Amino acid dipepetide frequency for Streptomyces sp. TverLS-915

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.446AlaAla: 22.446 ± 0.167
1.023AlaCys: 1.023 ± 0.029
7.898AlaAsp: 7.898 ± 0.079
9.532AlaGlu: 9.532 ± 0.087
3.533AlaPhe: 3.533 ± 0.047
14.179AlaGly: 14.179 ± 0.098
3.452AlaHis: 3.452 ± 0.049
2.995AlaIle: 2.995 ± 0.041
2.993AlaLys: 2.993 ± 0.053
15.939AlaLeu: 15.939 ± 0.139
2.314AlaMet: 2.314 ± 0.034
1.785AlaAsn: 1.785 ± 0.035
8.757AlaPro: 8.757 ± 0.095
3.49AlaGln: 3.49 ± 0.047
12.074AlaArg: 12.074 ± 0.109
6.188AlaSer: 6.188 ± 0.062
7.117AlaThr: 7.117 ± 0.062
11.89AlaVal: 11.89 ± 0.082
1.892AlaTrp: 1.892 ± 0.028
2.816AlaTyr: 2.816 ± 0.032
0.0AlaXaa: 0.0 ± 0.0
Cys
1.159CysAla: 1.159 ± 0.026
0.093CysCys: 0.093 ± 0.007
0.396CysAsp: 0.396 ± 0.013
0.36CysGlu: 0.36 ± 0.016
0.208CysPhe: 0.208 ± 0.01
0.988CysGly: 0.988 ± 0.025
0.171CysHis: 0.171 ± 0.011
0.101CysIle: 0.101 ± 0.006
0.089CysLys: 0.089 ± 0.006
0.717CysLeu: 0.717 ± 0.021
0.091CysMet: 0.091 ± 0.007
0.109CysAsn: 0.109 ± 0.007
0.478CysPro: 0.478 ± 0.016
0.134CysGln: 0.134 ± 0.007
0.533CysArg: 0.533 ± 0.02
0.338CysSer: 0.338 ± 0.013
0.408CysThr: 0.408 ± 0.016
0.665CysVal: 0.665 ± 0.02
0.119CysTrp: 0.119 ± 0.007
0.131CysTyr: 0.131 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.821AspAla: 7.821 ± 0.066
0.372AspCys: 0.372 ± 0.015
3.182AspAsp: 3.182 ± 0.054
3.766AspGlu: 3.766 ± 0.051
1.613AspPhe: 1.613 ± 0.032
6.114AspGly: 6.114 ± 0.071
1.297AspHis: 1.297 ± 0.024
1.637AspIle: 1.637 ± 0.031
1.215AspLys: 1.215 ± 0.031
5.951AspLeu: 5.951 ± 0.057
0.742AspMet: 0.742 ± 0.021
0.882AspAsn: 0.882 ± 0.025
4.538AspPro: 4.538 ± 0.052
1.302AspGln: 1.302 ± 0.028
4.479AspArg: 4.479 ± 0.056
2.396AspSer: 2.396 ± 0.038
3.223AspThr: 3.223 ± 0.047
4.485AspVal: 4.485 ± 0.054
0.969AspTrp: 0.969 ± 0.021
1.041AspTyr: 1.041 ± 0.024
0.0AspXaa: 0.0 ± 0.0
Glu
8.108GluAla: 8.108 ± 0.083
0.329GluCys: 0.329 ± 0.014
3.119GluAsp: 3.119 ± 0.045
4.116GluGlu: 4.116 ± 0.057
1.316GluPhe: 1.316 ± 0.027
5.089GluGly: 5.089 ± 0.063
1.53GluHis: 1.53 ± 0.032
2.044GluIle: 2.044 ± 0.042
1.456GluLys: 1.456 ± 0.034
6.245GluLeu: 6.245 ± 0.077
0.792GluMet: 0.792 ± 0.022
1.05GluAsn: 1.05 ± 0.025
3.648GluPro: 3.648 ± 0.052
1.941GluGln: 1.941 ± 0.035
5.915GluArg: 5.915 ± 0.071
2.538GluSer: 2.538 ± 0.039
3.033GluThr: 3.033 ± 0.043
4.481GluVal: 4.481 ± 0.055
0.78GluTrp: 0.78 ± 0.019
1.094GluTyr: 1.094 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
3.813PheAla: 3.813 ± 0.044
0.245PheCys: 0.245 ± 0.012
1.812PheAsp: 1.812 ± 0.033
1.201PheGlu: 1.201 ± 0.025
0.851PhePhe: 0.851 ± 0.023
2.959PheGly: 2.959 ± 0.041
0.605PheHis: 0.605 ± 0.02
0.578PheIle: 0.578 ± 0.019
0.487PheLys: 0.487 ± 0.019
2.667PheLeu: 2.667 ± 0.041
0.34PheMet: 0.34 ± 0.012
0.526PheAsn: 0.526 ± 0.018
1.395PhePro: 1.395 ± 0.029
0.628PheGln: 0.628 ± 0.02
1.794PheArg: 1.794 ± 0.033
1.325PheSer: 1.325 ± 0.027
1.992PheThr: 1.992 ± 0.032
2.243PheVal: 2.243 ± 0.033
0.404PheTrp: 0.404 ± 0.015
0.544PheTyr: 0.544 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
12.776GlyAla: 12.776 ± 0.096
0.791GlyCys: 0.791 ± 0.025
5.201GlyAsp: 5.201 ± 0.064
5.817GlyGlu: 5.817 ± 0.059
2.852GlyPhe: 2.852 ± 0.043
9.799GlyGly: 9.799 ± 0.09
2.35GlyHis: 2.35 ± 0.034
3.348GlyIle: 3.348 ± 0.047
2.519GlyLys: 2.519 ± 0.046
9.936GlyLeu: 9.936 ± 0.092
1.934GlyMet: 1.934 ± 0.032
1.718GlyAsn: 1.718 ± 0.036
5.848GlyPro: 5.848 ± 0.07
2.519GlyGln: 2.519 ± 0.04
7.982GlyArg: 7.982 ± 0.066
5.273GlySer: 5.273 ± 0.052
7.023GlyThr: 7.023 ± 0.068
7.486GlyVal: 7.486 ± 0.06
1.696GlyTrp: 1.696 ± 0.03
2.225GlyTyr: 2.225 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.84HisAla: 2.84 ± 0.039
0.183HisCys: 0.183 ± 0.01
1.335HisAsp: 1.335 ± 0.026
1.357HisGlu: 1.357 ± 0.029
0.647HisPhe: 0.647 ± 0.018
2.473HisGly: 2.473 ± 0.046
0.729HisHis: 0.729 ± 0.024
0.574HisIle: 0.574 ± 0.017
0.36HisLys: 0.36 ± 0.014
2.533HisLeu: 2.533 ± 0.042
0.304HisMet: 0.304 ± 0.012
0.313HisAsn: 0.313 ± 0.012
1.923HisPro: 1.923 ± 0.033
0.573HisGln: 0.573 ± 0.015
2.086HisArg: 2.086 ± 0.039
0.972HisSer: 0.972 ± 0.022
1.36HisThr: 1.36 ± 0.032
1.791HisVal: 1.791 ± 0.034
0.388HisTrp: 0.388 ± 0.015
0.468HisTyr: 0.468 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
4.035IleAla: 4.035 ± 0.052
0.226IleCys: 0.226 ± 0.01
1.928IleAsp: 1.928 ± 0.033
1.664IleGlu: 1.664 ± 0.03
0.601IlePhe: 0.601 ± 0.019
3.152IleGly: 3.152 ± 0.044
0.488IleHis: 0.488 ± 0.016
0.707IleIle: 0.707 ± 0.023
0.637IleLys: 0.637 ± 0.021
2.138IleLeu: 2.138 ± 0.039
0.379IleMet: 0.379 ± 0.016
0.573IleAsn: 0.573 ± 0.021
1.608IlePro: 1.608 ± 0.034
0.553IleGln: 0.553 ± 0.017
1.819IleArg: 1.819 ± 0.037
1.354IleSer: 1.354 ± 0.027
1.758IleThr: 1.758 ± 0.036
2.272IleVal: 2.272 ± 0.044
0.299IleTrp: 0.299 ± 0.012
0.447IleTyr: 0.447 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
2.841LysAla: 2.841 ± 0.053
0.103LysCys: 0.103 ± 0.008
1.445LysAsp: 1.445 ± 0.033
1.2LysGlu: 1.2 ± 0.032
0.441LysPhe: 0.441 ± 0.015
2.003LysGly: 2.003 ± 0.041
0.399LysHis: 0.399 ± 0.014
0.778LysIle: 0.778 ± 0.023
0.946LysLys: 0.946 ± 0.038
1.946LysLeu: 1.946 ± 0.033
0.317LysMet: 0.317 ± 0.015
0.544LysAsn: 0.544 ± 0.02
1.305LysPro: 1.305 ± 0.028
0.628LysGln: 0.628 ± 0.02
1.408LysArg: 1.408 ± 0.03
1.108LysSer: 1.108 ± 0.027
1.28LysThr: 1.28 ± 0.034
1.704LysVal: 1.704 ± 0.041
0.251LysTrp: 0.251 ± 0.012
0.454LysTyr: 0.454 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
16.522LeuAla: 16.522 ± 0.126
0.843LeuCys: 0.843 ± 0.02
6.902LeuAsp: 6.902 ± 0.068
4.109LeuGlu: 4.109 ± 0.053
2.548LeuPhe: 2.548 ± 0.042
10.005LeuGly: 10.005 ± 0.09
2.332LeuHis: 2.332 ± 0.04
2.581LeuIle: 2.581 ± 0.044
1.828LeuLys: 1.828 ± 0.04
12.081LeuLeu: 12.081 ± 0.131
1.407LeuMet: 1.407 ± 0.03
1.536LeuAsn: 1.536 ± 0.029
6.931LeuPro: 6.931 ± 0.077
1.915LeuGln: 1.915 ± 0.033
9.273LeuArg: 9.273 ± 0.088
5.251LeuSer: 5.251 ± 0.057
6.797LeuThr: 6.797 ± 0.062
9.475LeuVal: 9.475 ± 0.079
1.322LeuTrp: 1.322 ± 0.028
1.811LeuTyr: 1.811 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
1.952MetAla: 1.952 ± 0.036
0.124MetCys: 0.124 ± 0.008
0.797MetAsp: 0.797 ± 0.021
0.664MetGlu: 0.664 ± 0.02
0.423MetPhe: 0.423 ± 0.017
1.145MetGly: 1.145 ± 0.028
0.289MetHis: 0.289 ± 0.013
0.568MetIle: 0.568 ± 0.019
0.352MetLys: 0.352 ± 0.014
1.457MetLeu: 1.457 ± 0.029
0.244MetMet: 0.244 ± 0.012
0.407MetAsn: 0.407 ± 0.014
1.061MetPro: 1.061 ± 0.025
0.324MetGln: 0.324 ± 0.014
1.314MetArg: 1.314 ± 0.024
1.282MetSer: 1.282 ± 0.027
1.406MetThr: 1.406 ± 0.024
1.045MetVal: 1.045 ± 0.025
0.182MetTrp: 0.182 ± 0.009
0.281MetTyr: 0.281 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.075AsnAla: 2.075 ± 0.034
0.131AsnCys: 0.131 ± 0.008
0.875AsnAsp: 0.875 ± 0.019
0.779AsnGlu: 0.779 ± 0.022
0.457AsnPhe: 0.457 ± 0.016
1.807AsnGly: 1.807 ± 0.04
0.34AsnHis: 0.34 ± 0.015
0.557AsnIle: 0.557 ± 0.018
0.414AsnLys: 0.414 ± 0.016
1.507AsnLeu: 1.507 ± 0.031
0.262AsnMet: 0.262 ± 0.013
0.398AsnAsn: 0.398 ± 0.019
1.239AsnPro: 1.239 ± 0.021
0.453AsnGln: 0.453 ± 0.017
1.101AsnArg: 1.101 ± 0.02
0.824AsnSer: 0.824 ± 0.025
1.068AsnThr: 1.068 ± 0.031
1.24AsnVal: 1.24 ± 0.026
0.246AsnTrp: 0.246 ± 0.012
0.371AsnTyr: 0.371 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
10.087ProAla: 10.087 ± 0.098
0.347ProCys: 0.347 ± 0.013
4.19ProAsp: 4.19 ± 0.053
5.007ProGlu: 5.007 ± 0.06
1.551ProPhe: 1.551 ± 0.025
7.758ProGly: 7.758 ± 0.079
1.652ProHis: 1.652 ± 0.033
0.941ProIle: 0.941 ± 0.022
1.165ProLys: 1.165 ± 0.031
6.019ProLeu: 6.019 ± 0.063
0.84ProMet: 0.84 ± 0.024
0.763ProAsn: 0.763 ± 0.021
4.385ProPro: 4.385 ± 0.084
1.629ProGln: 1.629 ± 0.039
4.904ProArg: 4.904 ± 0.065
3.198ProSer: 3.198 ± 0.045
3.014ProThr: 3.014 ± 0.044
5.702ProVal: 5.702 ± 0.053
0.949ProTrp: 0.949 ± 0.024
1.58ProTyr: 1.58 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.223GlnAla: 3.223 ± 0.044
0.134GlnCys: 0.134 ± 0.009
1.295GlnAsp: 1.295 ± 0.027
1.316GlnGlu: 1.316 ± 0.024
0.625GlnPhe: 0.625 ± 0.021
2.226GlnGly: 2.226 ± 0.041
0.57GlnHis: 0.57 ± 0.017
0.863GlnIle: 0.863 ± 0.021
0.574GlnLys: 0.574 ± 0.02
2.555GlnLeu: 2.555 ± 0.038
0.374GlnMet: 0.374 ± 0.015
0.443GlnAsn: 0.443 ± 0.016
1.509GlnPro: 1.509 ± 0.031
0.968GlnGln: 0.968 ± 0.032
2.097GlnArg: 2.097 ± 0.037
1.161GlnSer: 1.161 ± 0.03
1.16GlnThr: 1.16 ± 0.026
2.021GlnVal: 2.021 ± 0.037
0.383GlnTrp: 0.383 ± 0.014
0.576GlnTyr: 0.576 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
11.697ArgAla: 11.697 ± 0.101
0.554ArgCys: 0.554 ± 0.02
4.22ArgAsp: 4.22 ± 0.049
5.479ArgGlu: 5.479 ± 0.055
2.246ArgPhe: 2.246 ± 0.034
6.657ArgGly: 6.657 ± 0.06
2.143ArgHis: 2.143 ± 0.033
2.59ArgIle: 2.59 ± 0.035
1.622ArgLys: 1.622 ± 0.032
9.224ArgLeu: 9.224 ± 0.088
1.57ArgMet: 1.57 ± 0.029
1.176ArgAsn: 1.176 ± 0.024
5.375ArgPro: 5.375 ± 0.067
2.004ArgGln: 2.004 ± 0.033
7.928ArgArg: 7.928 ± 0.11
3.65ArgSer: 3.65 ± 0.053
5.82ArgThr: 5.82 ± 0.055
6.516ArgVal: 6.516 ± 0.065
1.399ArgTrp: 1.399 ± 0.027
1.777ArgTyr: 1.777 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.868SerAla: 6.868 ± 0.072
0.359SerCys: 0.359 ± 0.013
2.333SerAsp: 2.333 ± 0.035
2.322SerGlu: 2.322 ± 0.033
1.553SerPhe: 1.553 ± 0.032
6.073SerGly: 6.073 ± 0.066
0.964SerHis: 0.964 ± 0.024
1.104SerIle: 1.104 ± 0.026
0.945SerLys: 0.945 ± 0.026
4.837SerLeu: 4.837 ± 0.052
0.856SerMet: 0.856 ± 0.022
0.742SerAsn: 0.742 ± 0.02
3.438SerPro: 3.438 ± 0.045
1.032SerGln: 1.032 ± 0.025
3.689SerArg: 3.689 ± 0.048
2.576SerSer: 2.576 ± 0.043
2.959SerThr: 2.959 ± 0.046
3.944SerVal: 3.944 ± 0.047
0.857SerTrp: 0.857 ± 0.022
1.166SerTyr: 1.166 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
9.028ThrAla: 9.028 ± 0.078
0.391ThrCys: 0.391 ± 0.014
3.348ThrAsp: 3.348 ± 0.043
3.377ThrGlu: 3.377 ± 0.047
1.492ThrPhe: 1.492 ± 0.028
6.975ThrGly: 6.975 ± 0.061
1.192ThrHis: 1.192 ± 0.024
1.442ThrIle: 1.442 ± 0.029
1.16ThrLys: 1.16 ± 0.032
5.796ThrLeu: 5.796 ± 0.063
0.781ThrMet: 0.781 ± 0.022
0.917ThrAsn: 0.917 ± 0.025
4.573ThrPro: 4.573 ± 0.049
1.169ThrGln: 1.169 ± 0.026
4.231ThrArg: 4.231 ± 0.045
3.249ThrSer: 3.249 ± 0.047
3.876ThrThr: 3.876 ± 0.064
5.693ThrVal: 5.693 ± 0.061
0.908ThrTrp: 0.908 ± 0.022
1.371ThrTyr: 1.371 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
10.54ValAla: 10.54 ± 0.082
0.703ValCys: 0.703 ± 0.018
4.578ValAsp: 4.578 ± 0.053
4.414ValGlu: 4.414 ± 0.055
2.309ValPhe: 2.309 ± 0.036
6.19ValGly: 6.19 ± 0.061
1.93ValHis: 1.93 ± 0.028
2.361ValIle: 2.361 ± 0.041
1.635ValLys: 1.635 ± 0.038
10.136ValLeu: 10.136 ± 0.087
1.286ValMet: 1.286 ± 0.026
1.533ValAsn: 1.533 ± 0.033
5.845ValPro: 5.845 ± 0.06
1.727ValGln: 1.727 ± 0.029
7.902ValArg: 7.902 ± 0.077
4.167ValSer: 4.167 ± 0.047
5.404ValThr: 5.404 ± 0.062
7.784ValVal: 7.784 ± 0.074
1.117ValTrp: 1.117 ± 0.025
1.503ValTyr: 1.503 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.666TrpAla: 1.666 ± 0.03
0.166TrpCys: 0.166 ± 0.011
0.79TrpAsp: 0.79 ± 0.02
0.799TrpGlu: 0.799 ± 0.019
0.499TrpPhe: 0.499 ± 0.017
1.093TrpGly: 1.093 ± 0.025
0.38TrpHis: 0.38 ± 0.012
0.471TrpIle: 0.471 ± 0.015
0.338TrpLys: 0.338 ± 0.014
1.746TrpLeu: 1.746 ± 0.038
0.27TrpMet: 0.27 ± 0.01
0.369TrpAsn: 0.369 ± 0.014
0.786TrpPro: 0.786 ± 0.02
0.535TrpGln: 0.535 ± 0.015
1.334TrpArg: 1.334 ± 0.028
0.917TrpSer: 0.917 ± 0.023
1.061TrpThr: 1.061 ± 0.025
0.943TrpVal: 0.943 ± 0.022
0.354TrpTrp: 0.354 ± 0.014
0.36TrpTyr: 0.36 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.819TyrAla: 2.819 ± 0.037
0.172TyrCys: 0.172 ± 0.009
1.381TyrAsp: 1.381 ± 0.038
1.344TyrGlu: 1.344 ± 0.029
0.641TyrPhe: 0.641 ± 0.021
2.411TyrGly: 2.411 ± 0.04
0.396TyrHis: 0.396 ± 0.014
0.399TyrIle: 0.399 ± 0.015
0.366TyrLys: 0.366 ± 0.014
2.038TyrLeu: 2.038 ± 0.031
0.214TyrMet: 0.214 ± 0.01
0.36TyrAsn: 0.36 ± 0.015
1.041TyrPro: 1.041 ± 0.026
0.552TyrGln: 0.552 ± 0.017
1.783TyrArg: 1.783 ± 0.029
0.848TyrSer: 0.848 ± 0.022
1.21TyrThr: 1.21 ± 0.029
1.683TyrVal: 1.683 ± 0.028
0.359TyrTrp: 0.359 ± 0.014
0.428TyrTyr: 0.428 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6283 proteins (2005380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski