Amino acid dipepetide frequency for Edaphobacter modestus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.264AlaAla: 12.264 ± 0.108	0.935AlaCys: 0.935 ± 0.024	4.892AlaAsp: 4.892 ± 0.053	5.867AlaGlu: 5.867 ± 0.072	3.778AlaPhe: 3.778 ± 0.048	8.385AlaGly: 8.385 ± 0.072	2.053AlaHis: 2.053 ± 0.035	5.657AlaIle: 5.657 ± 0.054	3.911AlaLys: 3.911 ± 0.049	10.198AlaLeu: 10.198 ± 0.084	2.695AlaMet: 2.695 ± 0.036	3.481AlaAsn: 3.481 ± 0.047	4.768AlaPro: 4.768 ± 0.055	4.098AlaGln: 4.098 ± 0.054	5.939AlaArg: 5.939 ± 0.062	6.818AlaSer: 6.818 ± 0.066	6.233AlaThr: 6.233 ± 0.061	7.411AlaVal: 7.411 ± 0.07	1.327AlaTrp: 1.327 ± 0.026	2.453AlaTyr: 2.453 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.021	0.167CysCys: 0.167 ± 0.011	0.467CysAsp: 0.467 ± 0.016	0.439CysGlu: 0.439 ± 0.016	0.393CysPhe: 0.393 ± 0.015	0.909CysGly: 0.909 ± 0.024	0.261CysHis: 0.261 ± 0.013	0.446CysIle: 0.446 ± 0.016	0.26CysLys: 0.26 ± 0.013	0.873CysLeu: 0.873 ± 0.025	0.184CysMet: 0.184 ± 0.009	0.268CysAsn: 0.268 ± 0.01	0.445CysPro: 0.445 ± 0.016	0.232CysGln: 0.232 ± 0.011	0.576CysArg: 0.576 ± 0.018	0.676CysSer: 0.676 ± 0.02	0.501CysThr: 0.501 ± 0.017	0.64CysVal: 0.64 ± 0.021	0.141CysTrp: 0.141 ± 0.009	0.244CysTyr: 0.244 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.2AspAla: 5.2 ± 0.059	0.405AspCys: 0.405 ± 0.015	2.432AspAsp: 2.432 ± 0.039	2.884AspGlu: 2.884 ± 0.047	2.111AspPhe: 2.111 ± 0.028	4.452AspGly: 4.452 ± 0.053	1.197AspHis: 1.197 ± 0.024	2.441AspIle: 2.441 ± 0.035	1.747AspLys: 1.747 ± 0.03	5.223AspLeu: 5.223 ± 0.054	0.911AspMet: 0.911 ± 0.021	1.492AspAsn: 1.492 ± 0.028	3.212AspPro: 3.212 ± 0.044	1.8AspGln: 1.8 ± 0.029	3.443AspArg: 3.443 ± 0.05	3.036AspSer: 3.036 ± 0.039	2.6AspThr: 2.6 ± 0.036	3.6AspVal: 3.6 ± 0.048	0.799AspTrp: 0.799 ± 0.018	1.552AspTyr: 1.552 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.683GluAla: 5.683 ± 0.074	0.394GluCys: 0.394 ± 0.015	2.537GluAsp: 2.537 ± 0.043	3.208GluGlu: 3.208 ± 0.051	1.988GluPhe: 1.988 ± 0.035	3.601GluGly: 3.601 ± 0.05	1.35GluHis: 1.35 ± 0.024	3.29GluIle: 3.29 ± 0.038	2.416GluLys: 2.416 ± 0.037	5.351GluLeu: 5.351 ± 0.058	1.438GluMet: 1.438 ± 0.028	1.698GluAsn: 1.698 ± 0.032	2.265GluPro: 2.265 ± 0.042	2.516GluGln: 2.516 ± 0.036	4.101GluArg: 4.101 ± 0.052	3.108GluSer: 3.108 ± 0.04	3.111GluThr: 3.111 ± 0.043	3.696GluVal: 3.696 ± 0.049	0.74GluTrp: 0.74 ± 0.017	1.357GluTyr: 1.357 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.177PheAla: 4.177 ± 0.049	0.425PheCys: 0.425 ± 0.015	2.447PheAsp: 2.447 ± 0.033	1.975PheGlu: 1.975 ± 0.038	1.78PhePhe: 1.78 ± 0.038	3.602PheGly: 3.602 ± 0.05	1.016PheHis: 1.016 ± 0.023	1.566PheIle: 1.566 ± 0.029	1.061PheLys: 1.061 ± 0.023	3.863PheLeu: 3.863 ± 0.052	0.707PheMet: 0.707 ± 0.021	1.494PheAsn: 1.494 ± 0.036	1.872PhePro: 1.872 ± 0.036	1.336PheGln: 1.336 ± 0.025	2.51PheArg: 2.51 ± 0.034	2.892PheSer: 2.892 ± 0.047	2.437PheThr: 2.437 ± 0.034	2.789PheVal: 2.789 ± 0.04	0.575PheTrp: 0.575 ± 0.02	1.233PheTyr: 1.233 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.28GlyAla: 7.28 ± 0.069	0.847GlyCys: 0.847 ± 0.022	3.796GlyAsp: 3.796 ± 0.047	3.885GlyGlu: 3.885 ± 0.052	3.372GlyPhe: 3.372 ± 0.041	6.409GlyGly: 6.409 ± 0.086	1.821GlyHis: 1.821 ± 0.03	4.529GlyIle: 4.529 ± 0.047	3.563GlyLys: 3.563 ± 0.047	7.366GlyLeu: 7.366 ± 0.067	1.994GlyMet: 1.994 ± 0.034	2.956GlyAsn: 2.956 ± 0.054	3.193GlyPro: 3.193 ± 0.043	2.956GlyGln: 2.956 ± 0.038	4.847GlyArg: 4.847 ± 0.06	5.531GlySer: 5.531 ± 0.065	5.338GlyThr: 5.338 ± 0.07	5.728GlyVal: 5.728 ± 0.057	1.305GlyTrp: 1.305 ± 0.027	2.518GlyTyr: 2.518 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.17HisAla: 2.17 ± 0.034	0.245HisCys: 0.245 ± 0.012	1.13HisAsp: 1.13 ± 0.023	1.152HisGlu: 1.152 ± 0.025	0.988HisPhe: 0.988 ± 0.025	1.928HisGly: 1.928 ± 0.027	0.637HisHis: 0.637 ± 0.021	1.148HisIle: 1.148 ± 0.025	0.663HisLys: 0.663 ± 0.019	2.386HisLeu: 2.386 ± 0.038	0.503HisMet: 0.503 ± 0.016	0.686HisAsn: 0.686 ± 0.017	1.495HisPro: 1.495 ± 0.026	0.779HisGln: 0.779 ± 0.022	1.516HisArg: 1.516 ± 0.03	1.406HisSer: 1.406 ± 0.027	1.24HisThr: 1.24 ± 0.022	1.548HisVal: 1.548 ± 0.025	0.38HisTrp: 0.38 ± 0.013	0.694HisTyr: 0.694 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.208IleAla: 6.208 ± 0.058	0.522IleCys: 0.522 ± 0.016	3.114IleAsp: 3.114 ± 0.038	3.106IleGlu: 3.106 ± 0.044	2.048IlePhe: 2.048 ± 0.034	4.306IleGly: 4.306 ± 0.051	1.233IleHis: 1.233 ± 0.027	1.948IleIle: 1.948 ± 0.04	1.487IleLys: 1.487 ± 0.031	4.622IleLeu: 4.622 ± 0.054	0.766IleMet: 0.766 ± 0.02	1.74IleAsn: 1.74 ± 0.035	2.948IlePro: 2.948 ± 0.039	1.754IleGln: 1.754 ± 0.031	3.279IleArg: 3.279 ± 0.046	3.531IleSer: 3.531 ± 0.043	3.201IleThr: 3.201 ± 0.05	3.98IleVal: 3.98 ± 0.048	0.581IleTrp: 0.581 ± 0.018	1.396IleTyr: 1.396 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.697LysAla: 3.697 ± 0.053	0.195LysCys: 0.195 ± 0.01	1.917LysAsp: 1.917 ± 0.028	2.036LysGlu: 2.036 ± 0.039	1.169LysPhe: 1.169 ± 0.026	2.614LysGly: 2.614 ± 0.044	0.798LysHis: 0.798 ± 0.019	2.029LysIle: 2.029 ± 0.036	1.847LysLys: 1.847 ± 0.04	3.707LysLeu: 3.707 ± 0.04	0.977LysMet: 0.977 ± 0.024	1.339LysAsn: 1.339 ± 0.026	2.127LysPro: 2.127 ± 0.036	1.64LysGln: 1.64 ± 0.031	2.378LysArg: 2.378 ± 0.034	2.227LysSer: 2.227 ± 0.032	2.484LysThr: 2.484 ± 0.04	2.543LysVal: 2.543 ± 0.038	0.444LysTrp: 0.444 ± 0.016	0.967LysTyr: 0.967 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	10.606LeuAla: 10.606 ± 0.089	0.992LeuCys: 0.992 ± 0.024	5.018LeuAsp: 5.018 ± 0.046	5.22LeuGlu: 5.22 ± 0.063	3.783LeuPhe: 3.783 ± 0.047	7.245LeuGly: 7.245 ± 0.068	2.335LeuHis: 2.335 ± 0.038	4.718LeuIle: 4.718 ± 0.056	3.822LeuLys: 3.822 ± 0.046	10.206LeuLeu: 10.206 ± 0.106	2.0LeuMet: 2.0 ± 0.033	3.452LeuAsn: 3.452 ± 0.051	5.557LeuPro: 5.557 ± 0.054	3.485LeuGln: 3.485 ± 0.046	7.017LeuArg: 7.017 ± 0.068	6.862LeuSer: 6.862 ± 0.063	6.15LeuThr: 6.15 ± 0.056	6.64LeuVal: 6.64 ± 0.063	1.344LeuTrp: 1.344 ± 0.03	2.439LeuTyr: 2.439 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.381MetAla: 2.381 ± 0.036	0.169MetCys: 0.169 ± 0.009	1.027MetAsp: 1.027 ± 0.023	1.127MetGlu: 1.127 ± 0.026	0.694MetPhe: 0.694 ± 0.019	1.575MetGly: 1.575 ± 0.028	0.513MetHis: 0.513 ± 0.017	1.105MetIle: 1.105 ± 0.024	1.116MetLys: 1.116 ± 0.026	2.283MetLeu: 2.283 ± 0.039	0.566MetMet: 0.566 ± 0.017	0.904MetAsn: 0.904 ± 0.021	1.316MetPro: 1.316 ± 0.024	0.973MetGln: 0.973 ± 0.022	1.612MetArg: 1.612 ± 0.026	1.532MetSer: 1.532 ± 0.027	1.476MetThr: 1.476 ± 0.027	1.475MetVal: 1.475 ± 0.031	0.224MetTrp: 0.224 ± 0.01	0.416MetTyr: 0.416 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.381AsnAla: 3.381 ± 0.051	0.322AsnCys: 0.322 ± 0.014	1.672AsnAsp: 1.672 ± 0.036	1.622AsnGlu: 1.622 ± 0.029	1.525AsnPhe: 1.525 ± 0.035	3.171AsnGly: 3.171 ± 0.061	0.771AsnHis: 0.771 ± 0.021	1.738AsnIle: 1.738 ± 0.035	1.028AsnLys: 1.028 ± 0.024	3.549AsnLeu: 3.549 ± 0.046	0.64AsnMet: 0.64 ± 0.018	1.336AsnAsn: 1.336 ± 0.037	2.395AsnPro: 2.395 ± 0.044	1.44AsnGln: 1.44 ± 0.029	2.109AsnArg: 2.109 ± 0.033	2.29AsnSer: 2.29 ± 0.045	2.011AsnThr: 2.011 ± 0.039	2.468AsnVal: 2.468 ± 0.037	0.515AsnTrp: 0.515 ± 0.016	1.191AsnTyr: 1.191 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.683ProAla: 5.683 ± 0.062	0.364ProCys: 0.364 ± 0.014	3.152ProAsp: 3.152 ± 0.044	3.463ProGlu: 3.463 ± 0.046	2.005ProPhe: 2.005 ± 0.033	4.473ProGly: 4.473 ± 0.055	1.166ProHis: 1.166 ± 0.023	2.507ProIle: 2.507 ± 0.038	1.871ProLys: 1.871 ± 0.035	4.687ProLeu: 4.687 ± 0.052	1.112ProMet: 1.112 ± 0.025	1.947ProAsn: 1.947 ± 0.037	2.731ProPro: 2.731 ± 0.053	2.108ProGln: 2.108 ± 0.039	2.723ProArg: 2.723 ± 0.039	3.653ProSer: 3.653 ± 0.046	3.054ProThr: 3.054 ± 0.041	3.995ProVal: 3.995 ± 0.04	0.678ProTrp: 0.678 ± 0.019	1.383ProTyr: 1.383 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.904GlnAla: 3.904 ± 0.057	0.249GlnCys: 0.249 ± 0.012	1.621GlnAsp: 1.621 ± 0.027	1.784GlnGlu: 1.784 ± 0.033	1.498GlnPhe: 1.498 ± 0.031	2.565GlnGly: 2.565 ± 0.042	0.885GlnHis: 0.885 ± 0.024	2.227GlnIle: 2.227 ± 0.032	1.524GlnLys: 1.524 ± 0.03	3.737GlnLeu: 3.737 ± 0.041	1.071GlnMet: 1.071 ± 0.022	1.405GlnAsn: 1.405 ± 0.037	2.135GlnPro: 2.135 ± 0.036	2.193GlnGln: 2.193 ± 0.038	2.649GlnArg: 2.649 ± 0.033	2.431GlnSer: 2.431 ± 0.036	2.399GlnThr: 2.399 ± 0.036	2.695GlnVal: 2.695 ± 0.041	0.537GlnTrp: 0.537 ± 0.015	1.061GlnTyr: 1.061 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.697ArgAla: 5.697 ± 0.057	0.554ArgCys: 0.554 ± 0.016	3.22ArgAsp: 3.22 ± 0.046	3.866ArgGlu: 3.866 ± 0.051	2.818ArgPhe: 2.818 ± 0.037	4.114ArgGly: 4.114 ± 0.045	1.473ArgHis: 1.473 ± 0.032	3.824ArgIle: 3.824 ± 0.051	2.501ArgLys: 2.501 ± 0.039	6.398ArgLeu: 6.398 ± 0.073	1.817ArgMet: 1.817 ± 0.032	2.295ArgAsn: 2.295 ± 0.035	3.002ArgPro: 3.002 ± 0.04	2.488ArgGln: 2.488 ± 0.036	4.732ArgArg: 4.732 ± 0.054	4.298ArgSer: 4.298 ± 0.051	3.604ArgThr: 3.604 ± 0.048	4.409ArgVal: 4.409 ± 0.056	1.141ArgTrp: 1.141 ± 0.022	1.959ArgTyr: 1.959 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.558SerAla: 6.558 ± 0.065	0.612SerCys: 0.612 ± 0.022	3.136SerAsp: 3.136 ± 0.04	3.297SerGlu: 3.297 ± 0.041	2.844SerPhe: 2.844 ± 0.045	6.087SerGly: 6.087 ± 0.075	1.459SerHis: 1.459 ± 0.028	3.706SerIle: 3.706 ± 0.045	2.33SerLys: 2.33 ± 0.035	6.667SerLeu: 6.667 ± 0.062	1.408SerMet: 1.408 ± 0.031	2.403SerAsn: 2.403 ± 0.049	3.653SerPro: 3.653 ± 0.039	2.393SerGln: 2.393 ± 0.038	4.075SerArg: 4.075 ± 0.05	5.092SerSer: 5.092 ± 0.064	4.154SerThr: 4.154 ± 0.056	4.626SerVal: 4.626 ± 0.053	0.907SerTrp: 0.907 ± 0.024	1.835SerTyr: 1.835 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.327ThrAla: 6.327 ± 0.063	0.503ThrCys: 0.503 ± 0.017	2.875ThrAsp: 2.875 ± 0.036	2.872ThrGlu: 2.872 ± 0.043	2.436ThrPhe: 2.436 ± 0.042	5.421ThrGly: 5.421 ± 0.067	1.296ThrHis: 1.296 ± 0.029	3.364ThrIle: 3.364 ± 0.049	1.947ThrLys: 1.947 ± 0.032	6.236ThrLeu: 6.236 ± 0.06	1.239ThrMet: 1.239 ± 0.024	2.132ThrAsn: 2.132 ± 0.05	3.835ThrPro: 3.835 ± 0.05	2.124ThrGln: 2.124 ± 0.031	3.246ThrArg: 3.246 ± 0.045	4.014ThrSer: 4.014 ± 0.061	3.873ThrThr: 3.873 ± 0.053	4.776ThrVal: 4.776 ± 0.058	0.802ThrTrp: 0.802 ± 0.02	1.642ThrTyr: 1.642 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.389ValAla: 7.389 ± 0.067	0.687ValCys: 0.687 ± 0.022	3.895ValAsp: 3.895 ± 0.047	4.036ValGlu: 4.036 ± 0.055	2.704ValPhe: 2.704 ± 0.042	5.063ValGly: 5.063 ± 0.048	1.481ValHis: 1.481 ± 0.026	3.546ValIle: 3.546 ± 0.048	2.535ValLys: 2.535 ± 0.041	7.337ValLeu: 7.337 ± 0.075	1.55ValMet: 1.55 ± 0.028	2.514ValAsn: 2.514 ± 0.043	3.801ValPro: 3.801 ± 0.049	2.561ValGln: 2.561 ± 0.041	4.486ValArg: 4.486 ± 0.054	4.936ValSer: 4.936 ± 0.052	4.521ValThr: 4.521 ± 0.057	5.516ValVal: 5.516 ± 0.06	0.888ValTrp: 0.888 ± 0.021	1.817ValTyr: 1.817 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.074TrpAla: 1.074 ± 0.022	0.138TrpCys: 0.138 ± 0.008	0.609TrpAsp: 0.609 ± 0.017	0.624TrpGlu: 0.624 ± 0.017	0.597TrpPhe: 0.597 ± 0.018	0.942TrpGly: 0.942 ± 0.025	0.344TrpHis: 0.344 ± 0.014	0.838TrpIle: 0.838 ± 0.023	0.648TrpLys: 0.648 ± 0.018	1.497TrpLeu: 1.497 ± 0.025	0.426TrpMet: 0.426 ± 0.015	0.614TrpAsn: 0.614 ± 0.017	0.605TrpPro: 0.605 ± 0.02	0.662TrpGln: 0.662 ± 0.018	0.965TrpArg: 0.965 ± 0.021	0.99TrpSer: 0.99 ± 0.024	0.905TrpThr: 0.905 ± 0.021	0.869TrpVal: 0.869 ± 0.024	0.223TrpTrp: 0.223 ± 0.011	0.398TrpTyr: 0.398 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.607TyrAla: 2.607 ± 0.037	0.277TyrCys: 0.277 ± 0.013	1.58TyrAsp: 1.58 ± 0.035	1.384TyrGlu: 1.384 ± 0.028	1.225TyrPhe: 1.225 ± 0.026	2.371TyrGly: 2.371 ± 0.035	0.606TyrHis: 0.606 ± 0.018	1.141TyrIle: 1.141 ± 0.023	0.858TyrLys: 0.858 ± 0.022	2.704TyrLeu: 2.704 ± 0.032	0.48TyrMet: 0.48 ± 0.015	1.022TyrAsn: 1.022 ± 0.028	1.401TyrPro: 1.401 ± 0.026	1.03TyrGln: 1.03 ± 0.029	2.007TyrArg: 2.007 ± 0.032	1.917TyrSer: 1.917 ± 0.035	1.67TyrThr: 1.67 ± 0.036	1.859TyrVal: 1.859 ± 0.031	0.416TyrTrp: 0.416 ± 0.016	0.791TyrTyr: 0.791 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6023 proteins (2031366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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