Amino acid dipepetide frequency for Phytohabitans rumicis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.202AlaAla: 23.202 ± 0.155
1.092AlaCys: 1.092 ± 0.019
8.458AlaAsp: 8.458 ± 0.063
7.59AlaGlu: 7.59 ± 0.07
3.534AlaPhe: 3.534 ± 0.038
14.242AlaGly: 14.242 ± 0.078
2.597AlaHis: 2.597 ± 0.03
4.621AlaIle: 4.621 ± 0.04
2.444AlaLys: 2.444 ± 0.035
14.314AlaLeu: 14.314 ± 0.103
2.519AlaMet: 2.519 ± 0.026
2.457AlaAsn: 2.457 ± 0.036
6.879AlaPro: 6.879 ± 0.053
3.849AlaGln: 3.849 ± 0.036
10.326AlaArg: 10.326 ± 0.064
6.197AlaSer: 6.197 ± 0.045
8.328AlaThr: 8.328 ± 0.061
12.817AlaVal: 12.817 ± 0.075
2.124AlaTrp: 2.124 ± 0.026
3.09AlaTyr: 3.09 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
1.088CysAla: 1.088 ± 0.02
0.138CysCys: 0.138 ± 0.007
0.48CysAsp: 0.48 ± 0.015
0.338CysGlu: 0.338 ± 0.011
0.222CysPhe: 0.222 ± 0.009
0.961CysGly: 0.961 ± 0.022
0.202CysHis: 0.202 ± 0.008
0.16CysIle: 0.16 ± 0.008
0.088CysLys: 0.088 ± 0.005
0.718CysLeu: 0.718 ± 0.015
0.13CysMet: 0.13 ± 0.007
0.133CysAsn: 0.133 ± 0.007
0.55CysPro: 0.55 ± 0.015
0.2CysGln: 0.2 ± 0.009
0.694CysArg: 0.694 ± 0.015
0.464CysSer: 0.464 ± 0.013
0.525CysThr: 0.525 ± 0.014
0.647CysVal: 0.647 ± 0.014
0.184CysTrp: 0.184 ± 0.008
0.179CysTyr: 0.179 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
7.677AspAla: 7.677 ± 0.056
0.388AspCys: 0.388 ± 0.012
3.645AspAsp: 3.645 ± 0.035
3.627AspGlu: 3.627 ± 0.04
1.587AspPhe: 1.587 ± 0.026
6.532AspGly: 6.532 ± 0.058
1.349AspHis: 1.349 ± 0.023
1.791AspIle: 1.791 ± 0.025
0.991AspLys: 0.991 ± 0.021
6.701AspLeu: 6.701 ± 0.054
0.752AspMet: 0.752 ± 0.014
1.065AspAsn: 1.065 ± 0.018
4.691AspPro: 4.691 ± 0.041
1.75AspGln: 1.75 ± 0.024
5.15AspArg: 5.15 ± 0.046
2.309AspSer: 2.309 ± 0.027
2.866AspThr: 2.866 ± 0.031
5.065AspVal: 5.065 ± 0.042
0.99AspTrp: 0.99 ± 0.017
1.171AspTyr: 1.171 ± 0.022
0.0AspXaa: 0.0 ± 0.0
Glu
6.306GluAla: 6.306 ± 0.064
0.32GluCys: 0.32 ± 0.01
2.122GluAsp: 2.122 ± 0.03
2.329GluGlu: 2.329 ± 0.036
1.422GluPhe: 1.422 ± 0.023
3.074GluGly: 3.074 ± 0.033
1.305GluHis: 1.305 ± 0.02
2.025GluIle: 2.025 ± 0.026
0.924GluLys: 0.924 ± 0.019
5.907GluLeu: 5.907 ± 0.051
0.813GluMet: 0.813 ± 0.016
0.762GluAsn: 0.762 ± 0.015
3.215GluPro: 3.215 ± 0.04
1.964GluGln: 1.964 ± 0.029
4.873GluArg: 4.873 ± 0.048
2.176GluSer: 2.176 ± 0.026
2.333GluThr: 2.333 ± 0.03
4.323GluVal: 4.323 ± 0.04
0.768GluTrp: 0.768 ± 0.015
1.133GluTyr: 1.133 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
3.91PheAla: 3.91 ± 0.037
0.264PheCys: 0.264 ± 0.009
2.061PheAsp: 2.061 ± 0.024
1.323PheGlu: 1.323 ± 0.018
0.914PhePhe: 0.914 ± 0.019
2.976PheGly: 2.976 ± 0.033
0.561PheHis: 0.561 ± 0.013
0.8PheIle: 0.8 ± 0.016
0.417PheLys: 0.417 ± 0.012
2.498PheLeu: 2.498 ± 0.029
0.363PheMet: 0.363 ± 0.01
0.628PheAsn: 0.628 ± 0.018
1.327PhePro: 1.327 ± 0.023
0.738PheGln: 0.738 ± 0.015
1.842PheArg: 1.842 ± 0.024
1.317PheSer: 1.317 ± 0.021
1.953PheThr: 1.953 ± 0.026
2.426PheVal: 2.426 ± 0.029
0.446PheTrp: 0.446 ± 0.011
0.632PheTyr: 0.632 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
11.207GlyAla: 11.207 ± 0.075
0.879GlyCys: 0.879 ± 0.017
5.181GlyAsp: 5.181 ± 0.042
4.393GlyGlu: 4.393 ± 0.041
2.811GlyPhe: 2.811 ± 0.034
8.662GlyGly: 8.662 ± 0.078
2.097GlyHis: 2.097 ± 0.028
3.331GlyIle: 3.331 ± 0.036
1.983GlyLys: 1.983 ± 0.027
9.235GlyLeu: 9.235 ± 0.067
1.818GlyMet: 1.818 ± 0.025
1.872GlyAsn: 1.872 ± 0.033
4.989GlyPro: 4.989 ± 0.047
3.008GlyGln: 3.008 ± 0.037
7.634GlyArg: 7.634 ± 0.054
4.895GlySer: 4.895 ± 0.046
6.008GlyThr: 6.008 ± 0.054
7.88GlyVal: 7.88 ± 0.053
1.96GlyTrp: 1.96 ± 0.027
2.504GlyTyr: 2.504 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.607HisAla: 2.607 ± 0.031
0.194HisCys: 0.194 ± 0.007
1.31HisAsp: 1.31 ± 0.02
1.075HisGlu: 1.075 ± 0.02
0.593HisPhe: 0.593 ± 0.015
2.09HisGly: 2.09 ± 0.025
0.645HisHis: 0.645 ± 0.017
0.636HisIle: 0.636 ± 0.014
0.278HisLys: 0.278 ± 0.01
2.378HisLeu: 2.378 ± 0.027
0.3HisMet: 0.3 ± 0.009
0.4HisAsn: 0.4 ± 0.011
1.668HisPro: 1.668 ± 0.025
0.669HisGln: 0.669 ± 0.015
2.048HisArg: 2.048 ± 0.027
0.889HisSer: 0.889 ± 0.015
1.149HisThr: 1.149 ± 0.021
1.689HisVal: 1.689 ± 0.021
0.36HisTrp: 0.36 ± 0.011
0.463HisTyr: 0.463 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
5.171IleAla: 5.171 ± 0.04
0.297IleCys: 0.297 ± 0.01
2.474IleAsp: 2.474 ± 0.026
2.014IleGlu: 2.014 ± 0.024
0.866IlePhe: 0.866 ± 0.02
3.705IleGly: 3.705 ± 0.034
0.633IleHis: 0.633 ± 0.014
0.993IleIle: 0.993 ± 0.019
0.676IleLys: 0.676 ± 0.015
2.658IleLeu: 2.658 ± 0.032
0.475IleMet: 0.475 ± 0.013
0.795IleAsn: 0.795 ± 0.017
1.801IlePro: 1.801 ± 0.024
0.826IleGln: 0.826 ± 0.017
2.544IleArg: 2.544 ± 0.03
1.703IleSer: 1.703 ± 0.025
2.215IleThr: 2.215 ± 0.031
3.067IleVal: 3.067 ± 0.034
0.467IleTrp: 0.467 ± 0.013
0.669IleTyr: 0.669 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
2.292LysAla: 2.292 ± 0.033
0.1LysCys: 0.1 ± 0.006
0.876LysAsp: 0.876 ± 0.019
0.775LysGlu: 0.775 ± 0.018
0.398LysPhe: 0.398 ± 0.012
1.256LysGly: 1.256 ± 0.023
0.361LysHis: 0.361 ± 0.011
0.757LysIle: 0.757 ± 0.018
0.465LysLys: 0.465 ± 0.017
1.81LysLeu: 1.81 ± 0.029
0.31LysMet: 0.31 ± 0.012
0.334LysAsn: 0.334 ± 0.012
1.13LysPro: 1.13 ± 0.021
0.573LysGln: 0.573 ± 0.015
1.29LysArg: 1.29 ± 0.025
0.917LysSer: 0.917 ± 0.02
1.093LysThr: 1.093 ± 0.018
1.603LysVal: 1.603 ± 0.023
0.251LysTrp: 0.251 ± 0.009
0.395LysTyr: 0.395 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
16.342LeuAla: 16.342 ± 0.11
0.777LeuCys: 0.777 ± 0.015
6.972LeuAsp: 6.972 ± 0.055
3.794LeuGlu: 3.794 ± 0.041
2.616LeuPhe: 2.616 ± 0.032
9.106LeuGly: 9.106 ± 0.06
2.116LeuHis: 2.116 ± 0.029
3.425LeuIle: 3.425 ± 0.036
1.409LeuLys: 1.409 ± 0.024
10.884LeuLeu: 10.884 ± 0.083
1.487LeuMet: 1.487 ± 0.024
1.731LeuAsn: 1.731 ± 0.023
6.38LeuPro: 6.38 ± 0.05
2.025LeuGln: 2.025 ± 0.028
8.809LeuArg: 8.809 ± 0.067
5.311LeuSer: 5.311 ± 0.048
6.65LeuThr: 6.65 ± 0.045
9.434LeuVal: 9.434 ± 0.073
1.304LeuTrp: 1.304 ± 0.021
1.849LeuTyr: 1.849 ± 0.022
0.0LeuXaa: 0.0 ± 0.0
Met
2.177MetAla: 2.177 ± 0.025
0.124MetCys: 0.124 ± 0.007
0.781MetAsp: 0.781 ± 0.018
0.611MetGlu: 0.611 ± 0.014
0.48MetPhe: 0.48 ± 0.013
1.132MetGly: 1.132 ± 0.021
0.331MetHis: 0.331 ± 0.008
0.715MetIle: 0.715 ± 0.013
0.341MetLys: 0.341 ± 0.009
1.816MetLeu: 1.816 ± 0.024
0.276MetMet: 0.276 ± 0.01
0.368MetAsn: 0.368 ± 0.012
1.108MetPro: 1.108 ± 0.019
0.432MetGln: 0.432 ± 0.013
1.534MetArg: 1.534 ± 0.021
1.178MetSer: 1.178 ± 0.018
1.443MetThr: 1.443 ± 0.02
1.37MetVal: 1.37 ± 0.02
0.252MetTrp: 0.252 ± 0.009
0.319MetTyr: 0.319 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.406AsnAla: 2.406 ± 0.032
0.164AsnCys: 0.164 ± 0.007
1.041AsnAsp: 1.041 ± 0.019
0.801AsnGlu: 0.801 ± 0.016
0.544AsnPhe: 0.544 ± 0.015
2.126AsnGly: 2.126 ± 0.036
0.426AsnHis: 0.426 ± 0.012
0.627AsnIle: 0.627 ± 0.013
0.345AsnLys: 0.345 ± 0.013
1.89AsnLeu: 1.89 ± 0.026
0.282AsnMet: 0.282 ± 0.009
0.543AsnAsn: 0.543 ± 0.018
1.54AsnPro: 1.54 ± 0.026
0.62AsnGln: 0.62 ± 0.018
1.372AsnArg: 1.372 ± 0.023
0.966AsnSer: 0.966 ± 0.022
1.188AsnThr: 1.188 ± 0.025
1.543AsnVal: 1.543 ± 0.022
0.348AsnTrp: 0.348 ± 0.013
0.469AsnTyr: 0.469 ± 0.012
0.0AsnXaa: 0.0 ± 0.0
Pro
9.384ProAla: 9.384 ± 0.059
0.367ProCys: 0.367 ± 0.012
4.777ProAsp: 4.777 ± 0.042
3.308ProGlu: 3.308 ± 0.034
1.535ProPhe: 1.535 ± 0.022
6.176ProGly: 6.176 ± 0.055
1.212ProHis: 1.212 ± 0.021
1.811ProIle: 1.811 ± 0.025
0.928ProLys: 0.928 ± 0.018
5.111ProLeu: 5.111 ± 0.042
1.109ProMet: 1.109 ± 0.019
1.132ProAsn: 1.132 ± 0.019
4.322ProPro: 4.322 ± 0.062
1.552ProGln: 1.552 ± 0.021
4.068ProArg: 4.068 ± 0.043
3.349ProSer: 3.349 ± 0.036
3.865ProThr: 3.865 ± 0.04
5.394ProVal: 5.394 ± 0.048
0.974ProTrp: 0.974 ± 0.018
1.408ProTyr: 1.408 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.841GlnAla: 3.841 ± 0.043
0.171GlnCys: 0.171 ± 0.008
1.205GlnAsp: 1.205 ± 0.02
1.175GlnGlu: 1.175 ± 0.022
0.773GlnPhe: 0.773 ± 0.014
1.907GlnGly: 1.907 ± 0.027
0.638GlnHis: 0.638 ± 0.018
1.221GlnIle: 1.221 ± 0.019
0.481GlnLys: 0.481 ± 0.014
3.12GlnLeu: 3.12 ± 0.035
0.518GlnMet: 0.518 ± 0.012
0.495GlnAsn: 0.495 ± 0.014
1.953GlnPro: 1.953 ± 0.027
1.173GlnGln: 1.173 ± 0.026
2.71GlnArg: 2.71 ± 0.027
1.25GlnSer: 1.25 ± 0.02
1.56GlnThr: 1.56 ± 0.021
2.715GlnVal: 2.715 ± 0.03
0.567GlnTrp: 0.567 ± 0.015
0.642GlnTyr: 0.642 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
10.232ArgAla: 10.232 ± 0.074
0.737ArgCys: 0.737 ± 0.018
4.565ArgAsp: 4.565 ± 0.036
3.998ArgGlu: 3.998 ± 0.042
2.379ArgPhe: 2.379 ± 0.03
5.781ArgGly: 5.781 ± 0.045
2.138ArgHis: 2.138 ± 0.03
3.133ArgIle: 3.133 ± 0.031
1.29ArgLys: 1.29 ± 0.022
9.236ArgLeu: 9.236 ± 0.068
1.759ArgMet: 1.759 ± 0.024
1.401ArgAsn: 1.401 ± 0.021
5.178ArgPro: 5.178 ± 0.046
2.597ArgGln: 2.597 ± 0.032
8.605ArgArg: 8.605 ± 0.071
4.173ArgSer: 4.173 ± 0.045
5.02ArgThr: 5.02 ± 0.04
6.461ArgVal: 6.461 ± 0.046
1.747ArgTrp: 1.747 ± 0.022
2.102ArgTyr: 2.102 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
6.533SerAla: 6.533 ± 0.052
0.486SerCys: 0.486 ± 0.014
2.453SerAsp: 2.453 ± 0.03
1.865SerGlu: 1.865 ± 0.026
1.477SerPhe: 1.477 ± 0.021
5.64SerGly: 5.64 ± 0.046
0.922SerHis: 0.922 ± 0.016
1.709SerIle: 1.709 ± 0.025
0.81SerLys: 0.81 ± 0.017
4.407SerLeu: 4.407 ± 0.036
1.066SerMet: 1.066 ± 0.017
0.974SerAsn: 0.974 ± 0.019
3.296SerPro: 3.296 ± 0.04
1.196SerGln: 1.196 ± 0.02
3.895SerArg: 3.895 ± 0.04
2.83SerSer: 2.83 ± 0.038
3.571SerThr: 3.571 ± 0.034
4.142SerVal: 4.142 ± 0.042
1.031SerTrp: 1.031 ± 0.016
1.263SerTyr: 1.263 ± 0.019
0.0SerXaa: 0.0 ± 0.0
Thr
8.76ThrAla: 8.76 ± 0.062
0.53ThrCys: 0.53 ± 0.012
3.44ThrAsp: 3.44 ± 0.04
2.771ThrGlu: 2.771 ± 0.028
1.731ThrPhe: 1.731 ± 0.028
6.429ThrGly: 6.429 ± 0.054
1.115ThrHis: 1.115 ± 0.018
2.2ThrIle: 2.2 ± 0.03
1.058ThrLys: 1.058 ± 0.024
5.877ThrLeu: 5.877 ± 0.046
1.076ThrMet: 1.076 ± 0.019
1.294ThrAsn: 1.294 ± 0.026
4.171ThrPro: 4.171 ± 0.043
1.444ThrGln: 1.444 ± 0.025
4.21ThrArg: 4.21 ± 0.038
3.249ThrSer: 3.249 ± 0.036
4.168ThrThr: 4.168 ± 0.057
6.404ThrVal: 6.404 ± 0.054
1.077ThrTrp: 1.077 ± 0.02
1.48ThrTyr: 1.48 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
12.66ValAla: 12.66 ± 0.071
0.702ValCys: 0.702 ± 0.016
5.887ValAsp: 5.887 ± 0.049
4.529ValGlu: 4.529 ± 0.042
2.355ValPhe: 2.355 ± 0.029
7.195ValGly: 7.195 ± 0.054
1.865ValHis: 1.865 ± 0.022
3.02ValIle: 3.02 ± 0.035
1.446ValLys: 1.446 ± 0.023
9.493ValLeu: 9.493 ± 0.066
1.198ValMet: 1.198 ± 0.021
1.873ValAsn: 1.873 ± 0.025
5.292ValPro: 5.292 ± 0.046
2.097ValGln: 2.097 ± 0.028
7.206ValArg: 7.206 ± 0.053
4.324ValSer: 4.324 ± 0.037
6.01ValThr: 6.01 ± 0.054
8.574ValVal: 8.574 ± 0.074
1.16ValTrp: 1.16 ± 0.02
1.715ValTyr: 1.715 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.826TrpAla: 1.826 ± 0.027
0.191TrpCys: 0.191 ± 0.007
0.84TrpAsp: 0.84 ± 0.018
0.618TrpGlu: 0.618 ± 0.014
0.501TrpPhe: 0.501 ± 0.012
1.052TrpGly: 1.052 ± 0.019
0.435TrpHis: 0.435 ± 0.013
0.576TrpIle: 0.576 ± 0.013
0.282TrpLys: 0.282 ± 0.01
1.989TrpLeu: 1.989 ± 0.024
0.303TrpMet: 0.303 ± 0.009
0.478TrpAsn: 0.478 ± 0.014
1.039TrpPro: 1.039 ± 0.019
0.67TrpGln: 0.67 ± 0.016
1.696TrpArg: 1.696 ± 0.023
1.125TrpSer: 1.125 ± 0.022
1.21TrpThr: 1.21 ± 0.019
1.146TrpVal: 1.146 ± 0.02
0.443TrpTrp: 0.443 ± 0.013
0.432TrpTyr: 0.432 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.058TyrAla: 3.058 ± 0.032
0.18TyrCys: 0.18 ± 0.007
1.528TyrAsp: 1.528 ± 0.032
1.161TyrGlu: 1.161 ± 0.022
0.656TyrPhe: 0.656 ± 0.014
2.305TyrGly: 2.305 ± 0.031
0.493TyrHis: 0.493 ± 0.013
0.497TyrIle: 0.497 ± 0.013
0.331TyrLys: 0.331 ± 0.011
2.376TyrLeu: 2.376 ± 0.024
0.231TyrMet: 0.231 ± 0.009
0.504TyrAsn: 0.504 ± 0.016
1.253TyrPro: 1.253 ± 0.021
0.732TyrGln: 0.732 ± 0.017
2.027TyrArg: 2.027 ± 0.024
0.949TyrSer: 0.949 ± 0.018
1.331TyrThr: 1.331 ± 0.026
1.901TyrVal: 1.901 ± 0.024
0.401TyrTrp: 0.401 ± 0.011
0.511TyrTyr: 0.511 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10307 proteins (3214334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski