Amino acid dipepetide frequency for Penicillium brasilianum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.804AlaAla: 8.804 ± 0.066	1.074AlaCys: 1.074 ± 0.016	4.272AlaAsp: 4.272 ± 0.026	5.189AlaGlu: 5.189 ± 0.05	3.198AlaPhe: 3.198 ± 0.027	5.76AlaGly: 5.76 ± 0.033	1.818AlaHis: 1.818 ± 0.017	4.4AlaIle: 4.4 ± 0.036	3.857AlaLys: 3.857 ± 0.036	7.847AlaLeu: 7.847 ± 0.048	2.002AlaMet: 2.002 ± 0.02	2.948AlaAsn: 2.948 ± 0.025	4.751AlaPro: 4.751 ± 0.045	3.455AlaGln: 3.455 ± 0.026	4.929AlaArg: 4.929 ± 0.032	7.436AlaSer: 7.436 ± 0.042	5.319AlaThr: 5.319 ± 0.037	5.368AlaVal: 5.368 ± 0.036	1.167AlaTrp: 1.167 ± 0.014	2.159AlaTyr: 2.159 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.955CysAla: 0.955 ± 0.014	0.237CysCys: 0.237 ± 0.008	0.699CysAsp: 0.699 ± 0.013	0.605CysGlu: 0.605 ± 0.011	0.563CysPhe: 0.563 ± 0.012	0.947CysGly: 0.947 ± 0.014	0.344CysHis: 0.344 ± 0.008	0.698CysIle: 0.698 ± 0.012	0.469CysLys: 0.469 ± 0.009	1.308CysLeu: 1.308 ± 0.015	0.288CysMet: 0.288 ± 0.007	0.426CysAsn: 0.426 ± 0.009	0.648CysPro: 0.648 ± 0.013	0.472CysGln: 0.472 ± 0.009	0.778CysArg: 0.778 ± 0.013	0.941CysSer: 0.941 ± 0.016	0.695CysThr: 0.695 ± 0.012	0.821CysVal: 0.821 ± 0.013	0.202CysTrp: 0.202 ± 0.006	0.351CysTyr: 0.351 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.621AspAla: 4.621 ± 0.035	0.633AspCys: 0.633 ± 0.01	3.897AspAsp: 3.897 ± 0.043	4.327AspGlu: 4.327 ± 0.032	2.192AspPhe: 2.192 ± 0.02	3.857AspGly: 3.857 ± 0.027	1.301AspHis: 1.301 ± 0.014	3.068AspIle: 3.068 ± 0.021	2.151AspLys: 2.151 ± 0.023	5.256AspLeu: 5.256 ± 0.031	1.237AspMet: 1.237 ± 0.016	1.834AspAsn: 1.834 ± 0.02	3.385AspPro: 3.385 ± 0.024	2.059AspGln: 2.059 ± 0.023	3.176AspArg: 3.176 ± 0.027	4.215AspSer: 4.215 ± 0.031	2.956AspThr: 2.956 ± 0.022	3.517AspVal: 3.517 ± 0.025	0.888AspTrp: 0.888 ± 0.014	1.607AspTyr: 1.607 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.244GluAla: 5.244 ± 0.042	0.616GluCys: 0.616 ± 0.011	4.1GluAsp: 4.1 ± 0.036	5.282GluGlu: 5.282 ± 0.062	1.968GluPhe: 1.968 ± 0.018	3.592GluGly: 3.592 ± 0.025	1.364GluHis: 1.364 ± 0.016	3.253GluIle: 3.253 ± 0.029	3.511GluLys: 3.511 ± 0.032	5.147GluLeu: 5.147 ± 0.031	1.507GluMet: 1.507 ± 0.015	2.351GluAsn: 2.351 ± 0.02	2.827GluPro: 2.827 ± 0.04	2.457GluGln: 2.457 ± 0.024	3.794GluArg: 3.794 ± 0.032	4.467GluSer: 4.467 ± 0.037	3.586GluThr: 3.586 ± 0.03	3.484GluVal: 3.484 ± 0.025	0.903GluTrp: 0.903 ± 0.012	1.649GluTyr: 1.649 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.116PheAla: 3.116 ± 0.028	0.581PheCys: 0.581 ± 0.011	2.339PheAsp: 2.339 ± 0.021	2.172PheGlu: 2.172 ± 0.021	1.722PhePhe: 1.722 ± 0.018	2.905PheGly: 2.905 ± 0.026	0.959PheHis: 0.959 ± 0.012	1.9PheIle: 1.9 ± 0.019	1.458PheLys: 1.458 ± 0.017	3.617PheLeu: 3.617 ± 0.029	0.815PheMet: 0.815 ± 0.012	1.46PheAsn: 1.46 ± 0.017	2.012PhePro: 2.012 ± 0.019	1.468PheGln: 1.468 ± 0.018	1.97PheArg: 1.97 ± 0.018	3.066PheSer: 3.066 ± 0.024	2.179PheThr: 2.179 ± 0.019	2.429PheVal: 2.429 ± 0.027	0.673PheTrp: 0.673 ± 0.012	1.154PheTyr: 1.154 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.34GlyAla: 5.34 ± 0.035	0.9GlyCys: 0.9 ± 0.016	3.576GlyAsp: 3.576 ± 0.031	3.467GlyGlu: 3.467 ± 0.026	2.832GlyPhe: 2.832 ± 0.027	5.36GlyGly: 5.36 ± 0.051	1.725GlyHis: 1.725 ± 0.023	3.606GlyIle: 3.606 ± 0.027	3.211GlyLys: 3.211 ± 0.023	6.225GlyLeu: 6.225 ± 0.033	1.586GlyMet: 1.586 ± 0.018	2.491GlyAsn: 2.491 ± 0.021	3.382GlyPro: 3.382 ± 0.029	2.631GlyGln: 2.631 ± 0.023	3.997GlyArg: 3.997 ± 0.033	5.841GlySer: 5.841 ± 0.038	3.904GlyThr: 3.904 ± 0.027	4.322GlyVal: 4.322 ± 0.03	1.185GlyTrp: 1.185 ± 0.014	2.181GlyTyr: 2.181 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.865HisAla: 1.865 ± 0.021	0.329HisCys: 0.329 ± 0.008	1.347HisAsp: 1.347 ± 0.017	1.361HisGlu: 1.361 ± 0.015	0.961HisPhe: 0.961 ± 0.012	1.764HisGly: 1.764 ± 0.018	0.862HisHis: 0.862 ± 0.017	1.236HisIle: 1.236 ± 0.013	0.857HisLys: 0.857 ± 0.013	2.301HisLeu: 2.301 ± 0.021	0.499HisMet: 0.499 ± 0.009	0.848HisAsn: 0.848 ± 0.014	1.694HisPro: 1.694 ± 0.017	1.02HisGln: 1.02 ± 0.014	1.61HisArg: 1.61 ± 0.019	1.904HisSer: 1.904 ± 0.021	1.292HisThr: 1.292 ± 0.016	1.438HisVal: 1.438 ± 0.015	0.364HisTrp: 0.364 ± 0.009	0.702HisTyr: 0.702 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.321IleAla: 4.321 ± 0.027	0.795IleCys: 0.795 ± 0.013	2.894IleAsp: 2.894 ± 0.024	2.893IleGlu: 2.893 ± 0.026	2.159IlePhe: 2.159 ± 0.021	3.331IleGly: 3.331 ± 0.027	1.249IleHis: 1.249 ± 0.016	2.622IleIle: 2.622 ± 0.024	2.068IleLys: 2.068 ± 0.019	4.792IleLeu: 4.792 ± 0.032	1.071IleMet: 1.071 ± 0.016	1.806IleAsn: 1.806 ± 0.022	3.197IlePro: 3.197 ± 0.027	2.034IleGln: 2.034 ± 0.019	2.839IleArg: 2.839 ± 0.022	4.057IleSer: 4.057 ± 0.032	2.889IleThr: 2.889 ± 0.023	3.203IleVal: 3.203 ± 0.025	0.769IleTrp: 0.769 ± 0.014	1.488IleTyr: 1.488 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.985LysAla: 3.985 ± 0.034	0.51LysCys: 0.51 ± 0.01	2.643LysAsp: 2.643 ± 0.023	3.146LysGlu: 3.146 ± 0.031	1.447LysPhe: 1.447 ± 0.016	2.739LysGly: 2.739 ± 0.025	1.058LysHis: 1.058 ± 0.015	2.221LysIle: 2.221 ± 0.02	2.94LysLys: 2.94 ± 0.037	3.895LysLeu: 3.895 ± 0.029	0.962LysMet: 0.962 ± 0.013	1.709LysAsn: 1.709 ± 0.019	2.545LysPro: 2.545 ± 0.026	1.758LysGln: 1.758 ± 0.018	3.16LysArg: 3.16 ± 0.031	3.401LysSer: 3.401 ± 0.028	2.671LysThr: 2.671 ± 0.024	2.684LysVal: 2.684 ± 0.023	0.643LysTrp: 0.643 ± 0.011	1.314LysTyr: 1.314 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.987LeuAla: 7.987 ± 0.049	1.228LeuCys: 1.228 ± 0.015	5.251LeuAsp: 5.251 ± 0.036	5.585LeuGlu: 5.585 ± 0.039	3.451LeuPhe: 3.451 ± 0.03	6.083LeuGly: 6.083 ± 0.038	2.298LeuHis: 2.298 ± 0.021	4.124LeuIle: 4.124 ± 0.03	4.047LeuLys: 4.047 ± 0.03	8.575LeuLeu: 8.575 ± 0.053	1.863LeuMet: 1.863 ± 0.017	3.273LeuAsn: 3.273 ± 0.026	5.453LeuPro: 5.453 ± 0.035	3.955LeuGln: 3.955 ± 0.03	5.815LeuArg: 5.815 ± 0.039	7.519LeuSer: 7.519 ± 0.042	4.814LeuThr: 4.814 ± 0.032	5.515LeuVal: 5.515 ± 0.035	1.242LeuTrp: 1.242 ± 0.017	2.441LeuTyr: 2.441 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.213MetAla: 2.213 ± 0.018	0.243MetCys: 0.243 ± 0.007	1.27MetAsp: 1.27 ± 0.015	1.318MetGlu: 1.318 ± 0.016	0.745MetPhe: 0.745 ± 0.011	1.513MetGly: 1.513 ± 0.019	0.506MetHis: 0.506 ± 0.009	1.1MetIle: 1.1 ± 0.015	0.977MetLys: 0.977 ± 0.013	1.847MetLeu: 1.847 ± 0.017	0.598MetMet: 0.598 ± 0.012	0.819MetAsn: 0.819 ± 0.013	1.264MetPro: 1.264 ± 0.017	0.894MetGln: 0.894 ± 0.015	1.247MetArg: 1.247 ± 0.016	1.926MetSer: 1.926 ± 0.017	1.371MetThr: 1.371 ± 0.015	1.319MetVal: 1.319 ± 0.017	0.273MetTrp: 0.273 ± 0.007	0.513MetTyr: 0.513 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.148AsnAla: 3.148 ± 0.025	0.46AsnCys: 0.46 ± 0.009	1.93AsnAsp: 1.93 ± 0.019	2.039AsnGlu: 2.039 ± 0.021	1.415AsnPhe: 1.415 ± 0.017	2.943AsnGly: 2.943 ± 0.026	0.86AsnHis: 0.86 ± 0.012	2.01AsnIle: 2.01 ± 0.018	1.445AsnLys: 1.445 ± 0.017	3.33AsnLeu: 3.33 ± 0.026	0.843AsnMet: 0.843 ± 0.011	1.368AsnAsn: 1.368 ± 0.017	2.485AsnPro: 2.485 ± 0.025	1.386AsnGln: 1.386 ± 0.018	1.922AsnArg: 1.922 ± 0.018	2.74AsnSer: 2.74 ± 0.023	2.128AsnThr: 2.128 ± 0.02	2.35AsnVal: 2.35 ± 0.02	0.573AsnTrp: 0.573 ± 0.011	1.071AsnTyr: 1.071 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.273ProAla: 5.273 ± 0.05	0.549ProCys: 0.549 ± 0.009	3.152ProAsp: 3.152 ± 0.025	3.931ProGlu: 3.931 ± 0.037	2.104ProPhe: 2.104 ± 0.021	3.916ProGly: 3.916 ± 0.032	1.345ProHis: 1.345 ± 0.017	2.625ProIle: 2.625 ± 0.022	2.481ProLys: 2.481 ± 0.024	4.757ProLeu: 4.757 ± 0.032	1.109ProMet: 1.109 ± 0.015	2.172ProAsn: 2.172 ± 0.019	4.751ProPro: 4.751 ± 0.059	2.452ProGln: 2.452 ± 0.031	3.507ProArg: 3.507 ± 0.032	6.133ProSer: 6.133 ± 0.049	3.972ProThr: 3.972 ± 0.032	3.681ProVal: 3.681 ± 0.036	0.785ProTrp: 0.785 ± 0.014	1.509ProTyr: 1.509 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.533GlnAla: 3.533 ± 0.025	0.469GlnCys: 0.469 ± 0.009	2.029GlnAsp: 2.029 ± 0.02	2.408GlnGlu: 2.408 ± 0.024	1.379GlnPhe: 1.379 ± 0.017	2.459GlnGly: 2.459 ± 0.024	1.067GlnHis: 1.067 ± 0.016	2.033GlnIle: 2.033 ± 0.018	1.969GlnLys: 1.969 ± 0.021	3.538GlnLeu: 3.538 ± 0.027	0.929GlnMet: 0.929 ± 0.013	1.591GlnAsn: 1.591 ± 0.017	2.593GlnPro: 2.593 ± 0.031	2.409GlnGln: 2.409 ± 0.045	2.648GlnArg: 2.648 ± 0.025	3.402GlnSer: 3.402 ± 0.029	2.383GlnThr: 2.383 ± 0.023	2.238GlnVal: 2.238 ± 0.02	0.598GlnTrp: 0.598 ± 0.011	1.196GlnTyr: 1.196 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.721ArgAla: 4.721 ± 0.034	0.728ArgCys: 0.728 ± 0.012	3.365ArgAsp: 3.365 ± 0.031	3.758ArgGlu: 3.758 ± 0.034	2.202ArgPhe: 2.202 ± 0.021	3.705ArgGly: 3.705 ± 0.034	1.547ArgHis: 1.547 ± 0.015	2.956ArgIle: 2.956 ± 0.022	3.251ArgLys: 3.251 ± 0.027	5.596ArgLeu: 5.596 ± 0.036	1.284ArgMet: 1.284 ± 0.015	2.181ArgAsn: 2.181 ± 0.018	3.53ArgPro: 3.53 ± 0.033	2.621ArgGln: 2.621 ± 0.026	5.018ArgArg: 5.018 ± 0.044	4.939ArgSer: 4.939 ± 0.047	3.272ArgThr: 3.272 ± 0.025	3.407ArgVal: 3.407 ± 0.026	0.953ArgTrp: 0.953 ± 0.014	1.645ArgTyr: 1.645 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.8SerAla: 6.8 ± 0.037	0.895SerCys: 0.895 ± 0.014	4.297SerAsp: 4.297 ± 0.033	4.292SerGlu: 4.292 ± 0.031	3.125SerPhe: 3.125 ± 0.025	5.679SerGly: 5.679 ± 0.037	2.098SerHis: 2.098 ± 0.02	4.158SerIle: 4.158 ± 0.025	3.655SerLys: 3.655 ± 0.028	7.495SerLeu: 7.495 ± 0.043	1.797SerMet: 1.797 ± 0.018	3.042SerAsn: 3.042 ± 0.024	5.601SerPro: 5.601 ± 0.048	3.494SerGln: 3.494 ± 0.028	5.105SerArg: 5.105 ± 0.046	8.98SerSer: 8.98 ± 0.072	5.805SerThr: 5.805 ± 0.041	4.758SerVal: 4.758 ± 0.033	1.217SerTrp: 1.217 ± 0.015	2.112SerTyr: 2.112 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.249ThrAla: 5.249 ± 0.034	0.755ThrCys: 0.755 ± 0.013	2.895ThrAsp: 2.895 ± 0.024	3.202ThrGlu: 3.202 ± 0.029	2.265ThrPhe: 2.265 ± 0.02	4.244ThrGly: 4.244 ± 0.033	1.295ThrHis: 1.295 ± 0.014	3.142ThrIle: 3.142 ± 0.027	2.496ThrLys: 2.496 ± 0.023	5.315ThrLeu: 5.315 ± 0.035	1.21ThrMet: 1.21 ± 0.015	2.055ThrAsn: 2.055 ± 0.022	4.286ThrPro: 4.286 ± 0.039	2.125ThrGln: 2.125 ± 0.019	3.138ThrArg: 3.138 ± 0.025	5.36ThrSer: 5.36 ± 0.039	4.25ThrThr: 4.25 ± 0.042	3.893ThrVal: 3.893 ± 0.031	0.874ThrTrp: 0.874 ± 0.013	1.598ThrTyr: 1.598 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.215ValAla: 5.215 ± 0.031	0.83ValCys: 0.83 ± 0.014	3.732ValAsp: 3.732 ± 0.025	3.761ValGlu: 3.761 ± 0.036	2.487ValPhe: 2.487 ± 0.028	3.944ValGly: 3.944 ± 0.031	1.422ValHis: 1.422 ± 0.016	3.111ValIle: 3.111 ± 0.027	2.734ValLys: 2.734 ± 0.026	5.57ValLeu: 5.57 ± 0.036	1.341ValMet: 1.341 ± 0.015	2.313ValAsn: 2.313 ± 0.021	3.654ValPro: 3.654 ± 0.032	2.43ValGln: 2.43 ± 0.02	3.424ValArg: 3.424 ± 0.022	4.837ValSer: 4.837 ± 0.029	3.567ValThr: 3.567 ± 0.025	4.18ValVal: 4.18 ± 0.031	0.837ValTrp: 0.837 ± 0.013	1.758ValTyr: 1.758 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.173TrpAla: 1.173 ± 0.015	0.202TrpCys: 0.202 ± 0.007	0.892TrpAsp: 0.892 ± 0.013	0.847TrpGlu: 0.847 ± 0.013	0.556TrpPhe: 0.556 ± 0.009	0.938TrpGly: 0.938 ± 0.014	0.362TrpHis: 0.362 ± 0.008	0.8TrpIle: 0.8 ± 0.012	0.813TrpLys: 0.813 ± 0.015	1.385TrpLeu: 1.385 ± 0.015	0.391TrpMet: 0.391 ± 0.009	0.648TrpAsn: 0.648 ± 0.012	0.614TrpPro: 0.614 ± 0.011	0.58TrpGln: 0.58 ± 0.011	0.971TrpArg: 0.971 ± 0.015	1.134TrpSer: 1.134 ± 0.014	0.956TrpThr: 0.956 ± 0.015	0.909TrpVal: 0.909 ± 0.014	0.294TrpTrp: 0.294 ± 0.008	0.432TrpTyr: 0.432 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.191TyrAla: 2.191 ± 0.019	0.413TyrCys: 0.413 ± 0.009	1.598TyrAsp: 1.598 ± 0.018	1.516TyrGlu: 1.516 ± 0.017	1.223TyrPhe: 1.223 ± 0.016	2.083TyrGly: 2.083 ± 0.022	0.773TyrHis: 0.773 ± 0.013	1.415TyrIle: 1.415 ± 0.016	1.042TyrLys: 1.042 ± 0.016	2.724TyrLeu: 2.724 ± 0.023	0.624TyrMet: 0.624 ± 0.012	1.112TyrAsn: 1.112 ± 0.014	1.531TyrPro: 1.531 ± 0.018	1.172TyrGln: 1.172 ± 0.015	1.631TyrArg: 1.631 ± 0.016	2.107TyrSer: 2.107 ± 0.022	1.64TyrThr: 1.64 ± 0.018	1.628TyrVal: 1.628 ± 0.017	0.456TyrTrp: 0.456 ± 0.009	0.956TyrTyr: 0.956 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11935 proteins (5855176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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