Amino acid dipepetide frequency for Subtercola sp. Z020

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.415AlaAla: 21.415 ± 0.252	0.583AlaCys: 0.583 ± 0.026	7.946AlaAsp: 7.946 ± 0.106	7.836AlaGlu: 7.836 ± 0.103	3.901AlaPhe: 3.901 ± 0.065	13.158AlaGly: 13.158 ± 0.153	2.236AlaHis: 2.236 ± 0.047	5.673AlaIle: 5.673 ± 0.091	2.735AlaLys: 2.735 ± 0.063	14.303AlaLeu: 14.303 ± 0.161	2.311AlaMet: 2.311 ± 0.046	2.652AlaAsn: 2.652 ± 0.057	6.998AlaPro: 6.998 ± 0.102	3.496AlaGln: 3.496 ± 0.063	8.579AlaArg: 8.579 ± 0.119	8.543AlaSer: 8.543 ± 0.113	7.904AlaThr: 7.904 ± 0.119	11.444AlaVal: 11.444 ± 0.129	1.622AlaTrp: 1.622 ± 0.042	2.326AlaTyr: 2.326 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.541CysAla: 0.541 ± 0.027	0.045CysCys: 0.045 ± 0.006	0.273CysAsp: 0.273 ± 0.016	0.214CysGlu: 0.214 ± 0.015	0.163CysPhe: 0.163 ± 0.012	0.534CysGly: 0.534 ± 0.023	0.115CysHis: 0.115 ± 0.009	0.18CysIle: 0.18 ± 0.014	0.05CysLys: 0.05 ± 0.007	0.49CysLeu: 0.49 ± 0.024	0.058CysMet: 0.058 ± 0.006	0.108CysAsn: 0.108 ± 0.011	0.264CysPro: 0.264 ± 0.017	0.108CysGln: 0.108 ± 0.011	0.304CysArg: 0.304 ± 0.019	0.379CysSer: 0.379 ± 0.02	0.32CysThr: 0.32 ± 0.019	0.401CysVal: 0.401 ± 0.018	0.07CysTrp: 0.07 ± 0.009	0.107CysTyr: 0.107 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.474AspAla: 8.474 ± 0.11	0.238AspCys: 0.238 ± 0.016	3.966AspAsp: 3.966 ± 0.077	3.864AspGlu: 3.864 ± 0.067	1.877AspPhe: 1.877 ± 0.046	5.379AspGly: 5.379 ± 0.094	1.081AspHis: 1.081 ± 0.036	2.468AspIle: 2.468 ± 0.06	0.899AspLys: 0.899 ± 0.036	5.982AspLeu: 5.982 ± 0.071	0.669AspMet: 0.669 ± 0.028	1.021AspAsn: 1.021 ± 0.034	3.821AspPro: 3.821 ± 0.065	1.496AspGln: 1.496 ± 0.041	4.056AspArg: 4.056 ± 0.079	3.105AspSer: 3.105 ± 0.052	3.048AspThr: 3.048 ± 0.061	4.956AspVal: 4.956 ± 0.072	0.838AspTrp: 0.838 ± 0.03	1.286AspTyr: 1.286 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.627GluAla: 6.627 ± 0.101	0.211GluCys: 0.211 ± 0.014	1.849GluAsp: 1.849 ± 0.044	2.408GluGlu: 2.408 ± 0.061	1.665GluPhe: 1.665 ± 0.042	3.724GluGly: 3.724 ± 0.068	1.402GluHis: 1.402 ± 0.034	2.504GluIle: 2.504 ± 0.053	1.367GluLys: 1.367 ± 0.043	6.311GluLeu: 6.311 ± 0.091	0.843GluMet: 0.843 ± 0.034	1.47GluAsn: 1.47 ± 0.045	2.876GluPro: 2.876 ± 0.052	2.188GluGln: 2.188 ± 0.051	4.379GluArg: 4.379 ± 0.072	2.831GluSer: 2.831 ± 0.058	3.055GluThr: 3.055 ± 0.055	4.126GluVal: 4.126 ± 0.065	0.816GluTrp: 0.816 ± 0.03	1.102GluTyr: 1.102 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.39PheAla: 4.39 ± 0.075	0.169PheCys: 0.169 ± 0.013	2.517PheAsp: 2.517 ± 0.054	1.749PheGlu: 1.749 ± 0.041	1.209PhePhe: 1.209 ± 0.04	3.676PheGly: 3.676 ± 0.072	0.508PheHis: 0.508 ± 0.02	1.299PheIle: 1.299 ± 0.041	0.489PheLys: 0.489 ± 0.023	2.826PheLeu: 2.826 ± 0.062	0.446PheMet: 0.446 ± 0.019	0.674PheAsn: 0.674 ± 0.025	1.419PhePro: 1.419 ± 0.042	0.774PheGln: 0.774 ± 0.026	1.82PheArg: 1.82 ± 0.038	2.083PheSer: 2.083 ± 0.046	2.263PheThr: 2.263 ± 0.05	3.125PheVal: 3.125 ± 0.058	0.515PheTrp: 0.515 ± 0.026	0.684PheTyr: 0.684 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.533GlyAla: 11.533 ± 0.152	0.552GlyCys: 0.552 ± 0.025	5.029GlyAsp: 5.029 ± 0.081	4.516GlyGlu: 4.516 ± 0.072	3.329GlyPhe: 3.329 ± 0.06	8.183GlyGly: 8.183 ± 0.122	1.87GlyHis: 1.87 ± 0.041	4.829GlyIle: 4.829 ± 0.064	2.026GlyLys: 2.026 ± 0.056	8.986GlyLeu: 8.986 ± 0.113	1.784GlyMet: 1.784 ± 0.045	1.856GlyAsn: 1.856 ± 0.047	3.848GlyPro: 3.848 ± 0.067	2.687GlyGln: 2.687 ± 0.054	6.191GlyArg: 6.191 ± 0.091	6.576GlySer: 6.576 ± 0.108	5.875GlyThr: 5.875 ± 0.084	7.836GlyVal: 7.836 ± 0.093	1.486GlyTrp: 1.486 ± 0.039	2.232GlyTyr: 2.232 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.079HisAla: 2.079 ± 0.042	0.1HisCys: 0.1 ± 0.01	1.246HisAsp: 1.246 ± 0.039	1.017HisGlu: 1.017 ± 0.032	0.601HisPhe: 0.601 ± 0.025	1.758HisGly: 1.758 ± 0.043	0.507HisHis: 0.507 ± 0.022	0.788HisIle: 0.788 ± 0.029	0.222HisLys: 0.222 ± 0.017	2.025HisLeu: 2.025 ± 0.044	0.266HisMet: 0.266 ± 0.015	0.368HisAsn: 0.368 ± 0.021	1.54HisPro: 1.54 ± 0.036	0.519HisGln: 0.519 ± 0.021	1.459HisArg: 1.459 ± 0.035	1.088HisSer: 1.088 ± 0.034	1.037HisThr: 1.037 ± 0.037	1.447HisVal: 1.447 ± 0.04	0.265HisTrp: 0.265 ± 0.019	0.451HisTyr: 0.451 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.541IleAla: 6.541 ± 0.071	0.264IleCys: 0.264 ± 0.014	3.38IleAsp: 3.38 ± 0.06	2.757IleGlu: 2.757 ± 0.061	1.284IlePhe: 1.284 ± 0.043	4.661IleGly: 4.661 ± 0.081	0.721IleHis: 0.721 ± 0.025	2.042IleIle: 2.042 ± 0.055	0.805IleLys: 0.805 ± 0.029	3.818IleLeu: 3.818 ± 0.078	0.598IleMet: 0.598 ± 0.025	0.925IleAsn: 0.925 ± 0.038	2.364IlePro: 2.364 ± 0.05	1.065IleGln: 1.065 ± 0.034	2.649IleArg: 2.649 ± 0.053	2.569IleSer: 2.569 ± 0.044	2.955IleThr: 2.955 ± 0.066	4.808IleVal: 4.808 ± 0.083	0.468IleTrp: 0.468 ± 0.02	0.796IleTyr: 0.796 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.466LysAla: 2.466 ± 0.057	0.056LysCys: 0.056 ± 0.007	0.942LysAsp: 0.942 ± 0.037	0.881LysGlu: 0.881 ± 0.038	0.559LysPhe: 0.559 ± 0.027	1.556LysGly: 1.556 ± 0.04	0.431LysHis: 0.431 ± 0.022	1.028LysIle: 1.028 ± 0.038	0.793LysLys: 0.793 ± 0.035	2.027LysLeu: 2.027 ± 0.044	0.38LysMet: 0.38 ± 0.019	0.629LysAsn: 0.629 ± 0.026	1.255LysPro: 1.255 ± 0.04	0.707LysGln: 0.707 ± 0.026	1.57LysArg: 1.57 ± 0.047	1.212LysSer: 1.212 ± 0.039	1.401LysThr: 1.401 ± 0.043	1.796LysVal: 1.796 ± 0.049	0.233LysTrp: 0.233 ± 0.016	0.489LysTyr: 0.489 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.962LeuAla: 14.962 ± 0.158	0.53LeuCys: 0.53 ± 0.021	6.45LeuAsp: 6.45 ± 0.089	4.878LeuGlu: 4.878 ± 0.076	3.09LeuPhe: 3.09 ± 0.067	9.407LeuGly: 9.407 ± 0.114	1.824LeuHis: 1.824 ± 0.048	4.492LeuIle: 4.492 ± 0.084	1.966LeuLys: 1.966 ± 0.05	10.654LeuLeu: 10.654 ± 0.143	1.539LeuMet: 1.539 ± 0.039	2.117LeuAsn: 2.117 ± 0.047	5.777LeuPro: 5.777 ± 0.079	2.758LeuGln: 2.758 ± 0.053	6.759LeuArg: 6.759 ± 0.097	6.423LeuSer: 6.423 ± 0.081	6.441LeuThr: 6.441 ± 0.082	9.612LeuVal: 9.612 ± 0.128	1.207LeuTrp: 1.207 ± 0.035	1.786LeuTyr: 1.786 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.867MetAla: 1.867 ± 0.044	0.074MetCys: 0.074 ± 0.008	0.658MetAsp: 0.658 ± 0.025	0.552MetGlu: 0.552 ± 0.024	0.49MetPhe: 0.49 ± 0.023	1.148MetGly: 1.148 ± 0.031	0.342MetHis: 0.342 ± 0.019	0.781MetIle: 0.781 ± 0.03	0.448MetLys: 0.448 ± 0.02	1.851MetLeu: 1.851 ± 0.042	0.265MetMet: 0.265 ± 0.017	0.506MetAsn: 0.506 ± 0.02	1.128MetPro: 1.128 ± 0.034	0.549MetGln: 0.549 ± 0.021	1.113MetArg: 1.113 ± 0.034	1.302MetSer: 1.302 ± 0.036	1.592MetThr: 1.592 ± 0.042	1.248MetVal: 1.248 ± 0.037	0.155MetTrp: 0.155 ± 0.012	0.254MetTyr: 0.254 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.757AsnAla: 2.757 ± 0.063	0.117AsnCys: 0.117 ± 0.011	1.387AsnAsp: 1.387 ± 0.039	1.012AsnGlu: 1.012 ± 0.03	0.714AsnPhe: 0.714 ± 0.025	2.221AsnGly: 2.221 ± 0.06	0.428AsnHis: 0.428 ± 0.022	0.99AsnIle: 0.99 ± 0.035	0.438AsnLys: 0.438 ± 0.023	2.185AsnLeu: 2.185 ± 0.048	0.307AsnMet: 0.307 ± 0.015	0.574AsnAsn: 0.574 ± 0.027	1.685AsnPro: 1.685 ± 0.04	0.612AsnGln: 0.612 ± 0.027	1.439AsnArg: 1.439 ± 0.038	1.241AsnSer: 1.241 ± 0.042	1.447AsnThr: 1.447 ± 0.042	1.837AsnVal: 1.837 ± 0.047	0.313AsnTrp: 0.313 ± 0.017	0.522AsnTyr: 0.522 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.755ProAla: 7.755 ± 0.113	0.192ProCys: 0.192 ± 0.014	3.721ProAsp: 3.721 ± 0.061	3.386ProGlu: 3.386 ± 0.064	1.805ProPhe: 1.805 ± 0.045	5.299ProGly: 5.299 ± 0.076	1.012ProHis: 1.012 ± 0.034	2.038ProIle: 2.038 ± 0.047	1.091ProLys: 1.091 ± 0.041	5.059ProLeu: 5.059 ± 0.08	0.801ProMet: 0.801 ± 0.031	1.274ProAsn: 1.274 ± 0.032	2.522ProPro: 2.522 ± 0.057	1.467ProGln: 1.467 ± 0.039	3.164ProArg: 3.164 ± 0.058	3.594ProSer: 3.594 ± 0.06	3.862ProThr: 3.862 ± 0.089	4.97ProVal: 4.97 ± 0.06	0.756ProTrp: 0.756 ± 0.028	1.021ProTyr: 1.021 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.555GlnAla: 3.555 ± 0.069	0.105GlnCys: 0.105 ± 0.011	0.904GlnAsp: 0.904 ± 0.03	1.005GlnGlu: 1.005 ± 0.034	0.962GlnPhe: 0.962 ± 0.028	2.072GlnGly: 2.072 ± 0.044	0.606GlnHis: 0.606 ± 0.029	1.463GlnIle: 1.463 ± 0.035	0.829GlnLys: 0.829 ± 0.03	3.377GlnLeu: 3.377 ± 0.057	0.48GlnMet: 0.48 ± 0.022	0.931GlnAsn: 0.931 ± 0.032	1.709GlnPro: 1.709 ± 0.043	1.258GlnGln: 1.258 ± 0.035	2.092GlnArg: 2.092 ± 0.047	1.771GlnSer: 1.771 ± 0.042	1.814GlnThr: 1.814 ± 0.041	2.398GlnVal: 2.398 ± 0.048	0.395GlnTrp: 0.395 ± 0.022	0.663GlnTyr: 0.663 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.227ArgAla: 8.227 ± 0.113	0.265ArgCys: 0.265 ± 0.014	3.629ArgAsp: 3.629 ± 0.066	3.72ArgGlu: 3.72 ± 0.069	2.296ArgPhe: 2.296 ± 0.05	5.1ArgGly: 5.1 ± 0.074	1.332ArgHis: 1.332 ± 0.036	3.218ArgIle: 3.218 ± 0.054	1.291ArgLys: 1.291 ± 0.043	7.065ArgLeu: 7.065 ± 0.101	1.509ArgMet: 1.509 ± 0.041	1.364ArgAsn: 1.364 ± 0.031	3.492ArgPro: 3.492 ± 0.062	2.116ArgGln: 2.116 ± 0.047	6.051ArgArg: 6.051 ± 0.103	4.49ArgSer: 4.49 ± 0.071	3.872ArgThr: 3.872 ± 0.051	5.557ArgVal: 5.557 ± 0.076	0.926ArgTrp: 0.926 ± 0.029	1.394ArgTyr: 1.394 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	8.429SerAla: 8.429 ± 0.114	0.266SerCys: 0.266 ± 0.018	3.551SerAsp: 3.551 ± 0.066	2.896SerGlu: 2.896 ± 0.059	2.157SerPhe: 2.157 ± 0.042	6.666SerGly: 6.666 ± 0.098	1.153SerHis: 1.153 ± 0.035	3.043SerIle: 3.043 ± 0.056	1.298SerLys: 1.298 ± 0.042	6.105SerLeu: 6.105 ± 0.076	1.172SerMet: 1.172 ± 0.033	1.427SerAsn: 1.427 ± 0.039	3.504SerPro: 3.504 ± 0.063	1.656SerGln: 1.656 ± 0.039	4.021SerArg: 4.021 ± 0.067	4.438SerSer: 4.438 ± 0.072	4.454SerThr: 4.454 ± 0.068	5.367SerVal: 5.367 ± 0.074	0.87SerTrp: 0.87 ± 0.03	1.416SerTyr: 1.416 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	8.36ThrAla: 8.36 ± 0.113	0.272ThrCys: 0.272 ± 0.019	3.686ThrAsp: 3.686 ± 0.066	2.94ThrGlu: 2.94 ± 0.054	2.121ThrPhe: 2.121 ± 0.046	6.229ThrGly: 6.229 ± 0.088	1.084ThrHis: 1.084 ± 0.029	2.914ThrIle: 2.914 ± 0.052	1.284ThrLys: 1.284 ± 0.035	6.444ThrLeu: 6.444 ± 0.085	0.954ThrMet: 0.954 ± 0.031	1.4ThrAsn: 1.4 ± 0.041	4.418ThrPro: 4.418 ± 0.081	1.474ThrGln: 1.474 ± 0.04	3.554ThrArg: 3.554 ± 0.061	4.077ThrSer: 4.077 ± 0.08	4.164ThrThr: 4.164 ± 0.082	6.142ThrVal: 6.142 ± 0.087	0.737ThrTrp: 0.737 ± 0.03	1.254ThrTyr: 1.254 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	11.941ValAla: 11.941 ± 0.133	0.468ValCys: 0.468 ± 0.021	5.53ValAsp: 5.53 ± 0.078	4.509ValGlu: 4.509 ± 0.073	3.144ValPhe: 3.144 ± 0.067	7.52ValGly: 7.52 ± 0.092	1.51ValHis: 1.51 ± 0.037	4.362ValIle: 4.362 ± 0.068	1.688ValLys: 1.688 ± 0.039	9.328ValLeu: 9.328 ± 0.129	1.352ValMet: 1.352 ± 0.035	1.962ValAsn: 1.962 ± 0.055	4.532ValPro: 4.532 ± 0.067	2.197ValGln: 2.197 ± 0.044	5.183ValArg: 5.183 ± 0.079	5.814ValSer: 5.814 ± 0.083	6.055ValThr: 6.055 ± 0.093	8.982ValVal: 8.982 ± 0.112	1.007ValTrp: 1.007 ± 0.033	1.601ValTyr: 1.601 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.408TrpAla: 1.408 ± 0.034	0.086TrpCys: 0.086 ± 0.009	0.536TrpAsp: 0.536 ± 0.024	0.533TrpGlu: 0.533 ± 0.024	0.521TrpPhe: 0.521 ± 0.025	0.994TrpGly: 0.994 ± 0.033	0.305TrpHis: 0.305 ± 0.017	0.619TrpIle: 0.619 ± 0.026	0.329TrpLys: 0.329 ± 0.017	1.582TrpLeu: 1.582 ± 0.046	0.314TrpMet: 0.314 ± 0.015	0.471TrpAsn: 0.471 ± 0.022	0.643TrpPro: 0.643 ± 0.028	0.645TrpGln: 0.645 ± 0.026	0.995TrpArg: 0.995 ± 0.031	1.001TrpSer: 1.001 ± 0.033	0.654TrpThr: 0.654 ± 0.023	1.035TrpVal: 1.035 ± 0.032	0.287TrpTrp: 0.287 ± 0.019	0.294TrpTyr: 0.294 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.336TyrAla: 2.336 ± 0.051	0.128TyrCys: 0.128 ± 0.011	1.325TyrAsp: 1.325 ± 0.034	1.082TyrGlu: 1.082 ± 0.032	0.746TyrPhe: 0.746 ± 0.027	1.939TyrGly: 1.939 ± 0.047	0.316TyrHis: 0.316 ± 0.017	0.739TyrIle: 0.739 ± 0.027	0.364TyrLys: 0.364 ± 0.018	2.255TyrLeu: 2.255 ± 0.048	0.272TyrMet: 0.272 ± 0.016	0.5TyrAsn: 0.5 ± 0.025	0.993TyrPro: 0.993 ± 0.031	0.619TyrGln: 0.619 ± 0.026	1.534TyrArg: 1.534 ± 0.041	1.352TyrSer: 1.352 ± 0.04	1.295TyrThr: 1.295 ± 0.039	1.598TyrVal: 1.598 ± 0.038	0.286TyrTrp: 0.286 ± 0.017	0.488TyrTyr: 0.488 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3250 proteins (1047158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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