Amino acid dipepetide frequency for Scytonema tolypothrichoides VB-61278

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.495AlaAla: 7.495 ± 0.093	0.832AlaCys: 0.832 ± 0.023	3.841AlaAsp: 3.841 ± 0.044	4.893AlaGlu: 4.893 ± 0.063	3.023AlaPhe: 3.023 ± 0.044	5.597AlaGly: 5.597 ± 0.072	1.406AlaHis: 1.406 ± 0.034	6.21AlaIle: 6.21 ± 0.069	4.126AlaLys: 4.126 ± 0.058	8.782AlaLeu: 8.782 ± 0.083	1.658AlaMet: 1.658 ± 0.029	3.193AlaAsn: 3.193 ± 0.053	2.802AlaPro: 2.802 ± 0.049	4.36AlaGln: 4.36 ± 0.059	3.907AlaArg: 3.907 ± 0.053	4.922AlaSer: 4.922 ± 0.07	4.603AlaThr: 4.603 ± 0.066	6.027AlaVal: 6.027 ± 0.062	1.002AlaTrp: 1.002 ± 0.025	2.37AlaTyr: 2.37 ± 0.042	0.001AlaXaa: 0.001 ± 0.001
Cys	0.689CysAla: 0.689 ± 0.021	0.179CysCys: 0.179 ± 0.012	0.58CysAsp: 0.58 ± 0.018	0.562CysGlu: 0.562 ± 0.021	0.438CysPhe: 0.438 ± 0.016	0.833CysGly: 0.833 ± 0.021	0.303CysHis: 0.303 ± 0.015	0.582CysIle: 0.582 ± 0.017	0.368CysLys: 0.368 ± 0.014	1.144CysLeu: 1.144 ± 0.03	0.174CysMet: 0.174 ± 0.009	0.349CysAsn: 0.349 ± 0.015	0.545CysPro: 0.545 ± 0.021	0.559CysGln: 0.559 ± 0.018	0.536CysArg: 0.536 ± 0.019	0.619CysSer: 0.619 ± 0.017	0.503CysThr: 0.503 ± 0.018	0.654CysVal: 0.654 ± 0.02	0.141CysTrp: 0.141 ± 0.008	0.363CysTyr: 0.363 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.641AspAla: 3.641 ± 0.042	0.501AspCys: 0.501 ± 0.018	2.175AspAsp: 2.175 ± 0.042	3.101AspGlu: 3.101 ± 0.047	2.281AspPhe: 2.281 ± 0.043	3.289AspGly: 3.289 ± 0.055	0.704AspHis: 0.704 ± 0.026	3.228AspIle: 3.228 ± 0.042	2.376AspLys: 2.376 ± 0.038	5.273AspLeu: 5.273 ± 0.055	0.799AspMet: 0.799 ± 0.022	1.934AspAsn: 1.934 ± 0.033	2.268AspPro: 2.268 ± 0.044	1.73AspGln: 1.73 ± 0.038	2.681AspArg: 2.681 ± 0.043	2.884AspSer: 2.884 ± 0.046	2.482AspThr: 2.482 ± 0.036	3.3AspVal: 3.3 ± 0.048	0.839AspTrp: 0.839 ± 0.024	1.792AspTyr: 1.792 ± 0.036	0.001AspXaa: 0.001 ± 0.001
Glu	5.367GluAla: 5.367 ± 0.059	0.531GluCys: 0.531 ± 0.02	2.677GluAsp: 2.677 ± 0.042	4.309GluGlu: 4.309 ± 0.066	2.451GluPhe: 2.451 ± 0.041	3.3GluGly: 3.3 ± 0.042	1.096GluHis: 1.096 ± 0.029	4.582GluIle: 4.582 ± 0.059	3.582GluLys: 3.582 ± 0.048	6.951GluLeu: 6.951 ± 0.078	1.303GluMet: 1.303 ± 0.025	2.683GluAsn: 2.683 ± 0.035	2.416GluPro: 2.416 ± 0.033	3.666GluGln: 3.666 ± 0.054	3.684GluArg: 3.684 ± 0.052	3.32GluSer: 3.32 ± 0.049	3.424GluThr: 3.424 ± 0.048	4.52GluVal: 4.52 ± 0.059	0.796GluTrp: 0.796 ± 0.024	1.908GluTyr: 1.908 ± 0.035	0.001GluXaa: 0.001 ± 0.001
