Amino acid dipepetide frequency for Pseudomonas jinjuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.775AlaAla: 13.775 ± 0.142	1.33AlaCys: 1.33 ± 0.03	6.271AlaAsp: 6.271 ± 0.07	7.86AlaGlu: 7.86 ± 0.078	3.944AlaPhe: 3.944 ± 0.059	10.049AlaGly: 10.049 ± 0.096	2.163AlaHis: 2.163 ± 0.039	5.15AlaIle: 5.15 ± 0.055	3.197AlaLys: 3.197 ± 0.058	13.706AlaLeu: 13.706 ± 0.116	2.938AlaMet: 2.938 ± 0.044	2.852AlaAsn: 2.852 ± 0.054	4.854AlaPro: 4.854 ± 0.055	4.722AlaGln: 4.722 ± 0.057	8.293AlaArg: 8.293 ± 0.085	6.155AlaSer: 6.155 ± 0.072	4.691AlaThr: 4.691 ± 0.06	7.408AlaVal: 7.408 ± 0.08	1.674AlaTrp: 1.674 ± 0.033	2.463AlaTyr: 2.463 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.179CysAla: 1.179 ± 0.028	0.151CysCys: 0.151 ± 0.009	0.556CysAsp: 0.556 ± 0.02	0.578CysGlu: 0.578 ± 0.021	0.347CysPhe: 0.347 ± 0.014	1.032CysGly: 1.032 ± 0.027	0.297CysHis: 0.297 ± 0.016	0.454CysIle: 0.454 ± 0.017	0.263CysLys: 0.263 ± 0.012	1.191CysLeu: 1.191 ± 0.028	0.215CysMet: 0.215 ± 0.01	0.274CysAsn: 0.274 ± 0.012	0.557CysPro: 0.557 ± 0.019	0.391CysGln: 0.391 ± 0.016	0.764CysArg: 0.764 ± 0.022	0.638CysSer: 0.638 ± 0.02	0.442CysThr: 0.442 ± 0.016	0.677CysVal: 0.677 ± 0.02	0.143CysTrp: 0.143 ± 0.009	0.269CysTyr: 0.269 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.004AspAla: 6.004 ± 0.07	0.592AspCys: 0.592 ± 0.02	3.043AspAsp: 3.043 ± 0.045	3.726AspGlu: 3.726 ± 0.045	2.19AspPhe: 2.19 ± 0.041	5.101AspGly: 5.101 ± 0.071	1.112AspHis: 1.112 ± 0.029	2.591AspIle: 2.591 ± 0.055	1.725AspLys: 1.725 ± 0.036	6.002AspLeu: 6.002 ± 0.058	1.183AspMet: 1.183 ± 0.026	1.563AspAsn: 1.563 ± 0.035	2.993AspPro: 2.993 ± 0.046	1.886AspGln: 1.886 ± 0.038	3.413AspArg: 3.413 ± 0.051	3.02AspSer: 3.02 ± 0.05	2.223AspThr: 2.223 ± 0.038	3.515AspVal: 3.515 ± 0.056	1.057AspTrp: 1.057 ± 0.028	1.738AspTyr: 1.738 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.918GluAla: 6.918 ± 0.068	0.491GluCys: 0.491 ± 0.019	2.732GluAsp: 2.732 ± 0.042	3.767GluGlu: 3.767 ± 0.062	1.909GluPhe: 1.909 ± 0.034	4.319GluGly: 4.319 ± 0.05	1.604GluHis: 1.604 ± 0.03	2.873GluIle: 2.873 ± 0.043	2.133GluLys: 2.133 ± 0.04	7.543GluLeu: 7.543 ± 0.085	1.412GluMet: 1.412 ± 0.027	1.544GluAsn: 1.544 ± 0.033	2.699GluPro: 2.699 ± 0.043	3.531GluGln: 3.531 ± 0.053	5.501GluArg: 5.501 ± 0.068	2.856GluSer: 2.856 ± 0.042	2.638GluThr: 2.638 ± 0.039	4.353GluVal: 4.353 ± 0.047	0.817GluTrp: 0.817 ± 0.019	1.278GluTyr: 1.278 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.191PheAla: 4.191 ± 0.054	0.469PheCys: 0.469 ± 0.018	2.46PheAsp: 2.46 ± 0.046	2.027PheGlu: 2.027 ± 0.032	1.449PhePhe: 1.449 ± 0.035	3.407PheGly: 3.407 ± 0.052	0.826PheHis: 0.826 ± 0.025	1.762PheIle: 1.762 ± 0.04	0.98PheLys: 0.98 ± 0.028	3.403PheLeu: 3.403 ± 0.057	0.811PheMet: 0.811 ± 0.023	1.186PheAsn: 1.186 ± 0.025	1.572PhePro: 1.572 ± 0.03	1.191PheGln: 1.191 ± 0.027	2.184PheArg: 2.184 ± 0.032	2.33PheSer: 2.33 ± 0.039	1.793PheThr: 1.793 ± 0.034	2.536PheVal: 2.536 ± 0.042	0.562PheTrp: 0.562 ± 0.019	1.041PheTyr: 1.041 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.222GlyAla: 8.222 ± 0.072	1.008GlyCys: 1.008 ± 0.027	4.363GlyAsp: 4.363 ± 0.074	5.571GlyGlu: 5.571 ± 0.058	3.343GlyPhe: 3.343 ± 0.044	6.918GlyGly: 6.918 ± 0.091	1.95GlyHis: 1.95 ± 0.04	4.26GlyIle: 4.26 ± 0.051	3.285GlyLys: 3.285 ± 0.052	9.376GlyLeu: 9.376 ± 0.079	2.402GlyMet: 2.402 ± 0.047	2.559GlyAsn: 2.559 ± 0.07	2.856GlyPro: 2.856 ± 0.039	3.58GlyGln: 3.58 ± 0.044	5.874GlyArg: 5.874 ± 0.061	4.885GlySer: 4.885 ± 0.066	3.822GlyThr: 3.822 ± 0.072	6.173GlyVal: 6.173 ± 0.068	1.465GlyTrp: 1.465 ± 0.032	2.525GlyTyr: 2.525 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.415HisAla: 2.415 ± 0.033	0.356HisCys: 0.356 ± 0.015	1.234HisAsp: 1.234 ± 0.03	1.255HisGlu: 1.255 ± 0.03	1.007HisPhe: 1.007 ± 0.024	2.129HisGly: 2.129 ± 0.048	0.596HisHis: 0.596 ± 0.023	0.929HisIle: 0.929 ± 0.026	0.577HisLys: 0.577 ± 0.02	2.591HisLeu: 2.591 ± 0.042	0.521HisMet: 0.521 ± 0.017	0.568HisAsn: 0.568 ± 0.016	1.493HisPro: 1.493 ± 0.036	0.816HisGln: 0.816 ± 0.022	1.414HisArg: 1.414 ± 0.028	1.206HisSer: 1.206 ± 0.03	0.857HisThr: 0.857 ± 0.022	1.39HisVal: 1.39 ± 0.027	0.429HisTrp: 0.429 ± 0.014	0.723HisTyr: 0.723 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.827IleAla: 5.827 ± 0.063	0.471IleCys: 0.471 ± 0.016	3.162IleAsp: 3.162 ± 0.047	3.16IleGlu: 3.16 ± 0.047	1.364IlePhe: 1.364 ± 0.03	4.649IleGly: 4.649 ± 0.054	0.979IleHis: 0.979 ± 0.026	1.737IleIle: 1.737 ± 0.036	1.257IleLys: 1.257 ± 0.031	4.059IleLeu: 4.059 ± 0.06	0.723IleMet: 0.723 ± 0.022	1.44IleAsn: 1.44 ± 0.034	2.321IlePro: 2.321 ± 0.035	1.527IleGln: 1.527 ± 0.029	3.159IleArg: 3.159 ± 0.048	2.622IleSer: 2.622 ± 0.046	2.208IleThr: 2.208 ± 0.041	3.151IleVal: 3.151 ± 0.049	0.472IleTrp: 0.472 ± 0.017	1.108IleTyr: 1.108 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.641LysAla: 3.641 ± 0.059	0.189LysCys: 0.189 ± 0.011	1.565LysAsp: 1.565 ± 0.038	1.592LysGlu: 1.592 ± 0.04	0.795LysPhe: 0.795 ± 0.023	2.455LysGly: 2.455 ± 0.045	0.63LysHis: 0.63 ± 0.018	1.348LysIle: 1.348 ± 0.036	1.105LysLys: 1.105 ± 0.038	3.295LysLeu: 3.295 ± 0.049	0.645LysMet: 0.645 ± 0.023	0.871LysAsn: 0.871 ± 0.026	1.943LysPro: 1.943 ± 0.047	1.279LysGln: 1.279 ± 0.028	2.172LysArg: 2.172 ± 0.037	1.619LysSer: 1.619 ± 0.038	1.557LysThr: 1.557 ± 0.038	2.518LysVal: 2.518 ± 0.046	0.336LysTrp: 0.336 ± 0.013	0.682LysTyr: 0.682 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.916LeuAla: 14.916 ± 0.124	1.285LeuCys: 1.285 ± 0.03	7.19LeuAsp: 7.19 ± 0.072	6.857LeuGlu: 6.857 ± 0.078	4.116LeuPhe: 4.116 ± 0.061	9.81LeuGly: 9.81 ± 0.085	2.516LeuHis: 2.516 ± 0.042	4.903LeuIle: 4.903 ± 0.059	3.844LeuLys: 3.844 ± 0.059	13.718LeuLeu: 13.718 ± 0.163	2.369LeuMet: 2.369 ± 0.04	3.209LeuAsn: 3.209 ± 0.049	6.527LeuPro: 6.527 ± 0.085	4.618LeuGln: 4.618 ± 0.061	8.216LeuArg: 8.216 ± 0.101	6.521LeuSer: 6.521 ± 0.08	5.106LeuThr: 5.106 ± 0.055	7.922LeuVal: 7.922 ± 0.078	1.384LeuTrp: 1.384 ± 0.031	2.526LeuTyr: 2.526 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.543MetAla: 2.543 ± 0.051	0.187MetCys: 0.187 ± 0.012	1.04MetAsp: 1.04 ± 0.024	0.99MetGlu: 0.99 ± 0.024	0.716MetPhe: 0.716 ± 0.022	1.701MetGly: 1.701 ± 0.033	0.538MetHis: 0.538 ± 0.018	1.033MetIle: 1.033 ± 0.026	0.845MetLys: 0.845 ± 0.025	2.688MetLeu: 2.688 ± 0.047	0.466MetMet: 0.466 ± 0.017	0.846MetAsn: 0.846 ± 0.019	1.37MetPro: 1.37 ± 0.031	1.049MetGln: 1.049 ± 0.021	1.621MetArg: 1.621 ± 0.029	1.642MetSer: 1.642 ± 0.029	1.361MetThr: 1.361 ± 0.03	1.513MetVal: 1.513 ± 0.029	0.191MetTrp: 0.191 ± 0.009	0.375MetTyr: 0.375 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.05	0.294AsnCys: 0.294 ± 0.015	1.489AsnAsp: 1.489 ± 0.038	1.316AsnGlu: 1.316 ± 0.027	1.051AsnPhe: 1.051 ± 0.028	2.543AsnGly: 2.543 ± 0.055	0.608AsnHis: 0.608 ± 0.023	1.347AsnIle: 1.347 ± 0.035	0.723AsnLys: 0.723 ± 0.022	3.365AsnLeu: 3.365 ± 0.045	0.56AsnMet: 0.56 ± 0.017	0.836AsnAsn: 0.836 ± 0.032	1.95AsnPro: 1.95 ± 0.034	1.084AsnGln: 1.084 ± 0.025	1.896AsnArg: 1.896 ± 0.033	1.404AsnSer: 1.404 ± 0.037	1.285AsnThr: 1.285 ± 0.034	1.872AsnVal: 1.872 ± 0.049	0.451AsnTrp: 0.451 ± 0.016	0.822AsnTyr: 0.822 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.149ProAla: 6.149 ± 0.069	0.391ProCys: 0.391 ± 0.016	2.928ProAsp: 2.928 ± 0.042	3.631ProGlu: 3.631 ± 0.049	1.844ProPhe: 1.844 ± 0.033	4.524ProGly: 4.524 ± 0.065	1.081ProHis: 1.081 ± 0.027	1.886ProIle: 1.886 ± 0.033	1.385ProLys: 1.385 ± 0.032	6.053ProLeu: 6.053 ± 0.077	1.129ProMet: 1.129 ± 0.025	1.306ProAsn: 1.306 ± 0.03	2.169ProPro: 2.169 ± 0.051	2.321ProGln: 2.321 ± 0.034	3.1ProArg: 3.1 ± 0.041	2.419ProSer: 2.419 ± 0.035	2.162ProThr: 2.162 ± 0.034	3.879ProVal: 3.879 ± 0.054	0.739ProTrp: 0.739 ± 0.021	1.214ProTyr: 1.214 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	5.418GlnAla: 5.418 ± 0.06	0.319GlnCys: 0.319 ± 0.014	1.781GlnAsp: 1.781 ± 0.037	1.951GlnGlu: 1.951 ± 0.039	1.281GlnPhe: 1.281 ± 0.027	3.193GlnGly: 3.193 ± 0.047	1.011GlnHis: 1.011 ± 0.026	1.767GlnIle: 1.767 ± 0.034	1.198GlnLys: 1.198 ± 0.029	5.134GlnLeu: 5.134 ± 0.065	0.971GlnMet: 0.971 ± 0.026	0.98GlnAsn: 0.98 ± 0.028	2.573GlnPro: 2.573 ± 0.042	2.314GlnGln: 2.314 ± 0.047	3.831GlnArg: 3.831 ± 0.064	2.0GlnSer: 2.0 ± 0.037	1.647GlnThr: 1.647 ± 0.031	3.327GlnVal: 3.327 ± 0.043	0.65GlnTrp: 0.65 ± 0.021	0.943GlnTyr: 0.943 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.814ArgAla: 6.814 ± 0.074	0.673ArgCys: 0.673 ± 0.025	3.892ArgAsp: 3.892 ± 0.043	4.999ArgGlu: 4.999 ± 0.061	2.99ArgPhe: 2.99 ± 0.041	4.617ArgGly: 4.617 ± 0.054	1.961ArgHis: 1.961 ± 0.04	3.771ArgIle: 3.771 ± 0.051	2.197ArgLys: 2.197 ± 0.044	9.372ArgLeu: 9.372 ± 0.112	1.799ArgMet: 1.799 ± 0.035	2.045ArgAsn: 2.045 ± 0.034	3.246ArgPro: 3.246 ± 0.044	3.652ArgGln: 3.652 ± 0.053	5.32ArgArg: 5.32 ± 0.078	3.601ArgSer: 3.601 ± 0.047	2.938ArgThr: 2.938 ± 0.048	4.851ArgVal: 4.851 ± 0.057	1.134ArgTrp: 1.134 ± 0.029	2.191ArgTyr: 2.191 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.935SerAla: 5.935 ± 0.05	0.526SerCys: 0.526 ± 0.019	2.762SerAsp: 2.762 ± 0.044	2.936SerGlu: 2.936 ± 0.037	2.144SerPhe: 2.144 ± 0.034	5.386SerGly: 5.386 ± 0.07	1.298SerHis: 1.298 ± 0.032	2.58SerIle: 2.58 ± 0.039	1.431SerLys: 1.431 ± 0.03	6.658SerLeu: 6.658 ± 0.071	1.314SerMet: 1.314 ± 0.027	1.469SerAsn: 1.469 ± 0.033	2.687SerPro: 2.687 ± 0.043	2.123SerGln: 2.123 ± 0.038	3.827SerArg: 3.827 ± 0.053	3.027SerSer: 3.027 ± 0.049	2.504SerThr: 2.504 ± 0.039	3.852SerVal: 3.852 ± 0.054	0.774SerTrp: 0.774 ± 0.024	1.477SerTyr: 1.477 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	4.833ThrAla: 4.833 ± 0.071	0.487ThrCys: 0.487 ± 0.02	2.222ThrAsp: 2.222 ± 0.043	2.197ThrGlu: 2.197 ± 0.039	1.677ThrPhe: 1.677 ± 0.035	4.16ThrGly: 4.16 ± 0.063	0.952ThrHis: 0.952 ± 0.027	1.873ThrIle: 1.873 ± 0.037	0.846ThrLys: 0.846 ± 0.028	6.124ThrLeu: 6.124 ± 0.076	0.76ThrMet: 0.76 ± 0.019	1.078ThrAsn: 1.078 ± 0.03	3.015ThrPro: 3.015 ± 0.046	1.596ThrGln: 1.596 ± 0.035	3.213ThrArg: 3.213 ± 0.043	2.456ThrSer: 2.456 ± 0.044	2.185ThrThr: 2.185 ± 0.041	3.178ThrVal: 3.178 ± 0.049	0.659ThrTrp: 0.659 ± 0.017	1.133ThrTyr: 1.133 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.879ValAla: 7.879 ± 0.073	0.731ValCys: 0.731 ± 0.02	3.96ValAsp: 3.96 ± 0.052	4.697ValGlu: 4.697 ± 0.053	2.485ValPhe: 2.485 ± 0.038	5.363ValGly: 5.363 ± 0.067	1.452ValHis: 1.452 ± 0.028	3.531ValIle: 3.531 ± 0.048	2.086ValLys: 2.086 ± 0.047	8.014ValLeu: 8.014 ± 0.08	1.64ValMet: 1.64 ± 0.036	2.122ValAsn: 2.122 ± 0.04	3.426ValPro: 3.426 ± 0.044	2.563ValGln: 2.563 ± 0.04	4.838ValArg: 4.838 ± 0.058	3.965ValSer: 3.965 ± 0.054	3.46ValThr: 3.46 ± 0.051	5.255ValVal: 5.255 ± 0.062	0.848ValTrp: 0.848 ± 0.024	1.543ValTyr: 1.543 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.199TrpAla: 1.199 ± 0.028	0.167TrpCys: 0.167 ± 0.01	0.641TrpAsp: 0.641 ± 0.019	0.627TrpGlu: 0.627 ± 0.022	0.549TrpPhe: 0.549 ± 0.018	0.95TrpGly: 0.95 ± 0.025	0.353TrpHis: 0.353 ± 0.014	0.636TrpIle: 0.636 ± 0.018	0.479TrpLys: 0.479 ± 0.018	2.253TrpLeu: 2.253 ± 0.049	0.388TrpMet: 0.388 ± 0.016	0.501TrpAsn: 0.501 ± 0.016	0.705TrpPro: 0.705 ± 0.023	0.876TrpGln: 0.876 ± 0.027	1.204TrpArg: 1.204 ± 0.029	0.829TrpSer: 0.829 ± 0.023	0.627TrpThr: 0.627 ± 0.022	0.899TrpVal: 0.899 ± 0.022	0.241TrpTrp: 0.241 ± 0.012	0.348TrpTyr: 0.348 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.046	0.3TyrCys: 0.3 ± 0.014	1.387TyrAsp: 1.387 ± 0.03	1.179TyrGlu: 1.179 ± 0.025	0.98TyrPhe: 0.98 ± 0.023	2.135TyrGly: 2.135 ± 0.037	0.58TyrHis: 0.58 ± 0.019	0.964TyrIle: 0.964 ± 0.025	0.681TyrLys: 0.681 ± 0.022	3.01TyrLeu: 3.01 ± 0.043	0.47TyrMet: 0.47 ± 0.017	0.715TyrAsn: 0.715 ± 0.024	1.354TyrPro: 1.354 ± 0.029	1.169TyrGln: 1.169 ± 0.028	2.223TyrArg: 2.223 ± 0.037	1.516TyrSer: 1.516 ± 0.032	1.138TyrThr: 1.138 ± 0.027	1.586TyrVal: 1.586 ± 0.031	0.442TyrTrp: 0.442 ± 0.015	0.758TyrTyr: 0.758 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5169 proteins (1739259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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