Amino acid dipepetide frequency for Rubidibacter lacunae KORDI 51-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.123AlaAla: 13.123 ± 0.183	1.245AlaCys: 1.245 ± 0.039	5.835AlaAsp: 5.835 ± 0.087	6.273AlaGlu: 6.273 ± 0.097	3.475AlaPhe: 3.475 ± 0.066	7.885AlaGly: 7.885 ± 0.109	1.635AlaHis: 1.635 ± 0.055	9.169AlaIle: 9.169 ± 0.116	2.637AlaLys: 2.637 ± 0.069	11.526AlaLeu: 11.526 ± 0.156	1.958AlaMet: 1.958 ± 0.051	3.032AlaAsn: 3.032 ± 0.069	4.69AlaPro: 4.69 ± 0.092	3.881AlaGln: 3.881 ± 0.07	7.812AlaArg: 7.812 ± 0.126	6.037AlaSer: 6.037 ± 0.083	6.083AlaThr: 6.083 ± 0.092	7.374AlaVal: 7.374 ± 0.095	1.421AlaTrp: 1.421 ± 0.045	2.465AlaTyr: 2.465 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.941CysAla: 0.941 ± 0.04	0.205CysCys: 0.205 ± 0.015	0.766CysAsp: 0.766 ± 0.034	0.616CysGlu: 0.616 ± 0.029	0.44CysPhe: 0.44 ± 0.02	0.99CysGly: 0.99 ± 0.037	0.281CysHis: 0.281 ± 0.019	0.553CysIle: 0.553 ± 0.024	0.295CysLys: 0.295 ± 0.016	1.25CysLeu: 1.25 ± 0.04	0.162CysMet: 0.162 ± 0.012	0.365CysAsn: 0.365 ± 0.019	0.645CysPro: 0.645 ± 0.031	0.533CysGln: 0.533 ± 0.024	0.841CysArg: 0.841 ± 0.032	0.714CysSer: 0.714 ± 0.029	0.542CysThr: 0.542 ± 0.027	0.692CysVal: 0.692 ± 0.023	0.234CysTrp: 0.234 ± 0.018	0.32CysTyr: 0.32 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.911AspAla: 5.911 ± 0.108	0.775AspCys: 0.775 ± 0.031	3.199AspAsp: 3.199 ± 0.106	3.236AspGlu: 3.236 ± 0.066	2.499AspPhe: 2.499 ± 0.07	4.627AspGly: 4.627 ± 0.136	0.585AspHis: 0.585 ± 0.029	2.857AspIle: 2.857 ± 0.063	1.302AspLys: 1.302 ± 0.036	6.664AspLeu: 6.664 ± 0.099	0.804AspMet: 0.804 ± 0.03	1.608AspAsn: 1.608 ± 0.054	3.457AspPro: 3.457 ± 0.08	0.963AspGln: 0.963 ± 0.033	6.98AspArg: 6.98 ± 0.109	3.086AspSer: 3.086 ± 0.073	2.811AspThr: 2.811 ± 0.075	3.664AspVal: 3.664 ± 0.073	1.028AspTrp: 1.028 ± 0.031	1.813AspTyr: 1.813 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.1GluAla: 6.1 ± 0.085	0.531GluCys: 0.531 ± 0.022	2.805GluAsp: 2.805 ± 0.067	3.199GluGlu: 3.199 ± 0.077	2.384GluPhe: 2.384 ± 0.05	3.511GluGly: 3.511 ± 0.077	1.072GluHis: 1.072 ± 0.032	3.549GluIle: 3.549 ± 0.073	1.815GluLys: 1.815 ± 0.057	7.498GluLeu: 7.498 ± 0.09	1.106GluMet: 1.106 ± 0.034	1.777GluAsn: 1.777 ± 0.045	3.039GluPro: 3.039 ± 0.065	2.953GluGln: 2.953 ± 0.062	5.295GluArg: 5.295 ± 0.085	3.258GluSer: 3.258 ± 0.053	3.417GluThr: 3.417 ± 0.067	4.2GluVal: 4.2 ± 0.069	0.774GluTrp: 0.774 ± 0.028	1.467GluTyr: 1.467 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.212PheAla: 4.212 ± 0.078	0.543PheCys: 0.543 ± 0.025	2.524PheAsp: 2.524 ± 0.073	2.375PheGlu: 2.375 ± 0.049	1.632PhePhe: 1.632 ± 0.052	3.489PheGly: 3.489 ± 0.066	0.651PheHis: 0.651 ± 0.028	1.565PheIle: 1.565 ± 0.043	0.905PheLys: 0.905 ± 0.03	3.8PheLeu: 3.8 ± 0.068	0.538PheMet: 0.538 ± 0.025	1.155PheAsn: 1.155 ± 0.037	1.852PhePro: 1.852 ± 0.045	1.385PheGln: 1.385 ± 0.037	2.046PheArg: 2.046 ± 0.044	2.376PheSer: 2.376 ± 0.05	1.861PheThr: 1.861 ± 0.052	2.882PheVal: 2.882 ± 0.058	0.717PheTrp: 0.717 ± 0.029	1.127PheTyr: 1.127 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.839GlyAla: 6.839 ± 0.098	1.021GlyCys: 1.021 ± 0.036	4.859GlyAsp: 4.859 ± 0.129	4.452GlyGlu: 4.452 ± 0.094	3.175GlyPhe: 3.175 ± 0.057	6.21GlyGly: 6.21 ± 0.17	1.315GlyHis: 1.315 ± 0.038	4.767GlyIle: 4.767 ± 0.07	2.843GlyLys: 2.843 ± 0.065	7.72GlyLeu: 7.72 ± 0.086	1.522GlyMet: 1.522 ± 0.049	3.153GlyAsn: 3.153 ± 0.144	2.391GlyPro: 2.391 ± 0.052	2.644GlyGln: 2.644 ± 0.049	4.955GlyArg: 4.955 ± 0.077	5.068GlySer: 5.068 ± 0.1	4.814GlyThr: 4.814 ± 0.096	5.239GlyVal: 5.239 ± 0.082	1.333GlyTrp: 1.333 ± 0.042	2.26GlyTyr: 2.26 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.69HisAla: 1.69 ± 0.045	0.301HisCys: 0.301 ± 0.016	0.919HisAsp: 0.919 ± 0.032	0.85HisGlu: 0.85 ± 0.026	0.819HisPhe: 0.819 ± 0.027	1.333HisGly: 1.333 ± 0.044	0.592HisHis: 0.592 ± 0.029	0.795HisIle: 0.795 ± 0.024	0.438HisLys: 0.438 ± 0.022	2.305HisLeu: 2.305 ± 0.054	0.274HisMet: 0.274 ± 0.017	0.523HisAsn: 0.523 ± 0.024	1.387HisPro: 1.387 ± 0.044	0.837HisGln: 0.837 ± 0.033	1.331HisArg: 1.331 ± 0.04	1.026HisSer: 1.026 ± 0.03	0.77HisThr: 0.77 ± 0.025	1.119HisVal: 1.119 ± 0.035	0.408HisTrp: 0.408 ± 0.021	0.626HisTyr: 0.626 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	9.04IleAla: 9.04 ± 0.113	0.653IleCys: 0.653 ± 0.026	3.563IleAsp: 3.563 ± 0.073	3.54IleGlu: 3.54 ± 0.057	1.864IlePhe: 1.864 ± 0.044	4.405IleGly: 4.405 ± 0.07	0.876IleHis: 0.876 ± 0.03	1.644IleIle: 1.644 ± 0.046	1.083IleLys: 1.083 ± 0.033	4.721IleLeu: 4.721 ± 0.087	0.53IleMet: 0.53 ± 0.023	1.325IleAsn: 1.325 ± 0.039	2.717IlePro: 2.717 ± 0.054	1.641IleGln: 1.641 ± 0.044	2.884IleArg: 2.884 ± 0.053	2.751IleSer: 2.751 ± 0.067	1.954IleThr: 1.954 ± 0.055	4.461IleVal: 4.461 ± 0.074	0.657IleTrp: 0.657 ± 0.025	1.436IleTyr: 1.436 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	2.616LysAla: 2.616 ± 0.066	0.234LysCys: 0.234 ± 0.016	1.277LysAsp: 1.277 ± 0.039	1.414LysGlu: 1.414 ± 0.044	0.977LysPhe: 0.977 ± 0.036	1.691LysGly: 1.691 ± 0.051	0.615LysHis: 0.615 ± 0.027	1.473LysIle: 1.473 ± 0.044	0.964LysLys: 0.964 ± 0.041	3.222LysLeu: 3.222 ± 0.064	0.51LysMet: 0.51 ± 0.025	0.818LysAsn: 0.818 ± 0.03	1.716LysPro: 1.716 ± 0.055	1.459LysGln: 1.459 ± 0.045	2.019LysArg: 2.019 ± 0.057	1.699LysSer: 1.699 ± 0.045	1.762LysThr: 1.762 ± 0.05	1.866LysVal: 1.866 ± 0.055	0.288LysTrp: 0.288 ± 0.016	0.747LysTyr: 0.747 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.428LeuAla: 12.428 ± 0.141	1.118LeuCys: 1.118 ± 0.034	6.633LeuAsp: 6.633 ± 0.086	6.905LeuGlu: 6.905 ± 0.107	3.734LeuPhe: 3.734 ± 0.073	8.773LeuGly: 8.773 ± 0.099	2.27LeuHis: 2.27 ± 0.053	4.36LeuIle: 4.36 ± 0.073	3.444LeuLys: 3.444 ± 0.08	12.341LeuLeu: 12.341 ± 0.145	1.916LeuMet: 1.916 ± 0.045	3.244LeuAsn: 3.244 ± 0.055	6.676LeuPro: 6.676 ± 0.092	5.544LeuGln: 5.544 ± 0.103	7.137LeuArg: 7.137 ± 0.127	7.109LeuSer: 7.109 ± 0.095	6.2LeuThr: 6.2 ± 0.088	8.117LeuVal: 8.117 ± 0.102	1.5LeuTrp: 1.5 ± 0.05	2.787LeuTyr: 2.787 ± 0.086	0.0LeuXaa: 0.0 ± 0.0
Met	1.801MetAla: 1.801 ± 0.046	0.138MetCys: 0.138 ± 0.012	0.718MetAsp: 0.718 ± 0.026	0.829MetGlu: 0.829 ± 0.031	0.538MetPhe: 0.538 ± 0.025	1.244MetGly: 1.244 ± 0.045	0.323MetHis: 0.323 ± 0.019	0.547MetIle: 0.547 ± 0.022	0.57MetLys: 0.57 ± 0.027	2.033MetLeu: 2.033 ± 0.051	0.366MetMet: 0.366 ± 0.02	0.537MetAsn: 0.537 ± 0.024	1.035MetPro: 1.035 ± 0.033	0.873MetGln: 0.873 ± 0.032	1.144MetArg: 1.144 ± 0.036	1.228MetSer: 1.228 ± 0.037	1.242MetThr: 1.242 ± 0.044	1.232MetVal: 1.232 ± 0.035	0.152MetTrp: 0.152 ± 0.011	0.291MetTyr: 0.291 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.927AsnAla: 2.927 ± 0.052	0.388AsnCys: 0.388 ± 0.02	1.771AsnAsp: 1.771 ± 0.097	1.342AsnGlu: 1.342 ± 0.039	1.301AsnPhe: 1.301 ± 0.04	2.475AsnGly: 2.475 ± 0.088	0.547AsnHis: 0.547 ± 0.021	1.445AsnIle: 1.445 ± 0.038	0.721AsnLys: 0.721 ± 0.025	3.649AsnLeu: 3.649 ± 0.072	0.447AsnMet: 0.447 ± 0.021	0.949AsnAsn: 0.949 ± 0.053	2.119AsnPro: 2.119 ± 0.049	1.022AsnGln: 1.022 ± 0.034	2.169AsnArg: 2.169 ± 0.054	1.761AsnSer: 1.761 ± 0.051	1.451AsnThr: 1.451 ± 0.044	1.981AsnVal: 1.981 ± 0.05	0.526AsnTrp: 0.526 ± 0.025	0.881AsnTyr: 0.881 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.13ProAla: 5.13 ± 0.083	0.444ProCys: 0.444 ± 0.024	3.801ProAsp: 3.801 ± 0.078	4.308ProGlu: 4.308 ± 0.072	1.832ProPhe: 1.832 ± 0.041	3.834ProGly: 3.834 ± 0.057	1.147ProHis: 1.147 ± 0.036	2.569ProIle: 2.569 ± 0.048	1.346ProLys: 1.346 ± 0.038	5.627ProLeu: 5.627 ± 0.085	0.818ProMet: 0.818 ± 0.029	1.68ProAsn: 1.68 ± 0.05	3.11ProPro: 3.11 ± 0.077	2.427ProGln: 2.427 ± 0.053	2.668ProArg: 2.668 ± 0.057	3.254ProSer: 3.254 ± 0.058	3.254ProThr: 3.254 ± 0.071	3.936ProVal: 3.936 ± 0.063	0.673ProTrp: 0.673 ± 0.025	1.292ProTyr: 1.292 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.21GlnAla: 4.21 ± 0.081	0.34GlnCys: 0.34 ± 0.019	1.711GlnAsp: 1.711 ± 0.045	2.155GlnGlu: 2.155 ± 0.054	1.508GlnPhe: 1.508 ± 0.042	2.434GlnGly: 2.434 ± 0.048	0.924GlnHis: 0.924 ± 0.034	2.216GlnIle: 2.216 ± 0.043	1.16GlnLys: 1.16 ± 0.039	5.358GlnLeu: 5.358 ± 0.087	0.805GlnMet: 0.805 ± 0.031	1.048GlnAsn: 1.048 ± 0.03	2.495GlnPro: 2.495 ± 0.055	2.795GlnGln: 2.795 ± 0.077	3.275GlnArg: 3.275 ± 0.077	2.441GlnSer: 2.441 ± 0.053	2.414GlnThr: 2.414 ± 0.045	3.073GlnVal: 3.073 ± 0.054	0.571GlnTrp: 0.571 ± 0.025	0.939GlnTyr: 0.939 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.37ArgAla: 7.37 ± 0.111	0.804ArgCys: 0.804 ± 0.031	4.431ArgAsp: 4.431 ± 0.073	4.342ArgGlu: 4.342 ± 0.073	2.714ArgPhe: 2.714 ± 0.056	4.635ArgGly: 4.635 ± 0.067	1.403ArgHis: 1.403 ± 0.039	3.409ArgIle: 3.409 ± 0.058	1.915ArgLys: 1.915 ± 0.051	8.201ArgLeu: 8.201 ± 0.117	1.232ArgMet: 1.232 ± 0.039	1.973ArgAsn: 1.973 ± 0.043	3.205ArgPro: 3.205 ± 0.07	3.649ArgGln: 3.649 ± 0.085	5.004ArgArg: 5.004 ± 0.092	4.629ArgSer: 4.629 ± 0.076	3.351ArgThr: 3.351 ± 0.05	5.122ArgVal: 5.122 ± 0.087	1.238ArgTrp: 1.238 ± 0.04	2.161ArgTyr: 2.161 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.874SerAla: 5.874 ± 0.071	0.641SerCys: 0.641 ± 0.027	3.762SerAsp: 3.762 ± 0.096	3.666SerGlu: 3.666 ± 0.068	2.279SerPhe: 2.279 ± 0.052	5.405SerGly: 5.405 ± 0.097	1.066SerHis: 1.066 ± 0.033	2.961SerIle: 2.961 ± 0.062	1.625SerLys: 1.625 ± 0.047	6.54SerLeu: 6.54 ± 0.09	1.11SerMet: 1.11 ± 0.034	1.911SerAsn: 1.911 ± 0.052	3.407SerPro: 3.407 ± 0.066	2.373SerGln: 2.373 ± 0.05	3.656SerArg: 3.656 ± 0.06	3.877SerSer: 3.877 ± 0.073	3.241SerThr: 3.241 ± 0.067	4.119SerVal: 4.119 ± 0.067	0.886SerTrp: 0.886 ± 0.037	1.532SerTyr: 1.532 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.871ThrAla: 5.871 ± 0.081	0.599ThrCys: 0.599 ± 0.028	3.068ThrAsp: 3.068 ± 0.083	2.985ThrGlu: 2.985 ± 0.052	2.048ThrPhe: 2.048 ± 0.056	4.443ThrGly: 4.443 ± 0.089	1.026ThrHis: 1.026 ± 0.034	3.261ThrIle: 3.261 ± 0.064	1.228ThrLys: 1.228 ± 0.041	6.149ThrLeu: 6.149 ± 0.096	0.795ThrMet: 0.795 ± 0.028	1.555ThrAsn: 1.555 ± 0.048	3.378ThrPro: 3.378 ± 0.064	1.997ThrGln: 1.997 ± 0.047	3.067ThrArg: 3.067 ± 0.054	3.061ThrSer: 3.061 ± 0.065	3.064ThrThr: 3.064 ± 0.076	4.276ThrVal: 4.276 ± 0.088	0.747ThrTrp: 0.747 ± 0.029	1.573ThrTyr: 1.573 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	8.068ValAla: 8.068 ± 0.1	0.811ValCys: 0.811 ± 0.03	3.928ValAsp: 3.928 ± 0.071	4.844ValGlu: 4.844 ± 0.072	2.645ValPhe: 2.645 ± 0.057	5.745ValGly: 5.745 ± 0.082	1.087ValHis: 1.087 ± 0.034	2.785ValIle: 2.785 ± 0.056	2.058ValLys: 2.058 ± 0.055	8.188ValLeu: 8.188 ± 0.106	1.261ValMet: 1.261 ± 0.04	2.002ValAsn: 2.002 ± 0.045	4.017ValPro: 4.017 ± 0.061	2.606ValGln: 2.606 ± 0.048	5.148ValArg: 5.148 ± 0.083	4.167ValSer: 4.167 ± 0.069	4.001ValThr: 4.001 ± 0.091	5.583ValVal: 5.583 ± 0.089	0.98ValTrp: 0.98 ± 0.036	1.602ValTyr: 1.602 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.036TrpAla: 1.036 ± 0.034	0.183TrpCys: 0.183 ± 0.015	0.695TrpAsp: 0.695 ± 0.031	0.903TrpGlu: 0.903 ± 0.03	0.647TrpPhe: 0.647 ± 0.027	1.089TrpGly: 1.089 ± 0.038	0.409TrpHis: 0.409 ± 0.02	0.652TrpIle: 0.652 ± 0.025	0.397TrpLys: 0.397 ± 0.02	2.179TrpLeu: 2.179 ± 0.057	0.346TrpMet: 0.346 ± 0.019	0.456TrpAsn: 0.456 ± 0.021	0.396TrpPro: 0.396 ± 0.019	1.187TrpGln: 1.187 ± 0.038	1.092TrpArg: 1.092 ± 0.037	0.894TrpSer: 0.894 ± 0.032	0.724TrpThr: 0.724 ± 0.039	0.955TrpVal: 0.955 ± 0.034	0.274TrpTrp: 0.274 ± 0.018	0.366TrpTyr: 0.366 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.37TyrAla: 2.37 ± 0.046	0.41TyrCys: 0.41 ± 0.018	1.604TyrAsp: 1.604 ± 0.099	1.515TyrGlu: 1.515 ± 0.048	1.122TyrPhe: 1.122 ± 0.033	2.362TyrGly: 2.362 ± 0.091	0.519TyrHis: 0.519 ± 0.023	1.169TyrIle: 1.169 ± 0.033	0.622TyrLys: 0.622 ± 0.027	3.265TyrLeu: 3.265 ± 0.062	0.341TyrMet: 0.341 ± 0.019	0.762TyrAsn: 0.762 ± 0.026	1.416TyrPro: 1.416 ± 0.039	1.106TyrGln: 1.106 ± 0.034	2.268TyrArg: 2.268 ± 0.053	1.492TyrSer: 1.492 ± 0.039	1.232TyrThr: 1.232 ± 0.052	1.638TyrVal: 1.638 ± 0.045	0.471TyrTrp: 0.471 ± 0.022	0.8TyrTyr: 0.8 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3455 proteins (1058787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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