Phe	3.187PheAla: 3.187 ± 0.045	0.576PheCys: 0.576 ± 0.019	2.169PheAsp: 2.169 ± 0.04	2.254PheGlu: 2.254 ± 0.038	1.807PhePhe: 1.807 ± 0.035	3.098PheGly: 3.098 ± 0.052	0.839PheHis: 0.839 ± 0.021	2.352PheIle: 2.352 ± 0.043	1.635PheLys: 1.635 ± 0.038	4.17PheLeu: 4.17 ± 0.054	0.689PheMet: 0.689 ± 0.02	1.662PheAsn: 1.662 ± 0.035	1.829PhePro: 1.829 ± 0.037	1.791PheGln: 1.791 ± 0.034	1.899PheArg: 1.899 ± 0.036	2.971PheSer: 2.971 ± 0.042	2.299PheThr: 2.299 ± 0.039	2.703PheVal: 2.703 ± 0.042	0.692PheTrp: 0.692 ± 0.02	1.356PheTyr: 1.356 ± 0.028	0.001PheXaa: 0.001 ± 0.001
Gly	4.934GlyAla: 4.934 ± 0.069	0.8GlyCys: 0.8 ± 0.023	3.244GlyAsp: 3.244 ± 0.047	4.243GlyGlu: 4.243 ± 0.05	3.032GlyPhe: 3.032 ± 0.046	4.907GlyGly: 4.907 ± 0.076	1.347GlyHis: 1.347 ± 0.032	4.839GlyIle: 4.839 ± 0.062	4.036GlyLys: 4.036 ± 0.054	7.087GlyLeu: 7.087 ± 0.054	1.551GlyMet: 1.551 ± 0.027	2.839GlyAsn: 2.839 ± 0.059	1.505GlyPro: 1.505 ± 0.034	2.866GlyGln: 2.866 ± 0.044	3.539GlyArg: 3.539 ± 0.051	4.176GlySer: 4.176 ± 0.06	3.861GlyThr: 3.861 ± 0.048	5.221GlyVal: 5.221 ± 0.068	1.099GlyTrp: 1.099 ± 0.027	2.393GlyTyr: 2.393 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.185HisAla: 1.185 ± 0.03	0.242HisCys: 0.242 ± 0.012	0.79HisAsp: 0.79 ± 0.024	0.991HisGlu: 0.991 ± 0.027	0.849HisPhe: 0.849 ± 0.025	1.185HisGly: 1.185 ± 0.023	0.608HisHis: 0.608 ± 0.023	1.117HisIle: 1.117 ± 0.028	0.854HisLys: 0.854 ± 0.019	2.335HisLeu: 2.335 ± 0.041	0.309HisMet: 0.309 ± 0.014	0.744HisAsn: 0.744 ± 0.019	1.319HisPro: 1.319 ± 0.029	1.119HisGln: 1.119 ± 0.031	1.131HisArg: 1.131 ± 0.025	1.322HisSer: 1.322 ± 0.03	1.01HisThr: 1.01 ± 0.025	0.961HisVal: 0.961 ± 0.023	0.371HisTrp: 0.371 ± 0.016	0.663HisTyr: 0.663 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.66IleAla: 6.66 ± 0.067	0.734IleCys: 0.734 ± 0.02	3.392IleAsp: 3.392 ± 0.05	4.024IleGlu: 4.024 ± 0.051	2.489IlePhe: 2.489 ± 0.047	4.399IleGly: 4.399 ± 0.058	1.27IleHis: 1.27 ± 0.028	3.679IleIle: 3.679 ± 0.052	2.866IleLys: 2.866 ± 0.046	6.541IleLeu: 6.541 ± 0.071	0.877IleMet: 0.877 ± 0.024	2.803IleAsn: 2.803 ± 0.046	3.436IlePro: 3.436 ± 0.046	2.899IleGln: 2.899 ± 0.043	3.153IleArg: 3.153 ± 0.043	4.388IleSer: 4.388 ± 0.049	3.608IleThr: 3.608 ± 0.048	4.382IleVal: 4.382 ± 0.051	0.823IleTrp: 0.823 ± 0.022	1.845IleTyr: 1.845 ± 0.036	0.002IleXaa: 0.002 ± 0.001
Lys	4.155LysAla: 4.155 ± 0.061	0.339LysCys: 0.339 ± 0.016	2.257LysAsp: 2.257 ± 0.04	3.084LysGlu: 3.084 ± 0.044	1.789LysPhe: 1.789 ± 0.035	2.802LysGly: 2.802 ± 0.047	0.85LysHis: 0.85 ± 0.026	3.341LysIle: 3.341 ± 0.046	2.522LysLys: 2.522 ± 0.053	5.327LysLeu: 5.327 ± 0.061	0.956LysMet: 0.956 ± 0.022	2.166LysAsn: 2.166 ± 0.039	2.601LysPro: 2.601 ± 0.04	2.955LysGln: 2.955 ± 0.049	2.584LysArg: 2.584 ± 0.039	3.062LysSer: 3.062 ± 0.05	3.069LysThr: 3.069 ± 0.044	3.443LysVal: 3.443 ± 0.05	0.519LysTrp: 0.519 ± 0.017	1.453LysTyr: 1.453 ± 0.034	0.001LysXaa: 0.001 ± 0.001
Leu	9.368LeuAla: 9.368 ± 0.083	1.08LeuCys: 1.08 ± 0.026	5.137LeuAsp: 5.137 ± 0.049	7.191LeuGlu: 7.191 ± 0.072	3.923LeuPhe: 3.923 ± 0.056	7.585LeuGly: 7.585 ± 0.076	1.919LeuHis: 1.919 ± 0.035	6.394LeuIle: 6.394 ± 0.076	5.67LeuLys: 5.67 ± 0.07	11.538LeuLeu: 11.538 ± 0.12	2.065LeuMet: 2.065 ± 0.041	4.469LeuAsn: 4.469 ± 0.056	5.731LeuPro: 5.731 ± 0.07	5.683LeuGln: 5.683 ± 0.064	5.805LeuArg: 5.805 ± 0.059	7.488LeuSer: 7.488 ± 0.078	6.374LeuThr: 6.374 ± 0.071	7.506LeuVal: 7.506 ± 0.072	1.417LeuTrp: 1.417 ± 0.036	2.716LeuTyr: 2.716 ± 0.04	0.001LeuXaa: 0.001 ± 0.001
Met	1.605MetAla: 1.605 ± 0.03	0.135MetCys: 0.135 ± 0.009	0.729MetAsp: 0.729 ± 0.022	1.022MetGlu: 1.022 ± 0.026	0.604MetPhe: 0.604 ± 0.019	1.306MetGly: 1.306 ± 0.031	0.341MetHis: 0.341 ± 0.015	1.12MetIle: 1.12 ± 0.028	1.018MetLys: 1.018 ± 0.027	1.966MetLeu: 1.966 ± 0.038	0.423MetMet: 0.423 ± 0.016	0.857MetAsn: 0.857 ± 0.021	0.931MetPro: 0.931 ± 0.024	0.964MetGln: 0.964 ± 0.026	1.006MetArg: 1.006 ± 0.022	1.379MetSer: 1.379 ± 0.026	1.454MetThr: 1.454 ± 0.03	1.314MetVal: 1.314 ± 0.03	0.161MetTrp: 0.161 ± 0.009	0.368MetTyr: 0.368 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.906AsnAla: 2.906 ± 0.045	0.474AsnCys: 0.474 ± 0.015	1.59AsnAsp: 1.59 ± 0.032	1.818AsnGlu: 1.818 ± 0.036	1.872AsnPhe: 1.872 ± 0.036	2.688AsnGly: 2.688 ± 0.051	0.855AsnHis: 0.855 ± 0.023	2.721AsnIle: 2.721 ± 0.05	1.755AsnLys: 1.755 ± 0.031	5.102AsnLeu: 5.102 ± 0.066	0.639AsnMet: 0.639 ± 0.021	1.888AsnAsn: 1.888 ± 0.042	2.8AsnPro: 2.8 ± 0.049	2.459AsnGln: 2.459 ± 0.038	2.379AsnArg: 2.379 ± 0.042	2.995AsnSer: 2.995 ± 0.046	2.342AsnThr: 2.342 ± 0.042	2.415AsnVal: 2.415 ± 0.041	0.699AsnTrp: 0.699 ± 0.023	1.404AsnTyr: 1.404 ± 0.032	0.001AsnXaa: 0.001 ± 0.001
Pro	3.214ProAla: 3.214 ± 0.051	0.356ProCys: 0.356 ± 0.015	2.834ProAsp: 2.834 ± 0.035	3.773ProGlu: 3.773 ± 0.047	1.773ProPhe: 1.773 ± 0.039	3.105ProGly: 3.105 ± 0.048	0.937ProHis: 0.937 ± 0.022	2.962ProIle: 2.962 ± 0.045	2.339ProLys: 2.339 ± 0.041	4.629ProLeu: 4.629 ± 0.052	0.786ProMet: 0.786 ± 0.022	2.176ProAsn: 2.176 ± 0.037	2.395ProPro: 2.395 ± 0.057	2.594ProGln: 2.594 ± 0.042	1.868ProArg: 1.868 ± 0.034	3.041ProSer: 3.041 ± 0.047	2.969ProThr: 2.969 ± 0.051	3.48ProVal: 3.48 ± 0.048	0.615ProTrp: 0.615 ± 0.021	1.331ProTyr: 1.331 ± 0.026	0.001ProXaa: 0.001 ± 0.001
Gln	4.772GlnAla: 4.772 ± 0.073	0.351GlnCys: 0.351 ± 0.017	2.09GlnAsp: 2.09 ± 0.034	3.721GlnGlu: 3.721 ± 0.059	1.756GlnPhe: 1.756 ± 0.03	3.194GlnGly: 3.194 ± 0.049	0.903GlnHis: 0.903 ± 0.019	3.463GlnIle: 3.463 ± 0.049	2.973GlnLys: 2.973 ± 0.047	5.952GlnLeu: 5.952 ± 0.075	1.13GlnMet: 1.13 ± 0.027	2.108GlnAsn: 2.108 ± 0.04	2.57GlnPro: 2.57 ± 0.038	3.916GlnGln: 3.916 ± 0.082	3.011GlnArg: 3.011 ± 0.045	2.857GlnSer: 2.857 ± 0.044	3.014GlnThr: 3.014 ± 0.04	3.913GlnVal: 3.913 ± 0.045	0.626GlnTrp: 0.626 ± 0.02	1.256GlnTyr: 1.256 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	3.513ArgAla: 3.513 ± 0.048	0.546ArgCys: 0.546 ± 0.02	2.517ArgAsp: 2.517 ± 0.041	3.436ArgGlu: 3.436 ± 0.048	2.28ArgPhe: 2.28 ± 0.036	3.194ArgGly: 3.194 ± 0.047	1.043ArgHis: 1.043 ± 0.025	3.323ArgIle: 3.323 ± 0.047	2.411ArgLys: 2.411 ± 0.036	6.178ArgLeu: 6.178 ± 0.07	1.089ArgMet: 1.089 ± 0.024	2.187ArgAsn: 2.187 ± 0.04	2.18ArgPro: 2.18 ± 0.041	3.228ArgGln: 3.228 ± 0.046	3.4ArgArg: 3.4 ± 0.05	3.185ArgSer: 3.185 ± 0.044	2.704ArgThr: 2.704 ± 0.043	3.765ArgVal: 3.765 ± 0.047	0.826ArgTrp: 0.826 ± 0.021	1.956ArgTyr: 1.956 ± 0.034	0.001ArgXaa: 0.001 ± 0.001
Ser	4.564SerAla: 4.564 ± 0.058	0.658SerCys: 0.658 ± 0.02	3.083SerAsp: 3.083 ± 0.044	3.651SerGlu: 3.651 ± 0.053	2.647SerPhe: 2.647 ± 0.044	4.709SerGly: 4.709 ± 0.067	1.385SerHis: 1.385 ± 0.031	3.74SerIle: 3.74 ± 0.046	2.901SerLys: 2.901 ± 0.05	7.143SerLeu: 7.143 ± 0.067	1.15SerMet: 1.15 ± 0.026	2.621SerAsn: 2.621 ± 0.044	3.351SerPro: 3.351 ± 0.058	3.628SerGln: 3.628 ± 0.05	3.362SerArg: 3.362 ± 0.044	4.564SerSer: 4.564 ± 0.07	3.648SerThr: 3.648 ± 0.054	4.453SerVal: 4.453 ± 0.05	0.94SerTrp: 0.94 ± 0.025	1.797SerTyr: 1.797 ± 0.032	0.002SerXaa: 0.002 ± 0.001
Thr	4.746ThrAla: 4.746 ± 0.051	0.504ThrCys: 0.504 ± 0.017	2.573ThrAsp: 2.573 ± 0.041	3.225ThrGlu: 3.225 ± 0.048	2.175ThrPhe: 2.175 ± 0.046	4.318ThrGly: 4.318 ± 0.053	1.091ThrHis: 1.091 ± 0.024	3.623ThrIle: 3.623 ± 0.054	2.438ThrLys: 2.438 ± 0.04	6.401ThrLeu: 6.401 ± 0.069	0.836ThrMet: 0.836 ± 0.024	2.284ThrAsn: 2.284 ± 0.037	3.578ThrPro: 3.578 ± 0.057	3.06ThrGln: 3.06 ± 0.045	2.631ThrArg: 2.631 ± 0.038	3.646ThrSer: 3.646 ± 0.051	3.542ThrThr: 3.542 ± 0.051	4.244ThrVal: 4.244 ± 0.052	0.722ThrTrp: 0.722 ± 0.022	1.585ThrTyr: 1.585 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	6.09ValAla: 6.09 ± 0.07	0.737ValCys: 0.737 ± 0.02	3.511ValAsp: 3.511 ± 0.05	4.682ValGlu: 4.682 ± 0.05	2.812ValPhe: 2.812 ± 0.052	5.038ValGly: 5.038 ± 0.063	1.184ValHis: 1.184 ± 0.029	4.458ValIle: 4.458 ± 0.052	3.461ValLys: 3.461 ± 0.05	7.312ValLeu: 7.312 ± 0.073	1.481ValMet: 1.481 ± 0.026	2.976ValAsn: 2.976 ± 0.04	3.092ValPro: 3.092 ± 0.044	3.168ValGln: 3.168 ± 0.045	3.607ValArg: 3.607 ± 0.047	4.508ValSer: 4.508 ± 0.054	4.066ValThr: 4.066 ± 0.06	5.462ValVal: 5.462 ± 0.069	0.893ValTrp: 0.893 ± 0.024	1.915ValTyr: 1.915 ± 0.03	0.001ValXaa: 0.001 ± 0.001
Trp	0.865TrpAla: 0.865 ± 0.023	0.162TrpCys: 0.162 ± 0.011	0.614TrpAsp: 0.614 ± 0.021	0.887TrpGlu: 0.887 ± 0.024	0.633TrpPhe: 0.633 ± 0.02	0.948TrpGly: 0.948 ± 0.026	0.33TrpHis: 0.33 ± 0.014	0.836TrpIle: 0.836 ± 0.023	0.604TrpLys: 0.604 ± 0.022	1.813TrpLeu: 1.813 ± 0.038	0.328TrpMet: 0.328 ± 0.015	0.641TrpAsn: 0.641 ± 0.02	0.236TrpPro: 0.236 ± 0.012	1.088TrpGln: 1.088 ± 0.026	0.86TrpArg: 0.86 ± 0.021	0.812TrpSer: 0.812 ± 0.023	0.658TrpThr: 0.658 ± 0.02	0.957TrpVal: 0.957 ± 0.024	0.25TrpTrp: 0.25 ± 0.012	0.408TrpTyr: 0.408 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.094TyrAla: 2.094 ± 0.032	0.381TyrCys: 0.381 ± 0.015	1.475TyrAsp: 1.475 ± 0.034	1.698TyrGlu: 1.698 ± 0.031	1.344TyrPhe: 1.344 ± 0.031	2.022TyrGly: 2.022 ± 0.042	0.694TyrHis: 0.694 ± 0.02	1.702TyrIle: 1.702 ± 0.03	1.338TyrLys: 1.338 ± 0.028	3.414TyrLeu: 3.414 ± 0.047	0.463TyrMet: 0.463 ± 0.017	1.22TyrAsn: 1.22 ± 0.027	1.592TyrPro: 1.592 ± 0.036	1.841TyrGln: 1.841 ± 0.039	1.92TyrArg: 1.92 ± 0.034	1.858TyrSer: 1.858 ± 0.036	1.591TyrThr: 1.591 ± 0.031	1.732TyrVal: 1.732 ± 0.032	0.499TyrTrp: 0.499 ± 0.018	1.057TyrTyr: 1.057 ± 0.027	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5627 proteins (1720987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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