Amino acid dipepetide frequency for Gluconacetobacter liquefaciens (Acetobacter liquefaciens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.387AlaAla: 17.387 ± 0.17	1.367AlaCys: 1.367 ± 0.033	6.866AlaAsp: 6.866 ± 0.084	6.695AlaGlu: 6.695 ± 0.102	4.113AlaPhe: 4.113 ± 0.064	11.932AlaGly: 11.932 ± 0.125	2.813AlaHis: 2.813 ± 0.048	6.05AlaIle: 6.05 ± 0.077	2.273AlaLys: 2.273 ± 0.052	13.983AlaLeu: 13.983 ± 0.142	3.622AlaMet: 3.622 ± 0.063	2.598AlaAsn: 2.598 ± 0.055	6.618AlaPro: 6.618 ± 0.09	4.142AlaGln: 4.142 ± 0.068	10.419AlaArg: 10.419 ± 0.131	6.418AlaSer: 6.418 ± 0.079	6.852AlaThr: 6.852 ± 0.087	8.71AlaVal: 8.71 ± 0.117	1.833AlaTrp: 1.833 ± 0.038	2.548AlaTyr: 2.548 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.242CysAla: 1.242 ± 0.031	0.144CysCys: 0.144 ± 0.011	0.536CysAsp: 0.536 ± 0.023	0.32CysGlu: 0.32 ± 0.017	0.307CysPhe: 0.307 ± 0.017	1.037CysGly: 1.037 ± 0.032	0.281CysHis: 0.281 ± 0.015	0.384CysIle: 0.384 ± 0.019	0.128CysLys: 0.128 ± 0.01	0.962CysLeu: 0.962 ± 0.029	0.21CysMet: 0.21 ± 0.013	0.211CysAsn: 0.211 ± 0.014	0.538CysPro: 0.538 ± 0.021	0.221CysGln: 0.221 ± 0.014	0.763CysArg: 0.763 ± 0.028	0.474CysSer: 0.474 ± 0.021	0.508CysThr: 0.508 ± 0.023	0.743CysVal: 0.743 ± 0.027	0.124CysTrp: 0.124 ± 0.01	0.193CysTyr: 0.193 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.139AspAla: 7.139 ± 0.087	0.492AspCys: 0.492 ± 0.022	3.092AspAsp: 3.092 ± 0.053	2.83AspGlu: 2.83 ± 0.047	1.947AspPhe: 1.947 ± 0.046	5.616AspGly: 5.616 ± 0.075	1.413AspHis: 1.413 ± 0.035	2.962AspIle: 2.962 ± 0.047	0.995AspLys: 0.995 ± 0.032	6.19AspLeu: 6.19 ± 0.078	1.439AspMet: 1.439 ± 0.036	1.229AspAsn: 1.229 ± 0.036	3.651AspPro: 3.651 ± 0.063	1.713AspGln: 1.713 ± 0.039	4.63AspArg: 4.63 ± 0.071	2.396AspSer: 2.396 ± 0.051	2.688AspThr: 2.688 ± 0.049	4.018AspVal: 4.018 ± 0.057	1.025AspTrp: 1.025 ± 0.03	1.464AspTyr: 1.464 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.505GluAla: 6.505 ± 0.088	0.323GluCys: 0.323 ± 0.018	2.497GluAsp: 2.497 ± 0.044	2.454GluGlu: 2.454 ± 0.049	1.251GluPhe: 1.251 ± 0.04	3.796GluGly: 3.796 ± 0.052	1.096GluHis: 1.096 ± 0.029	2.875GluIle: 2.875 ± 0.053	1.467GluLys: 1.467 ± 0.043	3.899GluLeu: 3.899 ± 0.063	1.249GluMet: 1.249 ± 0.03	1.302GluAsn: 1.302 ± 0.035	2.152GluPro: 2.152 ± 0.042	2.02GluGln: 2.02 ± 0.047	4.368GluArg: 4.368 ± 0.07	2.259GluSer: 2.259 ± 0.046	3.125GluThr: 3.125 ± 0.047	2.811GluVal: 2.811 ± 0.06	0.638GluTrp: 0.638 ± 0.022	0.848GluTyr: 0.848 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.032PheAla: 4.032 ± 0.06	0.41PheCys: 0.41 ± 0.021	2.333PheAsp: 2.333 ± 0.045	1.536PheGlu: 1.536 ± 0.041	1.305PhePhe: 1.305 ± 0.041	3.465PheGly: 3.465 ± 0.061	0.891PheHis: 0.891 ± 0.025	1.421PheIle: 1.421 ± 0.037	0.612PheLys: 0.612 ± 0.024	3.381PheLeu: 3.381 ± 0.057	0.858PheMet: 0.858 ± 0.026	1.005PheAsn: 1.005 ± 0.035	1.607PhePro: 1.607 ± 0.035	0.95PheGln: 0.95 ± 0.029	2.407PheArg: 2.407 ± 0.044	2.268PheSer: 2.268 ± 0.043	2.001PheThr: 2.001 ± 0.039	2.58PheVal: 2.58 ± 0.056	0.49PheTrp: 0.49 ± 0.019	0.876PheTyr: 0.876 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.057GlyAla: 10.057 ± 0.114	0.966GlyCys: 0.966 ± 0.029	4.166GlyAsp: 4.166 ± 0.059	3.917GlyGlu: 3.917 ± 0.066	3.466GlyPhe: 3.466 ± 0.046	8.176GlyGly: 8.176 ± 0.128	2.321GlyHis: 2.321 ± 0.044	4.383GlyIle: 4.383 ± 0.062	2.287GlyLys: 2.287 ± 0.051	9.529GlyLeu: 9.529 ± 0.113	2.669GlyMet: 2.669 ± 0.051	2.182GlyAsn: 2.182 ± 0.064	3.934GlyPro: 3.934 ± 0.059	3.346GlyGln: 3.346 ± 0.059	7.156GlyArg: 7.156 ± 0.078	4.648GlySer: 4.648 ± 0.076	5.473GlyThr: 5.473 ± 0.092	6.555GlyVal: 6.555 ± 0.092	1.598GlyTrp: 1.598 ± 0.041	2.306GlyTyr: 2.306 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	3.12HisAla: 3.12 ± 0.059	0.234HisCys: 0.234 ± 0.012	1.6HisAsp: 1.6 ± 0.036	1.092HisGlu: 1.092 ± 0.032	0.899HisPhe: 0.899 ± 0.026	2.348HisGly: 2.348 ± 0.051	0.69HisHis: 0.69 ± 0.024	1.029HisIle: 1.029 ± 0.035	0.391HisLys: 0.391 ± 0.019	2.361HisLeu: 2.361 ± 0.043	0.575HisMet: 0.575 ± 0.021	0.541HisAsn: 0.541 ± 0.02	1.729HisPro: 1.729 ± 0.04	0.692HisGln: 0.692 ± 0.027	1.688HisArg: 1.688 ± 0.041	0.994HisSer: 0.994 ± 0.031	1.114HisThr: 1.114 ± 0.031	1.873HisVal: 1.873 ± 0.04	0.419HisTrp: 0.419 ± 0.018	0.675HisTyr: 0.675 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.779IleAla: 6.779 ± 0.081	0.494IleCys: 0.494 ± 0.019	3.187IleAsp: 3.187 ± 0.057	2.607IleGlu: 2.607 ± 0.051	1.44IlePhe: 1.44 ± 0.037	4.827IleGly: 4.827 ± 0.066	1.04IleHis: 1.04 ± 0.03	1.873IleIle: 1.873 ± 0.045	0.835IleLys: 0.835 ± 0.028	4.641IleLeu: 4.641 ± 0.072	1.033IleMet: 1.033 ± 0.035	1.196IleAsn: 1.196 ± 0.036	2.458IlePro: 2.458 ± 0.045	1.249IleGln: 1.249 ± 0.033	3.443IleArg: 3.443 ± 0.055	2.637IleSer: 2.637 ± 0.056	2.534IleThr: 2.534 ± 0.051	4.087IleVal: 4.087 ± 0.064	0.545IleTrp: 0.545 ± 0.021	1.004IleTyr: 1.004 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.616LysAla: 2.616 ± 0.059	0.119LysCys: 0.119 ± 0.01	1.121LysAsp: 1.121 ± 0.033	0.916LysGlu: 0.916 ± 0.03	0.588LysPhe: 0.588 ± 0.021	1.852LysGly: 1.852 ± 0.041	0.414LysHis: 0.414 ± 0.021	1.257LysIle: 1.257 ± 0.033	0.799LysLys: 0.799 ± 0.034	2.05LysLeu: 2.05 ± 0.048	0.553LysMet: 0.553 ± 0.019	0.586LysAsn: 0.586 ± 0.025	1.358LysPro: 1.358 ± 0.037	0.723LysGln: 0.723 ± 0.027	1.516LysArg: 1.516 ± 0.043	1.116LysSer: 1.116 ± 0.037	1.351LysThr: 1.351 ± 0.036	1.55LysVal: 1.55 ± 0.042	0.282LysTrp: 0.282 ± 0.015	0.495LysTyr: 0.495 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.084LeuAla: 14.084 ± 0.172	1.084LeuCys: 1.084 ± 0.029	6.223LeuAsp: 6.223 ± 0.075	4.329LeuGlu: 4.329 ± 0.066	3.65LeuPhe: 3.65 ± 0.061	8.248LeuGly: 8.248 ± 0.086	2.523LeuHis: 2.523 ± 0.051	4.296LeuIle: 4.296 ± 0.067	2.36LeuLys: 2.36 ± 0.055	10.291LeuLeu: 10.291 ± 0.137	2.397LeuMet: 2.397 ± 0.046	2.511LeuAsn: 2.511 ± 0.052	6.767LeuPro: 6.767 ± 0.078	2.721LeuGln: 2.721 ± 0.053	8.085LeuArg: 8.085 ± 0.1	6.868LeuSer: 6.868 ± 0.09	6.013LeuThr: 6.013 ± 0.085	7.331LeuVal: 7.331 ± 0.097	1.268LeuTrp: 1.268 ± 0.031	2.147LeuTyr: 2.147 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.329MetAla: 3.329 ± 0.068	0.152MetCys: 0.152 ± 0.01	1.214MetAsp: 1.214 ± 0.039	1.084MetGlu: 1.084 ± 0.031	0.72MetPhe: 0.72 ± 0.024	1.947MetGly: 1.947 ± 0.039	0.47MetHis: 0.47 ± 0.022	1.277MetIle: 1.277 ± 0.031	0.722MetLys: 0.722 ± 0.024	2.71MetLeu: 2.71 ± 0.043	0.681MetMet: 0.681 ± 0.023	0.794MetAsn: 0.794 ± 0.023	1.752MetPro: 1.752 ± 0.043	0.872MetGln: 0.872 ± 0.027	1.987MetArg: 1.987 ± 0.045	1.556MetSer: 1.556 ± 0.038	2.071MetThr: 2.071 ± 0.041	1.893MetVal: 1.893 ± 0.041	0.205MetTrp: 0.205 ± 0.014	0.311MetTyr: 0.311 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.984AsnAla: 2.984 ± 0.053	0.212AsnCys: 0.212 ± 0.014	1.346AsnAsp: 1.346 ± 0.039	0.957AsnGlu: 0.957 ± 0.031	0.896AsnPhe: 0.896 ± 0.033	2.37AsnGly: 2.37 ± 0.052	0.562AsnHis: 0.562 ± 0.023	1.325AsnIle: 1.325 ± 0.042	0.49AsnLys: 0.49 ± 0.026	2.453AsnLeu: 2.453 ± 0.054	0.57AsnMet: 0.57 ± 0.023	0.695AsnAsn: 0.695 ± 0.029	1.676AsnPro: 1.676 ± 0.038	0.793AsnGln: 0.793 ± 0.027	1.781AsnArg: 1.781 ± 0.043	1.149AsnSer: 1.149 ± 0.04	1.264AsnThr: 1.264 ± 0.036	1.831AsnVal: 1.831 ± 0.051	0.447AsnTrp: 0.447 ± 0.024	0.731AsnTyr: 0.731 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	7.693ProAla: 7.693 ± 0.1	0.415ProCys: 0.415 ± 0.019	4.453ProAsp: 4.453 ± 0.065	3.407ProGlu: 3.407 ± 0.049	2.071ProPhe: 2.071 ± 0.047	5.314ProGly: 5.314 ± 0.065	1.361ProHis: 1.361 ± 0.036	2.118ProIle: 2.118 ± 0.043	1.064ProLys: 1.064 ± 0.034	5.162ProLeu: 5.162 ± 0.068	1.374ProMet: 1.374 ± 0.034	1.229ProAsn: 1.229 ± 0.034	3.569ProPro: 3.569 ± 0.082	1.733ProGln: 1.733 ± 0.043	3.374ProArg: 3.374 ± 0.057	3.087ProSer: 3.087 ± 0.055	2.924ProThr: 2.924 ± 0.057	4.942ProVal: 4.942 ± 0.069	0.839ProTrp: 0.839 ± 0.027	1.322ProTyr: 1.322 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.68GlnAla: 4.68 ± 0.068	0.232GlnCys: 0.232 ± 0.013	1.799GlnAsp: 1.799 ± 0.036	1.414GlnGlu: 1.414 ± 0.036	1.084GlnPhe: 1.084 ± 0.03	2.591GlnGly: 2.591 ± 0.046	0.71GlnHis: 0.71 ± 0.023	1.961GlnIle: 1.961 ± 0.043	0.899GlnLys: 0.899 ± 0.028	2.431GlnLeu: 2.431 ± 0.055	0.858GlnMet: 0.858 ± 0.023	0.919GlnAsn: 0.919 ± 0.038	1.911GlnPro: 1.911 ± 0.043	1.263GlnGln: 1.263 ± 0.038	2.206GlnArg: 2.206 ± 0.046	1.883GlnSer: 1.883 ± 0.046	1.995GlnThr: 1.995 ± 0.042	2.512GlnVal: 2.512 ± 0.05	0.424GlnTrp: 0.424 ± 0.02	0.753GlnTyr: 0.753 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.226ArgAla: 9.226 ± 0.115	0.574ArgCys: 0.574 ± 0.024	4.444ArgAsp: 4.444 ± 0.068	3.595ArgGlu: 3.595 ± 0.066	2.926ArgPhe: 2.926 ± 0.049	5.301ArgGly: 5.301 ± 0.072	2.276ArgHis: 2.276 ± 0.043	4.037ArgIle: 4.037 ± 0.063	1.714ArgLys: 1.714 ± 0.038	8.923ArgLeu: 8.923 ± 0.121	2.134ArgMet: 2.134 ± 0.045	1.886ArgAsn: 1.886 ± 0.044	4.354ArgPro: 4.354 ± 0.068	3.17ArgGln: 3.17 ± 0.059	6.938ArgArg: 6.938 ± 0.111	3.622ArgSer: 3.622 ± 0.049	4.119ArgThr: 4.119 ± 0.055	5.228ArgVal: 5.228 ± 0.071	1.084ArgTrp: 1.084 ± 0.032	1.97ArgTyr: 1.97 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.395SerAla: 6.395 ± 0.075	0.545SerCys: 0.545 ± 0.022	2.92SerAsp: 2.92 ± 0.047	2.183SerGlu: 2.183 ± 0.043	2.167SerPhe: 2.167 ± 0.04	5.596SerGly: 5.596 ± 0.089	1.258SerHis: 1.258 ± 0.03	2.468SerIle: 2.468 ± 0.048	0.934SerLys: 0.934 ± 0.032	5.647SerLeu: 5.647 ± 0.071	1.337SerMet: 1.337 ± 0.032	1.247SerAsn: 1.247 ± 0.041	3.193SerPro: 3.193 ± 0.051	1.569SerGln: 1.569 ± 0.043	3.81SerArg: 3.81 ± 0.061	3.133SerSer: 3.133 ± 0.07	2.899SerThr: 2.899 ± 0.059	4.284SerVal: 4.284 ± 0.06	0.849SerTrp: 0.849 ± 0.024	1.425SerTyr: 1.425 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.605ThrAla: 6.605 ± 0.086	0.479ThrCys: 0.479 ± 0.021	3.093ThrAsp: 3.093 ± 0.054	2.398ThrGlu: 2.398 ± 0.037	1.804ThrPhe: 1.804 ± 0.034	5.59ThrGly: 5.59 ± 0.086	1.333ThrHis: 1.333 ± 0.037	3.08ThrIle: 3.08 ± 0.057	0.99ThrLys: 0.99 ± 0.031	6.764ThrLeu: 6.764 ± 0.08	1.342ThrMet: 1.342 ± 0.034	1.38ThrAsn: 1.38 ± 0.044	3.938ThrPro: 3.938 ± 0.068	1.745ThrGln: 1.745 ± 0.045	3.936ThrArg: 3.936 ± 0.063	2.834ThrSer: 2.834 ± 0.061	3.184ThrThr: 3.184 ± 0.068	4.469ThrVal: 4.469 ± 0.058	0.745ThrTrp: 0.745 ± 0.026	1.315ThrTyr: 1.315 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	9.521ValAla: 9.521 ± 0.106	0.677ValCys: 0.677 ± 0.023	3.817ValAsp: 3.817 ± 0.057	3.645ValGlu: 3.645 ± 0.059	2.394ValPhe: 2.394 ± 0.047	5.842ValGly: 5.842 ± 0.102	1.564ValHis: 1.564 ± 0.041	3.555ValIle: 3.555 ± 0.062	1.417ValLys: 1.417 ± 0.035	7.921ValLeu: 7.921 ± 0.104	2.011ValMet: 2.011 ± 0.045	1.788ValAsn: 1.788 ± 0.043	4.408ValPro: 4.408 ± 0.06	2.125ValGln: 2.125 ± 0.04	5.613ValArg: 5.613 ± 0.078	4.446ValSer: 4.446 ± 0.068	4.85ValThr: 4.85 ± 0.069	5.819ValVal: 5.819 ± 0.083	0.979ValTrp: 0.979 ± 0.032	1.386ValTyr: 1.386 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.3TrpAla: 1.3 ± 0.037	0.161TrpCys: 0.161 ± 0.012	0.673TrpAsp: 0.673 ± 0.026	0.504TrpGlu: 0.504 ± 0.023	0.515TrpPhe: 0.515 ± 0.022	1.015TrpGly: 1.015 ± 0.031	0.476TrpHis: 0.476 ± 0.018	0.67TrpIle: 0.67 ± 0.022	0.413TrpLys: 0.413 ± 0.019	1.765TrpLeu: 1.765 ± 0.043	0.387TrpMet: 0.387 ± 0.018	0.469TrpAsn: 0.469 ± 0.021	0.724TrpPro: 0.724 ± 0.027	0.653TrpGln: 0.653 ± 0.024	1.421TrpArg: 1.421 ± 0.035	0.893TrpSer: 0.893 ± 0.028	0.837TrpThr: 0.837 ± 0.027	0.89TrpVal: 0.89 ± 0.025	0.218TrpTrp: 0.218 ± 0.013	0.34TrpTyr: 0.34 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.548TyrAla: 2.548 ± 0.049	0.245TyrCys: 0.245 ± 0.014	1.549TyrAsp: 1.549 ± 0.043	1.05TyrGlu: 1.05 ± 0.03	0.887TyrPhe: 0.887 ± 0.032	2.273TyrGly: 2.273 ± 0.054	0.574TyrHis: 0.574 ± 0.02	0.889TyrIle: 0.889 ± 0.027	0.47TyrLys: 0.47 ± 0.024	2.131TyrLeu: 2.131 ± 0.048	0.448TyrMet: 0.448 ± 0.019	0.763TyrAsn: 0.763 ± 0.034	1.113TyrPro: 1.113 ± 0.034	0.826TyrGln: 0.826 ± 0.028	1.982TyrArg: 1.982 ± 0.044	1.181TyrSer: 1.181 ± 0.036	1.219TyrThr: 1.219 ± 0.043	1.651TyrVal: 1.651 ± 0.046	0.312TyrTrp: 0.312 ± 0.017	0.707TyrTyr: 0.707 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3696 proteins (1239589 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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