Amino acid dipepetide frequency for Avrilella dinanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.57AlaAla: 3.57 ± 0.101	0.597AlaCys: 0.597 ± 0.035	3.707AlaAsp: 3.707 ± 0.088	4.676AlaGlu: 4.676 ± 0.116	3.123AlaPhe: 3.123 ± 0.066	4.278AlaGly: 4.278 ± 0.091	1.076AlaHis: 1.076 ± 0.037	4.977AlaIle: 4.977 ± 0.101	4.561AlaLys: 4.561 ± 0.085	5.913AlaLeu: 5.913 ± 0.099	1.527AlaMet: 1.527 ± 0.054	3.131AlaAsn: 3.131 ± 0.068	1.676AlaPro: 1.676 ± 0.056	2.781AlaGln: 2.781 ± 0.072	2.197AlaArg: 2.197 ± 0.062	3.384AlaSer: 3.384 ± 0.068	3.537AlaThr: 3.537 ± 0.086	4.62AlaVal: 4.62 ± 0.097	0.527AlaTrp: 0.527 ± 0.032	2.613AlaTyr: 2.613 ± 0.072	0.001AlaXaa: 0.001 ± 0.001
Cys	0.429CysAla: 0.429 ± 0.026	0.097CysCys: 0.097 ± 0.013	0.434CysAsp: 0.434 ± 0.026	0.521CysGlu: 0.521 ± 0.03	0.394CysPhe: 0.394 ± 0.024	0.636CysGly: 0.636 ± 0.036	0.153CysHis: 0.153 ± 0.018	0.514CysIle: 0.514 ± 0.027	0.417CysLys: 0.417 ± 0.025	0.601CysLeu: 0.601 ± 0.029	0.156CysMet: 0.156 ± 0.015	0.374CysAsn: 0.374 ± 0.024	0.327CysPro: 0.327 ± 0.028	0.244CysGln: 0.244 ± 0.019	0.237CysArg: 0.237 ± 0.018	0.479CysSer: 0.479 ± 0.03	0.416CysThr: 0.416 ± 0.025	0.477CysVal: 0.477 ± 0.026	0.067CysTrp: 0.067 ± 0.009	0.291CysTyr: 0.291 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.411AspAla: 3.411 ± 0.073	0.466AspCys: 0.466 ± 0.032	2.983AspAsp: 2.983 ± 0.069	4.408AspGlu: 4.408 ± 0.098	3.833AspPhe: 3.833 ± 0.079	3.476AspGly: 3.476 ± 0.103	0.777AspHis: 0.777 ± 0.034	4.666AspIle: 4.666 ± 0.091	4.263AspLys: 4.263 ± 0.096	5.053AspLeu: 5.053 ± 0.092	1.206AspMet: 1.206 ± 0.045	3.263AspAsn: 3.263 ± 0.065	1.401AspPro: 1.401 ± 0.062	1.297AspGln: 1.297 ± 0.044	1.964AspArg: 1.964 ± 0.056	2.951AspSer: 2.951 ± 0.07	2.71AspThr: 2.71 ± 0.063	3.521AspVal: 3.521 ± 0.08	0.764AspTrp: 0.764 ± 0.034	3.101AspTyr: 3.101 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	4.09GluAla: 4.09 ± 0.09	0.324GluCys: 0.324 ± 0.024	3.584GluAsp: 3.584 ± 0.072	5.858GluGlu: 5.858 ± 0.118	2.831GluPhe: 2.831 ± 0.062	3.668GluGly: 3.668 ± 0.073	1.117GluHis: 1.117 ± 0.045	6.3GluIle: 6.3 ± 0.109	6.523GluLys: 6.523 ± 0.118	6.423GluLeu: 6.423 ± 0.112	1.824GluMet: 1.824 ± 0.047	5.413GluAsn: 5.413 ± 0.094	1.73GluPro: 1.73 ± 0.052	3.177GluGln: 3.177 ± 0.073	2.667GluArg: 2.667 ± 0.068	3.567GluSer: 3.567 ± 0.078	3.796GluThr: 3.796 ± 0.079	4.393GluVal: 4.393 ± 0.093	0.707GluTrp: 0.707 ± 0.034	2.718GluTyr: 2.718 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.223PheAla: 3.223 ± 0.073	0.453PheCys: 0.453 ± 0.027	3.493PheAsp: 3.493 ± 0.068	3.467PheGlu: 3.467 ± 0.068	2.791PhePhe: 2.791 ± 0.082	3.726PheGly: 3.726 ± 0.083	0.896PheHis: 0.896 ± 0.04	3.771PheIle: 3.771 ± 0.086	3.018PheLys: 3.018 ± 0.074	4.63PheLeu: 4.63 ± 0.109	1.153PheMet: 1.153 ± 0.04	2.801PheAsn: 2.801 ± 0.07	1.739PhePro: 1.739 ± 0.047	1.606PheGln: 1.606 ± 0.047	1.863PheArg: 1.863 ± 0.05	3.94PheSer: 3.94 ± 0.08	2.924PheThr: 2.924 ± 0.065	3.584PheVal: 3.584 ± 0.07	0.599PheTrp: 0.599 ± 0.031	2.208PheTyr: 2.208 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	3.98GlyAla: 3.98 ± 0.099	0.571GlyCys: 0.571 ± 0.034	2.977GlyAsp: 2.977 ± 0.073	3.753GlyGlu: 3.753 ± 0.085	3.528GlyPhe: 3.528 ± 0.069	4.46GlyGly: 4.46 ± 0.112	1.113GlyHis: 1.113 ± 0.042	5.32GlyIle: 5.32 ± 0.098	4.927GlyLys: 4.927 ± 0.086	5.647GlyLeu: 5.647 ± 0.103	1.669GlyMet: 1.669 ± 0.045	3.666GlyAsn: 3.666 ± 0.084	1.141GlyPro: 1.141 ± 0.048	2.061GlyGln: 2.061 ± 0.057	2.087GlyArg: 2.087 ± 0.059	3.684GlySer: 3.684 ± 0.086	3.837GlyThr: 3.837 ± 0.099	4.291GlyVal: 4.291 ± 0.074	0.709GlyTrp: 0.709 ± 0.034	2.85GlyTyr: 2.85 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	0.947HisAla: 0.947 ± 0.036	0.169HisCys: 0.169 ± 0.015	0.866HisAsp: 0.866 ± 0.038	1.037HisGlu: 1.037 ± 0.041	1.233HisPhe: 1.233 ± 0.043	1.011HisGly: 1.011 ± 0.04	0.519HisHis: 0.519 ± 0.031	1.65HisIle: 1.65 ± 0.056	1.16HisLys: 1.16 ± 0.04	1.814HisLeu: 1.814 ± 0.056	0.303HisMet: 0.303 ± 0.023	0.936HisAsn: 0.936 ± 0.037	0.726HisPro: 0.726 ± 0.033	0.974HisGln: 0.974 ± 0.035	0.77HisArg: 0.77 ± 0.033	1.1HisSer: 1.1 ± 0.048	1.017HisThr: 1.017 ± 0.039	0.871HisVal: 0.871 ± 0.037	0.207HisTrp: 0.207 ± 0.018	0.861HisTyr: 0.861 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.497IleAla: 5.497 ± 0.11	0.624IleCys: 0.624 ± 0.031	5.147IleAsp: 5.147 ± 0.081	5.82IleGlu: 5.82 ± 0.11	3.761IlePhe: 3.761 ± 0.094	5.091IleGly: 5.091 ± 0.093	1.424IleHis: 1.424 ± 0.051	6.205IleIle: 6.205 ± 0.115	5.36IleLys: 5.36 ± 0.1	7.053IleLeu: 7.053 ± 0.118	1.457IleMet: 1.457 ± 0.049	4.813IleAsn: 4.813 ± 0.081	3.236IlePro: 3.236 ± 0.064	3.016IleGln: 3.016 ± 0.067	2.933IleArg: 2.933 ± 0.072	5.484IleSer: 5.484 ± 0.096	4.851IleThr: 4.851 ± 0.092	4.854IleVal: 4.854 ± 0.093	0.679IleTrp: 0.679 ± 0.028	2.997IleTyr: 2.997 ± 0.074	0.001IleXaa: 0.001 ± 0.001
Lys	4.594LysAla: 4.594 ± 0.099	0.281LysCys: 0.281 ± 0.021	4.016LysAsp: 4.016 ± 0.085	5.853LysGlu: 5.853 ± 0.121	2.788LysPhe: 2.788 ± 0.065	3.887LysGly: 3.887 ± 0.092	1.281LysHis: 1.281 ± 0.046	6.368LysIle: 6.368 ± 0.109	6.624LysLys: 6.624 ± 0.127	6.0LysLeu: 6.0 ± 0.094	2.12LysMet: 2.12 ± 0.053	5.28LysAsn: 5.28 ± 0.099	2.293LysPro: 2.293 ± 0.064	3.038LysGln: 3.038 ± 0.078	2.727LysArg: 2.727 ± 0.063	4.436LysSer: 4.436 ± 0.091	4.466LysThr: 4.466 ± 0.086	4.491LysVal: 4.491 ± 0.09	0.771LysTrp: 0.771 ± 0.031	3.127LysTyr: 3.127 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.787LeuAla: 5.787 ± 0.103	0.681LeuCys: 0.681 ± 0.03	4.717LeuAsp: 4.717 ± 0.089	5.641LeuGlu: 5.641 ± 0.091	4.927LeuPhe: 4.927 ± 0.111	5.568LeuGly: 5.568 ± 0.099	1.691LeuHis: 1.691 ± 0.065	7.108LeuIle: 7.108 ± 0.123	6.745LeuLys: 6.745 ± 0.116	8.545LeuLeu: 8.545 ± 0.151	2.226LeuMet: 2.226 ± 0.06	5.391LeuAsn: 5.391 ± 0.099	3.571LeuPro: 3.571 ± 0.079	3.543LeuGln: 3.543 ± 0.076	3.171LeuArg: 3.171 ± 0.073	6.998LeuSer: 6.998 ± 0.114	5.183LeuThr: 5.183 ± 0.082	5.131LeuVal: 5.131 ± 0.099	0.773LeuTrp: 0.773 ± 0.038	3.371LeuTyr: 3.371 ± 0.086	0.001LeuXaa: 0.001 ± 0.001
Met	1.693MetAla: 1.693 ± 0.046	0.151MetCys: 0.151 ± 0.014	1.156MetAsp: 1.156 ± 0.048	1.434MetGlu: 1.434 ± 0.047	0.949MetPhe: 0.949 ± 0.039	1.396MetGly: 1.396 ± 0.053	0.38MetHis: 0.38 ± 0.026	1.731MetIle: 1.731 ± 0.054	2.306MetLys: 2.306 ± 0.058	2.081MetLeu: 2.081 ± 0.055	0.686MetMet: 0.686 ± 0.036	1.449MetAsn: 1.449 ± 0.048	0.853MetPro: 0.853 ± 0.033	0.999MetGln: 0.999 ± 0.041	0.957MetArg: 0.957 ± 0.04	1.531MetSer: 1.531 ± 0.053	1.231MetThr: 1.231 ± 0.042	1.407MetVal: 1.407 ± 0.04	0.19MetTrp: 0.19 ± 0.014	0.836MetTyr: 0.836 ± 0.032	0.001MetXaa: 0.001 ± 0.002
Asn	3.717AsnAla: 3.717 ± 0.076	0.417AsnCys: 0.417 ± 0.025	3.181AsnAsp: 3.181 ± 0.066	4.116AsnGlu: 4.116 ± 0.085	2.881AsnPhe: 2.881 ± 0.07	3.754AsnGly: 3.754 ± 0.091	1.27AsnHis: 1.27 ± 0.041	4.891AsnIle: 4.891 ± 0.081	4.248AsnLys: 4.248 ± 0.091	5.077AsnLeu: 5.077 ± 0.101	1.344AsnMet: 1.344 ± 0.046	3.836AsnAsn: 3.836 ± 0.093	3.011AsnPro: 3.011 ± 0.067	2.926AsnGln: 2.926 ± 0.069	2.306AsnArg: 2.306 ± 0.066	3.244AsnSer: 3.244 ± 0.073	3.334AsnThr: 3.334 ± 0.082	3.298AsnVal: 3.298 ± 0.07	0.671AsnTrp: 0.671 ± 0.031	2.788AsnTyr: 2.788 ± 0.073	0.001AsnXaa: 0.001 ± 0.001
Pro	2.02ProAla: 2.02 ± 0.063	0.241ProCys: 0.241 ± 0.016	2.211ProAsp: 2.211 ± 0.06	3.061ProGlu: 3.061 ± 0.068	1.8ProPhe: 1.8 ± 0.05	1.883ProGly: 1.883 ± 0.063	0.601ProHis: 0.601 ± 0.031	2.446ProIle: 2.446 ± 0.062	2.307ProLys: 2.307 ± 0.055	2.761ProLeu: 2.761 ± 0.059	0.78ProMet: 0.78 ± 0.03	2.111ProAsn: 2.111 ± 0.062	0.774ProPro: 0.774 ± 0.03	1.233ProGln: 1.233 ± 0.038	0.876ProArg: 0.876 ± 0.039	1.833ProSer: 1.833 ± 0.059	1.863ProThr: 1.863 ± 0.053	2.66ProVal: 2.66 ± 0.071	0.28ProTrp: 0.28 ± 0.022	1.399ProTyr: 1.399 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.363GlnAla: 2.363 ± 0.054	0.157GlnCys: 0.157 ± 0.015	1.744GlnAsp: 1.744 ± 0.048	2.591GlnGlu: 2.591 ± 0.059	1.739GlnPhe: 1.739 ± 0.05	1.89GlnGly: 1.89 ± 0.052	0.789GlnHis: 0.789 ± 0.035	3.254GlnIle: 3.254 ± 0.071	3.393GlnLys: 3.393 ± 0.088	3.778GlnLeu: 3.778 ± 0.077	0.95GlnMet: 0.95 ± 0.036	2.674GlnAsn: 2.674 ± 0.072	1.459GlnPro: 1.459 ± 0.051	2.097GlnGln: 2.097 ± 0.065	1.514GlnArg: 1.514 ± 0.059	2.354GlnSer: 2.354 ± 0.067	2.476GlnThr: 2.476 ± 0.056	2.187GlnVal: 2.187 ± 0.052	0.427GlnTrp: 0.427 ± 0.025	1.557GlnTyr: 1.557 ± 0.045	0.001GlnXaa: 0.001 ± 0.001
Arg	2.058ArgAla: 2.058 ± 0.053	0.181ArgCys: 0.181 ± 0.017	1.684ArgAsp: 1.684 ± 0.051	2.533ArgGlu: 2.533 ± 0.068	2.06ArgPhe: 2.06 ± 0.055	1.814ArgGly: 1.814 ± 0.046	0.683ArgHis: 0.683 ± 0.031	3.128ArgIle: 3.128 ± 0.078	3.088ArgLys: 3.088 ± 0.074	3.523ArgLeu: 3.523 ± 0.082	1.087ArgMet: 1.087 ± 0.042	2.337ArgAsn: 2.337 ± 0.058	1.106ArgPro: 1.106 ± 0.042	1.397ArgGln: 1.397 ± 0.054	1.384ArgArg: 1.384 ± 0.053	1.71ArgSer: 1.71 ± 0.057	1.827ArgThr: 1.827 ± 0.052	2.117ArgVal: 2.117 ± 0.063	0.401ArgTrp: 0.401 ± 0.026	1.61ArgTyr: 1.61 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.89SerAla: 3.89 ± 0.079	0.563SerCys: 0.563 ± 0.031	3.531SerAsp: 3.531 ± 0.078	4.298SerGlu: 4.298 ± 0.078	3.628SerPhe: 3.628 ± 0.084	4.604SerGly: 4.604 ± 0.101	1.061SerHis: 1.061 ± 0.037	4.498SerIle: 4.498 ± 0.094	4.097SerLys: 4.097 ± 0.067	5.641SerLeu: 5.641 ± 0.097	1.331SerMet: 1.331 ± 0.041	3.218SerAsn: 3.218 ± 0.078	1.891SerPro: 1.891 ± 0.048	2.237SerGln: 2.237 ± 0.052	2.116SerArg: 2.116 ± 0.06	4.02SerSer: 4.02 ± 0.105	3.276SerThr: 3.276 ± 0.074	4.33SerVal: 4.33 ± 0.087	0.64SerTrp: 0.64 ± 0.036	2.736SerTyr: 2.736 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	3.831ThrAla: 3.831 ± 0.088	0.307ThrCys: 0.307 ± 0.023	3.591ThrAsp: 3.591 ± 0.079	4.057ThrGlu: 4.057 ± 0.08	2.903ThrPhe: 2.903 ± 0.06	3.973ThrGly: 3.973 ± 0.099	1.114ThrHis: 1.114 ± 0.039	4.651ThrIle: 4.651 ± 0.091	3.574ThrLys: 3.574 ± 0.081	5.081ThrLeu: 5.081 ± 0.092	1.051ThrMet: 1.051 ± 0.039	2.984ThrAsn: 2.984 ± 0.075	2.35ThrPro: 2.35 ± 0.062	2.158ThrGln: 2.158 ± 0.059	1.654ThrArg: 1.654 ± 0.057	3.371ThrSer: 3.371 ± 0.068	3.406ThrThr: 3.406 ± 0.078	3.748ThrVal: 3.748 ± 0.091	0.454ThrTrp: 0.454 ± 0.028	2.301ThrTyr: 2.301 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	4.168ValAla: 4.168 ± 0.093	0.583ValCys: 0.583 ± 0.03	3.538ValAsp: 3.538 ± 0.069	4.348ValGlu: 4.348 ± 0.09	3.498ValPhe: 3.498 ± 0.061	3.891ValGly: 3.891 ± 0.079	1.053ValHis: 1.053 ± 0.041	4.936ValIle: 4.936 ± 0.094	4.351ValLys: 4.351 ± 0.08	5.981ValLeu: 5.981 ± 0.097	1.476ValMet: 1.476 ± 0.054	3.568ValAsn: 3.568 ± 0.068	2.16ValPro: 2.16 ± 0.064	2.078ValGln: 2.078 ± 0.055	2.198ValArg: 2.198 ± 0.056	4.353ValSer: 4.353 ± 0.083	3.51ValThr: 3.51 ± 0.088	4.47ValVal: 4.47 ± 0.1	0.599ValTrp: 0.599 ± 0.028	2.691ValTyr: 2.691 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.654TrpAla: 0.654 ± 0.034	0.087TrpCys: 0.087 ± 0.011	0.553TrpAsp: 0.553 ± 0.024	0.613TrpGlu: 0.613 ± 0.03	0.556TrpPhe: 0.556 ± 0.026	0.639TrpGly: 0.639 ± 0.037	0.201TrpHis: 0.201 ± 0.017	0.789TrpIle: 0.789 ± 0.032	0.774TrpLys: 0.774 ± 0.034	1.076TrpLeu: 1.076 ± 0.043	0.227TrpMet: 0.227 ± 0.018	0.614TrpAsn: 0.614 ± 0.033	0.143TrpPro: 0.143 ± 0.014	0.46TrpGln: 0.46 ± 0.028	0.33TrpArg: 0.33 ± 0.021	0.561TrpSer: 0.561 ± 0.031	0.53TrpThr: 0.53 ± 0.028	0.64TrpVal: 0.64 ± 0.035	0.123TrpTrp: 0.123 ± 0.014	0.451TrpTyr: 0.451 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.068	0.313TyrCys: 0.313 ± 0.022	2.398TyrAsp: 2.398 ± 0.059	2.624TyrGlu: 2.624 ± 0.069	2.66TyrPhe: 2.66 ± 0.072	2.626TyrGly: 2.626 ± 0.062	0.971TyrHis: 0.971 ± 0.04	3.097TyrIle: 3.097 ± 0.067	2.706TyrLys: 2.706 ± 0.073	4.093TyrLeu: 4.093 ± 0.093	0.84TyrMet: 0.84 ± 0.033	2.454TyrAsn: 2.454 ± 0.067	1.554TyrPro: 1.554 ± 0.053	2.071TyrGln: 2.071 ± 0.059	1.779TyrArg: 1.779 ± 0.054	2.607TyrSer: 2.607 ± 0.073	2.374TyrThr: 2.374 ± 0.07	2.358TyrVal: 2.358 ± 0.054	0.433TyrTrp: 0.433 ± 0.023	2.041TyrTyr: 2.041 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.003XaaMet: 0.003 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2179 proteins (700026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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