Amino acid dipepetide frequency for Marinobacter santoriniensis NKSG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.32AlaAla: 9.32 ± 0.105	1.018AlaCys: 1.018 ± 0.031	5.701AlaAsp: 5.701 ± 0.077	6.198AlaGlu: 6.198 ± 0.078	3.671AlaPhe: 3.671 ± 0.06	8.238AlaGly: 8.238 ± 0.086	1.9AlaHis: 1.9 ± 0.037	5.402AlaIle: 5.402 ± 0.066	3.062AlaLys: 3.062 ± 0.064	11.17AlaLeu: 11.17 ± 0.131	2.985AlaMet: 2.985 ± 0.053	2.872AlaAsn: 2.872 ± 0.054	3.899AlaPro: 3.899 ± 0.063	3.257AlaGln: 3.257 ± 0.054	6.876AlaArg: 6.876 ± 0.082	5.903AlaSer: 5.903 ± 0.065	4.659AlaThr: 4.659 ± 0.064	6.947AlaVal: 6.947 ± 0.089	1.359AlaTrp: 1.359 ± 0.04	2.209AlaTyr: 2.209 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.808CysAla: 0.808 ± 0.028	0.122CysCys: 0.122 ± 0.011	0.592CysAsp: 0.592 ± 0.023	0.565CysGlu: 0.565 ± 0.022	0.344CysPhe: 0.344 ± 0.017	0.89CysGly: 0.89 ± 0.029	0.302CysHis: 0.302 ± 0.014	0.424CysIle: 0.424 ± 0.022	0.29CysLys: 0.29 ± 0.017	0.972CysLeu: 0.972 ± 0.029	0.204CysMet: 0.204 ± 0.012	0.267CysAsn: 0.267 ± 0.014	0.51CysPro: 0.51 ± 0.023	0.379CysGln: 0.379 ± 0.016	0.699CysArg: 0.699 ± 0.025	0.544CysSer: 0.544 ± 0.017	0.437CysThr: 0.437 ± 0.02	0.632CysVal: 0.632 ± 0.021	0.12CysTrp: 0.12 ± 0.011	0.266CysTyr: 0.266 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.346AspAla: 5.346 ± 0.072	0.515AspCys: 0.515 ± 0.024	3.496AspAsp: 3.496 ± 0.062	4.101AspGlu: 4.101 ± 0.062	2.315AspPhe: 2.315 ± 0.046	4.672AspGly: 4.672 ± 0.076	1.43AspHis: 1.43 ± 0.036	3.373AspIle: 3.373 ± 0.061	2.06AspLys: 2.06 ± 0.046	6.07AspLeu: 6.07 ± 0.078	1.524AspMet: 1.524 ± 0.035	1.934AspAsn: 1.934 ± 0.044	3.016AspPro: 3.016 ± 0.049	2.647AspGln: 2.647 ± 0.048	4.231AspArg: 4.231 ± 0.062	3.167AspSer: 3.167 ± 0.052	2.952AspThr: 2.952 ± 0.054	4.14AspVal: 4.14 ± 0.063	1.031AspTrp: 1.031 ± 0.03	1.923AspTyr: 1.923 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.784GluAla: 6.784 ± 0.086	0.463GluCys: 0.463 ± 0.02	3.478GluAsp: 3.478 ± 0.055	4.271GluGlu: 4.271 ± 0.07	2.14GluPhe: 2.14 ± 0.043	4.455GluGly: 4.455 ± 0.065	1.663GluHis: 1.663 ± 0.04	3.31GluIle: 3.31 ± 0.065	2.996GluLys: 2.996 ± 0.064	6.774GluLeu: 6.774 ± 0.082	1.568GluMet: 1.568 ± 0.037	2.115GluAsn: 2.115 ± 0.047	2.896GluPro: 2.896 ± 0.056	3.466GluGln: 3.466 ± 0.067	4.686GluArg: 4.686 ± 0.068	3.616GluSer: 3.616 ± 0.055	3.629GluThr: 3.629 ± 0.056	4.187GluVal: 4.187 ± 0.059	0.767GluTrp: 0.767 ± 0.027	1.444GluTyr: 1.444 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.372PheAla: 3.372 ± 0.058	0.432PheCys: 0.432 ± 0.019	2.58PheAsp: 2.58 ± 0.049	2.339PheGlu: 2.339 ± 0.049	1.583PhePhe: 1.583 ± 0.042	3.274PheGly: 3.274 ± 0.055	0.828PheHis: 0.828 ± 0.026	1.886PheIle: 1.886 ± 0.05	1.181PheLys: 1.181 ± 0.033	3.744PheLeu: 3.744 ± 0.06	0.884PheMet: 0.884 ± 0.028	1.342PheAsn: 1.342 ± 0.033	1.671PhePro: 1.671 ± 0.038	1.259PheGln: 1.259 ± 0.03	2.609PheArg: 2.609 ± 0.043	2.686PheSer: 2.686 ± 0.044	1.974PheThr: 1.974 ± 0.045	2.663PheVal: 2.663 ± 0.051	0.568PheTrp: 0.568 ± 0.021	1.121PheTyr: 1.121 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.631GlyAla: 6.631 ± 0.082	0.925GlyCys: 0.925 ± 0.03	4.51GlyAsp: 4.51 ± 0.068	5.067GlyGlu: 5.067 ± 0.068	3.428GlyPhe: 3.428 ± 0.056	5.935GlyGly: 5.935 ± 0.079	1.928GlyHis: 1.928 ± 0.044	4.701GlyIle: 4.701 ± 0.058	3.453GlyLys: 3.453 ± 0.066	8.518GlyLeu: 8.518 ± 0.106	2.268GlyMet: 2.268 ± 0.046	2.395GlyAsn: 2.395 ± 0.05	2.632GlyPro: 2.632 ± 0.045	3.231GlyGln: 3.231 ± 0.054	4.846GlyArg: 4.846 ± 0.07	4.487GlySer: 4.487 ± 0.065	4.037GlyThr: 4.037 ± 0.065	5.807GlyVal: 5.807 ± 0.07	1.228GlyTrp: 1.228 ± 0.032	2.497GlyTyr: 2.497 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.873HisAla: 1.873 ± 0.038	0.304HisCys: 0.304 ± 0.016	1.217HisAsp: 1.217 ± 0.033	1.276HisGlu: 1.276 ± 0.036	0.988HisPhe: 0.988 ± 0.028	1.826HisGly: 1.826 ± 0.036	0.714HisHis: 0.714 ± 0.027	1.121HisIle: 1.121 ± 0.033	0.731HisLys: 0.731 ± 0.026	2.314HisLeu: 2.314 ± 0.048	0.526HisMet: 0.526 ± 0.024	0.66HisAsn: 0.66 ± 0.022	1.424HisPro: 1.424 ± 0.039	0.985HisGln: 0.985 ± 0.027	1.619HisArg: 1.619 ± 0.037	1.316HisSer: 1.316 ± 0.036	1.05HisThr: 1.05 ± 0.027	1.291HisVal: 1.291 ± 0.036	0.389HisTrp: 0.389 ± 0.02	0.809HisTyr: 0.809 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.456IleAla: 5.456 ± 0.082	0.512IleCys: 0.512 ± 0.021	3.327IleAsp: 3.327 ± 0.059	3.613IleGlu: 3.613 ± 0.055	1.667IlePhe: 1.667 ± 0.042	4.369IleGly: 4.369 ± 0.064	1.194IleHis: 1.194 ± 0.035	2.43IleIle: 2.43 ± 0.06	1.81IleLys: 1.81 ± 0.045	4.917IleLeu: 4.917 ± 0.066	1.062IleMet: 1.062 ± 0.027	1.952IleAsn: 1.952 ± 0.045	2.663IlePro: 2.663 ± 0.047	1.825IleGln: 1.825 ± 0.036	3.942IleArg: 3.942 ± 0.057	3.207IleSer: 3.207 ± 0.054	2.927IleThr: 2.927 ± 0.058	3.648IleVal: 3.648 ± 0.063	0.552IleTrp: 0.552 ± 0.021	1.205IleTyr: 1.205 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.049LysAla: 4.049 ± 0.073	0.211LysCys: 0.211 ± 0.015	2.165LysAsp: 2.165 ± 0.044	2.224LysGlu: 2.224 ± 0.046	0.953LysPhe: 0.953 ± 0.032	2.735LysGly: 2.735 ± 0.052	0.754LysHis: 0.754 ± 0.024	1.723LysIle: 1.723 ± 0.045	1.782LysLys: 1.782 ± 0.054	3.734LysLeu: 3.734 ± 0.062	0.844LysMet: 0.844 ± 0.027	1.141LysAsn: 1.141 ± 0.036	2.069LysPro: 2.069 ± 0.047	1.623LysGln: 1.623 ± 0.039	2.501LysArg: 2.501 ± 0.044	2.101LysSer: 2.101 ± 0.047	2.149LysThr: 2.149 ± 0.043	2.802LysVal: 2.802 ± 0.058	0.391LysTrp: 0.391 ± 0.016	0.797LysTyr: 0.797 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.729LeuAla: 11.729 ± 0.116	1.021LeuCys: 1.021 ± 0.028	6.394LeuAsp: 6.394 ± 0.08	6.87LeuGlu: 6.87 ± 0.08	4.025LeuPhe: 4.025 ± 0.074	8.024LeuGly: 8.024 ± 0.095	2.064LeuHis: 2.064 ± 0.043	5.507LeuIle: 5.507 ± 0.076	4.439LeuLys: 4.439 ± 0.058	10.687LeuLeu: 10.687 ± 0.132	2.765LeuMet: 2.765 ± 0.052	3.541LeuAsn: 3.541 ± 0.051	5.306LeuPro: 5.306 ± 0.078	3.654LeuGln: 3.654 ± 0.056	6.435LeuArg: 6.435 ± 0.08	7.135LeuSer: 7.135 ± 0.077	5.838LeuThr: 5.838 ± 0.066	7.674LeuVal: 7.674 ± 0.096	1.24LeuTrp: 1.24 ± 0.032	2.353LeuTyr: 2.353 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.082MetAla: 3.082 ± 0.056	0.173MetCys: 0.173 ± 0.011	1.417MetAsp: 1.417 ± 0.035	1.462MetGlu: 1.462 ± 0.039	0.738MetPhe: 0.738 ± 0.028	1.941MetGly: 1.941 ± 0.042	0.487MetHis: 0.487 ± 0.021	1.285MetIle: 1.285 ± 0.036	1.145MetLys: 1.145 ± 0.032	2.567MetLeu: 2.567 ± 0.046	0.693MetMet: 0.693 ± 0.028	0.99MetAsn: 0.99 ± 0.03	1.321MetPro: 1.321 ± 0.033	0.913MetGln: 0.913 ± 0.029	1.377MetArg: 1.377 ± 0.036	1.736MetSer: 1.736 ± 0.038	1.655MetThr: 1.655 ± 0.04	1.882MetVal: 1.882 ± 0.043	0.17MetTrp: 0.17 ± 0.013	0.444MetTyr: 0.444 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.064AsnAla: 3.064 ± 0.052	0.283AsnCys: 0.283 ± 0.014	1.822AsnAsp: 1.822 ± 0.038	1.751AsnGlu: 1.751 ± 0.037	1.087AsnPhe: 1.087 ± 0.033	2.664AsnGly: 2.664 ± 0.057	0.776AsnHis: 0.776 ± 0.024	1.604AsnIle: 1.604 ± 0.037	1.008AsnLys: 1.008 ± 0.031	3.53AsnLeu: 3.53 ± 0.061	0.699AsnMet: 0.699 ± 0.028	1.058AsnAsn: 1.058 ± 0.034	2.06AsnPro: 2.06 ± 0.043	1.363AsnGln: 1.363 ± 0.037	2.424AsnArg: 2.424 ± 0.048	1.591AsnSer: 1.591 ± 0.04	1.673AsnThr: 1.673 ± 0.041	2.124AsnVal: 2.124 ± 0.051	0.483AsnTrp: 0.483 ± 0.022	0.866AsnTyr: 0.866 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.582ProAla: 4.582 ± 0.069	0.313ProCys: 0.313 ± 0.016	3.954ProAsp: 3.954 ± 0.057	4.432ProGlu: 4.432 ± 0.066	1.799ProPhe: 1.799 ± 0.042	4.165ProGly: 4.165 ± 0.061	0.898ProHis: 0.898 ± 0.028	2.087ProIle: 2.087 ± 0.045	1.55ProLys: 1.55 ± 0.041	4.663ProLeu: 4.663 ± 0.069	1.147ProMet: 1.147 ± 0.029	1.286ProAsn: 1.286 ± 0.035	1.865ProPro: 1.865 ± 0.045	1.429ProGln: 1.429 ± 0.033	2.412ProArg: 2.412 ± 0.048	2.6ProSer: 2.6 ± 0.049	2.133ProThr: 2.133 ± 0.038	4.299ProVal: 4.299 ± 0.062	0.726ProTrp: 0.726 ± 0.022	1.1ProTyr: 1.1 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.276GlnAla: 4.276 ± 0.067	0.331GlnCys: 0.331 ± 0.017	1.876GlnAsp: 1.876 ± 0.04	2.205GlnGlu: 2.205 ± 0.043	1.386GlnPhe: 1.386 ± 0.033	2.917GlnGly: 2.917 ± 0.043	0.839GlnHis: 0.839 ± 0.028	1.928GlnIle: 1.928 ± 0.039	1.579GlnLys: 1.579 ± 0.037	4.141GlnLeu: 4.141 ± 0.069	1.024GlnMet: 1.024 ± 0.026	1.193GlnAsn: 1.193 ± 0.033	1.929GlnPro: 1.929 ± 0.042	1.972GlnGln: 1.972 ± 0.051	2.814GlnArg: 2.814 ± 0.051	2.388GlnSer: 2.388 ± 0.049	2.082GlnThr: 2.082 ± 0.04	2.892GlnVal: 2.892 ± 0.054	0.684GlnTrp: 0.684 ± 0.026	0.948GlnTyr: 0.948 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.503ArgAla: 5.503 ± 0.084	0.593ArgCys: 0.593 ± 0.021	3.917ArgAsp: 3.917 ± 0.063	4.881ArgGlu: 4.881 ± 0.067	3.054ArgPhe: 3.054 ± 0.061	3.862ArgGly: 3.862 ± 0.058	1.736ArgHis: 1.736 ± 0.039	3.845ArgIle: 3.845 ± 0.051	2.865ArgLys: 2.865 ± 0.047	7.649ArgLeu: 7.649 ± 0.102	1.757ArgMet: 1.757 ± 0.035	2.287ArgAsn: 2.287 ± 0.042	2.838ArgPro: 2.838 ± 0.052	3.252ArgGln: 3.252 ± 0.053	4.604ArgArg: 4.604 ± 0.07	3.603ArgSer: 3.603 ± 0.057	3.084ArgThr: 3.084 ± 0.048	4.736ArgVal: 4.736 ± 0.065	1.072ArgTrp: 1.072 ± 0.033	2.096ArgTyr: 2.096 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.614SerAla: 5.614 ± 0.063	0.49SerCys: 0.49 ± 0.022	3.772SerAsp: 3.772 ± 0.064	3.839SerGlu: 3.839 ± 0.064	2.205SerPhe: 2.205 ± 0.036	5.595SerGly: 5.595 ± 0.076	1.336SerHis: 1.336 ± 0.035	2.904SerIle: 2.904 ± 0.051	1.885SerLys: 1.885 ± 0.043	6.476SerLeu: 6.476 ± 0.076	1.539SerMet: 1.539 ± 0.035	1.73SerAsn: 1.73 ± 0.043	2.818SerPro: 2.818 ± 0.047	2.29SerGln: 2.29 ± 0.044	4.011SerArg: 4.011 ± 0.06	3.413SerSer: 3.413 ± 0.055	2.789SerThr: 2.789 ± 0.05	4.388SerVal: 4.388 ± 0.064	0.786SerTrp: 0.786 ± 0.026	1.448SerTyr: 1.448 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.878ThrAla: 4.878 ± 0.067	0.476ThrCys: 0.476 ± 0.023	3.125ThrAsp: 3.125 ± 0.05	3.007ThrGlu: 3.007 ± 0.048	1.967ThrPhe: 1.967 ± 0.04	5.042ThrGly: 5.042 ± 0.068	1.099ThrHis: 1.099 ± 0.027	2.625ThrIle: 2.625 ± 0.045	1.236ThrLys: 1.236 ± 0.037	6.368ThrLeu: 6.368 ± 0.081	1.156ThrMet: 1.156 ± 0.031	1.458ThrAsn: 1.458 ± 0.038	3.057ThrPro: 3.057 ± 0.05	1.523ThrGln: 1.523 ± 0.034	3.402ThrArg: 3.402 ± 0.057	2.864ThrSer: 2.864 ± 0.054	2.655ThrThr: 2.655 ± 0.05	4.057ThrVal: 4.057 ± 0.052	0.717ThrTrp: 0.717 ± 0.025	1.247ThrTyr: 1.247 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.169ValAla: 7.169 ± 0.088	0.735ValCys: 0.735 ± 0.021	4.412ValAsp: 4.412 ± 0.067	4.482ValGlu: 4.482 ± 0.069	2.985ValPhe: 2.985 ± 0.051	4.994ValGly: 4.994 ± 0.076	1.464ValHis: 1.464 ± 0.036	4.284ValIle: 4.284 ± 0.07	2.442ValLys: 2.442 ± 0.05	7.439ValLeu: 7.439 ± 0.095	1.964ValMet: 1.964 ± 0.042	2.47ValAsn: 2.47 ± 0.04	3.483ValPro: 3.483 ± 0.053	2.235ValGln: 2.235 ± 0.041	4.613ValArg: 4.613 ± 0.063	4.671ValSer: 4.671 ± 0.07	4.269ValThr: 4.269 ± 0.064	5.804ValVal: 5.804 ± 0.079	0.881ValTrp: 0.881 ± 0.03	1.702ValTyr: 1.702 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.008TrpAla: 1.008 ± 0.03	0.166TrpCys: 0.166 ± 0.012	0.645TrpAsp: 0.645 ± 0.023	0.621TrpGlu: 0.621 ± 0.023	0.631TrpPhe: 0.631 ± 0.024	0.858TrpGly: 0.858 ± 0.026	0.398TrpHis: 0.398 ± 0.018	0.726TrpIle: 0.726 ± 0.024	0.472TrpLys: 0.472 ± 0.021	2.001TrpLeu: 2.001 ± 0.044	0.358TrpMet: 0.358 ± 0.017	0.441TrpAsn: 0.441 ± 0.022	0.633TrpPro: 0.633 ± 0.022	0.835TrpGln: 0.835 ± 0.031	0.977TrpArg: 0.977 ± 0.027	0.812TrpSer: 0.812 ± 0.025	0.665TrpThr: 0.665 ± 0.026	0.936TrpVal: 0.936 ± 0.033	0.213TrpTrp: 0.213 ± 0.013	0.376TrpTyr: 0.376 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.101TyrAla: 2.101 ± 0.041	0.282TyrCys: 0.282 ± 0.015	1.544TyrAsp: 1.544 ± 0.042	1.505TyrGlu: 1.505 ± 0.033	1.03TyrPhe: 1.03 ± 0.031	2.07TyrGly: 2.07 ± 0.042	0.626TyrHis: 0.626 ± 0.025	1.113TyrIle: 1.113 ± 0.029	0.76TyrLys: 0.76 ± 0.024	2.969TyrLeu: 2.969 ± 0.049	0.507TyrMet: 0.507 ± 0.02	0.798TyrAsn: 0.798 ± 0.028	1.35TyrPro: 1.35 ± 0.033	1.265TyrGln: 1.265 ± 0.033	2.156TyrArg: 2.156 ± 0.043	1.488TyrSer: 1.488 ± 0.037	1.301TyrThr: 1.301 ± 0.038	1.592TyrVal: 1.592 ± 0.038	0.394TyrTrp: 0.394 ± 0.021	0.761TyrTyr: 0.761 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3692 proteins (1219654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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