Amino acid dipepetide frequency for Sutterella sp. AM11-39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.309AlaAla: 13.309 ± 0.197
1.517AlaCys: 1.517 ± 0.057
5.835AlaAsp: 5.835 ± 0.11
6.179AlaGlu: 6.179 ± 0.14
4.114AlaPhe: 4.114 ± 0.089
8.443AlaGly: 8.443 ± 0.137
1.932AlaHis: 1.932 ± 0.062
5.165AlaIle: 5.165 ± 0.09
5.338AlaLys: 5.338 ± 0.108
10.905AlaLeu: 10.905 ± 0.16
3.049AlaMet: 3.049 ± 0.072
2.8AlaAsn: 2.8 ± 0.071
3.735AlaPro: 3.735 ± 0.087
4.479AlaGln: 4.479 ± 0.111
6.25AlaArg: 6.25 ± 0.103
5.793AlaSer: 5.793 ± 0.102
4.74AlaThr: 4.74 ± 0.094
9.158AlaVal: 9.158 ± 0.153
1.15AlaTrp: 1.15 ± 0.048
2.398AlaTyr: 2.398 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.531CysAla: 1.531 ± 0.042
0.267CysCys: 0.267 ± 0.027
0.756CysAsp: 0.756 ± 0.038
0.852CysGlu: 0.852 ± 0.033
0.485CysPhe: 0.485 ± 0.028
1.357CysGly: 1.357 ± 0.055
0.345CysHis: 0.345 ± 0.032
0.66CysIle: 0.66 ± 0.034
0.461CysLys: 0.461 ± 0.032
1.206CysLeu: 1.206 ± 0.047
0.301CysMet: 0.301 ± 0.023
0.373CysAsn: 0.373 ± 0.025
0.762CysPro: 0.762 ± 0.044
0.339CysGln: 0.339 ± 0.023
0.94CysArg: 0.94 ± 0.04
0.799CysSer: 0.799 ± 0.035
0.71CysThr: 0.71 ± 0.036
1.081CysVal: 1.081 ± 0.045
0.186CysTrp: 0.186 ± 0.017
0.322CysTyr: 0.322 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.502AspAla: 5.502 ± 0.093
0.717AspCys: 0.717 ± 0.043
2.775AspAsp: 2.775 ± 0.081
3.761AspGlu: 3.761 ± 0.074
2.607AspPhe: 2.607 ± 0.055
3.897AspGly: 3.897 ± 0.085
0.839AspHis: 0.839 ± 0.04
3.277AspIle: 3.277 ± 0.066
2.773AspLys: 2.773 ± 0.075
4.961AspLeu: 4.961 ± 0.098
1.374AspMet: 1.374 ± 0.045
1.844AspAsn: 1.844 ± 0.068
2.803AspPro: 2.803 ± 0.07
1.309AspGln: 1.309 ± 0.048
3.078AspArg: 3.078 ± 0.066
2.678AspSer: 2.678 ± 0.078
2.582AspThr: 2.582 ± 0.067
4.347AspVal: 4.347 ± 0.096
0.843AspTrp: 0.843 ± 0.035
1.529AspTyr: 1.529 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
6.779GluAla: 6.779 ± 0.122
0.623GluCys: 0.623 ± 0.03
3.024GluAsp: 3.024 ± 0.07
4.295GluGlu: 4.295 ± 0.109
2.171GluPhe: 2.171 ± 0.058
4.383GluGly: 4.383 ± 0.108
1.187GluHis: 1.187 ± 0.041
3.783GluIle: 3.783 ± 0.083
3.982GluLys: 3.982 ± 0.089
6.335GluLeu: 6.335 ± 0.13
1.651GluMet: 1.651 ± 0.051
2.399GluAsn: 2.399 ± 0.067
2.501GluPro: 2.501 ± 0.078
2.308GluGln: 2.308 ± 0.065
4.217GluArg: 4.217 ± 0.097
3.316GluSer: 3.316 ± 0.074
3.661GluThr: 3.661 ± 0.08
4.333GluVal: 4.333 ± 0.088
0.62GluTrp: 0.62 ± 0.032
1.331GluTyr: 1.331 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
4.59PheAla: 4.59 ± 0.099
0.673PheCys: 0.673 ± 0.031
2.812PheAsp: 2.812 ± 0.068
2.859PheGlu: 2.859 ± 0.08
1.854PhePhe: 1.854 ± 0.059
3.52PheGly: 3.52 ± 0.094
0.662PheHis: 0.662 ± 0.028
2.008PheIle: 2.008 ± 0.062
1.617PheLys: 1.617 ± 0.052
3.649PheLeu: 3.649 ± 0.091
1.062PheMet: 1.062 ± 0.045
1.419PheAsn: 1.419 ± 0.051
1.364PhePro: 1.364 ± 0.047
0.915PheGln: 0.915 ± 0.039
1.679PheArg: 1.679 ± 0.048
2.676PheSer: 2.676 ± 0.062
2.099PheThr: 2.099 ± 0.063
3.571PheVal: 3.571 ± 0.086
0.57PheTrp: 0.57 ± 0.032
1.105PheTyr: 1.105 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
7.039GlyAla: 7.039 ± 0.125
1.32GlyCys: 1.32 ± 0.047
3.672GlyAsp: 3.672 ± 0.085
4.434GlyGlu: 4.434 ± 0.097
3.471GlyPhe: 3.471 ± 0.076
5.419GlyGly: 5.419 ± 0.121
1.503GlyHis: 1.503 ± 0.056
4.925GlyIle: 4.925 ± 0.096
4.528GlyLys: 4.528 ± 0.091
7.54GlyLeu: 7.54 ± 0.122
2.174GlyMet: 2.174 ± 0.065
2.568GlyAsn: 2.568 ± 0.08
2.166GlyPro: 2.166 ± 0.068
2.345GlyGln: 2.345 ± 0.068
4.411GlyArg: 4.411 ± 0.085
4.493GlySer: 4.493 ± 0.098
4.456GlyThr: 4.456 ± 0.107
6.117GlyVal: 6.117 ± 0.105
1.163GlyTrp: 1.163 ± 0.043
2.186GlyTyr: 2.186 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.81HisAla: 1.81 ± 0.054
0.32HisCys: 0.32 ± 0.022
0.982HisAsp: 0.982 ± 0.039
1.031HisGlu: 1.031 ± 0.045
0.897HisPhe: 0.897 ± 0.038
1.481HisGly: 1.481 ± 0.054
0.492HisHis: 0.492 ± 0.049
1.062HisIle: 1.062 ± 0.039
0.781HisLys: 0.781 ± 0.034
1.758HisLeu: 1.758 ± 0.055
0.45HisMet: 0.45 ± 0.027
0.642HisAsn: 0.642 ± 0.032
1.18HisPro: 1.18 ± 0.052
0.526HisGln: 0.526 ± 0.029
1.098HisArg: 1.098 ± 0.044
0.942HisSer: 0.942 ± 0.041
0.996HisThr: 0.996 ± 0.043
1.422HisVal: 1.422 ± 0.045
0.284HisTrp: 0.284 ± 0.02
0.536HisTyr: 0.536 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.246IleAla: 6.246 ± 0.125
0.849IleCys: 0.849 ± 0.038
3.746IleAsp: 3.746 ± 0.075
4.194IleGlu: 4.194 ± 0.082
2.18IlePhe: 2.18 ± 0.068
4.457IleGly: 4.457 ± 0.098
0.872IleHis: 0.872 ± 0.04
2.328IleIle: 2.328 ± 0.069
2.444IleLys: 2.444 ± 0.058
4.816IleLeu: 4.816 ± 0.102
1.071IleMet: 1.071 ± 0.039
2.099IleAsn: 2.099 ± 0.06
2.299IlePro: 2.299 ± 0.062
1.296IleGln: 1.296 ± 0.043
3.166IleArg: 3.166 ± 0.075
3.24IleSer: 3.24 ± 0.082
2.883IleThr: 2.883 ± 0.077
4.517IleVal: 4.517 ± 0.097
0.557IleTrp: 0.557 ± 0.031
