Amino acid dipepetide frequency for Candidatus Burkholderia verschuerenii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.272AlaAla: 15.272 ± 0.132	1.259AlaCys: 1.259 ± 0.031	6.764AlaAsp: 6.764 ± 0.075	5.889AlaGlu: 5.889 ± 0.066	4.407AlaPhe: 4.407 ± 0.059	9.085AlaGly: 9.085 ± 0.093	2.806AlaHis: 2.806 ± 0.048	6.11AlaIle: 6.11 ± 0.071	4.463AlaLys: 4.463 ± 0.068	13.606AlaLeu: 13.606 ± 0.121	3.505AlaMet: 3.505 ± 0.054	3.364AlaAsn: 3.364 ± 0.051	5.378AlaPro: 5.378 ± 0.076	5.106AlaGln: 5.106 ± 0.057	8.903AlaArg: 8.903 ± 0.097	7.572AlaSer: 7.572 ± 0.073	6.068AlaThr: 6.068 ± 0.08	8.21AlaVal: 8.21 ± 0.091	1.547AlaTrp: 1.547 ± 0.035	2.657AlaTyr: 2.657 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.261CysAla: 1.261 ± 0.029	0.13CysCys: 0.13 ± 0.011	0.588CysAsp: 0.588 ± 0.022	0.51CysGlu: 0.51 ± 0.019	0.359CysPhe: 0.359 ± 0.015	0.98CysGly: 0.98 ± 0.031	0.26CysHis: 0.26 ± 0.013	0.442CysIle: 0.442 ± 0.018	0.268CysLys: 0.268 ± 0.013	0.752CysLeu: 0.752 ± 0.024	0.213CysMet: 0.213 ± 0.011	0.233CysAsn: 0.233 ± 0.013	0.453CysPro: 0.453 ± 0.021	0.221CysGln: 0.221 ± 0.014	0.602CysArg: 0.602 ± 0.025	0.554CysSer: 0.554 ± 0.02	0.494CysThr: 0.494 ± 0.018	0.807CysVal: 0.807 ± 0.025	0.114CysTrp: 0.114 ± 0.01	0.232CysTyr: 0.232 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.314AspAla: 8.314 ± 0.099	0.504AspCys: 0.504 ± 0.016	3.668AspAsp: 3.668 ± 0.059	3.709AspGlu: 3.709 ± 0.053	2.083AspPhe: 2.083 ± 0.036	4.633AspGly: 4.633 ± 0.061	1.24AspHis: 1.24 ± 0.032	2.9AspIle: 2.9 ± 0.052	1.922AspLys: 1.922 ± 0.045	5.237AspLeu: 5.237 ± 0.065	1.314AspMet: 1.314 ± 0.032	1.406AspAsn: 1.406 ± 0.036	2.857AspPro: 2.857 ± 0.047	1.719AspGln: 1.719 ± 0.032	3.632AspArg: 3.632 ± 0.051	2.678AspSer: 2.678 ± 0.046	2.919AspThr: 2.919 ± 0.049	4.575AspVal: 4.575 ± 0.058	0.898AspTrp: 0.898 ± 0.023	1.588AspTyr: 1.588 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.41GluAla: 6.41 ± 0.067	0.437GluCys: 0.437 ± 0.018	2.324GluAsp: 2.324 ± 0.044	2.577GluGlu: 2.577 ± 0.047	1.878GluPhe: 1.878 ± 0.037	3.504GluGly: 3.504 ± 0.049	1.526GluHis: 1.526 ± 0.032	2.853GluIle: 2.853 ± 0.052	2.111GluLys: 2.111 ± 0.048	5.461GluLeu: 5.461 ± 0.069	1.401GluMet: 1.401 ± 0.034	1.511GluAsn: 1.511 ± 0.033	2.447GluPro: 2.447 ± 0.041	2.331GluGln: 2.331 ± 0.045	4.898GluArg: 4.898 ± 0.072	2.906GluSer: 2.906 ± 0.05	2.966GluThr: 2.966 ± 0.043	3.535GluVal: 3.535 ± 0.061	0.779GluTrp: 0.779 ± 0.024	1.2GluTyr: 1.2 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.729PheAla: 4.729 ± 0.059	0.436PheCys: 0.436 ± 0.019	2.966PheAsp: 2.966 ± 0.049	2.119PheGlu: 2.119 ± 0.043	1.547PhePhe: 1.547 ± 0.04	3.712PheGly: 3.712 ± 0.066	0.777PheHis: 0.777 ± 0.026	1.798PheIle: 1.798 ± 0.04	1.174PheLys: 1.174 ± 0.03	3.026PheLeu: 3.026 ± 0.056	0.849PheMet: 0.849 ± 0.026	1.166PheAsn: 1.166 ± 0.027	1.55PhePro: 1.55 ± 0.035	1.012PheGln: 1.012 ± 0.027	2.0PheArg: 2.0 ± 0.037	2.35PheSer: 2.35 ± 0.043	1.965PheThr: 1.965 ± 0.035	3.137PheVal: 3.137 ± 0.046	0.507PheTrp: 0.507 ± 0.021	0.967PheTyr: 0.967 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.903GlyAla: 8.903 ± 0.09	0.856GlyCys: 0.856 ± 0.029	4.072GlyAsp: 4.072 ± 0.053	4.277GlyGlu: 4.277 ± 0.056	3.405GlyPhe: 3.405 ± 0.052	6.374GlyGly: 6.374 ± 0.083	1.843GlyHis: 1.843 ± 0.04	4.479GlyIle: 4.479 ± 0.063	3.412GlyLys: 3.412 ± 0.049	7.456GlyLeu: 7.456 ± 0.082	2.334GlyMet: 2.334 ± 0.04	2.307GlyAsn: 2.307 ± 0.051	2.709GlyPro: 2.709 ± 0.048	2.54GlyGln: 2.54 ± 0.041	5.076GlyArg: 5.076 ± 0.072	4.322GlySer: 4.322 ± 0.056	4.271GlyThr: 4.271 ± 0.063	6.404GlyVal: 6.404 ± 0.079	1.239GlyTrp: 1.239 ± 0.031	2.293GlyTyr: 2.293 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	3.09HisAla: 3.09 ± 0.054	0.256HisCys: 0.256 ± 0.014	1.492HisAsp: 1.492 ± 0.031	1.258HisGlu: 1.258 ± 0.032	0.931HisPhe: 0.931 ± 0.026	2.135HisGly: 2.135 ± 0.041	0.627HisHis: 0.627 ± 0.025	1.068HisIle: 1.068 ± 0.024	0.595HisLys: 0.595 ± 0.02	2.12HisLeu: 2.12 ± 0.04	0.536HisMet: 0.536 ± 0.017	0.527HisAsn: 0.527 ± 0.018	1.327HisPro: 1.327 ± 0.034	0.682HisGln: 0.682 ± 0.022	1.607HisArg: 1.607 ± 0.036	1.078HisSer: 1.078 ± 0.028	1.072HisThr: 1.072 ± 0.028	1.697HisVal: 1.697 ± 0.035	0.373HisTrp: 0.373 ± 0.016	0.669HisTyr: 0.669 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.661IleAla: 7.661 ± 0.08	0.475IleCys: 0.475 ± 0.017	3.948IleAsp: 3.948 ± 0.057	3.563IleGlu: 3.563 ± 0.051	1.597IlePhe: 1.597 ± 0.04	5.178IleGly: 5.178 ± 0.069	0.959IleHis: 0.959 ± 0.027	1.934IleIle: 1.934 ± 0.037	1.615IleLys: 1.615 ± 0.037	3.525IleLeu: 3.525 ± 0.064	0.873IleMet: 0.873 ± 0.031	1.565IleAsn: 1.565 ± 0.034	2.157IlePro: 2.157 ± 0.04	1.309IleGln: 1.309 ± 0.031	2.897IleArg: 2.897 ± 0.05	2.626IleSer: 2.626 ± 0.043	2.522IleThr: 2.522 ± 0.045	4.824IleVal: 4.824 ± 0.064	0.491IleTrp: 0.491 ± 0.02	1.103IleTyr: 1.103 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.834LysAla: 3.834 ± 0.062	0.205LysCys: 0.205 ± 0.013	1.751LysAsp: 1.751 ± 0.04	1.701LysGlu: 1.701 ± 0.041	1.072LysPhe: 1.072 ± 0.032	2.407LysGly: 2.407 ± 0.041	0.842LysHis: 0.842 ± 0.023	1.861LysIle: 1.861 ± 0.039	1.656LysLys: 1.656 ± 0.05	3.792LysLeu: 3.792 ± 0.057	0.916LysMet: 0.916 ± 0.029	1.127LysAsn: 1.127 ± 0.03	2.274LysPro: 2.274 ± 0.044	1.522LysGln: 1.522 ± 0.037	2.929LysArg: 2.929 ± 0.05	2.119LysSer: 2.119 ± 0.04	2.15LysThr: 2.15 ± 0.042	2.471LysVal: 2.471 ± 0.047	0.427LysTrp: 0.427 ± 0.015	0.799LysTyr: 0.799 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.927LeuAla: 12.927 ± 0.125	0.965LeuCys: 0.965 ± 0.029	6.266LeuAsp: 6.266 ± 0.079	4.835LeuGlu: 4.835 ± 0.067	3.579LeuPhe: 3.579 ± 0.059	7.557LeuGly: 7.557 ± 0.078	2.201LeuHis: 2.201 ± 0.041	4.973LeuIle: 4.973 ± 0.072	3.688LeuLys: 3.688 ± 0.062	9.422LeuLeu: 9.422 ± 0.108	2.37LeuMet: 2.37 ± 0.047	2.904LeuAsn: 2.904 ± 0.045	5.33LeuPro: 5.33 ± 0.059	3.191LeuGln: 3.191 ± 0.045	6.779LeuArg: 6.779 ± 0.076	6.341LeuSer: 6.341 ± 0.076	5.456LeuThr: 5.456 ± 0.066	7.041LeuVal: 7.041 ± 0.08	1.034LeuTrp: 1.034 ± 0.027	2.139LeuTyr: 2.139 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.521MetAla: 2.521 ± 0.04	0.214MetCys: 0.214 ± 0.013	1.028MetAsp: 1.028 ± 0.025	1.045MetGlu: 1.045 ± 0.027	0.893MetPhe: 0.893 ± 0.024	1.579MetGly: 1.579 ± 0.037	0.591MetHis: 0.591 ± 0.022	1.296MetIle: 1.296 ± 0.033	1.187MetLys: 1.187 ± 0.03	2.826MetLeu: 2.826 ± 0.047	0.682MetMet: 0.682 ± 0.024	1.046MetAsn: 1.046 ± 0.028	1.603MetPro: 1.603 ± 0.032	1.081MetGln: 1.081 ± 0.029	2.013MetArg: 2.013 ± 0.04	1.902MetSer: 1.902 ± 0.038	1.717MetThr: 1.717 ± 0.038	1.514MetVal: 1.514 ± 0.031	0.233MetTrp: 0.233 ± 0.013	0.414MetTyr: 0.414 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.675AsnAla: 3.675 ± 0.058	0.283AsnCys: 0.283 ± 0.015	1.693AsnAsp: 1.693 ± 0.037	1.447AsnGlu: 1.447 ± 0.032	1.078AsnPhe: 1.078 ± 0.026	2.69AsnGly: 2.69 ± 0.056	0.552AsnHis: 0.552 ± 0.018	1.415AsnIle: 1.415 ± 0.033	0.887AsnLys: 0.887 ± 0.03	2.813AsnLeu: 2.813 ± 0.051	0.631AsnMet: 0.631 ± 0.02	0.917AsnAsn: 0.917 ± 0.033	1.875AsnPro: 1.875 ± 0.036	0.954AsnGln: 0.954 ± 0.029	1.883AsnArg: 1.883 ± 0.036	1.359AsnSer: 1.359 ± 0.038	1.573AsnThr: 1.573 ± 0.032	2.386AsnVal: 2.386 ± 0.049	0.44AsnTrp: 0.44 ± 0.018	0.734AsnTyr: 0.734 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.636ProAla: 5.636 ± 0.062	0.346ProCys: 0.346 ± 0.014	3.231ProAsp: 3.231 ± 0.048	3.054ProGlu: 3.054 ± 0.053	1.917ProPhe: 1.917 ± 0.039	3.711ProGly: 3.711 ± 0.049	1.24ProHis: 1.24 ± 0.035	2.236ProIle: 2.236 ± 0.035	1.755ProLys: 1.755 ± 0.041	4.722ProLeu: 4.722 ± 0.058	1.161ProMet: 1.161 ± 0.027	1.592ProAsn: 1.592 ± 0.036	2.289ProPro: 2.289 ± 0.051	1.818ProGln: 1.818 ± 0.034	2.752ProArg: 2.752 ± 0.048	2.941ProSer: 2.941 ± 0.043	2.608ProThr: 2.608 ± 0.043	4.004ProVal: 4.004 ± 0.055	0.581ProTrp: 0.581 ± 0.019	1.185ProTyr: 1.185 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.289GlnAla: 4.289 ± 0.058	0.286GlnCys: 0.286 ± 0.014	1.445GlnAsp: 1.445 ± 0.034	1.466GlnGlu: 1.466 ± 0.037	1.293GlnPhe: 1.293 ± 0.029	2.486GlnGly: 2.486 ± 0.044	0.84GlnHis: 0.84 ± 0.025	2.028GlnIle: 2.028 ± 0.038	1.314GlnLys: 1.314 ± 0.036	3.449GlnLeu: 3.449 ± 0.053	1.062GlnMet: 1.062 ± 0.026	0.997GlnAsn: 0.997 ± 0.03	1.853GlnPro: 1.853 ± 0.038	1.707GlnGln: 1.707 ± 0.039	2.776GlnArg: 2.776 ± 0.045	2.145GlnSer: 2.145 ± 0.037	2.061GlnThr: 2.061 ± 0.038	2.365GlnVal: 2.365 ± 0.044	0.546GlnTrp: 0.546 ± 0.022	0.917GlnTyr: 0.917 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.465ArgAla: 8.465 ± 0.099	0.668ArgCys: 0.668 ± 0.023	4.165ArgAsp: 4.165 ± 0.062	4.466ArgGlu: 4.466 ± 0.07	2.988ArgPhe: 2.988 ± 0.05	4.604ArgGly: 4.604 ± 0.064	1.874ArgHis: 1.874 ± 0.045	3.751ArgIle: 3.751 ± 0.059	2.242ArgLys: 2.242 ± 0.042	6.845ArgLeu: 6.845 ± 0.086	1.948ArgMet: 1.948 ± 0.041	1.894ArgAsn: 1.894 ± 0.04	2.936ArgPro: 2.936 ± 0.04	2.385ArgGln: 2.385 ± 0.047	5.299ArgArg: 5.299 ± 0.081	3.349ArgSer: 3.349 ± 0.049	3.338ArgThr: 3.338 ± 0.05	5.347ArgVal: 5.347 ± 0.073	1.015ArgTrp: 1.015 ± 0.028	1.943ArgTyr: 1.943 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.779SerAla: 6.779 ± 0.069	0.502SerCys: 0.502 ± 0.021	3.148SerAsp: 3.148 ± 0.044	2.669SerGlu: 2.669 ± 0.046	2.258SerPhe: 2.258 ± 0.042	5.19SerGly: 5.19 ± 0.067	1.199SerHis: 1.199 ± 0.03	3.096SerIle: 3.096 ± 0.045	2.018SerLys: 2.018 ± 0.033	5.801SerLeu: 5.801 ± 0.066	1.551SerMet: 1.551 ± 0.038	1.846SerAsn: 1.846 ± 0.038	2.773SerPro: 2.773 ± 0.043	1.848SerGln: 1.848 ± 0.03	3.794SerArg: 3.794 ± 0.057	3.57SerSer: 3.57 ± 0.056	3.188SerThr: 3.188 ± 0.055	4.347SerVal: 4.347 ± 0.06	0.68SerTrp: 0.68 ± 0.022	1.368SerTyr: 1.368 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.62ThrAla: 5.62 ± 0.07	0.452ThrCys: 0.452 ± 0.019	2.805ThrAsp: 2.805 ± 0.045	2.382ThrGlu: 2.382 ± 0.042	1.998ThrPhe: 1.998 ± 0.038	4.461ThrGly: 4.461 ± 0.06	1.339ThrHis: 1.339 ± 0.032	2.786ThrIle: 2.786 ± 0.044	1.565ThrLys: 1.565 ± 0.03	6.324ThrLeu: 6.324 ± 0.074	1.28ThrMet: 1.28 ± 0.029	1.439ThrAsn: 1.439 ± 0.036	3.414ThrPro: 3.414 ± 0.046	2.018ThrGln: 2.018 ± 0.041	3.646ThrArg: 3.646 ± 0.05	2.991ThrSer: 2.991 ± 0.052	2.962ThrThr: 2.962 ± 0.051	4.316ThrVal: 4.316 ± 0.059	0.639ThrTrp: 0.639 ± 0.023	1.276ThrTyr: 1.276 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.829ValAla: 8.829 ± 0.083	0.799ValCys: 0.799 ± 0.026	4.412ValAsp: 4.412 ± 0.059	4.281ValGlu: 4.281 ± 0.059	2.882ValPhe: 2.882 ± 0.048	5.317ValGly: 5.317 ± 0.069	1.538ValHis: 1.538 ± 0.035	4.07ValIle: 4.07 ± 0.056	2.768ValLys: 2.768 ± 0.055	7.607ValLeu: 7.607 ± 0.083	1.935ValMet: 1.935 ± 0.036	2.288ValAsn: 2.288 ± 0.043	3.736ValPro: 3.736 ± 0.058	2.413ValGln: 2.413 ± 0.044	5.044ValArg: 5.044 ± 0.06	4.715ValSer: 4.715 ± 0.064	4.44ValThr: 4.44 ± 0.063	6.017ValVal: 6.017 ± 0.082	0.912ValTrp: 0.912 ± 0.025	1.705ValTyr: 1.705 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.088TrpAla: 1.088 ± 0.029	0.149TrpCys: 0.149 ± 0.009	0.613TrpAsp: 0.613 ± 0.022	0.506TrpGlu: 0.506 ± 0.02	0.533TrpPhe: 0.533 ± 0.021	0.797TrpGly: 0.797 ± 0.026	0.381TrpHis: 0.381 ± 0.017	0.792TrpIle: 0.792 ± 0.025	0.476TrpLys: 0.476 ± 0.017	1.77TrpLeu: 1.77 ± 0.042	0.339TrpMet: 0.339 ± 0.016	0.456TrpAsn: 0.456 ± 0.02	0.62TrpPro: 0.62 ± 0.022	0.607TrpGln: 0.607 ± 0.021	1.13TrpArg: 1.13 ± 0.029	0.778TrpSer: 0.778 ± 0.024	0.688TrpThr: 0.688 ± 0.021	0.814TrpVal: 0.814 ± 0.026	0.207TrpTrp: 0.207 ± 0.011	0.308TrpTyr: 0.308 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.667TyrAla: 2.667 ± 0.052	0.25TyrCys: 0.25 ± 0.014	1.418TyrAsp: 1.418 ± 0.033	1.301TyrGlu: 1.301 ± 0.034	1.085TyrPhe: 1.085 ± 0.026	2.173TyrGly: 2.173 ± 0.037	0.505TyrHis: 0.505 ± 0.019	0.934TyrIle: 0.934 ± 0.025	0.743TyrLys: 0.743 ± 0.023	2.441TyrLeu: 2.441 ± 0.042	0.485TyrMet: 0.485 ± 0.02	0.701TyrAsn: 0.701 ± 0.023	1.197TyrPro: 1.197 ± 0.028	0.861TyrGln: 0.861 ± 0.024	1.864TyrArg: 1.864 ± 0.038	1.328TyrSer: 1.328 ± 0.035	1.256TyrThr: 1.256 ± 0.03	1.899TyrVal: 1.899 ± 0.035	0.39TyrTrp: 0.39 ± 0.018	0.642TyrTyr: 0.642 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4492 proteins (1394682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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