Amino acid dipepetide frequency for Sphingobium fluviale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.74AlaAla: 17.74 ± 0.207	1.169AlaCys: 1.169 ± 0.042	7.648AlaAsp: 7.648 ± 0.158	8.083AlaGlu: 8.083 ± 0.129	4.002AlaPhe: 4.002 ± 0.07	10.972AlaGly: 10.972 ± 0.271	2.628AlaHis: 2.628 ± 0.064	6.64AlaIle: 6.64 ± 0.088	4.346AlaLys: 4.346 ± 0.09	14.619AlaLeu: 14.619 ± 0.182	3.999AlaMet: 3.999 ± 0.081	3.235AlaAsn: 3.235 ± 0.073	6.093AlaPro: 6.093 ± 0.105	5.052AlaGln: 5.052 ± 0.097	9.751AlaArg: 9.751 ± 0.145	6.692AlaSer: 6.692 ± 0.098	6.036AlaThr: 6.036 ± 0.099	8.33AlaVal: 8.33 ± 0.11	1.473AlaTrp: 1.473 ± 0.042	2.577AlaTyr: 2.577 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.245CysAla: 1.245 ± 0.042	0.118CysCys: 0.118 ± 0.013	0.538CysAsp: 0.538 ± 0.022	0.423CysGlu: 0.423 ± 0.022	0.315CysPhe: 0.315 ± 0.018	0.919CysGly: 0.919 ± 0.04	0.217CysHis: 0.217 ± 0.017	0.424CysIle: 0.424 ± 0.023	0.226CysLys: 0.226 ± 0.019	0.758CysLeu: 0.758 ± 0.028	0.17CysMet: 0.17 ± 0.014	0.23CysAsn: 0.23 ± 0.018	0.501CysPro: 0.501 ± 0.026	0.217CysGln: 0.217 ± 0.015	0.579CysArg: 0.579 ± 0.024	0.486CysSer: 0.486 ± 0.025	0.445CysThr: 0.445 ± 0.023	0.6CysVal: 0.6 ± 0.026	0.121CysTrp: 0.121 ± 0.012	0.201CysTyr: 0.201 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.74AspAla: 7.74 ± 0.094	0.522AspCys: 0.522 ± 0.024	3.299AspAsp: 3.299 ± 0.104	3.423AspGlu: 3.423 ± 0.08	2.121AspPhe: 2.121 ± 0.048	5.367AspGly: 5.367 ± 0.138	1.245AspHis: 1.245 ± 0.042	3.333AspIle: 3.333 ± 0.075	1.925AspLys: 1.925 ± 0.047	5.49AspLeu: 5.49 ± 0.084	1.674AspMet: 1.674 ± 0.043	1.372AspAsn: 1.372 ± 0.038	3.333AspPro: 3.333 ± 0.062	1.73AspGln: 1.73 ± 0.041	4.04AspArg: 4.04 ± 0.071	2.501AspSer: 2.501 ± 0.058	2.868AspThr: 2.868 ± 0.245	4.028AspVal: 4.028 ± 0.078	1.043AspTrp: 1.043 ± 0.037	1.686AspTyr: 1.686 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	8.1GluAla: 8.1 ± 0.134	0.409GluCys: 0.409 ± 0.021	2.816GluAsp: 2.816 ± 0.068	3.113GluGlu: 3.113 ± 0.08	1.539GluPhe: 1.539 ± 0.042	4.663GluGly: 4.663 ± 0.087	1.21GluHis: 1.21 ± 0.042	3.158GluIle: 3.158 ± 0.072	2.153GluLys: 2.153 ± 0.062	4.971GluLeu: 4.971 ± 0.081	1.598GluMet: 1.598 ± 0.045	1.43GluAsn: 1.43 ± 0.042	2.412GluPro: 2.412 ± 0.054	2.311GluGln: 2.311 ± 0.053	5.012GluArg: 5.012 ± 0.09	2.474GluSer: 2.474 ± 0.051	3.022GluThr: 3.022 ± 0.06	3.461GluVal: 3.461 ± 0.068	0.744GluTrp: 0.744 ± 0.03	0.997GluTyr: 0.997 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.555PheAla: 4.555 ± 0.077	0.317PheCys: 0.317 ± 0.02	2.435PheAsp: 2.435 ± 0.061	1.911PheGlu: 1.911 ± 0.049	1.266PhePhe: 1.266 ± 0.045	3.407PheGly: 3.407 ± 0.07	0.712PheHis: 0.712 ± 0.027	1.563PheIle: 1.563 ± 0.045	0.908PheLys: 0.908 ± 0.03	3.063PheLeu: 3.063 ± 0.066	0.827PheMet: 0.827 ± 0.03	0.997PheAsn: 0.997 ± 0.036	1.498PhePro: 1.498 ± 0.039	0.802PheGln: 0.802 ± 0.027	2.064PheArg: 2.064 ± 0.056	2.061PheSer: 2.061 ± 0.051	1.855PheThr: 1.855 ± 0.05	2.474PheVal: 2.474 ± 0.062	0.487PheTrp: 0.487 ± 0.025	0.844PheTyr: 0.844 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.271GlyAla: 10.271 ± 0.242	0.839GlyCys: 0.839 ± 0.032	4.815GlyAsp: 4.815 ± 0.215	4.691GlyGlu: 4.691 ± 0.077	3.362GlyPhe: 3.362 ± 0.063	8.279GlyGly: 8.279 ± 0.377	1.895GlyHis: 1.895 ± 0.057	4.544GlyIle: 4.544 ± 0.082	3.631GlyLys: 3.631 ± 0.068	8.506GlyLeu: 8.506 ± 0.101	2.451GlyMet: 2.451 ± 0.057	2.476GlyAsn: 2.476 ± 0.139	3.253GlyPro: 3.253 ± 0.064	2.999GlyGln: 2.999 ± 0.061	6.139GlyArg: 6.139 ± 0.091	4.867GlySer: 4.867 ± 0.17	4.694GlyThr: 4.694 ± 0.126	6.046GlyVal: 6.046 ± 0.09	1.537GlyTrp: 1.537 ± 0.046	2.259GlyTyr: 2.259 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.388HisAla: 2.388 ± 0.056	0.284HisCys: 0.284 ± 0.017	1.227HisAsp: 1.227 ± 0.031	1.053HisGlu: 1.053 ± 0.037	0.847HisPhe: 0.847 ± 0.033	1.902HisGly: 1.902 ± 0.048	0.613HisHis: 0.613 ± 0.03	1.223HisIle: 1.223 ± 0.034	0.573HisLys: 0.573 ± 0.026	1.965HisLeu: 1.965 ± 0.045	0.572HisMet: 0.572 ± 0.026	0.482HisAsn: 0.482 ± 0.024	1.269HisPro: 1.269 ± 0.046	0.639HisGln: 0.639 ± 0.025	1.432HisArg: 1.432 ± 0.039	1.005HisSer: 1.005 ± 0.039	0.729HisThr: 0.729 ± 0.028	1.539HisVal: 1.539 ± 0.038	0.368HisTrp: 0.368 ± 0.021	0.618HisTyr: 0.618 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.994IleAla: 7.994 ± 0.095	0.499IleCys: 0.499 ± 0.023	3.852IleAsp: 3.852 ± 0.072	3.887IleGlu: 3.887 ± 0.081	1.697IlePhe: 1.697 ± 0.052	5.245IleGly: 5.245 ± 0.093	0.955IleHis: 0.955 ± 0.033	2.602IleIle: 2.602 ± 0.064	1.392IleLys: 1.392 ± 0.041	4.349IleLeu: 4.349 ± 0.081	1.079IleMet: 1.079 ± 0.036	1.525IleAsn: 1.525 ± 0.049	2.282IlePro: 2.282 ± 0.046	1.233IleGln: 1.233 ± 0.042	3.315IleArg: 3.315 ± 0.066	3.147IleSer: 3.147 ± 0.06	2.786IleThr: 2.786 ± 0.06	4.091IleVal: 4.091 ± 0.067	0.647IleTrp: 0.647 ± 0.027	1.061IleTyr: 1.061 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.624LysAla: 4.624 ± 0.079	0.168LysCys: 0.168 ± 0.013	1.796LysAsp: 1.796 ± 0.049	1.529LysGlu: 1.529 ± 0.04	0.887LysPhe: 0.887 ± 0.029	2.877LysGly: 2.877 ± 0.06	0.578LysHis: 0.578 ± 0.029	1.691LysIle: 1.691 ± 0.044	1.247LysLys: 1.247 ± 0.046	3.35LysLeu: 3.35 ± 0.069	0.899LysMet: 0.899 ± 0.036	0.825LysAsn: 0.825 ± 0.031	2.164LysPro: 2.164 ± 0.049	1.08LysGln: 1.08 ± 0.037	2.404LysArg: 2.404 ± 0.056	1.807LysSer: 1.807 ± 0.051	1.782LysThr: 1.782 ± 0.044	2.169LysVal: 2.169 ± 0.049	0.421LysTrp: 0.421 ± 0.021	0.661LysTyr: 0.661 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.467LeuAla: 13.467 ± 0.169	0.963LeuCys: 0.963 ± 0.036	6.159LeuAsp: 6.159 ± 0.089	4.964LeuGlu: 4.964 ± 0.091	3.43LeuPhe: 3.43 ± 0.073	8.412LeuGly: 8.412 ± 0.106	1.922LeuHis: 1.922 ± 0.048	5.277LeuIle: 5.277 ± 0.077	3.352LeuLys: 3.352 ± 0.065	9.318LeuLeu: 9.318 ± 0.138	2.401LeuMet: 2.401 ± 0.059	2.601LeuAsn: 2.601 ± 0.058	5.383LeuPro: 5.383 ± 0.089	2.374LeuGln: 2.374 ± 0.052	6.757LeuArg: 6.757 ± 0.112	6.75LeuSer: 6.75 ± 0.096	5.276LeuThr: 5.276 ± 0.081	6.996LeuVal: 6.996 ± 0.102	1.311LeuTrp: 1.311 ± 0.043	2.06LeuTyr: 2.06 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.538MetAla: 3.538 ± 0.072	0.174MetCys: 0.174 ± 0.015	1.243MetAsp: 1.243 ± 0.035	1.26MetGlu: 1.26 ± 0.034	0.71MetPhe: 0.71 ± 0.032	1.975MetGly: 1.975 ± 0.05	0.451MetHis: 0.451 ± 0.024	1.482MetIle: 1.482 ± 0.04	1.031MetLys: 1.031 ± 0.037	2.797MetLeu: 2.797 ± 0.058	0.762MetMet: 0.762 ± 0.036	0.771MetAsn: 0.771 ± 0.029	1.602MetPro: 1.602 ± 0.044	0.887MetGln: 0.887 ± 0.031	2.031MetArg: 2.031 ± 0.05	1.571MetSer: 1.571 ± 0.038	1.753MetThr: 1.753 ± 0.044	1.624MetVal: 1.624 ± 0.044	0.212MetTrp: 0.212 ± 0.015	0.306MetTyr: 0.306 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.411AsnAla: 3.411 ± 0.07	0.252AsnCys: 0.252 ± 0.017	1.622AsnAsp: 1.622 ± 0.116	1.244AsnGlu: 1.244 ± 0.039	0.984AsnPhe: 0.984 ± 0.036	2.614AsnGly: 2.614 ± 0.078	0.513AsnHis: 0.513 ± 0.024	1.563AsnIle: 1.563 ± 0.052	0.713AsnLys: 0.713 ± 0.027	2.493AsnLeu: 2.493 ± 0.056	0.614AsnMet: 0.614 ± 0.026	0.71AsnAsn: 0.71 ± 0.033	1.823AsnPro: 1.823 ± 0.053	0.774AsnGln: 0.774 ± 0.031	1.838AsnArg: 1.838 ± 0.046	1.384AsnSer: 1.384 ± 0.04	1.184AsnThr: 1.184 ± 0.038	1.806AsnVal: 1.806 ± 0.052	0.378AsnTrp: 0.378 ± 0.022	0.665AsnTyr: 0.665 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.511ProAla: 6.511 ± 0.092	0.369ProCys: 0.369 ± 0.02	3.646ProAsp: 3.646 ± 0.071	3.341ProGlu: 3.341 ± 0.061	1.728ProPhe: 1.728 ± 0.046	4.39ProGly: 4.39 ± 0.084	1.133ProHis: 1.133 ± 0.037	2.355ProIle: 2.355 ± 0.061	1.563ProLys: 1.563 ± 0.044	4.893ProLeu: 4.893 ± 0.087	1.24ProMet: 1.24 ± 0.041	1.243ProAsn: 1.243 ± 0.037	2.724ProPro: 2.724 ± 0.072	1.717ProGln: 1.717 ± 0.047	2.816ProArg: 2.816 ± 0.063	2.718ProSer: 2.718 ± 0.063	2.369ProThr: 2.369 ± 0.05	4.172ProVal: 4.172 ± 0.085	0.69ProTrp: 0.69 ± 0.031	1.116ProTyr: 1.116 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.436GlnAla: 4.436 ± 0.075	0.274GlnCys: 0.274 ± 0.019	1.5GlnAsp: 1.5 ± 0.037	1.452GlnGlu: 1.452 ± 0.042	1.045GlnPhe: 1.045 ± 0.035	2.577GlnGly: 2.577 ± 0.057	0.672GlnHis: 0.672 ± 0.027	2.026GlnIle: 2.026 ± 0.048	0.961GlnLys: 0.961 ± 0.033	3.083GlnLeu: 3.083 ± 0.06	0.961GlnMet: 0.961 ± 0.032	0.878GlnAsn: 0.878 ± 0.028	1.807GlnPro: 1.807 ± 0.057	1.218GlnGln: 1.218 ± 0.049	2.433GlnArg: 2.433 ± 0.057	1.863GlnSer: 1.863 ± 0.05	1.683GlnThr: 1.683 ± 0.039	2.123GlnVal: 2.123 ± 0.046	0.465GlnTrp: 0.465 ± 0.023	0.597GlnTyr: 0.597 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	8.791ArgAla: 8.791 ± 0.143	0.553ArgCys: 0.553 ± 0.027	3.958ArgAsp: 3.958 ± 0.067	3.95ArgGlu: 3.95 ± 0.089	2.891ArgPhe: 2.891 ± 0.065	4.758ArgGly: 4.758 ± 0.079	1.738ArgHis: 1.738 ± 0.047	4.355ArgIle: 4.355 ± 0.078	2.382ArgLys: 2.382 ± 0.056	8.199ArgLeu: 8.199 ± 0.117	1.909ArgMet: 1.909 ± 0.041	1.843ArgAsn: 1.843 ± 0.048	3.358ArgPro: 3.358 ± 0.069	2.469ArgGln: 2.469 ± 0.062	5.213ArgArg: 5.213 ± 0.106	3.657ArgSer: 3.657 ± 0.077	3.376ArgThr: 3.376 ± 0.065	4.494ArgVal: 4.494 ± 0.079	1.118ArgTrp: 1.118 ± 0.035	1.813ArgTyr: 1.813 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	7.347SerAla: 7.347 ± 0.153	0.454SerCys: 0.454 ± 0.025	3.057SerAsp: 3.057 ± 0.061	2.699SerGlu: 2.699 ± 0.062	2.158SerPhe: 2.158 ± 0.054	5.799SerGly: 5.799 ± 0.153	1.061SerHis: 1.061 ± 0.033	2.921SerIle: 2.921 ± 0.074	1.615SerLys: 1.615 ± 0.049	5.503SerLeu: 5.503 ± 0.095	1.348SerMet: 1.348 ± 0.037	1.456SerAsn: 1.456 ± 0.045	2.777SerPro: 2.777 ± 0.057	1.711SerGln: 1.711 ± 0.04	3.559SerArg: 3.559 ± 0.065	3.031SerSer: 3.031 ± 0.086	2.729SerThr: 2.729 ± 0.061	3.931SerVal: 3.931 ± 0.074	0.729SerTrp: 0.729 ± 0.027	1.384SerTyr: 1.384 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.955ThrAla: 5.955 ± 0.101	0.41ThrCys: 0.41 ± 0.02	2.869ThrAsp: 2.869 ± 0.061	2.553ThrGlu: 2.553 ± 0.063	1.63ThrPhe: 1.63 ± 0.044	5.22ThrGly: 5.22 ± 0.174	1.011ThrHis: 1.011 ± 0.035	3.027ThrIle: 3.027 ± 0.069	1.43ThrLys: 1.43 ± 0.048	5.602ThrLeu: 5.602 ± 0.152	1.147ThrMet: 1.147 ± 0.033	1.356ThrAsn: 1.356 ± 0.041	3.162ThrPro: 3.162 ± 0.066	1.504ThrGln: 1.504 ± 0.047	3.322ThrArg: 3.322 ± 0.074	2.833ThrSer: 2.833 ± 0.066	2.616ThrThr: 2.616 ± 0.072	3.843ThrVal: 3.843 ± 0.075	0.532ThrTrp: 0.532 ± 0.026	1.115ThrTyr: 1.115 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.776ValAla: 8.776 ± 0.121	0.577ValCys: 0.577 ± 0.029	4.086ValAsp: 4.086 ± 0.075	4.213ValGlu: 4.213 ± 0.084	2.083ValPhe: 2.083 ± 0.048	5.14ValGly: 5.14 ± 0.078	1.369ValHis: 1.369 ± 0.041	3.868ValIle: 3.868 ± 0.07	2.382ValLys: 2.382 ± 0.057	6.408ValLeu: 6.408 ± 0.078	1.709ValMet: 1.709 ± 0.051	2.076ValAsn: 2.076 ± 0.052	3.61ValPro: 3.61 ± 0.073	2.039ValGln: 2.039 ± 0.046	5.066ValArg: 5.066 ± 0.076	4.316ValSer: 4.316 ± 0.071	4.199ValThr: 4.199 ± 0.07	4.975ValVal: 4.975 ± 0.086	0.816ValTrp: 0.816 ± 0.034	1.37ValTyr: 1.37 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.451TrpAla: 1.451 ± 0.042	0.128TrpCys: 0.128 ± 0.012	0.617TrpAsp: 0.617 ± 0.028	0.602TrpGlu: 0.602 ± 0.026	0.488TrpPhe: 0.488 ± 0.025	0.936TrpGly: 0.936 ± 0.034	0.308TrpHis: 0.308 ± 0.018	0.661TrpIle: 0.661 ± 0.027	0.495TrpLys: 0.495 ± 0.024	1.738TrpLeu: 1.738 ± 0.051	0.366TrpMet: 0.366 ± 0.017	0.453TrpAsn: 0.453 ± 0.023	0.694TrpPro: 0.694 ± 0.031	0.591TrpGln: 0.591 ± 0.027	1.327TrpArg: 1.327 ± 0.046	0.83TrpSer: 0.83 ± 0.031	0.662TrpThr: 0.662 ± 0.029	0.822TrpVal: 0.822 ± 0.035	0.218TrpTrp: 0.218 ± 0.018	0.275TrpTyr: 0.275 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.746TyrAla: 2.746 ± 0.058	0.256TyrCys: 0.256 ± 0.016	1.558TyrAsp: 1.558 ± 0.038	1.202TyrGlu: 1.202 ± 0.035	0.862TyrPhe: 0.862 ± 0.028	2.102TyrGly: 2.102 ± 0.056	0.496TyrHis: 0.496 ± 0.024	0.927TyrIle: 0.927 ± 0.031	0.631TyrLys: 0.631 ± 0.028	2.067TyrLeu: 2.067 ± 0.043	0.452TyrMet: 0.452 ± 0.021	0.627TyrAsn: 0.627 ± 0.029	0.994TyrPro: 0.994 ± 0.037	0.708TyrGln: 0.708 ± 0.026	1.727TyrArg: 1.727 ± 0.05	1.274TyrSer: 1.274 ± 0.061	1.074TyrThr: 1.074 ± 0.037	1.554TyrVal: 1.554 ± 0.045	0.352TyrTrp: 0.352 ± 0.023	0.623TyrTyr: 0.623 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2932 proteins (915520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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