Amino acid dipepetide frequency for Streptococcus phage Javan336

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.712AlaAla: 2.712 ± 0.556
0.479AlaCys: 0.479 ± 0.176
5.424AlaAsp: 5.424 ± 0.768
5.344AlaGlu: 5.344 ± 0.721
2.233AlaPhe: 2.233 ± 0.594
5.185AlaGly: 5.185 ± 0.768
0.479AlaHis: 0.479 ± 0.206
4.706AlaIle: 4.706 ± 0.661
4.945AlaLys: 4.945 ± 0.615
6.222AlaLeu: 6.222 ± 0.789
2.233AlaMet: 2.233 ± 0.521
2.792AlaAsn: 2.792 ± 0.505
1.914AlaPro: 1.914 ± 0.674
2.313AlaGln: 2.313 ± 0.382
2.632AlaArg: 2.632 ± 0.439
3.27AlaSer: 3.27 ± 0.411
4.706AlaThr: 4.706 ± 0.699
3.35AlaVal: 3.35 ± 0.537
1.037AlaTrp: 1.037 ± 0.29
1.755AlaTyr: 1.755 ± 0.371
0.0AlaXaa: 0.0 ± 0.0
Cys
0.319CysAla: 0.319 ± 0.185
0.16CysCys: 0.16 ± 0.117
0.479CysAsp: 0.479 ± 0.213
0.558CysGlu: 0.558 ± 0.216
0.239CysPhe: 0.239 ± 0.129
0.479CysGly: 0.479 ± 0.225
0.16CysHis: 0.16 ± 0.106
0.399CysIle: 0.399 ± 0.184
0.319CysLys: 0.319 ± 0.15
0.479CysLeu: 0.479 ± 0.202
0.0CysMet: 0.0 ± 0.0
0.399CysAsn: 0.399 ± 0.172
0.239CysPro: 0.239 ± 0.136
0.239CysGln: 0.239 ± 0.129
0.399CysArg: 0.399 ± 0.154
0.399CysSer: 0.399 ± 0.224
0.239CysThr: 0.239 ± 0.126
0.638CysVal: 0.638 ± 0.228
0.08CysTrp: 0.08 ± 0.083
0.239CysTyr: 0.239 ± 0.13
0.0CysXaa: 0.0 ± 0.0
Asp
2.712AspAla: 2.712 ± 0.494
0.319AspCys: 0.319 ± 0.157
3.829AspAsp: 3.829 ± 0.502
5.663AspGlu: 5.663 ± 0.594
2.712AspPhe: 2.712 ± 0.467
5.264AspGly: 5.264 ± 0.738
0.718AspHis: 0.718 ± 0.21
5.264AspIle: 5.264 ± 0.627
6.142AspLys: 6.142 ± 0.764
5.504AspLeu: 5.504 ± 0.629
2.074AspMet: 2.074 ± 0.37
3.191AspAsn: 3.191 ± 0.484
0.957AspPro: 0.957 ± 0.257
1.675AspGln: 1.675 ± 0.417
1.914AspArg: 1.914 ± 0.446
4.227AspSer: 4.227 ± 0.619
3.43AspThr: 3.43 ± 0.401
4.068AspVal: 4.068 ± 0.474
0.798AspTrp: 0.798 ± 0.226
2.792AspTyr: 2.792 ± 0.422
0.0AspXaa: 0.0 ± 0.0
Glu
5.424GluAla: 5.424 ± 0.845
0.877GluCys: 0.877 ± 0.325
4.547GluAsp: 4.547 ± 0.779
6.381GluGlu: 6.381 ± 1.006
3.27GluPhe: 3.27 ± 0.473
3.191GluGly: 3.191 ± 0.51
1.276GluHis: 1.276 ± 0.345
5.424GluIle: 5.424 ± 0.733
7.338GluLys: 7.338 ± 0.985
8.056GluLeu: 8.056 ± 0.769
2.074GluMet: 2.074 ± 0.343
4.068GluAsn: 4.068 ± 0.566
2.074GluPro: 2.074 ± 0.54
3.43GluGln: 3.43 ± 0.628
3.51GluArg: 3.51 ± 0.654
4.387GluSer: 4.387 ± 0.664
4.866GluThr: 4.866 ± 0.684
6.62GluVal: 6.62 ± 0.778
0.877GluTrp: 0.877 ± 0.263
2.792GluTyr: 2.792 ± 0.473
0.0GluXaa: 0.0 ± 0.0
Phe
2.872PheAla: 2.872 ± 0.555
0.319PheCys: 0.319 ± 0.145
1.994PheAsp: 1.994 ± 0.396
3.191PheGlu: 3.191 ± 0.541
1.675PhePhe: 1.675 ± 0.354
2.313PheGly: 2.313 ± 0.365
0.399PheHis: 0.399 ± 0.204
2.951PheIle: 2.951 ± 0.413
3.908PheLys: 3.908 ± 0.666
2.872PheLeu: 2.872 ± 0.412
0.957PheMet: 0.957 ± 0.257
1.675PheAsn: 1.675 ± 0.302
1.436PhePro: 1.436 ± 0.371
1.675PheGln: 1.675 ± 0.38
2.313PheArg: 2.313 ± 0.418
2.154PheSer: 2.154 ± 0.402
1.835PheThr: 1.835 ± 0.371
2.951PheVal: 2.951 ± 0.516
0.319PheTrp: 0.319 ± 0.167
1.196PheTyr: 1.196 ± 0.328
0.0PheXaa: 0.0 ± 0.0
Gly
3.749GlyAla: 3.749 ± 0.641
0.08GlyCys: 0.08 ± 0.089
3.749GlyAsp: 3.749 ± 0.588
4.068GlyGlu: 4.068 ± 0.579
3.111GlyPhe: 3.111 ± 0.614
4.626GlyGly: 4.626 ± 0.725
1.117GlyHis: 1.117 ± 0.381
4.467GlyIle: 4.467 ± 0.773
5.823GlyLys: 5.823 ± 0.887
5.025GlyLeu: 5.025 ± 0.615
1.436GlyMet: 1.436 ± 0.31
3.988GlyAsn: 3.988 ± 0.608
0.718GlyPro: 0.718 ± 0.207
2.792GlyGln: 2.792 ± 0.593
3.669GlyArg: 3.669 ± 0.605
2.792GlySer: 2.792 ± 0.465
3.589GlyThr: 3.589 ± 0.53
5.424GlyVal: 5.424 ± 0.629
1.276GlyTrp: 1.276 ± 0.52
3.031GlyTyr: 3.031 ± 0.515
0.0GlyXaa: 0.0 ± 0.0
His
0.638HisAla: 0.638 ± 0.246
0.239HisCys: 0.239 ± 0.129
1.037HisAsp: 1.037 ± 0.308
1.835HisGlu: 1.835 ± 0.456
0.479HisPhe: 0.479 ± 0.2
1.276HisGly: 1.276 ± 0.291
0.08HisHis: 0.08 ± 0.086
1.117HisIle: 1.117 ± 0.275
1.436HisLys: 1.436 ± 0.39
1.436HisLeu: 1.436 ± 0.316
0.08HisMet: 0.08 ± 0.081
0.957HisAsn: 0.957 ± 0.29
0.638HisPro: 0.638 ± 0.217
0.638HisGln: 0.638 ± 0.243
0.798HisArg: 0.798 ± 0.254
0.558HisSer: 0.558 ± 0.191
0.877HisThr: 0.877 ± 0.187
0.877HisVal: 0.877 ± 0.256
0.239HisTrp: 0.239 ± 0.125
0.718HisTyr: 0.718 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
4.786IleAla: 4.786 ± 0.796
0.479IleCys: 0.479 ± 0.221
6.222IleAsp: 6.222 ± 0.682
4.467IleGlu: 4.467 ± 0.48
2.473IlePhe: 2.473 ± 0.42
4.706IleGly: 4.706 ± 0.866
1.276IleHis: 1.276 ± 0.346
4.068IleIle: 4.068 ± 0.57
6.541IleLys: 6.541 ± 0.718
4.866IleLeu: 4.866 ± 0.624
1.276IleMet: 1.276 ± 0.38
4.227IleAsn: 4.227 ± 0.579
1.436IlePro: 1.436 ± 0.382
2.872IleGln: 2.872 ± 0.44
2.792IleArg: 2.792 ± 0.525
4.307IleSer: 4.307 ± 0.707
3.829IleThr: 3.829 ± 0.54
3.749IleVal: 3.749 ± 0.624
0.558IleTrp: 0.558 ± 0.177
2.792IleTyr: 2.792 ± 0.612
0.0IleXaa: 0.0 ± 0.0
Lys
6.301LysAla: 6.301 ± 0.605
0.239LysCys: 0.239 ± 0.122
4.467LysAsp: 4.467 ± 0.629
7.817LysGlu: 7.817 ± 0.907
2.074LysPhe: 2.074 ± 0.405
4.786LysGly: 4.786 ± 0.542
1.835LysHis: 1.835 ± 0.332
5.504LysIle: 5.504 ± 0.719
8.535LysLys: 8.535 ± 1.084
7.657LysLeu: 7.657 ± 0.692
2.712LysMet: 2.712 ± 0.421
4.626LysAsn: 4.626 ± 0.568
2.313LysPro: 2.313 ± 0.471
4.547LysGln: 4.547 ± 0.632
4.626LysArg: 4.626 ± 0.634
5.424LysSer: 5.424 ± 0.593
4.148LysThr: 4.148 ± 0.61
6.301LysVal: 6.301 ± 0.869
0.877LysTrp: 0.877 ± 0.294
3.43LysTyr: 3.43 ± 0.37
0.0LysXaa: 0.0 ± 0.0
Leu
5.743LeuAla: 5.743 ± 0.705
0.399LeuCys: 0.399 ± 0.158
6.461LeuAsp: 6.461 ± 0.737
8.295LeuGlu: 8.295 ± 0.83
2.632LeuPhe: 2.632 ± 0.496
6.7LeuGly: 6.7 ± 0.614
1.356LeuHis: 1.356 ± 0.343
4.706LeuIle: 4.706 ± 0.566
7.338LeuLys: 7.338 ± 0.787
7.019LeuLeu: 7.019 ± 0.723
2.154LeuMet: 2.154 ± 0.464
4.387LeuAsn: 4.387 ± 0.589
1.914LeuPro: 1.914 ± 0.36
3.111LeuGln: 3.111 ± 0.437
3.829LeuArg: 3.829 ± 0.667
3.51LeuSer: 3.51 ± 0.521
5.823LeuThr: 5.823 ± 0.653
4.866LeuVal: 4.866 ± 0.517
1.037LeuTrp: 1.037 ± 0.37
2.313LeuTyr: 2.313 ± 0.403
0.0LeuXaa: 0.0 ± 0.0
Met
2.872MetAla: 2.872 ± 0.684
0.239MetCys: 0.239 ± 0.131
1.755MetAsp: 1.755 ± 0.382
1.755MetGlu: 1.755 ± 0.375
1.117MetPhe: 1.117 ± 0.365
0.877MetGly: 0.877 ± 0.268
0.558MetHis: 0.558 ± 0.248
2.393MetIle: 2.393 ± 0.385
2.632MetLys: 2.632 ± 0.48
1.755MetLeu: 1.755 ± 0.47
0.638MetMet: 0.638 ± 0.335
1.037MetAsn: 1.037 ± 0.3
0.638MetPro: 0.638 ± 0.202
0.718MetGln: 0.718 ± 0.202
1.276MetArg: 1.276 ± 0.327
1.196MetSer: 1.196 ± 0.348
1.994MetThr: 1.994 ± 0.475
1.356MetVal: 1.356 ± 0.334
0.319MetTrp: 0.319 ± 0.161
0.798MetTyr: 0.798 ± 0.262
0.0MetXaa: 0.0 ± 0.0
Asn
3.35AsnAla: 3.35 ± 0.563
0.239AsnCys: 0.239 ± 0.133
3.669AsnAsp: 3.669 ± 0.632
2.951AsnGlu: 2.951 ± 0.527
1.436AsnPhe: 1.436 ± 0.378
4.148AsnGly: 4.148 ± 0.604
1.196AsnHis: 1.196 ± 0.347
2.792AsnIle: 2.792 ± 0.46
3.589AsnLys: 3.589 ± 0.631
3.51AsnLeu: 3.51 ± 0.639
1.994AsnMet: 1.994 ± 0.384
2.951AsnAsn: 2.951 ± 0.565
1.595AsnPro: 1.595 ± 0.355
2.792AsnGln: 2.792 ± 0.51
3.031AsnArg: 3.031 ± 0.504
2.473AsnSer: 2.473 ± 0.48
2.313AsnThr: 2.313 ± 0.374
4.148AsnVal: 4.148 ± 0.658
1.196AsnTrp: 1.196 ± 0.306
2.393AsnTyr: 2.393 ± 0.447
0.0AsnXaa: 0.0 ± 0.0
Pro
1.595ProAla: 1.595 ± 0.554
0.638ProCys: 0.638 ± 0.209
1.835ProAsp: 1.835 ± 0.344
2.712ProGlu: 2.712 ± 0.478
1.117ProPhe: 1.117 ± 0.279
0.957ProGly: 0.957 ± 0.34
0.479ProHis: 0.479 ± 0.196
2.074ProIle: 2.074 ± 0.404
2.473ProLys: 2.473 ± 0.514
1.117ProLeu: 1.117 ± 0.303
0.399ProMet: 0.399 ± 0.178
1.276ProAsn: 1.276 ± 0.279
0.957ProPro: 0.957 ± 0.334
1.196ProGln: 1.196 ± 0.248
0.718ProArg: 0.718 ± 0.235
1.755ProSer: 1.755 ± 0.382
2.313ProThr: 2.313 ± 0.499
1.755ProVal: 1.755 ± 0.312
0.08ProTrp: 0.08 ± 0.079
0.877ProTyr: 0.877 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
3.669GlnAla: 3.669 ± 0.584
0.399GlnCys: 0.399 ± 0.163
2.313GlnAsp: 2.313 ± 0.392
3.51GlnGlu: 3.51 ± 0.545
1.755GlnPhe: 1.755 ± 0.378
2.074GlnGly: 2.074 ± 0.484
0.08GlnHis: 0.08 ± 0.095
2.632GlnIle: 2.632 ± 0.465
2.393GlnLys: 2.393 ± 0.378
3.589GlnLeu: 3.589 ± 0.508
1.037GlnMet: 1.037 ± 0.324
2.313GlnAsn: 2.313 ± 0.388
1.436GlnPro: 1.436 ± 0.471
1.914GlnGln: 1.914 ± 0.392
2.074GlnArg: 2.074 ± 0.44
2.233GlnSer: 2.233 ± 0.395
2.233GlnThr: 2.233 ± 0.522
2.792GlnVal: 2.792 ± 0.424
0.319GlnTrp: 0.319 ± 0.158
1.516GlnTyr: 1.516 ± 0.45
0.0GlnXaa: 0.0 ± 0.0
Arg
2.313ArgAla: 2.313 ± 0.422
0.16ArgCys: 0.16 ± 0.106
2.233ArgAsp: 2.233 ± 0.422
4.068ArgGlu: 4.068 ± 0.646
2.313ArgPhe: 2.313 ± 0.514
2.951ArgGly: 2.951 ± 0.536
0.638ArgHis: 0.638 ± 0.199
2.872ArgIle: 2.872 ± 0.455
4.307ArgLys: 4.307 ± 0.574
5.105ArgLeu: 5.105 ± 0.691
1.276ArgMet: 1.276 ± 0.319
2.074ArgAsn: 2.074 ± 0.527
1.117ArgPro: 1.117 ± 0.276
1.755ArgGln: 1.755 ± 0.348
1.914ArgArg: 1.914 ± 0.5
2.393ArgSer: 2.393 ± 0.445
2.792ArgThr: 2.792 ± 0.45
3.031ArgVal: 3.031 ± 0.654
0.558ArgTrp: 0.558 ± 0.214
2.154ArgTyr: 2.154 ± 0.476
0.0ArgXaa: 0.0 ± 0.0
Ser
2.712SerAla: 2.712 ± 0.474
0.08SerCys: 0.08 ± 0.073
2.872SerAsp: 2.872 ± 0.468
3.988SerGlu: 3.988 ± 0.586
2.872SerPhe: 2.872 ± 0.588
4.547SerGly: 4.547 ± 0.485
0.957SerHis: 0.957 ± 0.26
3.988SerIle: 3.988 ± 0.501
5.185SerLys: 5.185 ± 0.561
4.148SerLeu: 4.148 ± 0.543
1.755SerMet: 1.755 ± 0.342
2.792SerAsn: 2.792 ± 0.415
1.516SerPro: 1.516 ± 0.346
2.393SerGln: 2.393 ± 0.427
2.233SerArg: 2.233 ± 0.493
3.43SerSer: 3.43 ± 0.596
2.792SerThr: 2.792 ± 0.523
4.307SerVal: 4.307 ± 0.577
0.718SerTrp: 0.718 ± 0.251
2.792SerTyr: 2.792 ± 0.514
0.0SerXaa: 0.0 ± 0.0
Thr
4.068ThrAla: 4.068 ± 0.617
0.16ThrCys: 0.16 ± 0.114
3.43ThrAsp: 3.43 ± 0.568
4.307ThrGlu: 4.307 ± 0.719
2.233ThrPhe: 2.233 ± 0.404
4.387ThrGly: 4.387 ± 0.906
0.957ThrHis: 0.957 ± 0.245
4.387ThrIle: 4.387 ± 0.44
5.504ThrLys: 5.504 ± 0.691
5.025ThrLeu: 5.025 ± 0.579
1.196ThrMet: 1.196 ± 0.27
2.233ThrAsn: 2.233 ± 0.455
2.473ThrPro: 2.473 ± 0.581
2.074ThrGln: 2.074 ± 0.469
2.393ThrArg: 2.393 ± 0.448
3.988ThrSer: 3.988 ± 0.6
4.068ThrThr: 4.068 ± 0.635
4.467ThrVal: 4.467 ± 0.835
0.558ThrTrp: 0.558 ± 0.258
1.914ThrTyr: 1.914 ± 0.367
0.0ThrXaa: 0.0 ± 0.0
Val
4.945ValAla: 4.945 ± 0.975
0.319ValCys: 0.319 ± 0.175
4.068ValAsp: 4.068 ± 0.507
5.185ValGlu: 5.185 ± 0.749
2.393ValPhe: 2.393 ± 0.49
3.35ValGly: 3.35 ± 0.618
1.117ValHis: 1.117 ± 0.357
3.829ValIle: 3.829 ± 0.598
5.424ValLys: 5.424 ± 0.675
5.823ValLeu: 5.823 ± 0.638
1.436ValMet: 1.436 ± 0.302
4.227ValAsn: 4.227 ± 0.6
1.914ValPro: 1.914 ± 0.384
2.074ValGln: 2.074 ± 0.471
3.191ValArg: 3.191 ± 0.514
5.105ValSer: 5.105 ± 0.699
5.424ValThr: 5.424 ± 0.821
4.626ValVal: 4.626 ± 0.719
0.798ValTrp: 0.798 ± 0.255
3.111ValTyr: 3.111 ± 0.464
0.0ValXaa: 0.0 ± 0.0
Trp
0.798TrpAla: 0.798 ± 0.206
0.16TrpCys: 0.16 ± 0.153
0.638TrpAsp: 0.638 ± 0.238
0.718TrpGlu: 0.718 ± 0.197
0.718TrpPhe: 0.718 ± 0.241
0.479TrpGly: 0.479 ± 0.164
0.319TrpHis: 0.319 ± 0.134
0.718TrpIle: 0.718 ± 0.224
0.957TrpLys: 0.957 ± 0.252
1.595TrpLeu: 1.595 ± 0.359
0.16TrpMet: 0.16 ± 0.115
0.718TrpAsn: 0.718 ± 0.262
0.0TrpPro: 0.0 ± 0.0
0.798TrpGln: 0.798 ± 0.202
0.638TrpArg: 0.638 ± 0.228
0.798TrpSer: 0.798 ± 0.222
0.479TrpThr: 0.479 ± 0.196
0.957TrpVal: 0.957 ± 0.269
0.479TrpTrp: 0.479 ± 0.226
0.877TrpTyr: 0.877 ± 0.489
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.154TyrAla: 2.154 ± 0.43
0.479TyrCys: 0.479 ± 0.186
2.233TyrAsp: 2.233 ± 0.339
3.669TyrGlu: 3.669 ± 0.641
2.154TyrPhe: 2.154 ± 0.359
2.233TyrGly: 2.233 ± 0.417
0.957TyrHis: 0.957 ± 0.318
3.43TyrIle: 3.43 ± 0.625
3.43TyrLys: 3.43 ± 0.448
2.792TyrLeu: 2.792 ± 0.538
0.957TyrMet: 0.957 ± 0.302
1.835TyrAsn: 1.835 ± 0.383
1.037TyrPro: 1.037 ± 0.338
1.276TyrGln: 1.276 ± 0.349
2.074TyrArg: 2.074 ± 0.41
1.755TyrSer: 1.755 ± 0.376
2.074TyrThr: 2.074 ± 0.481
2.074TyrVal: 2.074 ± 0.402
0.877TyrTrp: 0.877 ± 0.26
1.994TyrTyr: 1.994 ± 0.417
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (12538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski