Amino acid dipepetide frequency for Moorea producens 3L

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.094AlaAla: 6.094 ± 0.071	0.813AlaCys: 0.813 ± 0.022	3.69AlaAsp: 3.69 ± 0.048	4.501AlaGlu: 4.501 ± 0.045	2.679AlaPhe: 2.679 ± 0.041	4.83AlaGly: 4.83 ± 0.059	1.263AlaHis: 1.263 ± 0.027	5.996AlaIle: 5.996 ± 0.069	4.091AlaLys: 4.091 ± 0.053	8.168AlaLeu: 8.168 ± 0.092	1.571AlaMet: 1.571 ± 0.032	3.221AlaAsn: 3.221 ± 0.058	2.682AlaPro: 2.682 ± 0.042	4.1AlaGln: 4.1 ± 0.054	3.456AlaArg: 3.456 ± 0.052	4.631AlaSer: 4.631 ± 0.056	4.181AlaThr: 4.181 ± 0.054	5.102AlaVal: 5.102 ± 0.055	0.988AlaTrp: 0.988 ± 0.026	2.276AlaTyr: 2.276 ± 0.042	0.004AlaXaa: 0.004 ± 0.001
Cys	0.616CysAla: 0.616 ± 0.023	0.182CysCys: 0.182 ± 0.009	0.605CysAsp: 0.605 ± 0.018	0.509CysGlu: 0.509 ± 0.016	0.444CysPhe: 0.444 ± 0.014	0.806CysGly: 0.806 ± 0.021	0.295CysHis: 0.295 ± 0.012	0.549CysIle: 0.549 ± 0.015	0.398CysLys: 0.398 ± 0.014	1.27CysLeu: 1.27 ± 0.027	0.164CysMet: 0.164 ± 0.009	0.38CysAsn: 0.38 ± 0.012	0.57CysPro: 0.57 ± 0.018	0.639CysGln: 0.639 ± 0.018	0.598CysArg: 0.598 ± 0.019	0.749CysSer: 0.749 ± 0.019	0.423CysThr: 0.423 ± 0.014	0.565CysVal: 0.565 ± 0.015	0.168CysTrp: 0.168 ± 0.009	0.444CysTyr: 0.444 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.292AspAla: 3.292 ± 0.037	0.566AspCys: 0.566 ± 0.021	2.418AspAsp: 2.418 ± 0.052	2.548AspGlu: 2.548 ± 0.04	2.343AspPhe: 2.343 ± 0.041	3.702AspGly: 3.702 ± 0.068	1.017AspHis: 1.017 ± 0.025	3.336AspIle: 3.336 ± 0.041	2.365AspLys: 2.365 ± 0.035	5.907AspLeu: 5.907 ± 0.052	0.827AspMet: 0.827 ± 0.022	2.403AspAsn: 2.403 ± 0.038	2.594AspPro: 2.594 ± 0.039	2.884AspGln: 2.884 ± 0.047	2.85AspArg: 2.85 ± 0.04	3.376AspSer: 3.376 ± 0.048	2.603AspThr: 2.603 ± 0.042	2.945AspVal: 2.945 ± 0.044	1.028AspTrp: 1.028 ± 0.025	2.109AspTyr: 2.109 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.262GluAla: 5.262 ± 0.059	0.503GluCys: 0.503 ± 0.017	2.852GluAsp: 2.852 ± 0.035	4.14GluGlu: 4.14 ± 0.056	2.442GluPhe: 2.442 ± 0.035	3.366GluGly: 3.366 ± 0.047	1.049GluHis: 1.049 ± 0.023	4.584GluIle: 4.584 ± 0.057	3.345GluLys: 3.345 ± 0.042	7.043GluLeu: 7.043 ± 0.062	1.197GluMet: 1.197 ± 0.025	2.524GluAsn: 2.524 ± 0.04	2.541GluPro: 2.541 ± 0.043	3.899GluGln: 3.899 ± 0.055	3.186GluArg: 3.186 ± 0.045	3.763GluSer: 3.763 ± 0.058	3.545GluThr: 3.545 ± 0.044	4.199GluVal: 4.199 ± 0.048	0.802GluTrp: 0.802 ± 0.023	1.772GluTyr: 1.772 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.567PheAla: 2.567 ± 0.039	0.574PheCys: 0.574 ± 0.017	2.31PheAsp: 2.31 ± 0.035	2.245PheGlu: 2.245 ± 0.036	1.6PhePhe: 1.6 ± 0.034	2.798PheGly: 2.798 ± 0.043	0.708PheHis: 0.708 ± 0.019	2.249PheIle: 2.249 ± 0.038	1.762PheLys: 1.762 ± 0.033	3.847PheLeu: 3.847 ± 0.044	0.676PheMet: 0.676 ± 0.016	1.849PheAsn: 1.849 ± 0.037	1.966PhePro: 1.966 ± 0.04	1.772PheGln: 1.772 ± 0.034	1.881PheArg: 1.881 ± 0.029	2.948PheSer: 2.948 ± 0.048	2.127PheThr: 2.127 ± 0.031	2.262PheVal: 2.262 ± 0.035	0.695PheTrp: 0.695 ± 0.02	1.39PheTyr: 1.39 ± 0.029	0.001PheXaa: 0.001 ± 0.001
Gly	4.477GlyAla: 4.477 ± 0.068	0.795GlyCys: 0.795 ± 0.021	3.552GlyAsp: 3.552 ± 0.065	4.139GlyGlu: 4.139 ± 0.045	3.006GlyPhe: 3.006 ± 0.043	4.564GlyGly: 4.564 ± 0.081	1.401GlyHis: 1.401 ± 0.035	5.284GlyIle: 5.284 ± 0.059	4.418GlyLys: 4.418 ± 0.048	7.031GlyLeu: 7.031 ± 0.073	1.596GlyMet: 1.596 ± 0.028	3.519GlyAsn: 3.519 ± 0.071	1.392GlyPro: 1.392 ± 0.031	3.114GlyGln: 3.114 ± 0.048	3.228GlyArg: 3.228 ± 0.04	4.487GlySer: 4.487 ± 0.065	3.833GlyThr: 3.833 ± 0.065	4.589GlyVal: 4.589 ± 0.054	1.233GlyTrp: 1.233 ± 0.028	2.353GlyTyr: 2.353 ± 0.041	0.002GlyXaa: 0.002 ± 0.001
His	0.946HisAla: 0.946 ± 0.022	0.292HisCys: 0.292 ± 0.013	0.796HisAsp: 0.796 ± 0.022	0.814HisGlu: 0.814 ± 0.02	0.755HisPhe: 0.755 ± 0.019	1.232HisGly: 1.232 ± 0.028	0.619HisHis: 0.619 ± 0.021	1.013HisIle: 1.013 ± 0.021	0.879HisLys: 0.879 ± 0.025	2.22HisLeu: 2.22 ± 0.037	0.266HisMet: 0.266 ± 0.012	0.786HisAsn: 0.786 ± 0.021	1.306HisPro: 1.306 ± 0.027	1.341HisGln: 1.341 ± 0.03	1.184HisArg: 1.184 ± 0.024	1.27HisSer: 1.27 ± 0.025	0.926HisThr: 0.926 ± 0.028	0.848HisVal: 0.848 ± 0.019	0.372HisTrp: 0.372 ± 0.014	0.749HisTyr: 0.749 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.147IleAla: 6.147 ± 0.063	0.742IleCys: 0.742 ± 0.02	3.722IleAsp: 3.722 ± 0.047	4.353IleGlu: 4.353 ± 0.049	2.299IlePhe: 2.299 ± 0.034	4.461IleGly: 4.461 ± 0.054	1.194IleHis: 1.194 ± 0.027	3.769IleIle: 3.769 ± 0.047	3.424IleLys: 3.424 ± 0.043	6.187IleLeu: 6.187 ± 0.061	0.899IleMet: 0.899 ± 0.025	3.021IleAsn: 3.021 ± 0.041	3.578IlePro: 3.578 ± 0.044	2.829IleGln: 2.829 ± 0.033	3.152IleArg: 3.152 ± 0.046	4.459IleSer: 4.459 ± 0.046	3.931IleThr: 3.931 ± 0.062	4.014IleVal: 4.014 ± 0.044	0.818IleTrp: 0.818 ± 0.025	1.969IleTyr: 1.969 ± 0.033	0.001IleXaa: 0.001 ± 0.001
Lys	4.18LysAla: 4.18 ± 0.059	0.402LysCys: 0.402 ± 0.014	2.416LysAsp: 2.416 ± 0.041	2.944LysGlu: 2.944 ± 0.046	1.802LysPhe: 1.802 ± 0.031	3.217LysGly: 3.217 ± 0.041	0.938LysHis: 0.938 ± 0.022	3.43LysIle: 3.43 ± 0.053	2.929LysLys: 2.929 ± 0.06	5.892LysLeu: 5.892 ± 0.062	0.905LysMet: 0.905 ± 0.022	2.118LysAsn: 2.118 ± 0.037	2.843LysPro: 2.843 ± 0.046	2.975LysGln: 2.975 ± 0.048	2.845LysArg: 2.845 ± 0.046	3.377LysSer: 3.377 ± 0.045	3.363LysThr: 3.363 ± 0.044	3.424LysVal: 3.424 ± 0.046	0.591LysTrp: 0.591 ± 0.019	1.483LysTyr: 1.483 ± 0.028	0.001LysXaa: 0.001 ± 0.001
Leu	9.093LeuAla: 9.093 ± 0.087	1.056LeuCys: 1.056 ± 0.023	5.742LeuAsp: 5.742 ± 0.061	7.584LeuGlu: 7.584 ± 0.081	3.608LeuPhe: 3.608 ± 0.054	7.875LeuGly: 7.875 ± 0.075	1.777LeuHis: 1.777 ± 0.032	6.563LeuIle: 6.563 ± 0.057	6.137LeuLys: 6.137 ± 0.062	10.996LeuLeu: 10.996 ± 0.108	2.113LeuMet: 2.113 ± 0.035	4.631LeuAsn: 4.631 ± 0.056	5.865LeuPro: 5.865 ± 0.071	4.972LeuGln: 4.972 ± 0.061	5.476LeuArg: 5.476 ± 0.054	7.838LeuSer: 7.838 ± 0.074	6.305LeuThr: 6.305 ± 0.054	7.279LeuVal: 7.279 ± 0.074	1.599LeuTrp: 1.599 ± 0.039	2.696LeuTyr: 2.696 ± 0.04	0.004LeuXaa: 0.004 ± 0.001
Met	1.808MetAla: 1.808 ± 0.031	0.108MetCys: 0.108 ± 0.008	0.79MetAsp: 0.79 ± 0.021	1.134MetGlu: 1.134 ± 0.024	0.579MetPhe: 0.579 ± 0.017	1.5MetGly: 1.5 ± 0.03	0.251MetHis: 0.251 ± 0.011	1.175MetIle: 1.175 ± 0.024	0.945MetLys: 0.945 ± 0.021	1.865MetLeu: 1.865 ± 0.032	0.388MetMet: 0.388 ± 0.015	0.729MetAsn: 0.729 ± 0.019	0.97MetPro: 0.97 ± 0.024	0.648MetGln: 0.648 ± 0.021	0.925MetArg: 0.925 ± 0.024	1.275MetSer: 1.275 ± 0.024	1.25MetThr: 1.25 ± 0.028	1.511MetVal: 1.511 ± 0.031	0.168MetTrp: 0.168 ± 0.01	0.348MetTyr: 0.348 ± 0.012	0.001MetXaa: 0.001 ± 0.001
Asn	2.687AsnAla: 2.687 ± 0.047	0.519AsnCys: 0.519 ± 0.016	1.824AsnAsp: 1.824 ± 0.038	1.554AsnGlu: 1.554 ± 0.028	1.778AsnPhe: 1.778 ± 0.032	2.897AsnGly: 2.897 ± 0.047	1.087AsnHis: 1.087 ± 0.024	2.34AsnIle: 2.34 ± 0.042	1.87AsnLys: 1.87 ± 0.038	5.706AsnLeu: 5.706 ± 0.082	0.61AsnMet: 0.61 ± 0.017	2.09AsnAsn: 2.09 ± 0.046	3.151AsnPro: 3.151 ± 0.046	3.246AsnGln: 3.246 ± 0.047	2.547AsnArg: 2.547 ± 0.039	3.175AsnSer: 3.175 ± 0.053	2.274AsnThr: 2.274 ± 0.037	2.076AsnVal: 2.076 ± 0.033	0.819AsnTrp: 0.819 ± 0.019	1.75AsnTyr: 1.75 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.909ProAla: 2.909 ± 0.048	0.399ProCys: 0.399 ± 0.015	3.257ProAsp: 3.257 ± 0.045	4.115ProGlu: 4.115 ± 0.066	1.686ProPhe: 1.686 ± 0.031	3.132ProGly: 3.132 ± 0.045	0.839ProHis: 0.839 ± 0.024	3.136ProIle: 3.136 ± 0.044	2.601ProLys: 2.601 ± 0.038	4.744ProLeu: 4.744 ± 0.062	0.912ProMet: 0.912 ± 0.023	2.371ProAsn: 2.371 ± 0.04	2.332ProPro: 2.332 ± 0.04	2.395ProGln: 2.395 ± 0.039	1.944ProArg: 1.944 ± 0.032	3.215ProSer: 3.215 ± 0.05	2.873ProThr: 2.873 ± 0.037	3.33ProVal: 3.33 ± 0.045	0.648ProTrp: 0.648 ± 0.018	1.341ProTyr: 1.341 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.451GlnAla: 4.451 ± 0.06	0.407GlnCys: 0.407 ± 0.016	2.501GlnAsp: 2.501 ± 0.037	3.704GlnGlu: 3.704 ± 0.047	1.737GlnPhe: 1.737 ± 0.03	3.604GlnGly: 3.604 ± 0.047	0.9GlnHis: 0.9 ± 0.023	3.241GlnIle: 3.241 ± 0.043	2.818GlnLys: 2.818 ± 0.041	6.64GlnLeu: 6.64 ± 0.08	0.991GlnMet: 0.991 ± 0.021	1.948GlnAsn: 1.948 ± 0.042	2.85GlnPro: 2.85 ± 0.054	3.877GlnGln: 3.877 ± 0.071	2.937GlnArg: 2.937 ± 0.042	3.141GlnSer: 3.141 ± 0.046	2.827GlnThr: 2.827 ± 0.045	3.836GlnVal: 3.836 ± 0.042	0.734GlnTrp: 0.734 ± 0.019	1.224GlnTyr: 1.224 ± 0.026	0.001GlnXaa: 0.001 ± 0.001
Arg	3.164ArgAla: 3.164 ± 0.045	0.597ArgCys: 0.597 ± 0.019	2.552ArgAsp: 2.552 ± 0.036	3.366ArgGlu: 3.366 ± 0.045	2.351ArgPhe: 2.351 ± 0.037	3.072ArgGly: 3.072 ± 0.042	0.999ArgHis: 0.999 ± 0.025	3.291ArgIle: 3.291 ± 0.043	2.617ArgLys: 2.617 ± 0.041	5.945ArgLeu: 5.945 ± 0.06	0.968ArgMet: 0.968 ± 0.023	2.103ArgAsn: 2.103 ± 0.035	2.042ArgPro: 2.042 ± 0.034	3.096ArgGln: 3.096 ± 0.044	3.012ArgArg: 3.012 ± 0.049	3.371ArgSer: 3.371 ± 0.047	2.394ArgThr: 2.394 ± 0.037	3.423ArgVal: 3.423 ± 0.044	0.882ArgTrp: 0.882 ± 0.021	1.978ArgTyr: 1.978 ± 0.028	0.001ArgXaa: 0.001 ± 0.001
Ser	4.528SerAla: 4.528 ± 0.055	0.699SerCys: 0.699 ± 0.017	3.509SerAsp: 3.509 ± 0.047	3.956SerGlu: 3.956 ± 0.051	2.602SerPhe: 2.602 ± 0.044	4.94SerGly: 4.94 ± 0.064	1.262SerHis: 1.262 ± 0.024	3.963SerIle: 3.963 ± 0.05	3.175SerLys: 3.175 ± 0.046	7.386SerLeu: 7.386 ± 0.069	1.212SerMet: 1.212 ± 0.026	3.02SerAsn: 3.02 ± 0.048	3.531SerPro: 3.531 ± 0.049	3.844SerGln: 3.844 ± 0.053	3.414SerArg: 3.414 ± 0.04	4.649SerSer: 4.649 ± 0.062	3.689SerThr: 3.689 ± 0.053	4.114SerVal: 4.114 ± 0.053	1.11SerTrp: 1.11 ± 0.026	2.148SerTyr: 2.148 ± 0.039	0.002SerXaa: 0.002 ± 0.001
Thr	4.185ThrAla: 4.185 ± 0.056	0.467ThrCys: 0.467 ± 0.016	2.833ThrAsp: 2.833 ± 0.05	3.368ThrGlu: 3.368 ± 0.045	2.058ThrPhe: 2.058 ± 0.039	4.267ThrGly: 4.267 ± 0.067	1.003ThrHis: 1.003 ± 0.022	4.005ThrIle: 4.005 ± 0.055	2.589ThrLys: 2.589 ± 0.036	6.263ThrLeu: 6.263 ± 0.065	0.863ThrMet: 0.863 ± 0.022	2.402ThrAsn: 2.402 ± 0.042	3.214ThrPro: 3.214 ± 0.052	2.634ThrGln: 2.634 ± 0.045	2.358ThrArg: 2.358 ± 0.036	3.598ThrSer: 3.598 ± 0.045	3.353ThrThr: 3.353 ± 0.063	4.065ThrVal: 4.065 ± 0.053	0.7ThrTrp: 0.7 ± 0.019	1.65ThrTyr: 1.65 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.234ValAla: 5.234 ± 0.056	0.668ValCys: 0.668 ± 0.018	3.421ValAsp: 3.421 ± 0.044	4.454ValGlu: 4.454 ± 0.055	2.535ValPhe: 2.535 ± 0.039	4.526ValGly: 4.526 ± 0.049	0.95ValHis: 0.95 ± 0.022	4.497ValIle: 4.497 ± 0.05	3.571ValLys: 3.571 ± 0.045	6.405ValLeu: 6.405 ± 0.067	1.427ValMet: 1.427 ± 0.028	2.934ValAsn: 2.934 ± 0.045	2.687ValPro: 2.687 ± 0.038	2.466ValGln: 2.466 ± 0.042	3.325ValArg: 3.325 ± 0.045	4.421ValSer: 4.421 ± 0.052	3.819ValThr: 3.819 ± 0.052	4.755ValVal: 4.755 ± 0.052	0.913ValTrp: 0.913 ± 0.023	1.898ValTyr: 1.898 ± 0.032	0.003ValXaa: 0.003 ± 0.001
Trp	0.881TrpAla: 0.881 ± 0.025	0.186TrpCys: 0.186 ± 0.008	0.77TrpAsp: 0.77 ± 0.025	0.967TrpGlu: 0.967 ± 0.024	0.61TrpPhe: 0.61 ± 0.015	1.037TrpGly: 1.037 ± 0.031	0.355TrpHis: 0.355 ± 0.013	0.888TrpIle: 0.888 ± 0.022	0.718TrpLys: 0.718 ± 0.019	2.04TrpLeu: 2.04 ± 0.04	0.338TrpMet: 0.338 ± 0.012	0.653TrpAsn: 0.653 ± 0.022	0.428TrpPro: 0.428 ± 0.017	1.16TrpGln: 1.16 ± 0.026	0.822TrpArg: 0.822 ± 0.023	0.97TrpSer: 0.97 ± 0.025	0.567TrpThr: 0.567 ± 0.017	1.031TrpVal: 1.031 ± 0.024	0.264TrpTrp: 0.264 ± 0.012	0.462TrpTyr: 0.462 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.814TyrAla: 1.814 ± 0.028	0.401TyrCys: 0.401 ± 0.014	1.552TyrAsp: 1.552 ± 0.031	1.621TyrGlu: 1.621 ± 0.032	1.309TyrPhe: 1.309 ± 0.026	2.184TyrGly: 2.184 ± 0.04	0.709TyrHis: 0.709 ± 0.022	1.657TyrIle: 1.657 ± 0.028	1.42TyrLys: 1.42 ± 0.028	3.651TyrLeu: 3.651 ± 0.044	0.443TyrMet: 0.443 ± 0.015	1.298TyrAsn: 1.298 ± 0.029	1.633TyrPro: 1.633 ± 0.033	2.481TyrGln: 2.481 ± 0.049	2.082TyrArg: 2.082 ± 0.036	2.037TyrSer: 2.037 ± 0.04	1.589TyrThr: 1.589 ± 0.031	1.541TyrVal: 1.541 ± 0.033	0.615TyrTrp: 0.615 ± 0.019	1.233TyrTyr: 1.233 ± 0.032	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.003XaaPhe: 0.003 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.917XaaXaa: 0.917 ± 0.218

Statistics based on 7382 proteins (2118520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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