Amino acid dipepetide frequency for Hyphomonas neptunium (strain ATCC 15444)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.869AlaAla: 17.869 ± 0.2	1.291AlaCys: 1.291 ± 0.038	7.085AlaAsp: 7.085 ± 0.083	8.473AlaGlu: 8.473 ± 0.117	4.633AlaPhe: 4.633 ± 0.073	11.55AlaGly: 11.55 ± 0.127	2.249AlaHis: 2.249 ± 0.04	6.17AlaIle: 6.17 ± 0.084	3.96AlaLys: 3.96 ± 0.085	13.513AlaLeu: 13.513 ± 0.151	3.425AlaMet: 3.425 ± 0.059	2.964AlaAsn: 2.964 ± 0.045	6.519AlaPro: 6.519 ± 0.101	3.881AlaGln: 3.881 ± 0.064	8.874AlaArg: 8.874 ± 0.103	6.925AlaSer: 6.925 ± 0.091	5.515AlaThr: 5.515 ± 0.069	7.971AlaVal: 7.971 ± 0.1	1.71AlaTrp: 1.71 ± 0.046	2.744AlaTyr: 2.744 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.11CysAla: 1.11 ± 0.032	0.093CysCys: 0.093 ± 0.01	0.493CysAsp: 0.493 ± 0.02	0.466CysGlu: 0.466 ± 0.019	0.338CysPhe: 0.338 ± 0.018	0.894CysGly: 0.894 ± 0.029	0.199CysHis: 0.199 ± 0.014	0.363CysIle: 0.363 ± 0.02	0.191CysLys: 0.191 ± 0.014	0.782CysLeu: 0.782 ± 0.028	0.17CysMet: 0.17 ± 0.012	0.218CysAsn: 0.218 ± 0.015	0.502CysPro: 0.502 ± 0.026	0.253CysGln: 0.253 ± 0.015	0.526CysArg: 0.526 ± 0.021	0.45CysSer: 0.45 ± 0.019	0.38CysThr: 0.38 ± 0.021	0.572CysVal: 0.572 ± 0.021	0.1CysTrp: 0.1 ± 0.01	0.214CysTyr: 0.214 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.136AspAla: 7.136 ± 0.084	0.426AspCys: 0.426 ± 0.023	3.013AspAsp: 3.013 ± 0.063	3.641AspGlu: 3.641 ± 0.073	2.233AspPhe: 2.233 ± 0.049	5.403AspGly: 5.403 ± 0.076	1.139AspHis: 1.139 ± 0.035	3.133AspIle: 3.133 ± 0.054	1.711AspLys: 1.711 ± 0.044	5.79AspLeu: 5.79 ± 0.074	1.457AspMet: 1.457 ± 0.034	1.239AspAsn: 1.239 ± 0.031	3.429AspPro: 3.429 ± 0.053	1.715AspGln: 1.715 ± 0.041	3.771AspArg: 3.771 ± 0.059	2.124AspSer: 2.124 ± 0.046	3.029AspThr: 3.029 ± 0.055	4.083AspVal: 4.083 ± 0.064	1.035AspTrp: 1.035 ± 0.032	1.651AspTyr: 1.651 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	9.12GluAla: 9.12 ± 0.117	0.358GluCys: 0.358 ± 0.019	3.586GluAsp: 3.586 ± 0.061	3.779GluGlu: 3.779 ± 0.075	1.995GluPhe: 1.995 ± 0.048	5.158GluGly: 5.158 ± 0.071	1.028GluHis: 1.028 ± 0.033	3.641GluIle: 3.641 ± 0.059	2.448GluLys: 2.448 ± 0.058	5.318GluLeu: 5.318 ± 0.072	1.821GluMet: 1.821 ± 0.047	1.789GluAsn: 1.789 ± 0.043	2.684GluPro: 2.684 ± 0.059	2.066GluGln: 2.066 ± 0.041	4.487GluArg: 4.487 ± 0.073	2.537GluSer: 2.537 ± 0.054	4.322GluThr: 4.322 ± 0.063	3.944GluVal: 3.944 ± 0.062	0.728GluTrp: 0.728 ± 0.028	1.177GluTyr: 1.177 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.57PheAla: 4.57 ± 0.071	0.374PheCys: 0.374 ± 0.018	2.635PheAsp: 2.635 ± 0.055	2.498PheGlu: 2.498 ± 0.045	1.409PhePhe: 1.409 ± 0.038	3.739PheGly: 3.739 ± 0.063	0.679PheHis: 0.679 ± 0.023	1.852PheIle: 1.852 ± 0.046	1.069PheLys: 1.069 ± 0.031	3.439PheLeu: 3.439 ± 0.07	0.879PheMet: 0.879 ± 0.031	1.183PheAsn: 1.183 ± 0.039	1.543PhePro: 1.543 ± 0.041	1.019PheGln: 1.019 ± 0.033	2.261PheArg: 2.261 ± 0.042	2.36PheSer: 2.36 ± 0.044	2.14PheThr: 2.14 ± 0.046	2.523PheVal: 2.523 ± 0.04	0.554PheTrp: 0.554 ± 0.022	0.91PheTyr: 0.91 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	10.588GlyAla: 10.588 ± 0.107	0.782GlyCys: 0.782 ± 0.03	4.628GlyAsp: 4.628 ± 0.07	5.339GlyGlu: 5.339 ± 0.073	3.652GlyPhe: 3.652 ± 0.054	7.671GlyGly: 7.671 ± 0.111	1.774GlyHis: 1.774 ± 0.039	4.395GlyIle: 4.395 ± 0.064	3.493GlyLys: 3.493 ± 0.067	8.843GlyLeu: 8.843 ± 0.1	2.365GlyMet: 2.365 ± 0.05	2.195GlyAsn: 2.195 ± 0.041	3.901GlyPro: 3.901 ± 0.057	2.98GlyGln: 2.98 ± 0.046	5.881GlyArg: 5.881 ± 0.079	4.413GlySer: 4.413 ± 0.06	4.362GlyThr: 4.362 ± 0.058	6.322GlyVal: 6.322 ± 0.079	1.524GlyTrp: 1.524 ± 0.041	2.381GlyTyr: 2.381 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.102HisAla: 2.102 ± 0.045	0.21HisCys: 0.21 ± 0.013	1.008HisAsp: 1.008 ± 0.028	1.035HisGlu: 1.035 ± 0.032	0.752HisPhe: 0.752 ± 0.026	1.692HisGly: 1.692 ± 0.043	0.469HisHis: 0.469 ± 0.021	0.992HisIle: 0.992 ± 0.035	0.547HisLys: 0.547 ± 0.023	1.773HisLeu: 1.773 ± 0.047	0.476HisMet: 0.476 ± 0.023	0.446HisAsn: 0.446 ± 0.02	1.229HisPro: 1.229 ± 0.033	0.525HisGln: 0.525 ± 0.023	1.168HisArg: 1.168 ± 0.032	0.903HisSer: 0.903 ± 0.031	0.892HisThr: 0.892 ± 0.026	1.283HisVal: 1.283 ± 0.037	0.343HisTrp: 0.343 ± 0.016	0.521HisTyr: 0.521 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.106IleAla: 7.106 ± 0.089	0.533IleCys: 0.533 ± 0.021	3.546IleAsp: 3.546 ± 0.058	3.616IleGlu: 3.616 ± 0.059	1.792IlePhe: 1.792 ± 0.041	4.724IleGly: 4.724 ± 0.073	0.965IleHis: 0.965 ± 0.028	2.536IleIle: 2.536 ± 0.049	1.355IleLys: 1.355 ± 0.036	4.864IleLeu: 4.864 ± 0.082	0.993IleMet: 0.993 ± 0.032	1.434IleAsn: 1.434 ± 0.039	2.326IlePro: 2.326 ± 0.049	1.3IleGln: 1.3 ± 0.03	3.336IleArg: 3.336 ± 0.05	3.205IleSer: 3.205 ± 0.048	2.784IleThr: 2.784 ± 0.053	3.71IleVal: 3.71 ± 0.055	0.651IleTrp: 0.651 ± 0.026	1.142IleTyr: 1.142 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.606LysAla: 4.606 ± 0.073	0.172LysCys: 0.172 ± 0.013	1.981LysAsp: 1.981 ± 0.048	1.783LysGlu: 1.783 ± 0.044	1.009LysPhe: 1.009 ± 0.033	2.851LysGly: 2.851 ± 0.063	0.6LysHis: 0.6 ± 0.025	1.633LysIle: 1.633 ± 0.041	1.373LysLys: 1.373 ± 0.045	3.248LysLeu: 3.248 ± 0.06	0.819LysMet: 0.819 ± 0.027	0.84LysAsn: 0.84 ± 0.026	2.149LysPro: 2.149 ± 0.047	1.0LysGln: 1.0 ± 0.033	2.368LysArg: 2.368 ± 0.052	1.958LysSer: 1.958 ± 0.04	2.03LysThr: 2.03 ± 0.044	2.453LysVal: 2.453 ± 0.054	0.409LysTrp: 0.409 ± 0.021	0.701LysTyr: 0.701 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.859LeuAla: 12.859 ± 0.139	0.787LeuCys: 0.787 ± 0.026	5.463LeuAsp: 5.463 ± 0.075	5.754LeuGlu: 5.754 ± 0.078	3.495LeuPhe: 3.495 ± 0.069	7.983LeuGly: 7.983 ± 0.086	1.606LeuHis: 1.606 ± 0.041	5.469LeuIle: 5.469 ± 0.082	4.038LeuLys: 4.038 ± 0.065	8.563LeuLeu: 8.563 ± 0.118	2.634LeuMet: 2.634 ± 0.05	2.642LeuAsn: 2.642 ± 0.052	5.448LeuPro: 5.448 ± 0.084	2.628LeuGln: 2.628 ± 0.051	6.148LeuArg: 6.148 ± 0.09	6.758LeuSer: 6.758 ± 0.089	5.978LeuThr: 5.978 ± 0.08	6.495LeuVal: 6.495 ± 0.084	1.149LeuTrp: 1.149 ± 0.039	2.071LeuTyr: 2.071 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.316MetAla: 3.316 ± 0.055	0.175MetCys: 0.175 ± 0.012	1.329MetAsp: 1.329 ± 0.037	1.322MetGlu: 1.322 ± 0.033	0.798MetPhe: 0.798 ± 0.029	2.011MetGly: 2.011 ± 0.048	0.429MetHis: 0.429 ± 0.022	1.407MetIle: 1.407 ± 0.035	1.185MetLys: 1.185 ± 0.033	2.314MetLeu: 2.314 ± 0.044	0.736MetMet: 0.736 ± 0.025	0.784MetAsn: 0.784 ± 0.026	1.497MetPro: 1.497 ± 0.041	0.848MetGln: 0.848 ± 0.027	1.777MetArg: 1.777 ± 0.044	1.719MetSer: 1.719 ± 0.042	1.968MetThr: 1.968 ± 0.044	1.531MetVal: 1.531 ± 0.042	0.215MetTrp: 0.215 ± 0.013	0.34MetTyr: 0.34 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.194AsnAla: 3.194 ± 0.061	0.244AsnCys: 0.244 ± 0.014	1.39AsnAsp: 1.39 ± 0.038	1.345AsnGlu: 1.345 ± 0.04	1.072AsnPhe: 1.072 ± 0.035	2.394AsnGly: 2.394 ± 0.049	0.473AsnHis: 0.473 ± 0.021	1.447AsnIle: 1.447 ± 0.036	0.709AsnLys: 0.709 ± 0.025	2.529AsnLeu: 2.529 ± 0.044	0.653AsnMet: 0.653 ± 0.029	0.674AsnAsn: 0.674 ± 0.026	1.862AsnPro: 1.862 ± 0.042	0.823AsnGln: 0.823 ± 0.028	1.667AsnArg: 1.667 ± 0.042	1.276AsnSer: 1.276 ± 0.036	1.423AsnThr: 1.423 ± 0.042	1.834AsnVal: 1.834 ± 0.042	0.417AsnTrp: 0.417 ± 0.017	0.702AsnTyr: 0.702 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.866ProAla: 6.866 ± 0.088	0.326ProCys: 0.326 ± 0.018	3.652ProAsp: 3.652 ± 0.059	4.578ProGlu: 4.578 ± 0.073	2.004ProPhe: 2.004 ± 0.043	5.024ProGly: 5.024 ± 0.075	0.957ProHis: 0.957 ± 0.028	2.235ProIle: 2.235 ± 0.043	1.812ProLys: 1.812 ± 0.05	4.634ProLeu: 4.634 ± 0.069	1.281ProMet: 1.281 ± 0.039	1.293ProAsn: 1.293 ± 0.034	3.043ProPro: 3.043 ± 0.076	1.681ProGln: 1.681 ± 0.042	2.798ProArg: 2.798 ± 0.055	2.83ProSer: 2.83 ± 0.055	2.144ProThr: 2.144 ± 0.051	4.378ProVal: 4.378 ± 0.062	0.647ProTrp: 0.647 ± 0.025	1.219ProTyr: 1.219 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.933GlnAla: 3.933 ± 0.068	0.197GlnCys: 0.197 ± 0.013	1.542GlnAsp: 1.542 ± 0.037	1.616GlnGlu: 1.616 ± 0.037	1.115GlnPhe: 1.115 ± 0.03	2.382GlnGly: 2.382 ± 0.044	0.523GlnHis: 0.523 ± 0.022	1.88GlnIle: 1.88 ± 0.04	1.149GlnLys: 1.149 ± 0.03	2.837GlnLeu: 2.837 ± 0.059	0.948GlnMet: 0.948 ± 0.027	0.818GlnAsn: 0.818 ± 0.028	1.642GlnPro: 1.642 ± 0.036	1.023GlnGln: 1.023 ± 0.033	2.133GlnArg: 2.133 ± 0.049	1.799GlnSer: 1.799 ± 0.039	1.94GlnThr: 1.94 ± 0.042	2.096GlnVal: 2.096 ± 0.044	0.375GlnTrp: 0.375 ± 0.019	0.641GlnTyr: 0.641 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.007ArgAla: 8.007 ± 0.104	0.468ArgCys: 0.468 ± 0.022	3.515ArgAsp: 3.515 ± 0.056	4.196ArgGlu: 4.196 ± 0.071	2.722ArgPhe: 2.722 ± 0.052	4.516ArgGly: 4.516 ± 0.07	1.329ArgHis: 1.329 ± 0.033	3.746ArgIle: 3.746 ± 0.056	2.298ArgLys: 2.298 ± 0.052	7.582ArgLeu: 7.582 ± 0.103	1.811ArgMet: 1.811 ± 0.037	1.736ArgAsn: 1.736 ± 0.038	3.523ArgPro: 3.523 ± 0.06	2.337ArgGln: 2.337 ± 0.049	5.002ArgArg: 5.002 ± 0.081	3.506ArgSer: 3.506 ± 0.063	3.318ArgThr: 3.318 ± 0.059	4.439ArgVal: 4.439 ± 0.068	0.924ArgTrp: 0.924 ± 0.028	1.644ArgTyr: 1.644 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.674SerAla: 6.674 ± 0.093	0.435SerCys: 0.435 ± 0.024	3.212SerAsp: 3.212 ± 0.056	3.293SerGlu: 3.293 ± 0.05	2.243SerPhe: 2.243 ± 0.053	5.883SerGly: 5.883 ± 0.072	0.974SerHis: 0.974 ± 0.031	2.702SerIle: 2.702 ± 0.047	1.69SerLys: 1.69 ± 0.038	5.761SerLeu: 5.761 ± 0.065	1.343SerMet: 1.343 ± 0.035	1.407SerAsn: 1.407 ± 0.039	3.193SerPro: 3.193 ± 0.051	1.728SerGln: 1.728 ± 0.038	3.549SerArg: 3.549 ± 0.056	3.093SerSer: 3.093 ± 0.064	2.513SerThr: 2.513 ± 0.057	4.075SerVal: 4.075 ± 0.069	0.787SerTrp: 0.787 ± 0.025	1.356SerTyr: 1.356 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.394ThrAla: 6.394 ± 0.083	0.445ThrCys: 0.445 ± 0.02	3.108ThrAsp: 3.108 ± 0.054	2.972ThrGlu: 2.972 ± 0.053	2.043ThrPhe: 2.043 ± 0.044	5.684ThrGly: 5.684 ± 0.074	1.006ThrHis: 1.006 ± 0.029	2.527ThrIle: 2.527 ± 0.049	1.418ThrLys: 1.418 ± 0.039	6.034ThrLeu: 6.034 ± 0.075	1.093ThrMet: 1.093 ± 0.033	1.326ThrAsn: 1.326 ± 0.037	3.549ThrPro: 3.549 ± 0.061	1.546ThrGln: 1.546 ± 0.036	3.327ThrArg: 3.327 ± 0.059	2.958ThrSer: 2.958 ± 0.054	2.533ThrThr: 2.533 ± 0.053	3.878ThrVal: 3.878 ± 0.059	0.625ThrTrp: 0.625 ± 0.025	1.38ThrTyr: 1.38 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.894ValAla: 7.894 ± 0.099	0.64ValCys: 0.64 ± 0.023	3.716ValAsp: 3.716 ± 0.062	4.193ValGlu: 4.193 ± 0.071	2.808ValPhe: 2.808 ± 0.057	4.751ValGly: 4.751 ± 0.07	1.241ValHis: 1.241 ± 0.036	4.052ValIle: 4.052 ± 0.065	2.342ValLys: 2.342 ± 0.054	6.445ValLeu: 6.445 ± 0.072	1.883ValMet: 1.883 ± 0.046	2.021ValAsn: 2.021 ± 0.045	3.523ValPro: 3.523 ± 0.054	1.924ValGln: 1.924 ± 0.041	4.698ValArg: 4.698 ± 0.069	4.852ValSer: 4.852 ± 0.082	4.465ValThr: 4.465 ± 0.063	4.65ValVal: 4.65 ± 0.08	1.01ValTrp: 1.01 ± 0.033	1.528ValTyr: 1.528 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.354TrpAla: 1.354 ± 0.038	0.138TrpCys: 0.138 ± 0.011	0.686TrpAsp: 0.686 ± 0.026	0.624TrpGlu: 0.624 ± 0.025	0.549TrpPhe: 0.549 ± 0.023	0.969TrpGly: 0.969 ± 0.032	0.295TrpHis: 0.295 ± 0.016	0.712TrpIle: 0.712 ± 0.023	0.49TrpLys: 0.49 ± 0.02	1.589TrpLeu: 1.589 ± 0.047	0.434TrpMet: 0.434 ± 0.02	0.447TrpAsn: 0.447 ± 0.021	0.73TrpPro: 0.73 ± 0.024	0.571TrpGln: 0.571 ± 0.023	1.167TrpArg: 1.167 ± 0.033	0.867TrpSer: 0.867 ± 0.03	0.846TrpThr: 0.846 ± 0.027	0.835TrpVal: 0.835 ± 0.031	0.217TrpTrp: 0.217 ± 0.016	0.272TrpTyr: 0.272 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.625TyrAla: 2.625 ± 0.048	0.22TyrCys: 0.22 ± 0.013	1.568TyrAsp: 1.568 ± 0.04	1.462TyrGlu: 1.462 ± 0.037	0.973TyrPhe: 0.973 ± 0.026	2.21TyrGly: 2.21 ± 0.054	0.433TyrHis: 0.433 ± 0.021	1.029TyrIle: 1.029 ± 0.031	0.703TyrLys: 0.703 ± 0.025	2.11TyrLeu: 2.11 ± 0.038	0.476TyrMet: 0.476 ± 0.023	0.677TyrAsn: 0.677 ± 0.027	1.111TyrPro: 1.111 ± 0.03	0.742TyrGln: 0.742 ± 0.026	1.68TyrArg: 1.68 ± 0.038	1.376TyrSer: 1.376 ± 0.036	1.264TyrThr: 1.264 ± 0.036	1.566TyrVal: 1.566 ± 0.038	0.37TyrTrp: 0.37 ± 0.017	0.636TyrTyr: 0.636 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3499 proteins (1112553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---