Amino acid dipepetide frequency for Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent) (Pneumocystis carinii f. sp. muris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.286AlaAla: 2.286 ± 0.043	0.799AlaCys: 0.799 ± 0.022	1.723AlaAsp: 1.723 ± 0.035	2.404AlaGlu: 2.404 ± 0.043	2.218AlaPhe: 2.218 ± 0.043	1.909AlaGly: 1.909 ± 0.041	0.863AlaHis: 0.863 ± 0.023	3.765AlaIle: 3.765 ± 0.061	3.158AlaLys: 3.158 ± 0.046	4.86AlaLeu: 4.86 ± 0.049	0.924AlaMet: 0.924 ± 0.025	1.98AlaAsn: 1.98 ± 0.041	1.515AlaPro: 1.515 ± 0.045	1.515AlaGln: 1.515 ± 0.034	1.974AlaArg: 1.974 ± 0.041	3.575AlaSer: 3.575 ± 0.049	2.177AlaThr: 2.177 ± 0.039	2.069AlaVal: 2.069 ± 0.04	0.481AlaTrp: 0.481 ± 0.018	1.575AlaTyr: 1.575 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.602CysAla: 0.602 ± 0.024	0.266CysCys: 0.266 ± 0.012	0.803CysAsp: 0.803 ± 0.023	1.006CysGlu: 1.006 ± 0.039	0.953CysPhe: 0.953 ± 0.026	0.833CysGly: 0.833 ± 0.026	0.397CysHis: 0.397 ± 0.016	1.468CysIle: 1.468 ± 0.029	1.348CysLys: 1.348 ± 0.053	1.831CysLeu: 1.831 ± 0.035	0.303CysMet: 0.303 ± 0.013	0.841CysAsn: 0.841 ± 0.025	0.609CysPro: 0.609 ± 0.021	0.583CysGln: 0.583 ± 0.02	0.697CysArg: 0.697 ± 0.025	1.31CysSer: 1.31 ± 0.035	0.779CysThr: 0.779 ± 0.027	0.761CysVal: 0.761 ± 0.022	0.159CysTrp: 0.159 ± 0.009	0.654CysTyr: 0.654 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.239AspAla: 2.239 ± 0.035	0.775AspCys: 0.775 ± 0.023	3.447AspAsp: 3.447 ± 0.067	4.123AspGlu: 4.123 ± 0.056	3.02AspPhe: 3.02 ± 0.046	2.237AspGly: 2.237 ± 0.048	1.009AspHis: 1.009 ± 0.028	5.721AspIle: 5.721 ± 0.062	3.961AspLys: 3.961 ± 0.057	5.337AspLeu: 5.337 ± 0.061	1.189AspMet: 1.189 ± 0.029	3.107AspAsn: 3.107 ± 0.044	2.059AspPro: 2.059 ± 0.04	1.616AspGln: 1.616 ± 0.03	1.96AspArg: 1.96 ± 0.039	4.397AspSer: 4.397 ± 0.059	2.658AspThr: 2.658 ± 0.041	2.736AspVal: 2.736 ± 0.042	0.558AspTrp: 0.558 ± 0.018	2.039AspTyr: 2.039 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	3.063GluAla: 3.063 ± 0.048	0.963GluCys: 0.963 ± 0.031	3.797GluAsp: 3.797 ± 0.063	5.888GluGlu: 5.888 ± 0.095	2.82GluPhe: 2.82 ± 0.045	2.445GluGly: 2.445 ± 0.04	1.274GluHis: 1.274 ± 0.028	6.239GluIle: 6.239 ± 0.064	7.89GluLys: 7.89 ± 0.112	6.626GluLeu: 6.626 ± 0.1	1.554GluMet: 1.554 ± 0.036	5.705GluAsn: 5.705 ± 0.071	1.673GluPro: 1.673 ± 0.047	2.26GluGln: 2.26 ± 0.042	3.07GluArg: 3.07 ± 0.056	4.952GluSer: 4.952 ± 0.063	3.748GluThr: 3.748 ± 0.053	2.79GluVal: 2.79 ± 0.045	0.77GluTrp: 0.77 ± 0.024	2.642GluTyr: 2.642 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	1.64PheAla: 1.64 ± 0.033	0.889PheCys: 0.889 ± 0.023	2.734PheAsp: 2.734 ± 0.044	3.136PheGlu: 3.136 ± 0.047	2.831PhePhe: 2.831 ± 0.057	2.265PheGly: 2.265 ± 0.049	1.183PheHis: 1.183 ± 0.03	4.037PheIle: 4.037 ± 0.064	3.37PheLys: 3.37 ± 0.043	5.194PheLeu: 5.194 ± 0.063	0.995PheMet: 0.995 ± 0.029	2.636PheAsn: 2.636 ± 0.041	1.979PhePro: 1.979 ± 0.034	1.917PheGln: 1.917 ± 0.034	2.008PheArg: 2.008 ± 0.034	5.361PheSer: 5.361 ± 0.066	2.06PheThr: 2.06 ± 0.035	2.368PheVal: 2.368 ± 0.041	0.556PheTrp: 0.556 ± 0.019	1.98PheTyr: 1.98 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	1.759GlyAla: 1.759 ± 0.038	0.689GlyCys: 0.689 ± 0.021	2.081GlyAsp: 2.081 ± 0.04	2.311GlyGlu: 2.311 ± 0.045	2.352GlyPhe: 2.352 ± 0.048	2.334GlyGly: 2.334 ± 0.05	1.03GlyHis: 1.03 ± 0.03	4.059GlyIle: 4.059 ± 0.055	3.6GlyLys: 3.6 ± 0.054	4.125GlyLeu: 4.125 ± 0.057	0.949GlyMet: 0.949 ± 0.024	2.41GlyAsn: 2.41 ± 0.039	1.342GlyPro: 1.342 ± 0.035	1.354GlyGln: 1.354 ± 0.032	1.985GlyArg: 1.985 ± 0.042	3.387GlySer: 3.387 ± 0.048	2.361GlyThr: 2.361 ± 0.042	2.309GlyVal: 2.309 ± 0.042	0.573GlyTrp: 0.573 ± 0.02	1.713GlyTyr: 1.713 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	0.891HisAla: 0.891 ± 0.024	0.355HisCys: 0.355 ± 0.015	1.119HisAsp: 1.119 ± 0.029	1.426HisGlu: 1.426 ± 0.029	1.145HisPhe: 1.145 ± 0.026	0.969HisGly: 0.969 ± 0.026	0.537HisHis: 0.537 ± 0.021	1.981HisIle: 1.981 ± 0.034	1.476HisLys: 1.476 ± 0.037	2.284HisLeu: 2.284 ± 0.04	0.43HisMet: 0.43 ± 0.018	1.131HisAsn: 1.131 ± 0.029	1.066HisPro: 1.066 ± 0.028	0.802HisGln: 0.802 ± 0.022	0.908HisArg: 0.908 ± 0.026	1.834HisSer: 1.834 ± 0.036	1.072HisThr: 1.072 ± 0.027	1.122HisVal: 1.122 ± 0.029	0.24HisTrp: 0.24 ± 0.013	0.78HisTyr: 0.78 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.622IleAla: 3.622 ± 0.056	1.554IleCys: 1.554 ± 0.034	4.832IleAsp: 4.832 ± 0.057	5.895IleGlu: 5.895 ± 0.074	4.477IlePhe: 4.477 ± 0.067	3.477IleGly: 3.477 ± 0.054	2.013IleHis: 2.013 ± 0.035	7.047IleIle: 7.047 ± 0.088	6.674IleLys: 6.674 ± 0.066	8.923IleLeu: 8.923 ± 0.095	1.73IleMet: 1.73 ± 0.036	5.055IleAsn: 5.055 ± 0.061	3.498IlePro: 3.498 ± 0.05	3.45IleGln: 3.45 ± 0.056	3.763IleArg: 3.763 ± 0.055	8.368IleSer: 8.368 ± 0.088	3.87IleThr: 3.87 ± 0.055	4.039IleVal: 4.039 ± 0.051	0.982IleTrp: 0.982 ± 0.028	3.387IleTyr: 3.387 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	3.477LysAla: 3.477 ± 0.053	1.463LysCys: 1.463 ± 0.073	4.878LysAsp: 4.878 ± 0.065	7.152LysGlu: 7.152 ± 0.108	3.006LysPhe: 3.006 ± 0.046	3.16LysGly: 3.16 ± 0.057	1.841LysHis: 1.841 ± 0.036	7.27LysIle: 7.27 ± 0.076	9.454LysLys: 9.454 ± 0.123	7.1LysLeu: 7.1 ± 0.064	1.846LysMet: 1.846 ± 0.038	6.66LysAsn: 6.66 ± 0.083	2.547LysPro: 2.547 ± 0.061	2.941LysGln: 2.941 ± 0.051	4.065LysArg: 4.065 ± 0.058	6.112LysSer: 6.112 ± 0.076	4.654LysThr: 4.654 ± 0.06	3.563LysVal: 3.563 ± 0.047	0.811LysTrp: 0.811 ± 0.024	3.323LysTyr: 3.323 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	4.152LeuAla: 4.152 ± 0.051	1.648LeuCys: 1.648 ± 0.036	5.489LeuAsp: 5.489 ± 0.053	7.601LeuGlu: 7.601 ± 0.091	4.776LeuPhe: 4.776 ± 0.063	4.202LeuGly: 4.202 ± 0.054	2.151LeuHis: 2.151 ± 0.033	7.111LeuIle: 7.111 ± 0.092	9.12LeuLys: 9.12 ± 0.09	9.588LeuLeu: 9.588 ± 0.096	1.838LeuMet: 1.838 ± 0.035	6.195LeuAsn: 6.195 ± 0.071	3.703LeuPro: 3.703 ± 0.054	3.818LeuGln: 3.818 ± 0.063	4.716LeuArg: 4.716 ± 0.061	9.435LeuSer: 9.435 ± 0.08	4.341LeuThr: 4.341 ± 0.057	4.495LeuVal: 4.495 ± 0.067	1.125LeuTrp: 1.125 ± 0.032	3.704LeuTyr: 3.704 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.143MetAla: 1.143 ± 0.027	0.225MetCys: 0.225 ± 0.01	1.296MetAsp: 1.296 ± 0.028	1.617MetGlu: 1.617 ± 0.03	0.922MetPhe: 0.922 ± 0.025	0.919MetGly: 0.919 ± 0.023	0.44MetHis: 0.44 ± 0.015	1.703MetIle: 1.703 ± 0.035	1.796MetLys: 1.796 ± 0.037	1.893MetLeu: 1.893 ± 0.036	0.428MetMet: 0.428 ± 0.016	1.351MetAsn: 1.351 ± 0.03	0.722MetPro: 0.722 ± 0.023	0.768MetGln: 0.768 ± 0.024	0.894MetArg: 0.894 ± 0.026	1.756MetSer: 1.756 ± 0.032	1.153MetThr: 1.153 ± 0.027	1.017MetVal: 1.017 ± 0.026	0.126MetTrp: 0.126 ± 0.009	0.598MetTyr: 0.598 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.371AsnAla: 2.371 ± 0.034	0.937AsnCys: 0.937 ± 0.027	3.704AsnAsp: 3.704 ± 0.053	4.511AsnGlu: 4.511 ± 0.057	2.847AsnPhe: 2.847 ± 0.042	2.424AsnGly: 2.424 ± 0.037	1.326AsnHis: 1.326 ± 0.026	6.73AsnIle: 6.73 ± 0.076	5.012AsnLys: 5.012 ± 0.058	5.587AsnLeu: 5.587 ± 0.067	1.451AsnMet: 1.451 ± 0.031	4.364AsnAsn: 4.364 ± 0.064	2.19AsnPro: 2.19 ± 0.038	2.075AsnGln: 2.075 ± 0.043	2.189AsnArg: 2.189 ± 0.043	5.24AsnSer: 5.24 ± 0.072	3.519AsnThr: 3.519 ± 0.059	3.02AsnVal: 3.02 ± 0.038	0.559AsnTrp: 0.559 ± 0.019	2.337AsnTyr: 2.337 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	1.437ProAla: 1.437 ± 0.046	0.482ProCys: 0.482 ± 0.017	1.771ProAsp: 1.771 ± 0.033	2.533ProGlu: 2.533 ± 0.036	1.903ProPhe: 1.903 ± 0.034	1.688ProGly: 1.688 ± 0.041	0.747ProHis: 0.747 ± 0.021	2.977ProIle: 2.977 ± 0.046	2.698ProLys: 2.698 ± 0.054	3.65ProLeu: 3.65 ± 0.044	0.598ProMet: 0.598 ± 0.02	1.937ProAsn: 1.937 ± 0.04	1.811ProPro: 1.811 ± 0.046	1.259ProGln: 1.259 ± 0.038	1.485ProArg: 1.485 ± 0.032	3.518ProSer: 3.518 ± 0.048	1.892ProThr: 1.892 ± 0.039	1.992ProVal: 1.992 ± 0.039	0.398ProTrp: 0.398 ± 0.016	1.544ProTyr: 1.544 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.642GlnAla: 1.642 ± 0.038	0.485GlnCys: 0.485 ± 0.017	1.909GlnAsp: 1.909 ± 0.033	2.81GlnGlu: 2.81 ± 0.044	1.429GlnPhe: 1.429 ± 0.029	1.419GlnGly: 1.419 ± 0.028	0.77GlnHis: 0.77 ± 0.023	2.847GlnIle: 2.847 ± 0.048	3.625GlnLys: 3.625 ± 0.049	3.313GlnLeu: 3.313 ± 0.046	0.759GlnMet: 0.759 ± 0.023	2.563GlnAsn: 2.563 ± 0.045	1.092GlnPro: 1.092 ± 0.034	1.494GlnGln: 1.494 ± 0.049	1.765GlnArg: 1.765 ± 0.035	2.63GlnSer: 2.63 ± 0.044	1.989GlnThr: 1.989 ± 0.042	1.633GlnVal: 1.633 ± 0.031	0.375GlnTrp: 0.375 ± 0.015	1.377GlnTyr: 1.377 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.959ArgAla: 1.959 ± 0.038	0.809ArgCys: 0.809 ± 0.027	2.109ArgAsp: 2.109 ± 0.042	2.752ArgGlu: 2.752 ± 0.042	2.111ArgPhe: 2.111 ± 0.034	1.859ArgGly: 1.859 ± 0.042	1.036ArgHis: 1.036 ± 0.029	3.82ArgIle: 3.82 ± 0.051	4.087ArgLys: 4.087 ± 0.057	4.483ArgLeu: 4.483 ± 0.062	0.972ArgMet: 0.972 ± 0.025	2.645ArgAsn: 2.645 ± 0.047	1.488ArgPro: 1.488 ± 0.033	1.703ArgGln: 1.703 ± 0.037	2.675ArgArg: 2.675 ± 0.056	3.258ArgSer: 3.258 ± 0.062	2.042ArgThr: 2.042 ± 0.037	2.132ArgVal: 2.132 ± 0.039	0.508ArgTrp: 0.508 ± 0.017	1.679ArgTyr: 1.679 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.16SerAla: 3.16 ± 0.049	1.349SerCys: 1.349 ± 0.03	4.514SerAsp: 4.514 ± 0.055	5.706SerGlu: 5.706 ± 0.062	4.643SerPhe: 4.643 ± 0.059	3.809SerGly: 3.809 ± 0.053	1.735SerHis: 1.735 ± 0.034	7.334SerIle: 7.334 ± 0.078	7.092SerLys: 7.092 ± 0.069	9.108SerLeu: 9.108 ± 0.076	1.739SerMet: 1.739 ± 0.032	5.369SerAsn: 5.369 ± 0.066	3.188SerPro: 3.188 ± 0.055	3.215SerGln: 3.215 ± 0.059	3.704SerArg: 3.704 ± 0.06	8.775SerSer: 8.775 ± 0.106	4.569SerThr: 4.569 ± 0.066	4.057SerVal: 4.057 ± 0.051	0.908SerTrp: 0.908 ± 0.024	3.151SerTyr: 3.151 ± 0.04	0.001SerXaa: 0.001 ± 0.001
Thr	2.157ThrAla: 2.157 ± 0.038	0.852ThrCys: 0.852 ± 0.024	2.353ThrAsp: 2.353 ± 0.04	3.1ThrGlu: 3.1 ± 0.063	2.562ThrPhe: 2.562 ± 0.043	2.362ThrGly: 2.362 ± 0.043	1.134ThrHis: 1.134 ± 0.027	4.209ThrIle: 4.209 ± 0.058	3.667ThrLys: 3.667 ± 0.054	5.337ThrLeu: 5.337 ± 0.056	1.027ThrMet: 1.027 ± 0.025	2.955ThrAsn: 2.955 ± 0.055	2.212ThrPro: 2.212 ± 0.046	1.802ThrGln: 1.802 ± 0.041	2.087ThrArg: 2.087 ± 0.038	4.806ThrSer: 4.806 ± 0.071	2.95ThrThr: 2.95 ± 0.095	2.513ThrVal: 2.513 ± 0.041	0.545ThrTrp: 0.545 ± 0.02	1.826ThrTyr: 1.826 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	2.166ValAla: 2.166 ± 0.04	0.818ValCys: 0.818 ± 0.024	2.699ValAsp: 2.699 ± 0.043	3.118ValGlu: 3.118 ± 0.044	2.622ValPhe: 2.622 ± 0.048	2.011ValGly: 2.011 ± 0.044	0.964ValHis: 0.964 ± 0.023	3.906ValIle: 3.906 ± 0.054	3.528ValLys: 3.528 ± 0.048	5.052ValLeu: 5.052 ± 0.059	0.97ValMet: 0.97 ± 0.025	2.522ValAsn: 2.522 ± 0.042	1.983ValPro: 1.983 ± 0.036	1.664ValGln: 1.664 ± 0.028	2.01ValArg: 2.01 ± 0.04	4.427ValSer: 4.427 ± 0.056	2.278ValThr: 2.278 ± 0.038	2.44ValVal: 2.44 ± 0.046	0.508ValTrp: 0.508 ± 0.02	1.716ValTyr: 1.716 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.478TrpAla: 0.478 ± 0.017	0.165TrpCys: 0.165 ± 0.012	0.72TrpAsp: 0.72 ± 0.026	0.658TrpGlu: 0.658 ± 0.022	0.431TrpPhe: 0.431 ± 0.019	0.461TrpGly: 0.461 ± 0.018	0.229TrpHis: 0.229 ± 0.011	1.019TrpIle: 1.019 ± 0.027	1.068TrpLys: 1.068 ± 0.027	0.931TrpLeu: 0.931 ± 0.027	0.261TrpMet: 0.261 ± 0.011	0.725TrpAsn: 0.725 ± 0.022	0.303TrpPro: 0.303 ± 0.014	0.304TrpGln: 0.304 ± 0.012	0.52TrpArg: 0.52 ± 0.019	0.813TrpSer: 0.813 ± 0.024	0.531TrpThr: 0.531 ± 0.017	0.569TrpVal: 0.569 ± 0.019	0.15TrpTrp: 0.15 ± 0.011	0.338TrpTyr: 0.338 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.525TyrAla: 1.525 ± 0.031	0.682TyrCys: 0.682 ± 0.021	2.209TyrAsp: 2.209 ± 0.04	2.424TyrGlu: 2.424 ± 0.036	2.071TyrPhe: 2.071 ± 0.037	1.942TyrGly: 1.942 ± 0.037	0.889TyrHis: 0.889 ± 0.024	3.412TyrIle: 3.412 ± 0.05	2.699TyrLys: 2.699 ± 0.037	3.986TyrLeu: 3.986 ± 0.057	0.8TyrMet: 0.8 ± 0.026	2.24TyrAsn: 2.24 ± 0.042	1.338TyrPro: 1.338 ± 0.034	1.387TyrGln: 1.387 ± 0.03	1.651TyrArg: 1.651 ± 0.035	3.173TyrSer: 3.173 ± 0.049	1.812TyrThr: 1.812 ± 0.033	1.781TyrVal: 1.781 ± 0.036	0.342TyrTrp: 0.342 ± 0.016	1.503TyrTyr: 1.503 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3635 proteins (1664453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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