1.306IleTyr: 1.306 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
5.539LysAla: 5.539 ± 0.114
0.501LysCys: 0.501 ± 0.029
2.619LysAsp: 2.619 ± 0.073
3.177LysGlu: 3.177 ± 0.074
1.5LysPhe: 1.5 ± 0.046
3.585LysGly: 3.585 ± 0.077
0.924LysHis: 0.924 ± 0.038
2.546LysIle: 2.546 ± 0.068
2.956LysLys: 2.956 ± 0.084
4.786LysLeu: 4.786 ± 0.095
1.309LysMet: 1.309 ± 0.042
2.036LysAsn: 2.036 ± 0.057
2.521LysPro: 2.521 ± 0.064
1.546LysGln: 1.546 ± 0.055
3.163LysArg: 3.163 ± 0.079
2.937LysSer: 2.937 ± 0.077
3.503LysThr: 3.503 ± 0.07
3.288LysVal: 3.288 ± 0.072
0.496LysTrp: 0.496 ± 0.029
1.152LysTyr: 1.152 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
10.409LeuAla: 10.409 ± 0.154
1.248LeuCys: 1.248 ± 0.05
4.893LeuAsp: 4.893 ± 0.089
5.882LeuGlu: 5.882 ± 0.118
3.911LeuPhe: 3.911 ± 0.093
7.215LeuGly: 7.215 ± 0.12
1.742LeuHis: 1.742 ± 0.047
5.028LeuIle: 5.028 ± 0.107
5.031LeuLys: 5.031 ± 0.08
8.747LeuLeu: 8.747 ± 0.161
2.631LeuMet: 2.631 ± 0.067
3.078LeuAsn: 3.078 ± 0.076
4.706LeuPro: 4.706 ± 0.099
3.217LeuGln: 3.217 ± 0.074
5.715LeuArg: 5.715 ± 0.109
6.849LeuSer: 6.849 ± 0.118
6.257LeuThr: 6.257 ± 0.107
6.86LeuVal: 6.86 ± 0.117
1.112LeuTrp: 1.112 ± 0.045
2.341LeuTyr: 2.341 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.716MetAla: 2.716 ± 0.076
0.291MetCys: 0.291 ± 0.021
1.096MetAsp: 1.096 ± 0.04
1.057MetGlu: 1.057 ± 0.043
0.836MetPhe: 0.836 ± 0.034
1.919MetGly: 1.919 ± 0.054
0.581MetHis: 0.581 ± 0.03
1.428MetIle: 1.428 ± 0.052
1.416MetLys: 1.416 ± 0.045
2.58MetLeu: 2.58 ± 0.062
0.719MetMet: 0.719 ± 0.037
0.92MetAsn: 0.92 ± 0.037
1.585MetPro: 1.585 ± 0.05
1.274MetGln: 1.274 ± 0.044
1.997MetArg: 1.997 ± 0.051
1.872MetSer: 1.872 ± 0.055
1.932MetThr: 1.932 ± 0.056
1.66MetVal: 1.66 ± 0.056
0.192MetTrp: 0.192 ± 0.021
0.433MetTyr: 0.433 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.604AsnAla: 3.604 ± 0.082
0.438AsnCys: 0.438 ± 0.03
1.728AsnAsp: 1.728 ± 0.058
1.976AsnGlu: 1.976 ± 0.059
1.296AsnPhe: 1.296 ± 0.046
2.75AsnGly: 2.75 ± 0.082
0.587AsnHis: 0.587 ± 0.03
1.807AsnIle: 1.807 ± 0.064
1.445AsnLys: 1.445 ± 0.049
3.152AsnLeu: 3.152 ± 0.063
0.839AsnMet: 0.839 ± 0.034
1.155AsnAsn: 1.155 ± 0.054
2.09AsnPro: 2.09 ± 0.059
0.903AsnGln: 0.903 ± 0.039
2.075AsnArg: 2.075 ± 0.064
1.657AsnSer: 1.657 ± 0.061
1.679AsnThr: 1.679 ± 0.055
2.531AsnVal: 2.531 ± 0.078
0.472AsnTrp: 0.472 ± 0.028
0.976AsnTyr: 0.976 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
4.428ProAla: 4.428 ± 0.109
0.496ProCys: 0.496 ± 0.031
2.671ProAsp: 2.671 ± 0.071
3.771ProGlu: 3.771 ± 0.09
1.769ProPhe: 1.769 ± 0.05
3.109ProGly: 3.109 ± 0.066
0.812ProHis: 0.812 ± 0.037
2.16ProIle: 2.16 ± 0.06
2.164ProLys: 2.164 ± 0.06
3.857ProLeu: 3.857 ± 0.093
1.204ProMet: 1.204 ± 0.047
1.314ProAsn: 1.314 ± 0.044
1.206ProPro: 1.206 ± 0.044
1.783ProGln: 1.783 ± 0.056
2.042ProArg: 2.042 ± 0.063
2.334ProSer: 2.334 ± 0.058
2.169ProThr: 2.169 ± 0.056
4.046ProVal: 4.046 ± 0.085
0.598ProTrp: 0.598 ± 0.032
1.217ProTyr: 1.217 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.99GlnAla: 3.99 ± 0.077
0.404GlnCys: 0.404 ± 0.025
1.388GlnAsp: 1.388 ± 0.046
1.934GlnGlu: 1.934 ± 0.064
1.245GlnPhe: 1.245 ± 0.046
2.215GlnGly: 2.215 ± 0.067
0.595GlnHis: 0.595 ± 0.036
1.936GlnIle: 1.936 ± 0.057
1.985GlnLys: 1.985 ± 0.058
2.86GlnLeu: 2.86 ± 0.067
0.979GlnMet: 0.979 ± 0.037
1.178GlnAsn: 1.178 ± 0.05
1.367GlnPro: 1.367 ± 0.047
1.24GlnGln: 1.24 ± 0.055
2.039GlnArg: 2.039 ± 0.065
1.991GlnSer: 1.991 ± 0.063
2.181GlnThr: 2.181 ± 0.062
2.169GlnVal: 2.169 ± 0.065
0.467GlnTrp: 0.467 ± 0.027
0.904GlnTyr: 0.904 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.634ArgAla: 5.634 ± 0.105
0.75ArgCys: 0.75 ± 0.039
3.004ArgAsp: 3.004 ± 0.071
4.193ArgGlu: 4.193 ± 0.1
2.698ArgPhe: 2.698 ± 0.063
3.523ArgGly: 3.523 ± 0.075
1.197ArgHis: 1.197 ± 0.045
3.938ArgIle: 3.938 ± 0.074
2.882ArgLys: 2.882 ± 0.078
6.263ArgLeu: 6.263 ± 0.12
1.741ArgMet: 1.741 ± 0.054
1.971ArgAsn: 1.971 ± 0.056
2.375ArgPro: 2.375 ± 0.063
2.079ArgGln: 2.079 ± 0.063
4.251ArgArg: 4.251 ± 0.113
3.228ArgSer: 3.228 ± 0.071
3.256ArgThr: 3.256 ± 0.067
4.329ArgVal: 4.329 ± 0.088
0.839ArgTrp: 0.839 ± 0.036
1.898ArgTyr: 1.898 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
6.056SerAla: 6.056 ± 0.117
0.767SerCys: 0.767 ± 0.038
3.163SerAsp: 3.163 ± 0.071
3.506SerGlu: 3.506 ± 0.077
2.491SerPhe: 2.491 ± 0.065
5.174SerGly: 5.174 ± 0.1
1.142SerHis: 1.142 ± 0.041
3.126SerIle: 3.126 ± 0.081
2.494SerLys: 2.494 ± 0.067
5.831SerLeu: 5.831 ± 0.099
1.552SerMet: 1.552 ± 0.054
1.823SerAsn: 1.823 ± 0.059
2.401SerPro: 2.401 ± 0.063
1.86SerGln: 1.86 ± 0.06
3.673SerArg: 3.673 ± 0.083
3.627SerSer: 3.627 ± 0.096
2.876SerThr: 2.876 ± 0.07
4.947SerVal: 4.947 ± 0.09
0.751SerTrp: 0.751 ± 0.031
1.495SerTyr: 1.495 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
5.793ThrAla: 5.793 ± 0.116
0.606ThrCys: 0.606 ± 0.033
3.222ThrAsp: 3.222 ± 0.085
3.25ThrGlu: 3.25 ± 0.07
2.24ThrPhe: 2.24 ± 0.07
4.856ThrGly: 4.856 ± 0.097
1.076ThrHis: 1.076 ± 0.04
3.101ThrIle: 3.101 ± 0.075
2.288ThrLys: 2.288 ± 0.059
5.745ThrLeu: 5.745 ± 0.107
1.337ThrMet: 1.337 ± 0.049
1.599ThrAsn: 1.599 ± 0.054
3.039ThrPro: 3.039 ± 0.07
1.846ThrGln: 1.846 ± 0.062
2.823ThrArg: 2.823 ± 0.073
3.053ThrSer: 3.053 ± 0.071
3.038ThrThr: 3.038 ± 0.069
5.049ThrVal: 5.049 ± 0.095
0.609ThrTrp: 0.609 ± 0.029
1.342ThrTyr: 1.342 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.71ValAla: 7.71 ± 0.124
1.323ValCys: 1.323 ± 0.047
4.038ValAsp: 4.038 ± 0.082
4.401ValGlu: 4.401 ± 0.092
3.285ValPhe: 3.285 ± 0.077
5.501ValGly: 5.501 ± 0.089
1.48ValHis: 1.48 ± 0.055
4.341ValIle: 4.341 ± 0.087
3.848ValLys: 3.848 ± 0.079
7.92ValLeu: 7.92 ± 0.144
2.106ValMet: 2.106 ± 0.065
2.659ValAsn: 2.659 ± 0.08
3.46ValPro: 3.46 ± 0.086
2.515ValGln: 2.515 ± 0.06
4.947ValArg: 4.947 ± 0.08
5.162ValSer: 5.162 ± 0.1
4.896ValThr: 4.896 ± 0.089
6.233ValVal: 6.233 ± 0.121
0.912ValTrp: 0.912 ± 0.043
1.795ValTyr: 1.795 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.118TrpAla: 1.118 ± 0.048
0.195TrpCys: 0.195 ± 0.018
0.589TrpAsp: 0.589 ± 0.031
0.598TrpGlu: 0.598 ± 0.032
0.54TrpPhe: 0.54 ± 0.027
0.9TrpGly: 0.9 ± 0.044
0.278TrpHis: 0.278 ± 0.022
0.741TrpIle: 0.741 ± 0.04
0.594TrpLys: 0.594 ± 0.029
1.514TrpLeu: 1.514 ± 0.05
0.417TrpMet: 0.417 ± 0.028
0.408TrpAsn: 0.408 ± 0.026
0.433TrpPro: 0.433 ± 0.028
0.529TrpGln: 0.529 ± 0.029
0.809TrpArg: 0.809 ± 0.037
0.655TrpSer: 0.655 ± 0.029
0.625TrpThr: 0.625 ± 0.032
0.965TrpVal: 0.965 ± 0.04
0.206TrpTrp: 0.206 ± 0.02
0.297TrpTyr: 0.297 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.487TyrAla: 2.487 ± 0.067
0.428TyrCys: 0.428 ± 0.028
1.486TyrAsp: 1.486 ± 0.054
1.551TyrGlu: 1.551 ± 0.054
1.118TyrPhe: 1.118 ± 0.044
2.223TyrGly: 2.223 ± 0.076
0.441TyrHis: 0.441 ± 0.026
1.206TyrIle: 1.206 ± 0.035
1.059TyrLys: 1.059 ± 0.043
2.447TyrLeu: 2.447 ± 0.058
0.536TyrMet: 0.536 ± 0.026
0.875TyrAsn: 0.875 ± 0.036
1.158TyrPro: 1.158 ± 0.048
0.759TyrGln: 0.759 ± 0.035
1.673TyrArg: 1.673 ± 0.049
1.452TyrSer: 1.452 ± 0.05
1.374TyrThr: 1.374 ± 0.05
1.908TyrVal: 1.908 ± 0.05
0.382TyrTrp: 0.382 ± 0.027
0.634TyrTyr: 0.634 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1912 proteins (646839 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski