.23 ± 0.034	2.386ArgGln: 2.386 ± 0.025	4.813ArgArg: 4.813 ± 0.051	4.418ArgSer: 4.418 ± 0.038	3.169ArgThr: 3.169 ± 0.027	3.289ArgVal: 3.289 ± 0.026	0.842ArgTrp: 0.842 ± 0.015	1.543ArgTyr: 1.543 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.655SerAla: 6.655 ± 0.044	0.881SerCys: 0.881 ± 0.014	4.129SerAsp: 4.129 ± 0.034	4.009SerGlu: 4.009 ± 0.029	2.94SerPhe: 2.94 ± 0.028	5.715SerGly: 5.715 ± 0.038	1.818SerHis: 1.818 ± 0.02	4.145SerIle: 4.145 ± 0.032	3.796SerLys: 3.796 ± 0.033	7.067SerLeu: 7.067 ± 0.046	1.7SerMet: 1.7 ± 0.019	3.064SerAsn: 3.064 ± 0.023	5.485SerPro: 5.485 ± 0.054	3.101SerGln: 3.101 ± 0.034	4.676SerArg: 4.676 ± 0.038	8.264SerSer: 8.264 ± 0.071	5.652SerThr: 5.652 ± 0.041	4.517SerVal: 4.517 ± 0.03	1.096SerTrp: 1.096 ± 0.016	2.093SerTyr: 2.093 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.424ThrAla: 5.424 ± 0.036	0.77ThrCys: 0.77 ± 0.011	2.882ThrAsp: 2.882 ± 0.025	3.182ThrGlu: 3.182 ± 0.027	2.278ThrPhe: 2.278 ± 0.024	4.358ThrGly: 4.358 ± 0.036	1.27ThrHis: 1.27 ± 0.017	3.263ThrIle: 3.263 ± 0.025	2.734ThrLys: 2.734 ± 0.026	5.24ThrLeu: 5.24 ± 0.039	1.206ThrMet: 1.206 ± 0.016	2.22ThrAsn: 2.22 ± 0.022	4.56ThrPro: 4.56 ± 0.039	2.037ThrGln: 2.037 ± 0.018	3.008ThrArg: 3.008 ± 0.026	5.405ThrSer: 5.405 ± 0.041	4.717ThrThr: 4.717 ± 0.044	3.719ThrVal: 3.719 ± 0.03	0.854ThrTrp: 0.854 ± 0.013	1.681ThrTyr: 1.681 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.674ValAla: 5.674 ± 0.037	0.782ValCys: 0.782 ± 0.014	3.75ValAsp: 3.75 ± 0.028	4.187ValGlu: 4.187 ± 0.039	2.417ValPhe: 2.417 ± 0.025	4.412ValGly: 4.412 ± 0.034	1.258ValHis: 1.258 ± 0.015	3.049ValIle: 3.049 ± 0.026	3.054ValLys: 3.054 ± 0.026	5.464ValLeu: 5.464 ± 0.043	1.376ValMet: 1.376 ± 0.02	2.251ValAsn: 2.251 ± 0.023	3.485ValPro: 3.485 ± 0.03	2.21ValGln: 2.21 ± 0.021	3.315ValArg: 3.315 ± 0.025	4.524ValSer: 4.524 ± 0.032	3.56ValThr: 3.56 ± 0.032	4.706ValVal: 4.706 ± 0.035	0.874ValTrp: 0.874 ± 0.013	1.705ValTyr: 1.705 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.182TrpAla: 1.182 ± 0.017	0.185TrpCys: 0.185 ± 0.006	0.877TrpAsp: 0.877 ± 0.014	0.876TrpGlu: 0.876 ± 0.013	0.526TrpPhe: 0.526 ± 0.012	1.035TrpGly: 1.035 ± 0.016	0.317TrpHis: 0.317 ± 0.007	0.725TrpIle: 0.725 ± 0.013	0.778TrpLys: 0.778 ± 0.014	1.263TrpLeu: 1.263 ± 0.017	0.375TrpMet: 0.375 ± 0.008	0.622TrpAsn: 0.622 ± 0.013	0.584TrpPro: 0.584 ± 0.012	0.516TrpGln: 0.516 ± 0.011	0.902TrpArg: 0.902 ± 0.015	1.027TrpSer: 1.027 ± 0.015	0.894TrpThr: 0.894 ± 0.014	0.932TrpVal: 0.932 ± 0.014	0.279TrpTrp: 0.279 ± 0.009	0.43TrpTyr: 0.43 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.023	0.414TyrCys: 0.414 ± 0.01	1.665TyrAsp: 1.665 ± 0.022	1.539TyrGlu: 1.539 ± 0.018	1.205TyrPhe: 1.205 ± 0.016	2.167TyrGly: 2.167 ± 0.024	0.695TyrHis: 0.695 ± 0.013	1.471TyrIle: 1.471 ± 0.019	1.171TyrLys: 1.171 ± 0.018	2.585TyrLeu: 2.585 ± 0.026	0.631TyrMet: 0.631 ± 0.011	1.209TyrAsn: 1.209 ± 0.017	1.474TyrPro: 1.474 ± 0.021	1.072TyrGln: 1.072 ± 0.013	1.493TyrArg: 1.493 ± 0.019	2.116TyrSer: 2.116 ± 0.021	1.691TyrThr: 1.691 ± 0.02	1.624TyrVal: 1.624 ± 0.019	0.424TyrTrp: 0.424 ± 0.009	0.94TyrTyr: 0.94 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10683 proteins (5291759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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