Amino acid dipepetide frequency for Streptococcus phage phiZJ20091101-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.249AlaAla: 5.249 ± 0.951
0.315AlaCys: 0.315 ± 0.183
5.144AlaAsp: 5.144 ± 0.692
6.509AlaGlu: 6.509 ± 0.639
3.254AlaPhe: 3.254 ± 0.63
6.404AlaGly: 6.404 ± 0.92
1.365AlaHis: 1.365 ± 0.384
5.984AlaIle: 5.984 ± 0.737
5.249AlaLys: 5.249 ± 0.699
6.299AlaLeu: 6.299 ± 1.062
2.624AlaMet: 2.624 ± 0.494
3.674AlaAsn: 3.674 ± 0.778
1.155AlaPro: 1.155 ± 0.299
3.674AlaGln: 3.674 ± 1.03
2.834AlaArg: 2.834 ± 0.581
4.409AlaSer: 4.409 ± 0.764
4.409AlaThr: 4.409 ± 0.761
4.619AlaVal: 4.619 ± 0.675
0.525AlaTrp: 0.525 ± 0.221
2.309AlaTyr: 2.309 ± 0.544
0.0AlaXaa: 0.0 ± 0.0
Cys
0.42CysAla: 0.42 ± 0.21
0.21CysCys: 0.21 ± 0.139
0.42CysAsp: 0.42 ± 0.235
0.525CysGlu: 0.525 ± 0.221
0.21CysPhe: 0.21 ± 0.157
1.05CysGly: 1.05 ± 0.388
0.105CysHis: 0.105 ± 0.102
0.42CysIle: 0.42 ± 0.213
0.42CysLys: 0.42 ± 0.199
0.735CysLeu: 0.735 ± 0.274
0.0CysMet: 0.0 ± 0.0
0.21CysAsn: 0.21 ± 0.15
0.42CysPro: 0.42 ± 0.186
0.315CysGln: 0.315 ± 0.221
0.42CysArg: 0.42 ± 0.274
0.84CysSer: 0.84 ± 0.263
0.21CysThr: 0.21 ± 0.126
0.42CysVal: 0.42 ± 0.238
0.0CysTrp: 0.0 ± 0.0
0.21CysTyr: 0.21 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
4.829AspAla: 4.829 ± 0.735
0.735AspCys: 0.735 ± 0.28
3.989AspAsp: 3.989 ± 0.636
3.569AspGlu: 3.569 ± 0.688
4.304AspPhe: 4.304 ± 0.739
4.199AspGly: 4.199 ± 0.678
1.26AspHis: 1.26 ± 0.317
4.724AspIle: 4.724 ± 0.748
4.304AspLys: 4.304 ± 0.673
5.564AspLeu: 5.564 ± 0.875
1.26AspMet: 1.26 ± 0.336
3.779AspAsn: 3.779 ± 0.633
1.68AspPro: 1.68 ± 0.35
1.785AspGln: 1.785 ± 0.554
2.939AspArg: 2.939 ± 0.602
3.464AspSer: 3.464 ± 0.509
3.989AspThr: 3.989 ± 0.547
3.569AspVal: 3.569 ± 0.641
0.945AspTrp: 0.945 ± 0.338
3.569AspTyr: 3.569 ± 0.608
0.0AspXaa: 0.0 ± 0.0
Glu
6.089GluAla: 6.089 ± 0.83
0.315GluCys: 0.315 ± 0.16
3.254GluAsp: 3.254 ± 0.614
6.299GluGlu: 6.299 ± 0.874
2.204GluPhe: 2.204 ± 0.46
3.149GluGly: 3.149 ± 0.595
1.575GluHis: 1.575 ± 0.347
5.249GluIle: 5.249 ± 0.885
5.879GluLys: 5.879 ± 0.915
7.453GluLeu: 7.453 ± 1.045
2.939GluMet: 2.939 ± 0.565
3.884GluAsn: 3.884 ± 0.493
1.365GluPro: 1.365 ± 0.409
3.254GluGln: 3.254 ± 0.609
3.044GluArg: 3.044 ± 0.46
4.619GluSer: 4.619 ± 0.6
2.309GluThr: 2.309 ± 0.48
4.514GluVal: 4.514 ± 0.79
0.42GluTrp: 0.42 ± 0.181
2.414GluTyr: 2.414 ± 0.592
0.0GluXaa: 0.0 ± 0.0
Phe
3.254PheAla: 3.254 ± 0.658
0.42PheCys: 0.42 ± 0.208
3.044PheAsp: 3.044 ± 0.501
4.304PheGlu: 4.304 ± 0.943
1.785PhePhe: 1.785 ± 0.384
2.1PheGly: 2.1 ± 0.547
0.315PheHis: 0.315 ± 0.17
2.309PheIle: 2.309 ± 0.406
2.624PheLys: 2.624 ± 0.388
3.149PheLeu: 3.149 ± 0.471
0.735PheMet: 0.735 ± 0.239
1.89PheAsn: 1.89 ± 0.463
1.575PhePro: 1.575 ± 0.446
1.575PheGln: 1.575 ± 0.59
1.575PheArg: 1.575 ± 0.416
1.68PheSer: 1.68 ± 0.486
2.729PheThr: 2.729 ± 0.567
2.414PheVal: 2.414 ± 0.48
0.63PheTrp: 0.63 ± 0.414
1.365PheTyr: 1.365 ± 0.385
0.0PheXaa: 0.0 ± 0.0
Gly
3.884GlyAla: 3.884 ± 0.625
0.315GlyCys: 0.315 ± 0.154
2.939GlyAsp: 2.939 ± 0.466
3.044GlyGlu: 3.044 ± 0.483
3.149GlyPhe: 3.149 ± 0.512
2.939GlyGly: 2.939 ± 0.641
1.575GlyHis: 1.575 ± 0.514
4.934GlyIle: 4.934 ± 0.745
4.829GlyLys: 4.829 ± 0.75
6.823GlyLeu: 6.823 ± 0.965
1.995GlyMet: 1.995 ± 0.461
1.89GlyAsn: 1.89 ± 0.423
0.735GlyPro: 0.735 ± 0.246
3.779GlyGln: 3.779 ± 0.52
3.359GlyArg: 3.359 ± 0.616
3.464GlySer: 3.464 ± 0.576
3.149GlyThr: 3.149 ± 0.53
3.884GlyVal: 3.884 ± 0.577
0.525GlyTrp: 0.525 ± 0.222
2.309GlyTyr: 2.309 ± 0.382
0.0GlyXaa: 0.0 ± 0.0
His
1.365HisAla: 1.365 ± 0.333
0.315HisCys: 0.315 ± 0.186
1.47HisAsp: 1.47 ± 0.417
1.155HisGlu: 1.155 ± 0.339
1.155HisPhe: 1.155 ± 0.395
0.735HisGly: 0.735 ± 0.277
0.315HisHis: 0.315 ± 0.172
1.155HisIle: 1.155 ± 0.376
1.575HisLys: 1.575 ± 0.29
1.47HisLeu: 1.47 ± 0.471
0.525HisMet: 0.525 ± 0.21
0.945HisAsn: 0.945 ± 0.228
1.05HisPro: 1.05 ± 0.333
1.155HisGln: 1.155 ± 0.381
0.945HisArg: 0.945 ± 0.313
1.26HisSer: 1.26 ± 0.341
0.735HisThr: 0.735 ± 0.271
0.735HisVal: 0.735 ± 0.237
0.0HisTrp: 0.0 ± 0.0
0.84HisTyr: 0.84 ± 0.343
0.0HisXaa: 0.0 ± 0.0
Ile
5.144IleAla: 5.144 ± 0.748
0.63IleCys: 0.63 ± 0.265
5.144IleAsp: 5.144 ± 0.603
4.199IleGlu: 4.199 ± 0.642
3.149IlePhe: 3.149 ± 0.733
3.569IleGly: 3.569 ± 0.599
1.26IleHis: 1.26 ± 0.311
3.149IleIle: 3.149 ± 0.567
5.669IleLys: 5.669 ± 0.799
6.509IleLeu: 6.509 ± 0.754
1.155IleMet: 1.155 ± 0.359
1.785IleAsn: 1.785 ± 0.431
1.89IlePro: 1.89 ± 0.406
3.569IleGln: 3.569 ± 0.625
3.149IleArg: 3.149 ± 0.652
4.934IleSer: 4.934 ± 0.686
3.569IleThr: 3.569 ± 0.558
4.409IleVal: 4.409 ± 0.883
0.84IleTrp: 0.84 ± 0.288
3.254IleTyr: 3.254 ± 0.806
0.0IleXaa: 0.0 ± 0.0
Lys
5.459LysAla: 5.459 ± 0.735
0.735LysCys: 0.735 ± 0.292
4.094LysAsp: 4.094 ± 0.711
6.613LysGlu: 6.613 ± 1.06
1.995LysPhe: 1.995 ± 0.476
3.569LysGly: 3.569 ± 0.695
1.26LysHis: 1.26 ± 0.475
6.613LysIle: 6.613 ± 0.709
8.818LysLys: 8.818 ± 1.08
4.829LysLeu: 4.829 ± 0.537
1.89LysMet: 1.89 ± 0.431
4.304LysAsn: 4.304 ± 0.677
1.26LysPro: 1.26 ± 0.307
4.304LysGln: 4.304 ± 0.688
3.674LysArg: 3.674 ± 0.721
4.094LysSer: 4.094 ± 0.545
4.829LysThr: 4.829 ± 0.794
5.774LysVal: 5.774 ± 0.871
1.26LysTrp: 1.26 ± 0.373
3.254LysTyr: 3.254 ± 0.687
0.0LysXaa: 0.0 ± 0.0
Leu
8.503LeuAla: 8.503 ± 1.039
0.84LeuCys: 0.84 ± 0.284
4.514LeuAsp: 4.514 ± 0.691
7.138LeuGlu: 7.138 ± 0.778
3.569LeuPhe: 3.569 ± 0.634
5.354LeuGly: 5.354 ± 0.839
1.155LeuHis: 1.155 ± 0.422
5.354LeuIle: 5.354 ± 0.697
7.243LeuLys: 7.243 ± 1.08
10.288LeuLeu: 10.288 ± 1.529
1.995LeuMet: 1.995 ± 0.4
4.829LeuAsn: 4.829 ± 0.904
3.674LeuPro: 3.674 ± 0.666
3.569LeuGln: 3.569 ± 0.654
3.989LeuArg: 3.989 ± 0.785
6.299LeuSer: 6.299 ± 0.747
4.934LeuThr: 4.934 ± 0.747
7.663LeuVal: 7.663 ± 1.123
0.315LeuTrp: 0.315 ± 0.166
2.204LeuTyr: 2.204 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
2.624MetAla: 2.624 ± 0.471
0.105MetCys: 0.105 ± 0.108
1.47MetAsp: 1.47 ± 0.38
1.89MetGlu: 1.89 ± 0.381
0.315MetPhe: 0.315 ± 0.228
0.945MetGly: 0.945 ± 0.289
0.42MetHis: 0.42 ± 0.217
1.995MetIle: 1.995 ± 0.441
2.204MetLys: 2.204 ± 0.42
1.995MetLeu: 1.995 ± 0.373
0.84MetMet: 0.84 ± 0.274
1.05MetAsn: 1.05 ± 0.324
0.63MetPro: 0.63 ± 0.219
0.84MetGln: 0.84 ± 0.257
0.735MetArg: 0.735 ± 0.279
1.68MetSer: 1.68 ± 0.558
2.414MetThr: 2.414 ± 0.502
1.575MetVal: 1.575 ± 0.36
0.21MetTrp: 0.21 ± 0.149
0.84MetTyr: 0.84 ± 0.385
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.696
0.315AsnCys: 0.315 ± 0.146
3.674AsnAsp: 3.674 ± 0.721
1.995AsnGlu: 1.995 ± 0.442
1.68AsnPhe: 1.68 ± 0.524
3.359AsnGly: 3.359 ± 0.535
1.05AsnHis: 1.05 ± 0.516
3.149AsnIle: 3.149 ± 0.656
3.044AsnLys: 3.044 ± 0.608
4.514AsnLeu: 4.514 ± 0.738
0.945AsnMet: 0.945 ± 0.433
3.044AsnAsn: 3.044 ± 0.661
3.464AsnPro: 3.464 ± 0.706
3.779AsnGln: 3.779 ± 0.531
2.519AsnArg: 2.519 ± 0.542
2.309AsnSer: 2.309 ± 0.543
1.89AsnThr: 1.89 ± 0.512
2.309AsnVal: 2.309 ± 0.458
0.315AsnTrp: 0.315 ± 0.19
2.204AsnTyr: 2.204 ± 0.503
0.0AsnXaa: 0.0 ± 0.0
Pro
2.204ProAla: 2.204 ± 0.58
0.21ProCys: 0.21 ± 0.16
2.519ProAsp: 2.519 ± 0.529
2.204ProGlu: 2.204 ± 0.504
1.26ProPhe: 1.26 ± 0.307
1.785ProGly: 1.785 ± 0.589
0.735ProHis: 0.735 ± 0.197
1.365ProIle: 1.365 ± 0.279
2.414ProLys: 2.414 ± 0.522
2.414ProLeu: 2.414 ± 0.441
0.84ProMet: 0.84 ± 0.314
2.519ProAsn: 2.519 ± 0.53
0.21ProPro: 0.21 ± 0.144
0.945ProGln: 0.945 ± 0.321
1.05ProArg: 1.05 ± 0.344
2.1ProSer: 2.1 ± 0.414
1.995ProThr: 1.995 ± 0.454
1.785ProVal: 1.785 ± 0.365
0.21ProTrp: 0.21 ± 0.121
0.735ProTyr: 0.735 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
5.249GlnAla: 5.249 ± 1.021
0.0GlnCys: 0.0 ± 0.0
4.094GlnAsp: 4.094 ± 0.538
2.939GlnGlu: 2.939 ± 0.567
1.785GlnPhe: 1.785 ± 0.3
1.47GlnGly: 1.47 ± 0.411
1.365GlnHis: 1.365 ± 0.355
2.414GlnIle: 2.414 ± 0.592
3.569GlnLys: 3.569 ± 0.548
5.564GlnLeu: 5.564 ± 0.837
0.63GlnMet: 0.63 ± 0.271
2.1GlnAsn: 2.1 ± 0.456
0.945GlnPro: 0.945 ± 0.369
1.47GlnGln: 1.47 ± 0.463
1.995GlnArg: 1.995 ± 0.533
2.624GlnSer: 2.624 ± 0.578
2.414GlnThr: 2.414 ± 0.467
3.464GlnVal: 3.464 ± 0.652
0.42GlnTrp: 0.42 ± 0.201
1.575GlnTyr: 1.575 ± 0.432
0.0GlnXaa: 0.0 ± 0.0
Arg
3.149ArgAla: 3.149 ± 0.613
0.315ArgCys: 0.315 ± 0.204
3.359ArgAsp: 3.359 ± 0.678
3.149ArgGlu: 3.149 ± 0.654
1.575ArgPhe: 1.575 ± 0.373
2.729ArgGly: 2.729 ± 0.504
0.735ArgHis: 0.735 ± 0.222
3.779ArgIle: 3.779 ± 0.604
3.884ArgLys: 3.884 ± 0.714
4.514ArgLeu: 4.514 ± 0.985
1.26ArgMet: 1.26 ± 0.341
2.414ArgAsn: 2.414 ± 0.573
1.47ArgPro: 1.47 ± 0.416
1.155ArgGln: 1.155 ± 0.302
2.834ArgArg: 2.834 ± 0.687
1.89ArgSer: 1.89 ± 0.42
2.519ArgThr: 2.519 ± 0.54
1.89ArgVal: 1.89 ± 0.38
0.42ArgTrp: 0.42 ± 0.197
2.414ArgTyr: 2.414 ± 0.37
0.0ArgXaa: 0.0 ± 0.0
Ser
3.254SerAla: 3.254 ± 0.642
0.42SerCys: 0.42 ± 0.192
3.464SerAsp: 3.464 ± 0.467
2.729SerGlu: 2.729 ± 0.438
2.1SerPhe: 2.1 ± 0.565
4.619SerGly: 4.619 ± 0.727
0.42SerHis: 0.42 ± 0.188
4.199SerIle: 4.199 ± 0.66
4.514SerLys: 4.514 ± 0.602
6.509SerLeu: 6.509 ± 0.997
1.995SerMet: 1.995 ± 0.486
3.779SerAsn: 3.779 ± 0.617
1.995SerPro: 1.995 ± 0.408
3.464SerGln: 3.464 ± 0.632
2.624SerArg: 2.624 ± 0.516
3.779SerSer: 3.779 ± 0.79
3.989SerThr: 3.989 ± 0.995
4.514SerVal: 4.514 ± 0.73
0.63SerTrp: 0.63 ± 0.278
1.89SerTyr: 1.89 ± 0.44
0.0SerXaa: 0.0 ± 0.0
Thr
5.249ThrAla: 5.249 ± 0.549
0.105ThrCys: 0.105 ± 0.111
2.519ThrAsp: 2.519 ± 0.427
3.674ThrGlu: 3.674 ± 0.821
1.785ThrPhe: 1.785 ± 0.363
5.144ThrGly: 5.144 ± 0.729
1.47ThrHis: 1.47 ± 0.505
3.464ThrIle: 3.464 ± 0.575
4.514ThrLys: 4.514 ± 0.684
4.094ThrLeu: 4.094 ± 0.596
0.945ThrMet: 0.945 ± 0.334
1.68ThrAsn: 1.68 ± 0.466
2.519ThrPro: 2.519 ± 0.484
2.414ThrGln: 2.414 ± 0.587
2.414ThrArg: 2.414 ± 0.521
4.199ThrSer: 4.199 ± 0.845
3.779ThrThr: 3.779 ± 0.692
3.674ThrVal: 3.674 ± 0.698
0.42ThrTrp: 0.42 ± 0.226
2.519ThrTyr: 2.519 ± 0.525
0.0ThrXaa: 0.0 ± 0.0
Val
4.619ValAla: 4.619 ± 0.63
0.735ValCys: 0.735 ± 0.276
5.144ValAsp: 5.144 ± 0.828
4.724ValGlu: 4.724 ± 0.655
2.1ValPhe: 2.1 ± 0.492
3.884ValGly: 3.884 ± 0.704
1.26ValHis: 1.26 ± 0.365
4.199ValIle: 4.199 ± 0.589
5.564ValLys: 5.564 ± 0.785
6.194ValLeu: 6.194 ± 1.061
1.26ValMet: 1.26 ± 0.38
3.149ValAsn: 3.149 ± 0.562
2.309ValPro: 2.309 ± 0.356
2.1ValGln: 2.1 ± 0.535
2.519ValArg: 2.519 ± 0.63
4.199ValSer: 4.199 ± 0.72
3.779ValThr: 3.779 ± 0.739
4.514ValVal: 4.514 ± 0.749
0.525ValTrp: 0.525 ± 0.215
2.309ValTyr: 2.309 ± 0.457
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.192
0.21TrpCys: 0.21 ± 0.135
0.42TrpAsp: 0.42 ± 0.165
1.155TrpGlu: 1.155 ± 0.329
0.315TrpPhe: 0.315 ± 0.193
0.63TrpGly: 0.63 ± 0.274
0.21TrpHis: 0.21 ± 0.159
0.525TrpIle: 0.525 ± 0.238
0.63TrpLys: 0.63 ± 0.212
0.84TrpLeu: 0.84 ± 0.306
0.315TrpMet: 0.315 ± 0.163
0.21TrpAsn: 0.21 ± 0.154
0.0TrpPro: 0.0 ± 0.0
0.525TrpGln: 0.525 ± 0.264
0.63TrpArg: 0.63 ± 0.227
0.315TrpSer: 0.315 ± 0.166
0.735TrpThr: 0.735 ± 0.269
0.63TrpVal: 0.63 ± 0.27
0.0TrpTrp: 0.0 ± 0.0
0.42TrpTyr: 0.42 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.204TyrAla: 2.204 ± 0.477
0.315TyrCys: 0.315 ± 0.186
3.779TyrAsp: 3.779 ± 0.558
2.414TyrGlu: 2.414 ± 0.387
1.785TyrPhe: 1.785 ± 0.318
1.89TyrGly: 1.89 ± 0.528
1.05TyrHis: 1.05 ± 0.49
1.995TyrIle: 1.995 ± 0.64
1.785TyrLys: 1.785 ± 0.524
3.674TyrLeu: 3.674 ± 0.572
0.525TyrMet: 0.525 ± 0.199
1.26TyrAsn: 1.26 ± 0.436
1.155TyrPro: 1.155 ± 0.297
2.414TyrGln: 2.414 ± 0.522
2.204TyrArg: 2.204 ± 0.475
2.729TyrSer: 2.729 ± 0.501
2.204TyrThr: 2.204 ± 0.56
2.729TyrVal: 2.729 ± 0.572
0.525TyrTrp: 0.525 ± 0.215
2.309TyrTyr: 2.309 ± 0.471
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (9527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski